ATE199716T1 - Verbindungen die sowohl starke calcium- antagonistische und antioxydatieve aktivitaet haben und deren verwendung als zellschuetzende mittel. - Google Patents

Verbindungen die sowohl starke calcium- antagonistische und antioxydatieve aktivitaet haben und deren verwendung als zellschuetzende mittel.

Info

Publication number
ATE199716T1
ATE199716T1 AT95904837T AT95904837T ATE199716T1 AT E199716 T1 ATE199716 T1 AT E199716T1 AT 95904837 T AT95904837 T AT 95904837T AT 95904837 T AT95904837 T AT 95904837T AT E199716 T1 ATE199716 T1 AT E199716T1
Authority
AT
Austria
Prior art keywords
compounds
antioxidant activity
calcium antagonist
protective agents
cell protective
Prior art date
Application number
AT95904837T
Other languages
English (en)
Inventor
Mark Hellberg
George Barnes
Robert J Collier Jr
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Application granted granted Critical
Publication of ATE199716T1 publication Critical patent/ATE199716T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT95904837T 1993-12-08 1994-12-07 Verbindungen die sowohl starke calcium- antagonistische und antioxydatieve aktivitaet haben und deren verwendung als zellschuetzende mittel. ATE199716T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16398093A 1993-12-08 1993-12-08
PCT/US1994/014069 WO1995015958A1 (en) 1993-12-08 1994-12-07 Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents

Publications (1)

Publication Number Publication Date
ATE199716T1 true ATE199716T1 (de) 2001-03-15

Family

ID=22592463

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95904837T ATE199716T1 (de) 1993-12-08 1994-12-07 Verbindungen die sowohl starke calcium- antagonistische und antioxydatieve aktivitaet haben und deren verwendung als zellschuetzende mittel.

Country Status (17)

Country Link
US (1) US5646149A (de)
EP (1) EP0682664B1 (de)
JP (1) JP3150155B2 (de)
KR (1) KR960701033A (de)
CN (1) CN1100774C (de)
AT (1) ATE199716T1 (de)
BR (1) BR9406080A (de)
CA (1) CA2153979C (de)
DE (1) DE69426871T2 (de)
DK (1) DK0682664T3 (de)
ES (1) ES2156934T3 (de)
FI (1) FI953748L (de)
GR (1) GR3035971T3 (de)
HK (1) HK1011685A1 (de)
NO (1) NO953093L (de)
PT (1) PT682664E (de)
WO (1) WO1995015958A1 (de)

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WO1995034299A1 (en) * 1994-06-10 1995-12-21 Telor Ophthalmic Pharmaceuticals, Inc. Inhibition of intraoperative miosis/production of mydriasis by calcium channel blockers
US5798356A (en) * 1995-08-07 1998-08-25 Alcon Laboratories, Inc. Angiostatic compounds
US5719167A (en) * 1995-08-07 1998-02-17 Alcon Laboratories, Inc. Angiostatic compounds
KR100452715B1 (ko) * 1995-12-21 2004-12-17 알콘 래보레이토리스, 인코퍼레이티드 녹내장및안구국소빈혈을치료하기위한특정이소퀴놀린술포닐화합물의용도
JPH11507081A (ja) * 1996-03-25 1999-06-22 アルコン ラボラトリーズ，インコーポレイテッド 細胞保護剤としてのチアゾリジン−４−カルボン酸誘導体
JP3562903B2 (ja) * 1996-05-31 2004-09-08 セイコープレシジョン株式会社 フォーカルプレーンシャッタ
DE19718826A1 (de) * 1997-05-05 1998-11-12 Marion S Dr Eckmiller Verwendung biologisch aktiver Wirkstoffe zum Beeinflussen des Extrazellulär-Raumes von Sinneszellen und Verfahren zur Wirkstoff-Administrationssteuerung
US6011035A (en) * 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
US20060084660A1 (en) * 1998-06-30 2006-04-20 Neuromed Technologies Inc. Calcium channel blockers comprising two benzhydril moieties
US6951862B2 (en) * 1998-06-30 2005-10-04 Neuromed Technologies, Inc. Calcium channel blockers comprising two benzhydril moieties
US6943168B2 (en) * 1998-06-30 2005-09-13 Neuromed Technologies Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US20040266784A1 (en) * 1998-06-30 2004-12-30 Snutch Terrance P. Calcium channel inhibitors comprising benzhydril spaced from piperazine
WO2004089922A2 (en) * 1998-06-30 2004-10-21 Neuromed Technologies, Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6492375B2 (en) 1998-06-30 2002-12-10 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
US20040259866A1 (en) * 1998-06-30 2004-12-23 Snutch Terrance P. Calcium channel blockers comprising two benzhydril moieties
US6387897B1 (en) 1998-06-30 2002-05-14 Neuromed Technologies, Inc. Preferentially substituted calcium channel blockers
US7186726B2 (en) * 1998-06-30 2007-03-06 Neuromed Pharmaceuticals Ltd. Preferentially substituted calcium channel blockers
US6310059B1 (en) * 1998-06-30 2001-10-30 Neuromed Technologies, Inc. Fused ring calcium channel blockers
AU4710401A (en) 1999-12-02 2001-06-18 University Of South Florida Method and composition for treatment of ischemic neuronal reperfusion injury
JP2003518107A (ja) 1999-12-20 2003-06-03 ニューロメド テクノロジーズ， インコーポレイテッド 部分飽和カルシウムチャネルブロッカー
US20030199523A1 (en) * 2002-02-28 2003-10-23 Snutch Terrance P. Heterocyclic calcium in channel blockers
CA2527159A1 (en) * 2003-05-30 2004-12-09 Neuromed Technologies, Inc. 3-aminomethyl-pyrrolidines as n-type calcium channel blockers
ITTO20030140U1 (it) * 2003-09-16 2005-03-17 Interfila Srl Matita cosmetica
US20050065099A1 (en) 2003-09-19 2005-03-24 Gail Walkinshaw Treatment of mitochondrial diseases
US7507760B2 (en) * 2004-01-22 2009-03-24 Neuromed Pharmaceuticals Ltd. N-type calcium channel blockers
US20050227999A1 (en) * 2004-04-09 2005-10-13 Neuromed Technologies Inc. Diarylamine derivatives as calcium channel blockers
CA2562371A1 (en) * 2004-04-09 2005-10-20 Neuromed Pharmaceuticals Ltd. Diarylamine derivatives as calcium channel blockers
CN101035783A (zh) * 2004-08-30 2007-09-12 神经医药品有限公司 作为钙通道阻断剂的脲衍生物
US7511077B2 (en) * 2005-02-09 2009-03-31 Neuromed Pharmaceuticals Ltd. Diamine calcium channel blockers
CA2633457A1 (en) * 2005-12-19 2007-06-28 Neuromed Pharmaceuticals Ltd. Heterocyclic amide derivatives as calcium channel blockers
CA2643924A1 (en) * 2006-04-17 2007-10-25 Neuromed Pharmaceuticals Ltd. Isoxazole derivatives as calcium channel blockers
EP2019676A2 (de) * 2006-05-11 2009-02-04 Neuromed Pharmaceuticals, Ltd. Verfahren zur erhöhung der bioverfügbarkeit von benzhydrylpiperazinhaltigen verbindungen
CA2653497A1 (en) * 2006-05-26 2007-12-06 Neuromed Pharmaceuticals Ltd. Heterocyclic compounds as calcium channel blockers
US20100168103A1 (en) * 2006-09-14 2010-07-01 Neuromed Pharmaceuticals Ltd. Diaryl piperidine compounds as calcium channel blockers
CA2666275A1 (en) * 2006-10-13 2008-04-17 Neuromed Pharmaceuticals Ltd. Cyclopropyl-piperazine compounds as calcium channel blockers
MX2013010306A (es) 2011-03-08 2013-12-09 Zalicus Pharmaceuticals Ltd Formulaciones de dispersion solida y metodos de uso de las mismas.
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof

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GB705979A (en) * 1951-03-22 1954-03-24 Henri Morren 1.4-aralkyl piperazines and process for the preparation thereof
BE790971A (fr) * 1971-11-09 1973-05-07 Janssen Pharmaceutica Nv Metode ter voorkoming van patologische reakties die de funktie van het komplement vereisen
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IT1213131B (it) * 1984-02-02 1989-12-14 Yason Srl Composto ad attivita' calcio antagonista periferica, anticonvulsivante ed eumetabolica cerebrale,metodo per la sua preparazione e composizioni farmaceutiche.
JPS60222472A (ja) * 1984-03-30 1985-11-07 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
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EP0369082A1 (de) * 1988-11-14 1990-05-23 Merrell Dow Pharmaceuticals Inc. Herzschutz-Tocopherolanaloge
IE68675B1 (en) * 1990-11-01 1996-07-10 Takeda Chemical Industries Ltd Aminocoumaran derivatives their production and use

Also Published As

Publication number Publication date
FI953748A0 (fi) 1995-08-07
JPH08507546A (ja) 1996-08-13
FI953748A7 (fi) 1995-08-07
EP0682664A1 (de) 1995-11-22
WO1995015958A1 (en) 1995-06-15
ES2156934T3 (es) 2001-08-01
DE69426871T2 (de) 2001-06-21
CA2153979A1 (en) 1995-06-15
AU697050B2 (en) 1998-09-24
CN1100774C (zh) 2003-02-05
FI953748L (fi) 1995-08-07
GR3035971T3 (en) 2001-08-31
HK1011685A1 (en) 1999-07-16
AU1336895A (en) 1995-06-27
US5646149A (en) 1997-07-08
DK0682664T3 (da) 2001-07-16
KR960701033A (ko) 1996-02-24
BR9406080A (pt) 1996-02-06
CN1117292A (zh) 1996-02-21
PT682664E (pt) 2001-06-29
NO953093L (no) 1995-10-09
NO953093D0 (no) 1995-08-07
DE69426871D1 (de) 2001-04-19
CA2153979C (en) 2003-10-21
JP3150155B2 (ja) 2001-03-26
EP0682664B1 (de) 2001-03-14

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee