FI851217L - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara piperazinderivat. - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara piperazinderivat.Info
- Publication number
- FI851217L FI851217L FI851217A FI851217A FI851217L FI 851217 L FI851217 L FI 851217L FI 851217 A FI851217 A FI 851217A FI 851217 A FI851217 A FI 851217A FI 851217 L FI851217 L FI 851217L
- Authority
- FI
- Finland
- Prior art keywords
- derivative
- therapeutic
- benzyl
- condensing
- addition salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59064464A JPS60222472A (ja) | 1984-03-30 | 1984-03-30 | 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物 |
JP6446484 | 1984-03-30 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI851217A0 FI851217A0 (fi) | 1985-03-26 |
FI851217L true FI851217L (fi) | 1985-10-01 |
FI79101B FI79101B (fi) | 1989-07-31 |
FI79101C FI79101C (fi) | 1989-11-10 |
Family
ID=13258978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI851217A FI79101C (fi) | 1984-03-30 | 1985-03-26 | Foerfarande foer framstaellning av ett nytt terapeutiskt anvaendbart 1-(2,3,4-trimetoxibensyl)-4-/bis(4- fluorfenyl)metyl/piperazin. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4663325A (fi) |
EP (1) | EP0159566B1 (fi) |
JP (1) | JPS60222472A (fi) |
AT (1) | ATE31411T1 (fi) |
CA (1) | CA1248110A (fi) |
DE (1) | DE3561199D1 (fi) |
ES (3) | ES8702393A1 (fi) |
FI (1) | FI79101C (fi) |
GR (1) | GR850787B (fi) |
NO (1) | NO163185C (fi) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61161272A (ja) * | 1985-01-11 | 1986-07-21 | Kanebo Ltd | 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物 |
US4792553A (en) * | 1986-02-04 | 1988-12-20 | Terumo Kabushiki Kaisha | Diene derivatives and vasodilators containing the same |
FR2614021B1 (fr) * | 1987-04-14 | 1991-03-01 | Andre Buzas | Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant |
DE4108527A1 (de) * | 1991-03-15 | 1992-09-17 | Basf Ag | Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung |
AU646926B2 (en) * | 1991-03-20 | 1994-03-10 | Duphar International Research B.V. | Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity |
DK0682664T3 (da) * | 1993-12-08 | 2001-07-16 | Alcon Lab Inc | Forbindelser med både potent calciumantagonist og antioxiderende aktivitet og anvendelse deraf som cytobeskyttende midler |
KR100585299B1 (ko) * | 1998-01-29 | 2006-06-01 | 악조 노벨 엔.브이. | 시신경유두 순환 개선제 |
ATE502635T1 (de) | 2002-08-19 | 2011-04-15 | Pfizer | Kombinationstherapie gegen hyperproliferative erkrankungen |
US7403561B2 (en) | 2003-04-04 | 2008-07-22 | Avid Technology, Inc. | Fixed bit rate, intraframe compression and decompression of video |
US7433519B2 (en) | 2003-04-04 | 2008-10-07 | Avid Technology, Inc. | Bitstream format for compressed image data |
WO2004093813A2 (en) * | 2003-04-22 | 2004-11-04 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders |
WO2004093816A2 (en) * | 2003-04-22 | 2004-11-04 | Pharmacia Corporation | Compositions comprising a selective cox-2 inhibitor and a calcium modulating agent |
AP2501A (en) * | 2003-05-30 | 2012-10-22 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives |
US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
AU2006223212A1 (en) * | 2005-03-11 | 2006-09-21 | Hong Kong Nitric Oxide Limited | Combination therapy for endothelial dysfunction, angina and diabetes |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
EP2111863B1 (en) | 2005-10-26 | 2012-03-28 | Asahi Kasei Pharma Corporation | Fasudil in combination with bosentan for the treament of pulmonary arterial hypertension |
EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
EP1948599A1 (en) * | 2005-11-08 | 2008-07-30 | Ranbaxy Laboratories Limited | Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
AR059838A1 (es) * | 2006-03-14 | 2008-04-30 | Ranbaxy Lab Ltd | Formulaciones para dosis estabilizantes de estatina |
TW200811101A (en) * | 2006-07-14 | 2008-03-01 | Ranbaxy Lab Ltd | Polymorphic forms of an HMG-CoA reductase inhibitor and uses thereof |
WO2008070496A2 (en) | 2006-12-01 | 2008-06-12 | Bristol-Myers Squibb Company | N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
AU2008220104B2 (en) | 2007-02-28 | 2012-09-27 | Asahi Kasei Pharma Corporation | Sulfonamide derivative |
US8883844B2 (en) | 2010-09-24 | 2014-11-11 | Nitrogenix Inc. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
CN102936233B (zh) * | 2012-11-16 | 2016-01-20 | 葛长乐 | 一种1-(二(4-氟苯基)甲基)-4-(2,3,4-三甲氧苯基)哌嗪二盐酸盐晶型 |
EP2986599A1 (en) | 2013-04-17 | 2016-02-24 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
WO2017069343A1 (ko) * | 2015-10-20 | 2017-04-27 | 한국표준과학연구원 | 위치조절이 용이한 전자현미경용 전자총 및 이를 포함하는 전자현미경 |
CN109666008A (zh) * | 2018-12-31 | 2019-04-23 | 辰欣药业股份有限公司 | 一种盐酸洛美利嗪的合成方法 |
US11248001B2 (en) | 2019-01-18 | 2022-02-15 | Astrazeneca Ab | PCSK9 inhibitors and methods of use thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB705979A (en) * | 1951-03-22 | 1954-03-24 | Henri Morren | 1.4-aralkyl piperazines and process for the preparation thereof |
FR1312427A (fr) * | 1961-04-12 | 1962-12-21 | Science Union Et Compagnie Soc | Nouveaux dérivés de la pipérazine et leurs préparations |
FR1303080A (fr) * | 1961-07-25 | 1962-09-07 | Science Union Et Compagnie Soc | Pipérazines disubstituées |
NL7306771A (fi) * | 1972-06-02 | 1973-12-04 | ||
DE2900810A1 (de) * | 1979-01-11 | 1980-07-24 | Cassella Ag | Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung |
GB8320701D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
-
1984
- 1984-03-30 JP JP59064464A patent/JPS60222472A/ja active Granted
-
1985
- 1985-03-25 US US06/715,813 patent/US4663325A/en not_active Expired - Lifetime
- 1985-03-26 CA CA000477468A patent/CA1248110A/en not_active Expired
- 1985-03-26 FI FI851217A patent/FI79101C/fi not_active IP Right Cessation
- 1985-03-27 AT AT85103707T patent/ATE31411T1/de not_active IP Right Cessation
- 1985-03-27 DE DE8585103707T patent/DE3561199D1/de not_active Expired
- 1985-03-27 EP EP85103707A patent/EP0159566B1/en not_active Expired
- 1985-03-28 GR GR850787A patent/GR850787B/el unknown
- 1985-03-29 NO NO851298A patent/NO163185C/no not_active IP Right Cessation
- 1985-03-29 ES ES541728A patent/ES8702393A1/es not_active Expired
-
1986
- 1986-07-29 ES ES556981A patent/ES8801237A1/es not_active Expired
- 1986-07-29 ES ES556980A patent/ES8801236A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES8801237A1 (es) | 1988-01-01 |
ES8702393A1 (es) | 1987-01-01 |
FI79101C (fi) | 1989-11-10 |
DE3561199D1 (en) | 1988-01-28 |
ES556980A0 (es) | 1988-01-01 |
FI79101B (fi) | 1989-07-31 |
GR850787B (fi) | 1985-11-25 |
ES541728A0 (es) | 1987-01-01 |
ATE31411T1 (de) | 1988-01-15 |
JPS60222472A (ja) | 1985-11-07 |
EP0159566B1 (en) | 1987-12-16 |
NO851298L (no) | 1985-10-01 |
NO163185C (no) | 1990-04-18 |
CA1248110A (en) | 1989-01-03 |
FI851217A0 (fi) | 1985-03-26 |
ES556981A0 (es) | 1988-01-01 |
EP0159566A1 (en) | 1985-10-30 |
ES8801236A1 (es) | 1988-01-01 |
JPH0313232B2 (fi) | 1991-02-22 |
US4663325A (en) | 1987-05-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Patent granted |
Owner name: AKZO NOBEL N.V. |
|
MA | Patent expired |