NO136574C - Analogifremgangsm}te for fremstilling av terapeutisk aktive pyrimidinderivater. - Google Patents

Analogifremgangsm}te for fremstilling av terapeutisk aktive pyrimidinderivater.

Info

Publication number
NO136574C
NO136574C NO3686/72A NO368672A NO136574C NO 136574 C NO136574 C NO 136574C NO 3686/72 A NO3686/72 A NO 3686/72A NO 368672 A NO368672 A NO 368672A NO 136574 C NO136574 C NO 136574C
Authority
NO
Norway
Prior art keywords
preparation
therapeutically active
pyrimidine derivatives
active pyrimidine
analogical procedure
Prior art date
Application number
NO3686/72A
Other languages
English (en)
Norwegian (no)
Other versions
NO136574B (fi
Inventor
Christopher Andrew Lipinski
John Gerritt Stam
Gerald George Deangelis
Hans-Jurgen Ernst Hess
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to NO763797A priority Critical patent/NO137596C/no
Publication of NO136574B publication Critical patent/NO136574B/no
Publication of NO136574C publication Critical patent/NO136574C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56One oxygen atom and one sulfur atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO3686/72A 1971-10-29 1972-10-13 Analogifremgangsm}te for fremstilling av terapeutisk aktive pyrimidinderivater. NO136574C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO763797A NO137596C (no) 1971-10-29 1976-11-08 Analogifremgangsmaate for fremstilling av terapeutisk aktive hydroksy-pyrimidinderivater

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19400671A 1971-10-29 1971-10-29

Publications (2)

Publication Number Publication Date
NO136574B NO136574B (fi) 1977-06-20
NO136574C true NO136574C (no) 1977-09-28

Family

ID=22715935

Family Applications (1)

Application Number Title Priority Date Filing Date
NO3686/72A NO136574C (no) 1971-10-29 1972-10-13 Analogifremgangsm}te for fremstilling av terapeutisk aktive pyrimidinderivater.

Country Status (25)

Country Link
JP (2) JPS5337870B2 (fi)
AR (2) AR198798A1 (fi)
AT (2) AT320656B (fi)
AU (1) AU467600B2 (fi)
BE (1) BE790125A (fi)
CA (1) CA980778A (fi)
CH (2) CH549579A (fi)
DE (3) DE2264657C2 (fi)
DK (1) DK131465B (fi)
EG (1) EG11013A (fi)
ES (2) ES407730A1 (fi)
FI (1) FI55503C (fi)
FR (1) FR2157865B1 (fi)
GB (2) GB1377308A (fi)
IE (1) IE37043B1 (fi)
IL (2) IL40458A (fi)
LU (1) LU66304A1 (fi)
NL (1) NL166470C (fi)
NO (1) NO136574C (fi)
PH (2) PH10129A (fi)
PL (2) PL84634B1 (fi)
SE (2) SE393376B (fi)
SU (2) SU498908A3 (fi)
YU (2) YU35125B (fi)
ZA (1) ZA727362B (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151912U (fi) * 1979-04-17 1980-11-01
JPS5752409Y2 (fi) * 1979-11-05 1982-11-15
DE3222914A1 (de) * 1982-06-18 1983-12-22 Beiersdorf Ag, 2000 Hamburg Substituierte 5-phenylthio-6-amino-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
JPH0655686B2 (ja) * 1988-08-30 1994-07-27 宇部興産株式会社 p−ブロモフェノキシアセトアルデヒドジアルキルアセタール類の製造方法
US7776870B2 (en) 2005-08-22 2010-08-17 Melior Pharmaceuticals I, Inc. Methods for modulating Lyn kinase activity and treating related disorders
US8552184B2 (en) 2008-07-03 2013-10-08 Melior Pharmaceuticals I, Inc. Compounds and methods for treating disorders related to glucose metabolism
WO2011150300A1 (en) 2010-05-28 2011-12-01 Melior Pharmaceuticals I, Inc. Prevention of pancreatic beta cell degeneration
BR112019021140A2 (pt) 2017-04-10 2020-05-19 Univ Louisiana State composição, método para reduzir os níveis de glicose no sangue, ganho de peso ou níveis de depósito de gordura, ou tratamento, método de indução do bege de adipócitos ou prevenção da degeneração das células beta do pâncreas, e, ativador de lyn cinase e agonista de trpm8 para uso na redução dos níveis de glicose no sangue, ganho de peso ou níveis de depósito de gordura, ou tratamento.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2913462A (en) * 1959-11-17 Eahl h
GB951431A (en) * 1959-03-17 1964-03-04 Wellcome Found Pyrimidine derivatives and the manufacture thereof

Also Published As

Publication number Publication date
IL48790A0 (en) 1976-03-31
CH555832A (fr) 1974-11-15
AR198798A1 (es) 1974-07-24
NL7213959A (fi) 1973-05-02
PH11594A (en) 1978-03-31
ES407730A1 (es) 1976-01-16
YU36295B (en) 1982-06-18
JPS4852780A (fi) 1973-07-24
SE397090B (sv) 1977-10-17
FI55503B (fi) 1979-04-30
YU99179A (en) 1981-08-31
FI55503C (fi) 1979-08-10
AR196263A1 (es) 1973-12-10
FR2157865A1 (fi) 1973-06-08
CH549579A (fr) 1974-05-31
DK131465B (da) 1975-07-21
IE37043L (en) 1973-04-29
DE2264374A1 (de) 1973-05-24
SE393376B (sv) 1977-05-09
JPS5337870B2 (fi) 1978-10-12
YU35125B (en) 1980-09-25
ZA727362B (en) 1973-11-28
AT321308B (de) 1975-03-25
FR2157865B1 (fi) 1975-10-31
AU4722872A (en) 1974-04-04
BE790125A (fr) 1973-04-16
PH10129A (en) 1976-09-02
JPS5422995B2 (fi) 1979-08-10
YU255172A (en) 1980-03-15
DK131465C (fi) 1975-12-08
SE7505279L (sv) 1975-05-06
EG11013A (en) 1976-11-30
NL166470B (nl) 1981-03-16
SU498908A3 (ru) 1976-01-05
IE37043B1 (en) 1977-04-27
JPS53116386A (en) 1978-10-11
DE2248741A1 (de) 1973-05-03
DE2248741C3 (de) 1975-06-26
ES436624A1 (es) 1977-02-01
LU66304A1 (fi) 1973-05-03
DE2264374C3 (de) 1981-07-23
AT320656B (de) 1975-02-25
IL40458A (en) 1976-05-31
DE2264657A1 (de) 1974-06-20
NL166470C (nl) 1981-08-17
CA980778A (en) 1975-12-30
NO136574B (fi) 1977-06-20
GB1377308A (en) 1974-12-11
DE2264657C2 (de) 1982-09-16
GB1377720A (en) 1974-12-18
IL40458A0 (en) 1972-11-28
IL48790A (en) 1976-05-31
DE2248741B2 (de) 1974-11-14
DE2264374B2 (de) 1980-08-07
PL89852B1 (fi) 1976-12-31
PL84634B1 (fi) 1976-04-30
SU505362A3 (ru) 1976-02-28
AU467600B2 (en) 1975-12-04

Similar Documents

Publication Publication Date Title
NO136837C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive pleuromutiliner
NO138805C (no) Analogifremgangsmaate for fremstilling av farmakologisk aktive triazolforbindelser
NO139560C (no) Analogifremgangsmaate til fremstilling av terapeutisk virksomme nonapeptidamid-derivater
NO140301C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazo(5,1-f)-as-triaziner
NO140381C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive arylpiperaziner
NO136298C (no) Analogifremgangsm}te til fremstilling av antibakterielt virksomme imidazolderivater
NO138565C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive piperazinyl-propyl-1,2,4-triazolinonderivater
NO136094C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive d-1-(4-amino-fenyl)-2-alkylamino-etanol-derivater.
NO136045C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive pyridazinoner.
NO137694C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzomorfaner
NO140058C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive substituerte piperidinoalkanol-oxim-derivater
NO138999C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive difenylyl-alkanoylaminopyridiner
NO136251C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive pyridazin-derivater.
SE396388B (sv) Analogiforfrande for framstellning av 2,3-dihydro-oxo-imidazo-/1,2-a/pyrimidiner
NO137858C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive indanoner
SE400551B (sv) Forfarande for framstellning av terapeutiskt aktiva 3-amino-5-karbamylbensoesyraderivat
NO136574C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive pyrimidinderivater.
FI49827C (fi) Menetelmä terapeuttisesti vaikuttavien substituoitujen 3-hydroksimetyy li-isokinoliinien valmistamiseksi.
NO137728C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrasi-4-oksyd-derivater
NO137696C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzodiazepin-derivater
NO137727C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-fenyl-3-hydroksy-3-metyltriazener
NO137695C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive n-tienylmetyl-heterocykliske forbindelser
NO136841C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive fenylimidazolidinoner
NO136977C (no) Analogifremgangsm}te for mstilling av terapeutisk aktive oksazolidiner
NO137893C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-m-trifluormetylfenyl-2-cyanoalkylaminopropaner