BR9406080A - Compostos que tem tanto antividade de anaonista potente de calcio como de antioxidante e uso dos mesmos como agentes citoprotetores - Google Patents
Compostos que tem tanto antividade de anaonista potente de calcio como de antioxidante e uso dos mesmos como agentes citoprotetoresInfo
- Publication number
- BR9406080A BR9406080A BR9406080A BR9406080A BR9406080A BR 9406080 A BR9406080 A BR 9406080A BR 9406080 A BR9406080 A BR 9406080A BR 9406080 A BR9406080 A BR 9406080A BR 9406080 A BR9406080 A BR 9406080A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- antioxidant activity
- antivity
- anaonist
- potent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16398093A | 1993-12-08 | 1993-12-08 | |
PCT/US1994/014069 WO1995015958A1 (en) | 1993-12-08 | 1994-12-07 | Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9406080A true BR9406080A (pt) | 1996-02-06 |
Family
ID=22592463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9406080A BR9406080A (pt) | 1993-12-08 | 1994-12-07 | Compostos que tem tanto antividade de anaonista potente de calcio como de antioxidante e uso dos mesmos como agentes citoprotetores |
Country Status (17)
Country | Link |
---|---|
US (1) | US5646149A (pt) |
EP (1) | EP0682664B1 (pt) |
JP (1) | JP3150155B2 (pt) |
KR (1) | KR960701033A (pt) |
CN (1) | CN1100774C (pt) |
AT (1) | ATE199716T1 (pt) |
BR (1) | BR9406080A (pt) |
CA (1) | CA2153979C (pt) |
DE (1) | DE69426871T2 (pt) |
DK (1) | DK0682664T3 (pt) |
ES (1) | ES2156934T3 (pt) |
FI (1) | FI953748A (pt) |
GR (1) | GR3035971T3 (pt) |
HK (1) | HK1011685A1 (pt) |
NO (1) | NO953093L (pt) |
PT (1) | PT682664E (pt) |
WO (1) | WO1995015958A1 (pt) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995034299A1 (en) * | 1994-06-10 | 1995-12-21 | Telor Ophthalmic Pharmaceuticals, Inc. | Inhibition of intraoperative miosis/production of mydriasis by calcium channel blockers |
US5798356A (en) * | 1995-08-07 | 1998-08-25 | Alcon Laboratories, Inc. | Angiostatic compounds |
US5719167A (en) * | 1995-08-07 | 1998-02-17 | Alcon Laboratories, Inc. | Angiostatic compounds |
EP0868186B1 (en) * | 1995-12-21 | 2005-03-02 | Alcon Laboratories, Inc. | Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia |
WO1997035852A1 (en) * | 1996-03-25 | 1997-10-02 | Alcon Laboratories, Inc. | Thiazolidine-4-carboxylic acid derivatives as cytoprotective agents |
JP3562903B2 (ja) * | 1996-05-31 | 2004-09-08 | セイコープレシジョン株式会社 | フォーカルプレーンシャッタ |
DE19718826A1 (de) * | 1997-05-05 | 1998-11-12 | Marion S Dr Eckmiller | Verwendung biologisch aktiver Wirkstoffe zum Beeinflussen des Extrazellulär-Raumes von Sinneszellen und Verfahren zur Wirkstoff-Administrationssteuerung |
US6492375B2 (en) | 1998-06-30 | 2002-12-10 | Neuromed Technologies, Inc. | Partially saturated calcium channel blockers |
US20040266784A1 (en) * | 1998-06-30 | 2004-12-30 | Snutch Terrance P. | Calcium channel inhibitors comprising benzhydril spaced from piperazine |
US6943168B2 (en) * | 1998-06-30 | 2005-09-13 | Neuromed Technologies Inc. | Calcium channel inhibitors comprising benzhydril spaced from piperazine |
US20060084660A1 (en) * | 1998-06-30 | 2006-04-20 | Neuromed Technologies Inc. | Calcium channel blockers comprising two benzhydril moieties |
US7186726B2 (en) * | 1998-06-30 | 2007-03-06 | Neuromed Pharmaceuticals Ltd. | Preferentially substituted calcium channel blockers |
WO2004089922A2 (en) * | 1998-06-30 | 2004-10-21 | Neuromed Technologies, Inc. | Calcium channel inhibitors comprising benzhydril spaced from piperazine |
US20040259866A1 (en) * | 1998-06-30 | 2004-12-23 | Snutch Terrance P. | Calcium channel blockers comprising two benzhydril moieties |
US6387897B1 (en) | 1998-06-30 | 2002-05-14 | Neuromed Technologies, Inc. | Preferentially substituted calcium channel blockers |
US6310059B1 (en) * | 1998-06-30 | 2001-10-30 | Neuromed Technologies, Inc. | Fused ring calcium channel blockers |
US6951862B2 (en) * | 1998-06-30 | 2005-10-04 | Neuromed Technologies, Inc. | Calcium channel blockers comprising two benzhydril moieties |
US6011035A (en) | 1998-06-30 | 2000-01-04 | Neuromed Technologies Inc. | Calcium channel blockers |
WO2001041756A2 (en) * | 1999-12-02 | 2001-06-14 | University Of South Florida | Method and composition for treatment of ischemic neuronal reperfusion injury |
JP2003518107A (ja) * | 1999-12-20 | 2003-06-03 | ニューロメド テクノロジーズ, インコーポレイテッド | 部分飽和カルシウムチャネルブロッカー |
US20030199523A1 (en) * | 2002-02-28 | 2003-10-23 | Snutch Terrance P. | Heterocyclic calcium in channel blockers |
MXPA05012899A (es) * | 2003-05-30 | 2006-06-23 | Neuromed Tech Inc | 3-aminometil-pirrolidinas como bloqueadores del canal de calcio tipo n. |
ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
US7470798B2 (en) * | 2003-09-19 | 2008-12-30 | Edison Pharmaceuticals, Inc. | 7,8-bicycloalkyl-chroman derivatives |
US7507760B2 (en) * | 2004-01-22 | 2009-03-24 | Neuromed Pharmaceuticals Ltd. | N-type calcium channel blockers |
CA2562371A1 (en) * | 2004-04-09 | 2005-10-20 | Neuromed Pharmaceuticals Ltd. | Diarylamine derivatives as calcium channel blockers |
US20050227999A1 (en) * | 2004-04-09 | 2005-10-13 | Neuromed Technologies Inc. | Diarylamine derivatives as calcium channel blockers |
CA2577398A1 (en) * | 2004-08-30 | 2006-03-09 | Neuromed Pharmaceuticals Ltd. | Urea derivatives as calcium channel blockers |
US7511077B2 (en) * | 2005-02-09 | 2009-03-31 | Neuromed Pharmaceuticals Ltd. | Diamine calcium channel blockers |
WO2007071035A1 (en) * | 2005-12-19 | 2007-06-28 | Neuromed Pharmaceuticals Ltd. | Heterocyclic amide derivatives as calcium channel blockers |
US20090286806A1 (en) * | 2006-04-17 | 2009-11-19 | Hassan Pajouhesh | Isoxazole derivatives as calcium channel blockers |
CA2651811A1 (en) * | 2006-05-11 | 2007-11-22 | Neuromed Pharmaceuticals Ltd. | Method for increasing the bioavailability of benzhydryl piperazine containing compounds |
CA2653497A1 (en) * | 2006-05-26 | 2007-12-06 | Neuromed Pharmaceuticals Ltd. | Heterocyclic compounds as calcium channel blockers |
WO2008031227A1 (en) * | 2006-09-14 | 2008-03-20 | Neuromed Pharmaceuticals Ltd. | Diaryl piperidine compounds as calcium channel blockers |
WO2008043183A1 (en) * | 2006-10-13 | 2008-04-17 | Neuromed Pharmaceuticals Ltd. | Cyclopropyl-piperazine compounds as calcium channel blockers |
US8409560B2 (en) | 2011-03-08 | 2013-04-02 | Zalicus Pharmaceuticals Ltd. | Solid dispersion formulations and methods of use thereof |
JP2014507424A (ja) | 2011-03-08 | 2014-03-27 | ザリカス ファーマスーティカルズ リミテッド | 固体分散物製剤およびその使用方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB705979A (en) * | 1951-03-22 | 1954-03-24 | Henri Morren | 1.4-aralkyl piperazines and process for the preparation thereof |
BE790971A (fr) * | 1971-11-09 | 1973-05-07 | Janssen Pharmaceutica Nv | Metode ter voorkoming van patologische reakties die de funktie van het komplement vereisen |
NL7306771A (pt) * | 1972-06-02 | 1973-12-04 | ||
DE2900810A1 (de) * | 1979-01-11 | 1980-07-24 | Cassella Ag | Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung |
US4550022A (en) * | 1981-10-05 | 1985-10-29 | Alcon Laboratories, Inc. | Tissue irrigating solution |
IT1213131B (it) * | 1984-02-02 | 1989-12-14 | Yason Srl | Composto ad attivita' calcio antagonista periferica, anticonvulsivante ed eumetabolica cerebrale,metodo per la sua preparazione e composizioni farmaceutiche. |
JPS60222472A (ja) * | 1984-03-30 | 1985-11-07 | Kanebo Ltd | 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物 |
WO1987005020A1 (en) * | 1986-02-21 | 1987-08-27 | Kuraray Co., Ltd. | 3,4-dihydro-2h-benzopyran derivatives and their medicinal use |
GB8626344D0 (en) * | 1986-11-04 | 1986-12-03 | Zyma Sa | Bicyclic compounds |
US5120843A (en) * | 1987-04-27 | 1992-06-09 | Upjohn | Pharmaceutically active amines |
CA1338012C (en) * | 1987-04-27 | 1996-01-30 | John Michael Mccall | Pharmaceutically active amines |
EP0487510A1 (en) * | 1987-04-27 | 1992-05-27 | The Upjohn Company | Pharmaceutically active amines |
WO1989005803A1 (en) * | 1987-12-24 | 1989-06-29 | Kuraray Co., Ltd. | 3,4-dihydro-2h-1,3-benzoxazine derivatives and their medicinal use |
US5015661A (en) * | 1988-08-09 | 1991-05-14 | Hoffmann-La Roche Inc. | Chromanes and their pharmaceutical compositions and methods |
EP0369082A1 (en) * | 1988-11-14 | 1990-05-23 | Merrell Dow Pharmaceuticals Inc. | Cardioprotective tocopherol analogs |
TW199152B (pt) * | 1990-11-01 | 1993-02-01 | Takeda Pharm Industry Co Ltd |
-
1994
- 1994-12-07 KR KR1019950703327A patent/KR960701033A/ko not_active Application Discontinuation
- 1994-12-07 AT AT95904837T patent/ATE199716T1/de not_active IP Right Cessation
- 1994-12-07 PT PT95904837T patent/PT682664E/pt unknown
- 1994-12-07 CN CN94191120A patent/CN1100774C/zh not_active Expired - Fee Related
- 1994-12-07 DE DE69426871T patent/DE69426871T2/de not_active Expired - Fee Related
- 1994-12-07 WO PCT/US1994/014069 patent/WO1995015958A1/en active IP Right Grant
- 1994-12-07 BR BR9406080A patent/BR9406080A/pt active Search and Examination
- 1994-12-07 JP JP51631295A patent/JP3150155B2/ja not_active Expired - Fee Related
- 1994-12-07 CA CA002153979A patent/CA2153979C/en not_active Expired - Fee Related
- 1994-12-07 DK DK95904837T patent/DK0682664T3/da active
- 1994-12-07 ES ES95904837T patent/ES2156934T3/es not_active Expired - Lifetime
- 1994-12-07 EP EP95904837A patent/EP0682664B1/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/472,685 patent/US5646149A/en not_active Expired - Fee Related
- 1995-08-07 FI FI953748A patent/FI953748A/fi unknown
- 1995-08-07 NO NO953093A patent/NO953093L/no not_active Application Discontinuation
-
1998
- 1998-12-07 HK HK98112876D patent/HK1011685A1/xx not_active IP Right Cessation
-
2001
- 2001-05-31 GR GR20010400822T patent/GR3035971T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5646149A (en) | 1997-07-08 |
CN1117292A (zh) | 1996-02-21 |
JPH08507546A (ja) | 1996-08-13 |
JP3150155B2 (ja) | 2001-03-26 |
KR960701033A (ko) | 1996-02-24 |
AU697050B2 (en) | 1998-09-24 |
ES2156934T3 (es) | 2001-08-01 |
DE69426871D1 (de) | 2001-04-19 |
FI953748A0 (fi) | 1995-08-07 |
EP0682664B1 (en) | 2001-03-14 |
DK0682664T3 (da) | 2001-07-16 |
CA2153979A1 (en) | 1995-06-15 |
FI953748A (fi) | 1995-08-07 |
EP0682664A1 (en) | 1995-11-22 |
NO953093L (no) | 1995-10-09 |
CN1100774C (zh) | 2003-02-05 |
CA2153979C (en) | 2003-10-21 |
DE69426871T2 (de) | 2001-06-21 |
NO953093D0 (no) | 1995-08-07 |
HK1011685A1 (en) | 1999-07-16 |
ATE199716T1 (de) | 2001-03-15 |
PT682664E (pt) | 2001-06-29 |
AU1336895A (en) | 1995-06-27 |
GR3035971T3 (en) | 2001-08-31 |
WO1995015958A1 (en) | 1995-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EG | Technical examination (opinion): publication of technical examination (opinion) | ||
FB36 | Technical and formal requirements: requirement - article 36 of industrial property law | ||
FC | Decision: refusal | ||
HKFB | Grant procedure suspended (deleted) | ||
CKFC | Appeal: appeal against refusal |