ES541728A0 - Un procedimiento para preparar un derivado de 1-bencil-4- benzhidril-piperazina - Google Patents
Un procedimiento para preparar un derivado de 1-bencil-4- benzhidril-piperazinaInfo
- Publication number
- ES541728A0 ES541728A0 ES541728A ES541728A ES541728A0 ES 541728 A0 ES541728 A0 ES 541728A0 ES 541728 A ES541728 A ES 541728A ES 541728 A ES541728 A ES 541728A ES 541728 A0 ES541728 A0 ES 541728A0
- Authority
- ES
- Spain
- Prior art keywords
- derivative
- benzyl
- condensing
- addition salt
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59064464A JPS60222472A (ja) | 1984-03-30 | 1984-03-30 | 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES541728A0 true ES541728A0 (es) | 1987-01-01 |
ES8702393A1 ES8702393A1 (es) | 1987-01-01 |
Family
ID=13258978
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES541728A Expired ES8702393A1 (es) | 1984-03-30 | 1985-03-29 | Un procedimiento para preparar un derivado de 1-bencil-4- benzhidril-piperazina |
ES556980A Expired ES8801236A1 (es) | 1984-03-30 | 1986-07-29 | Un procedimiento para preparar un derivado de 1-bencil-4-benzhidrilpiperazina |
ES556981A Expired ES8801237A1 (es) | 1984-03-30 | 1986-07-29 | Un procedimiento para preparar un derivado de 1-bencil-4-benzhidrilpiperazina |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES556980A Expired ES8801236A1 (es) | 1984-03-30 | 1986-07-29 | Un procedimiento para preparar un derivado de 1-bencil-4-benzhidrilpiperazina |
ES556981A Expired ES8801237A1 (es) | 1984-03-30 | 1986-07-29 | Un procedimiento para preparar un derivado de 1-bencil-4-benzhidrilpiperazina |
Country Status (10)
Country | Link |
---|---|
US (1) | US4663325A (es) |
EP (1) | EP0159566B1 (es) |
JP (1) | JPS60222472A (es) |
AT (1) | ATE31411T1 (es) |
CA (1) | CA1248110A (es) |
DE (1) | DE3561199D1 (es) |
ES (3) | ES8702393A1 (es) |
FI (1) | FI79101C (es) |
GR (1) | GR850787B (es) |
NO (1) | NO163185C (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61161272A (ja) * | 1985-01-11 | 1986-07-21 | Kanebo Ltd | 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物 |
US4792553A (en) * | 1986-02-04 | 1988-12-20 | Terumo Kabushiki Kaisha | Diene derivatives and vasodilators containing the same |
FR2614021B1 (fr) * | 1987-04-14 | 1991-03-01 | Andre Buzas | Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant |
DE4108527A1 (de) * | 1991-03-15 | 1992-09-17 | Basf Ag | Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung |
AU646926B2 (en) * | 1991-03-20 | 1994-03-10 | Duphar International Research B.V. | Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity |
KR960701033A (ko) * | 1993-12-08 | 1996-02-24 | 그레그 씨.브라운 | 효능있는 칼슘 길항 및 산화방지 활성을 모두 갖는 화합물, 및 세포보호제로서 그것의 사용방법(compounds having both potent calcium antagonist and antioxidant activity and use there of as cytoprotective agents) |
KR100585299B1 (ko) * | 1998-01-29 | 2006-06-01 | 악조 노벨 엔.브이. | 시신경유두 순환 개선제 |
AP2005003232A0 (en) | 2002-08-19 | 2005-03-31 | Pfizer Prod Inc | Combination therapy for hyperproliferative diseases. |
US7433519B2 (en) | 2003-04-04 | 2008-10-07 | Avid Technology, Inc. | Bitstream format for compressed image data |
US7403561B2 (en) | 2003-04-04 | 2008-07-22 | Avid Technology, Inc. | Fixed bit rate, intraframe compression and decompression of video |
US20050159403A1 (en) * | 2003-04-22 | 2005-07-21 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of central nervous system damage |
WO2004093813A2 (en) * | 2003-04-22 | 2004-11-04 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders |
GEP20084406B (en) * | 2003-05-30 | 2008-06-25 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives and their use as hmg-co inhibitors |
US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
WO2006099244A1 (en) * | 2005-03-11 | 2006-09-21 | Hong Kong Nitric Oxide Limited | Combination therapy for endothelial dysfunction, angina and diabetes |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
US7893050B2 (en) * | 2005-10-26 | 2011-02-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
AU2006313430B2 (en) * | 2005-11-08 | 2012-09-06 | Ranbaxy Laboratories Limited | Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
WO2008020314A2 (en) * | 2006-03-14 | 2008-02-21 | Ranbaxy Laboratories Limited | Statin stabilizing dosage formulations |
AU2007274724B2 (en) * | 2006-07-14 | 2012-07-26 | Ranbaxy Laboratories Limited | Polymorphic forms of an HMG-CoA reductase inhibitor and uses thereof |
US8404896B2 (en) | 2006-12-01 | 2013-03-26 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
EP2130828A4 (en) | 2007-02-28 | 2010-12-29 | Asahi Kasei Pharma Corp | sulfonamide |
US8883844B2 (en) | 2010-09-24 | 2014-11-11 | Nitrogenix Inc. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
CN102936233B (zh) * | 2012-11-16 | 2016-01-20 | 葛长乐 | 一种1-(二(4-氟苯基)甲基)-4-(2,3,4-三甲氧苯基)哌嗪二盐酸盐晶型 |
BR112015026513A2 (pt) | 2013-04-17 | 2017-07-25 | Pfizer | derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
US10128077B2 (en) * | 2015-10-20 | 2018-11-13 | Korea Research Institute Of Standards And Science | Electron microscope electron gun for facilitating position adjustment and electron microscope including same |
CN109666008A (zh) * | 2018-12-31 | 2019-04-23 | 辰欣药业股份有限公司 | 一种盐酸洛美利嗪的合成方法 |
MX2021008533A (es) | 2019-01-18 | 2021-08-19 | Astrazeneca Ab | Inhibidores de la pcsk9 y metodos de uso de los mismos. |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB705979A (en) * | 1951-03-22 | 1954-03-24 | Henri Morren | 1.4-aralkyl piperazines and process for the preparation thereof |
FR1312427A (fr) * | 1961-04-12 | 1962-12-21 | Science Union Et Compagnie Soc | Nouveaux dérivés de la pipérazine et leurs préparations |
FR1303080A (fr) * | 1961-07-25 | 1962-09-07 | Science Union Et Compagnie Soc | Pipérazines disubstituées |
NL7306771A (es) * | 1972-06-02 | 1973-12-04 | ||
DE2900810A1 (de) * | 1979-01-11 | 1980-07-24 | Cassella Ag | Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung |
GB8320701D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
-
1984
- 1984-03-30 JP JP59064464A patent/JPS60222472A/ja active Granted
-
1985
- 1985-03-25 US US06/715,813 patent/US4663325A/en not_active Expired - Lifetime
- 1985-03-26 FI FI851217A patent/FI79101C/fi not_active IP Right Cessation
- 1985-03-26 CA CA000477468A patent/CA1248110A/en not_active Expired
- 1985-03-27 DE DE8585103707T patent/DE3561199D1/de not_active Expired
- 1985-03-27 AT AT85103707T patent/ATE31411T1/de not_active IP Right Cessation
- 1985-03-27 EP EP85103707A patent/EP0159566B1/en not_active Expired
- 1985-03-28 GR GR850787A patent/GR850787B/el unknown
- 1985-03-29 NO NO851298A patent/NO163185C/no not_active IP Right Cessation
- 1985-03-29 ES ES541728A patent/ES8702393A1/es not_active Expired
-
1986
- 1986-07-29 ES ES556980A patent/ES8801236A1/es not_active Expired
- 1986-07-29 ES ES556981A patent/ES8801237A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FI851217L (fi) | 1985-10-01 |
EP0159566A1 (en) | 1985-10-30 |
DE3561199D1 (en) | 1988-01-28 |
FI79101B (fi) | 1989-07-31 |
GR850787B (es) | 1985-11-25 |
NO851298L (no) | 1985-10-01 |
JPS60222472A (ja) | 1985-11-07 |
NO163185C (no) | 1990-04-18 |
ES8801236A1 (es) | 1988-01-01 |
US4663325A (en) | 1987-05-05 |
ES556980A0 (es) | 1988-01-01 |
ATE31411T1 (de) | 1988-01-15 |
CA1248110A (en) | 1989-01-03 |
FI851217A0 (fi) | 1985-03-26 |
EP0159566B1 (en) | 1987-12-16 |
ES556981A0 (es) | 1988-01-01 |
JPH0313232B2 (es) | 1991-02-22 |
ES8702393A1 (es) | 1987-01-01 |
FI79101C (fi) | 1989-11-10 |
ES8801237A1 (es) | 1988-01-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC1A | Transfer granted | ||
FD1A | Patent lapsed |
Effective date: 20061014 |