ES8702393A1 - Un procedimiento para preparar un derivado de 1-bencil-4- benzhidril-piperazina - Google Patents

Un procedimiento para preparar un derivado de 1-bencil-4- benzhidril-piperazina

Info

Publication number
ES8702393A1
ES8702393A1 ES541728A ES541728A ES8702393A1 ES 8702393 A1 ES8702393 A1 ES 8702393A1 ES 541728 A ES541728 A ES 541728A ES 541728 A ES541728 A ES 541728A ES 8702393 A1 ES8702393 A1 ES 8702393A1
Authority
ES
Spain
Prior art keywords
derivative
benzyl
compounds
processes
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541728A
Other languages
English (en)
Other versions
ES541728A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Publication of ES8702393A1 publication Critical patent/ES8702393A1/es
Publication of ES541728A0 publication Critical patent/ES541728A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 1-BENCIL-4-BENZHIDRIL-PIPERIZINA, DE FORMULA (I) Y DE SUS SALES DE ADICION DE ACIDO. CONSISTE EN LA REACCION DE CONDENSACION REDUCTIVA DE UN DERIVADO DE BENZALDEHIDO, DE FORMULA (II), CON UNA FLUOROBENZHIDRILPIPERAZINA, DE FORMULA (III), PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LA QUE R1 REPRESENTA HIDROGENO O METOXI Y R2 ES HIDROGENO O FLUOR. LA REACCION SE EFECTUA POR FUSION DE AMBOS REACTIVOS Y POSTERIOR CONDENSACION EN PRESENCIA DE ACIDO FORMICO A UNA TEMPERATURA COMPRENDIDA ENTRE 100JC Y 150JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES CEREBROVASCULARES.
ES541728A 1984-03-30 1985-03-29 Un procedimiento para preparar un derivado de 1-bencil-4- benzhidril-piperazina Expired ES8702393A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59064464A JPS60222472A (ja) 1984-03-30 1984-03-30 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物

Publications (2)

Publication Number Publication Date
ES8702393A1 true ES8702393A1 (es) 1987-01-01
ES541728A0 ES541728A0 (es) 1987-01-01

Family

ID=13258978

Family Applications (3)

Application Number Title Priority Date Filing Date
ES541728A Expired ES8702393A1 (es) 1984-03-30 1985-03-29 Un procedimiento para preparar un derivado de 1-bencil-4- benzhidril-piperazina
ES556980A Expired ES8801236A1 (es) 1984-03-30 1986-07-29 Un procedimiento para preparar un derivado de 1-bencil-4-benzhidrilpiperazina
ES556981A Expired ES8801237A1 (es) 1984-03-30 1986-07-29 Un procedimiento para preparar un derivado de 1-bencil-4-benzhidrilpiperazina

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES556980A Expired ES8801236A1 (es) 1984-03-30 1986-07-29 Un procedimiento para preparar un derivado de 1-bencil-4-benzhidrilpiperazina
ES556981A Expired ES8801237A1 (es) 1984-03-30 1986-07-29 Un procedimiento para preparar un derivado de 1-bencil-4-benzhidrilpiperazina

Country Status (10)

Country Link
US (1) US4663325A (es)
EP (1) EP0159566B1 (es)
JP (1) JPS60222472A (es)
AT (1) ATE31411T1 (es)
CA (1) CA1248110A (es)
DE (1) DE3561199D1 (es)
ES (3) ES8702393A1 (es)
FI (1) FI79101C (es)
GR (1) GR850787B (es)
NO (1) NO163185C (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61161272A (ja) * 1985-01-11 1986-07-21 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
JPS62277370A (ja) * 1986-02-04 1987-12-02 Terumo Corp ジエン誘導体およびこれを含有する血管拡張剤
FR2614021B1 (fr) * 1987-04-14 1991-03-01 Andre Buzas Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
AU646926B2 (en) * 1991-03-20 1994-03-10 Duphar International Research B.V. Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity
WO1995015958A1 (en) * 1993-12-08 1995-06-15 Alcon Laboratories, Inc. Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents
ES2224597T3 (es) 1998-01-29 2005-03-01 Akzo Nobel N.V. Agentes que mejoran la circulacion optica papilar.
CN1681495B (zh) 2002-08-19 2010-05-12 辉瑞产品公司 用于治疗过度增生性疾病的组合物
US7403561B2 (en) 2003-04-04 2008-07-22 Avid Technology, Inc. Fixed bit rate, intraframe compression and decompression of video
US7433519B2 (en) 2003-04-04 2008-10-07 Avid Technology, Inc. Bitstream format for compressed image data
US20060135506A1 (en) * 2003-04-22 2006-06-22 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders
US20050159403A1 (en) * 2003-04-22 2005-07-21 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of central nervous system damage
WO2004106299A2 (en) * 2003-05-30 2004-12-09 Ranbaxy Laboratories Limited Substituted pyrrole derivatives and their use as hmg-co inhibitors
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
AU2006223212A1 (en) * 2005-03-11 2006-09-21 Hong Kong Nitric Oxide Limited Combination therapy for endothelial dysfunction, angina and diabetes
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7893050B2 (en) * 2005-10-26 2011-02-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
KR101329112B1 (ko) * 2005-11-08 2013-11-14 랜박시 래보러터리스 리미티드 (3ｒ,5ｒ)-7-〔2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-〔(4-히드록시 메틸 페닐 아미노)카르보닐〕-피롤-1-일〕-3,5-디히드록시 헵탄산 헤미 칼슘염의 제조 방법
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
WO2008020314A2 (en) * 2006-03-14 2008-02-21 Ranbaxy Laboratories Limited Statin stabilizing dosage formulations
MX2009000439A (es) * 2006-07-14 2009-02-04 Ranbaxy Lab Ltd Formas polimorficas de un inhibidor de hmg-coa reductasa y usos de las mismas.
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
AU2008220104B2 (en) 2007-02-28 2012-09-27 Asahi Kasei Pharma Corporation Sulfonamide derivative
US8883844B2 (en) 2010-09-24 2014-11-11 Nitrogenix Inc. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
CN102936233B (zh) * 2012-11-16 2016-01-20 葛长乐 一种1-(二(4-氟苯基)甲基)-4-(2,3,4-三甲氧苯基)哌嗪二盐酸盐晶型
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
US10128077B2 (en) * 2015-10-20 2018-11-13 Korea Research Institute Of Standards And Science Electron microscope electron gun for facilitating position adjustment and electron microscope including same
CN109666008A (zh) * 2018-12-31 2019-04-23 辰欣药业股份有限公司 一种盐酸洛美利嗪的合成方法
CN113574055A (zh) 2019-01-18 2021-10-29 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB705979A (en) * 1951-03-22 1954-03-24 Henri Morren 1.4-aralkyl piperazines and process for the preparation thereof
FR1312427A (fr) * 1961-04-12 1962-12-21 Science Union Et Compagnie Soc Nouveaux dérivés de la pipérazine et leurs préparations
FR1303080A (fr) * 1961-07-25 1962-09-07 Science Union Et Compagnie Soc Pipérazines disubstituées
NL7306771A (es) * 1972-06-02 1973-12-04
DE2900810A1 (de) * 1979-01-11 1980-07-24 Cassella Ag Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent

Also Published As

Publication number Publication date
ES556980A0 (es) 1988-01-01
NO163185C (no) 1990-04-18
FI79101B (fi) 1989-07-31
GR850787B (es) 1985-11-25
ES8801236A1 (es) 1988-01-01
FI851217L (fi) 1985-10-01
EP0159566B1 (en) 1987-12-16
JPH0313232B2 (es) 1991-02-22
JPS60222472A (ja) 1985-11-07
DE3561199D1 (en) 1988-01-28
ES556981A0 (es) 1988-01-01
US4663325A (en) 1987-05-05
ATE31411T1 (de) 1988-01-15
NO851298L (no) 1985-10-01
CA1248110A (en) 1989-01-03
EP0159566A1 (en) 1985-10-30
ES8801237A1 (es) 1988-01-01
ES541728A0 (es) 1987-01-01
FI79101C (fi) 1989-11-10
FI851217A0 (fi) 1985-03-26

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20061014