DE69426871T2 - Verbindungen die sowohl starke calcium-antagonistische und antioxydatieve aktivitaet haben und deren verwendung als zellschuetzende mittel. - Google Patents

Verbindungen die sowohl starke calcium-antagonistische und antioxydatieve aktivitaet haben und deren verwendung als zellschuetzende mittel.

Info

Publication number
DE69426871T2
DE69426871T2 DE69426871T DE69426871T DE69426871T2 DE 69426871 T2 DE69426871 T2 DE 69426871T2 DE 69426871 T DE69426871 T DE 69426871T DE 69426871 T DE69426871 T DE 69426871T DE 69426871 T2 DE69426871 T2 DE 69426871T2
Authority
DE
Germany
Prior art keywords
activity
antioxydate
antagonistic
connections
protective agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69426871T
Other languages
English (en)
Other versions
DE69426871D1 (de
Inventor
Mark Hellberg
George Barnes
J Collier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Application granted granted Critical
Publication of DE69426871D1 publication Critical patent/DE69426871D1/de
Publication of DE69426871T2 publication Critical patent/DE69426871T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69426871T 1993-12-08 1994-12-07 Verbindungen die sowohl starke calcium-antagonistische und antioxydatieve aktivitaet haben und deren verwendung als zellschuetzende mittel. Expired - Fee Related DE69426871T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16398093A 1993-12-08 1993-12-08
PCT/US1994/014069 WO1995015958A1 (en) 1993-12-08 1994-12-07 Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents

Publications (2)

Publication Number Publication Date
DE69426871D1 DE69426871D1 (de) 2001-04-19
DE69426871T2 true DE69426871T2 (de) 2001-06-21

Family

ID=22592463

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69426871T Expired - Fee Related DE69426871T2 (de) 1993-12-08 1994-12-07 Verbindungen die sowohl starke calcium-antagonistische und antioxydatieve aktivitaet haben und deren verwendung als zellschuetzende mittel.

Country Status (17)

Country Link
US (1) US5646149A (de)
EP (1) EP0682664B1 (de)
JP (1) JP3150155B2 (de)
KR (1) KR960701033A (de)
CN (1) CN1100774C (de)
AT (1) ATE199716T1 (de)
BR (1) BR9406080A (de)
CA (1) CA2153979C (de)
DE (1) DE69426871T2 (de)
DK (1) DK0682664T3 (de)
ES (1) ES2156934T3 (de)
FI (1) FI953748A (de)
GR (1) GR3035971T3 (de)
HK (1) HK1011685A1 (de)
NO (1) NO953093L (de)
PT (1) PT682664E (de)
WO (1) WO1995015958A1 (de)

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WO1995034299A1 (en) * 1994-06-10 1995-12-21 Telor Ophthalmic Pharmaceuticals, Inc. Inhibition of intraoperative miosis/production of mydriasis by calcium channel blockers
US5798356A (en) * 1995-08-07 1998-08-25 Alcon Laboratories, Inc. Angiostatic compounds
US5719167A (en) * 1995-08-07 1998-02-17 Alcon Laboratories, Inc. Angiostatic compounds
KR100452715B1 (ko) 1995-12-21 2004-12-17 알콘 래보레이토리스, 인코퍼레이티드 녹내장및안구국소빈혈을치료하기위한특정이소퀴놀린술포닐화합물의용도
DK0842165T3 (da) * 1996-03-25 2001-08-06 Alcon Lab Inc Thiazolidin-4-carboxylsyrederivater som cytobeskyttende midler
JP3562903B2 (ja) * 1996-05-31 2004-09-08 セイコープレシジョン株式会社 フォーカルプレーンシャッタ
DE19718826A1 (de) * 1997-05-05 1998-11-12 Marion S Dr Eckmiller Verwendung biologisch aktiver Wirkstoffe zum Beeinflussen des Extrazellulär-Raumes von Sinneszellen und Verfahren zur Wirkstoff-Administrationssteuerung
WO2004089922A2 (en) * 1998-06-30 2004-10-21 Neuromed Technologies, Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6011035A (en) 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
US6387897B1 (en) 1998-06-30 2002-05-14 Neuromed Technologies, Inc. Preferentially substituted calcium channel blockers
US20040259866A1 (en) * 1998-06-30 2004-12-23 Snutch Terrance P. Calcium channel blockers comprising two benzhydril moieties
US20060084660A1 (en) * 1998-06-30 2006-04-20 Neuromed Technologies Inc. Calcium channel blockers comprising two benzhydril moieties
US6310059B1 (en) * 1998-06-30 2001-10-30 Neuromed Technologies, Inc. Fused ring calcium channel blockers
US20040266784A1 (en) * 1998-06-30 2004-12-30 Snutch Terrance P. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US7186726B2 (en) * 1998-06-30 2007-03-06 Neuromed Pharmaceuticals Ltd. Preferentially substituted calcium channel blockers
US6492375B2 (en) 1998-06-30 2002-12-10 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
US6943168B2 (en) * 1998-06-30 2005-09-13 Neuromed Technologies Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6951862B2 (en) * 1998-06-30 2005-10-04 Neuromed Technologies, Inc. Calcium channel blockers comprising two benzhydril moieties
AU4710401A (en) * 1999-12-02 2001-06-18 University Of South Florida Method and composition for treatment of ischemic neuronal reperfusion injury
WO2001046166A2 (en) 1999-12-20 2001-06-28 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
US20030199523A1 (en) * 2002-02-28 2003-10-23 Snutch Terrance P. Heterocyclic calcium in channel blockers
WO2004105750A1 (en) * 2003-05-30 2004-12-09 Neuromed Technologies, Inc. 3-aminomethyl-pyrrolidines as n-type calcium channel blockers
ITTO20030140U1 (it) * 2003-09-16 2005-03-17 Interfila Srl Matita cosmetica
CA2580584C (en) * 2003-09-19 2015-07-28 Galileo Pharmaceuticals, Inc. Use of alpha-tocotrienol for treatment of mitochondrial diseases
US7507760B2 (en) * 2004-01-22 2009-03-24 Neuromed Pharmaceuticals Ltd. N-type calcium channel blockers
US20050227999A1 (en) * 2004-04-09 2005-10-13 Neuromed Technologies Inc. Diarylamine derivatives as calcium channel blockers
EP1745042A4 (de) * 2004-04-09 2010-07-14 Neuromed Pharmaceuticals Ltd Diarylaminderivate als calciumkanalblocker
BRPI0515133A (pt) * 2004-08-30 2008-07-08 Neuromed Pharmaceuticals Ltd derivados de uréia como bloqueadores do canal de cálcio
US7511077B2 (en) * 2005-02-09 2009-03-31 Neuromed Pharmaceuticals Ltd. Diamine calcium channel blockers
EP1976841A4 (de) * 2005-12-19 2010-07-28 Neuromed Pharmaceuticals Ltd Heterocyclische amidderivte als calciumkanalblocker
WO2007118323A1 (en) * 2006-04-17 2007-10-25 Neuromed Pharmaceuticals Ltd. Isoxazole derivatives as calcium channel blockers
US8362021B2 (en) * 2006-05-11 2013-01-29 Zalicus Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
CA2653497A1 (en) * 2006-05-26 2007-12-06 Neuromed Pharmaceuticals Ltd. Heterocyclic compounds as calcium channel blockers
US20100168103A1 (en) * 2006-09-14 2010-07-01 Neuromed Pharmaceuticals Ltd. Diaryl piperidine compounds as calcium channel blockers
WO2008043183A1 (en) * 2006-10-13 2008-04-17 Neuromed Pharmaceuticals Ltd. Cyclopropyl-piperazine compounds as calcium channel blockers
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
WO2012122279A1 (en) 2011-03-08 2012-09-13 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof

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GB705979A (en) * 1951-03-22 1954-03-24 Henri Morren 1.4-aralkyl piperazines and process for the preparation thereof
BE790971A (fr) * 1971-11-09 1973-05-07 Janssen Pharmaceutica Nv Metode ter voorkoming van patologische reakties die de funktie van het komplement vereisen
NL7306771A (de) * 1972-06-02 1973-12-04
DE2900810A1 (de) * 1979-01-11 1980-07-24 Cassella Ag Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung
US4550022A (en) * 1981-10-05 1985-10-29 Alcon Laboratories, Inc. Tissue irrigating solution
IT1213131B (it) * 1984-02-02 1989-12-14 Yason Srl Composto ad attivita' calcio antagonista periferica, anticonvulsivante ed eumetabolica cerebrale,metodo per la sua preparazione e composizioni farmaceutiche.
JPS60222472A (ja) * 1984-03-30 1985-11-07 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
WO1987005020A1 (en) * 1986-02-21 1987-08-27 Kuraray Co., Ltd. 3,4-dihydro-2h-benzopyran derivatives and their medicinal use
GB8626344D0 (en) * 1986-11-04 1986-12-03 Zyma Sa Bicyclic compounds
US5120843A (en) * 1987-04-27 1992-06-09 Upjohn Pharmaceutically active amines
EP0487510A1 (de) * 1987-04-27 1992-05-27 The Upjohn Company Pharmazeutisch wirksame Aminen
CA1338012C (en) * 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines
WO1989005803A1 (en) * 1987-12-24 1989-06-29 Kuraray Co., Ltd. 3,4-dihydro-2h-1,3-benzoxazine derivatives and their medicinal use
US5015661A (en) * 1988-08-09 1991-05-14 Hoffmann-La Roche Inc. Chromanes and their pharmaceutical compositions and methods
EP0369082A1 (de) * 1988-11-14 1990-05-23 Merrell Dow Pharmaceuticals Inc. Herzschutz-Tocopherolanaloge
IE68675B1 (en) * 1990-11-01 1996-07-10 Takeda Chemical Industries Ltd Aminocoumaran derivatives their production and use

Also Published As

Publication number Publication date
CN1117292A (zh) 1996-02-21
FI953748A0 (fi) 1995-08-07
JP3150155B2 (ja) 2001-03-26
FI953748A (fi) 1995-08-07
AU1336895A (en) 1995-06-27
JPH08507546A (ja) 1996-08-13
GR3035971T3 (en) 2001-08-31
CA2153979A1 (en) 1995-06-15
EP0682664A1 (de) 1995-11-22
DK0682664T3 (da) 2001-07-16
HK1011685A1 (en) 1999-07-16
BR9406080A (pt) 1996-02-06
AU697050B2 (en) 1998-09-24
ATE199716T1 (de) 2001-03-15
NO953093D0 (no) 1995-08-07
WO1995015958A1 (en) 1995-06-15
CN1100774C (zh) 2003-02-05
US5646149A (en) 1997-07-08
EP0682664B1 (de) 2001-03-14
DE69426871D1 (de) 2001-04-19
KR960701033A (ko) 1996-02-24
PT682664E (pt) 2001-06-29
CA2153979C (en) 2003-10-21
NO953093L (no) 1995-10-09
ES2156934T3 (es) 2001-08-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee