DE3561199D1 - Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient - Google Patents

Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient

Info

Publication number
DE3561199D1
DE3561199D1 DE8585103707T DE3561199T DE3561199D1 DE 3561199 D1 DE3561199 D1 DE 3561199D1 DE 8585103707 T DE8585103707 T DE 8585103707T DE 3561199 T DE3561199 T DE 3561199T DE 3561199 D1 DE3561199 D1 DE 3561199D1
Authority
DE
Germany
Prior art keywords
derivative
benzyl
compounds
processes
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585103707T
Other languages
German (de)
English (en)
Inventor
Hiroshi Ohtaka
Toshiro Kanazawa
Keizo Ito
Goro Tsukamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Application granted granted Critical
Publication of DE3561199D1 publication Critical patent/DE3561199D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8585103707T 1984-03-30 1985-03-27 Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient Expired DE3561199D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59064464A JPS60222472A (ja) 1984-03-30 1984-03-30 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物

Publications (1)

Publication Number Publication Date
DE3561199D1 true DE3561199D1 (en) 1988-01-28

Family

ID=13258978

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585103707T Expired DE3561199D1 (en) 1984-03-30 1985-03-27 Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient

Country Status (10)

Country Link
US (1) US4663325A (enExample)
EP (1) EP0159566B1 (enExample)
JP (1) JPS60222472A (enExample)
AT (1) ATE31411T1 (enExample)
CA (1) CA1248110A (enExample)
DE (1) DE3561199D1 (enExample)
ES (3) ES8702393A1 (enExample)
FI (1) FI79101C (enExample)
GR (1) GR850787B (enExample)
NO (1) NO163185C (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61161272A (ja) * 1985-01-11 1986-07-21 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
JPS62277370A (ja) * 1986-02-04 1987-12-02 Terumo Corp ジエン誘導体およびこれを含有する血管拡張剤
FR2614021B1 (fr) * 1987-04-14 1991-03-01 Andre Buzas Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
AU646926B2 (en) * 1991-03-20 1994-03-10 Duphar International Research B.V. Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity
FI953748A7 (fi) * 1993-12-08 1995-08-07 Alcon Lab Inc Yhdisteitä, joilla on sekä voimakas kalsium antagonisti- että antioksi danttiaktiivisuus sekä niiden käyttö solua suojaavina aineina
PT1051973E (pt) * 1998-01-29 2004-11-30 Akzo Nobel Nv Agentes de melhoramento da circulacao optica papilar
RU2204556C2 (ru) * 2001-06-18 2003-05-20 Федеральное государственное унитарное предприятие "Новокузнецкий научно-исследовательский химико-фармацевтический институт" Способ получения 1-(парахлорбензгидрил)-4-(2-оксиэтил)пиперазина
BR0313593A (pt) 2002-08-19 2005-07-12 Pfizer Prod Inc Terapia de combinação para doenças hiperproliferativas
US7403561B2 (en) 2003-04-04 2008-07-22 Avid Technology, Inc. Fixed bit rate, intraframe compression and decompression of video
US7433519B2 (en) 2003-04-04 2008-10-07 Avid Technology, Inc. Bitstream format for compressed image data
WO2004093816A2 (en) * 2003-04-22 2004-11-04 Pharmacia Corporation Compositions comprising a selective cox-2 inhibitor and a calcium modulating agent
WO2004093813A2 (en) * 2003-04-22 2004-11-04 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders
AP2501A (en) * 2003-05-30 2012-10-22 Ranbaxy Lab Ltd Substituted pyrrole derivatives
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
AU2006223212A1 (en) * 2005-03-11 2006-09-21 Hong Kong Nitric Oxide Limited Combination therapy for endothelial dysfunction, angina and diabetes
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
ATE551059T1 (de) 2005-10-26 2012-04-15 Asahi Kasei Pharma Corp Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie
KR101329112B1 (ko) * 2005-11-08 2013-11-14 랜박시 래보러터리스 리미티드 (3ｒ,5ｒ)-7-〔2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-〔(4-히드록시 메틸 페닐 아미노)카르보닐〕-피롤-1-일〕-3,5-디히드록시 헵탄산 헤미 칼슘염의 제조 방법
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
AR059838A1 (es) * 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulaciones para dosis estabilizantes de estatina
AR063469A1 (es) * 2006-07-14 2009-01-28 Ranbaxy Lab Ltd Formas polimorficas de ácido (3r,5r)-7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]-pirrol-1-il]-3, 5-dihidroxi-heptanoico, sal hemicalcio, metodos de preparacion de las mismas, una composicion farmaceutica que las comprende y su uso en el tratamiento de enfermedades
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
AU2008220104B2 (en) 2007-02-28 2012-09-27 Asahi Kasei Pharma Corporation Sulfonamide derivative
US8883844B2 (en) 2010-09-24 2014-11-11 Nitrogenix Inc. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
CN102936233B (zh) * 2012-11-16 2016-01-20 葛长乐 一种1-(二(4-氟苯基)甲基)-4-(2,3,4-三甲氧苯基)哌嗪二盐酸盐晶型
EP2986599A1 (en) 2013-04-17 2016-02-24 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN107636792B (zh) * 2015-10-20 2019-05-14 韩国标准科学研究院 易于位置调节的电子显微镜用电子枪及包括其的电子显微镜
CN109666008A (zh) * 2018-12-31 2019-04-23 辰欣药业股份有限公司 一种盐酸洛美利嗪的合成方法
CN119119023A (zh) 2019-01-18 2024-12-13 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB705979A (en) * 1951-03-22 1954-03-24 Henri Morren 1.4-aralkyl piperazines and process for the preparation thereof
FR1312427A (fr) * 1961-04-12 1962-12-21 Science Union Et Compagnie Soc Nouveaux dérivés de la pipérazine et leurs préparations
FR1303080A (fr) * 1961-07-25 1962-09-07 Science Union Et Compagnie Soc Pipérazines disubstituées
NL7306771A (enExample) * 1972-06-02 1973-12-04
DE2900810A1 (de) * 1979-01-11 1980-07-24 Cassella Ag Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent

Also Published As

Publication number Publication date
CA1248110A (en) 1989-01-03
FI79101B (fi) 1989-07-31
GR850787B (enExample) 1985-11-25
ES8702393A1 (es) 1987-01-01
FI851217L (fi) 1985-10-01
EP0159566A1 (en) 1985-10-30
NO163185C (no) 1990-04-18
JPS60222472A (ja) 1985-11-07
FI851217A0 (fi) 1985-03-26
FI79101C (fi) 1989-11-10
JPH0313232B2 (enExample) 1991-02-22
ES556981A0 (es) 1988-01-01
EP0159566B1 (en) 1987-12-16
ES556980A0 (es) 1988-01-01
ES8801236A1 (es) 1988-01-01
ES8801237A1 (es) 1988-01-01
ES541728A0 (es) 1987-01-01
NO851298L (no) 1985-10-01
US4663325A (en) 1987-05-05
ATE31411T1 (de) 1988-01-15

Similar Documents

Publication Publication Date Title
DE3561199D1 (en) Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient
AU538424B2 (en) Piperazino phenylindane
AU8794291A (en) New oxazolopyridine derivatives, processes for preparing these and pharmaceutical compositions containing them
DE3271269D1 (en) Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
PT69823A (de) 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saureadditionssalze diese enthaltene arzneimittel und verfahrenzu deren herstellung
IE820401L (en) N-£4-(indolyl)-piperidino-alkyl|-benzimidazolines
NO940523D0 (no) Nye pyrazin-derivater
ATE2265T1 (de) Sekundaere amine, ihre herstellung und verwendung in pharmazeutischen zusammensetzungen.
KR960034205A (ko) 피페리딘 유도체와 그것의 제조방법 및 치료적 이용
JPS562968A (en) Novel pyrimidine derivative
ES504206A0 (es) Procedimiento para la preparacion de nuevas 5,10-dihidro -11h-dibenzo b,e 1,4 diazepin-11-onas, sustituidas en posi- cion 5
GB1567958A (en) Piperazine and piperazine homologue derivatives and preparation and use thereof
DE3876711D1 (de) Piperidin-derivate, deren herstellung und deren verwendung als heilmittel.
GR860045B (en) Novel piperazine derivatives processes for production thereof and pharmaceutical compositions comprising said compounds as active ingredient
ES452735A1 (es) Un procedimiento para preparar compuestos de aroilfenilnaf- taleno.
SE8703494L (sv) Mellanprodukter anvendbara vid framstellning av 2-tiofen-ettiksyraderivat
PT72255B (de) Neue substituierte 4-amino-2,6-diaryl-tetrahydrothiopyrane deren saureadditionssalze verfahren zu ihrer herstellung ihre verwendung und pharmazeutische zusammensetzungen
JPS5681583A (en) Nbbquaternary 100bromsandwicinn and 100bromisosandwicin derivative* their manufacture* ringgopen aldehyde base and hearttbeat periodic trouble remedy
ES467100A1 (es) Un procedimiento para la obtencion de (+,-)-cis-alfa-(3- (2,6-dimetil-1-piperidinil) propil)alfa-fenil-2-piridin-me- tanol.
JPS5318581A (en) Novel o-nitrobutyrophenone derivatives
JPS57116052A (en) Quinazoline derivative and its preparation
DK214884D0 (da) Chlorphenoxyacetatderivat

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AKZO NOBEL N.V., ARNHEIM/ARNHEM, NL