IL40458A - Pyrimidinones,their preparation and pharmaceutical compositions containing them - Google Patents

Pyrimidinones,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL40458A
IL40458A IL40458A IL4045872A IL40458A IL 40458 A IL40458 A IL 40458A IL 40458 A IL40458 A IL 40458A IL 4045872 A IL4045872 A IL 4045872A IL 40458 A IL40458 A IL 40458A
Authority
IL
Israel
Prior art keywords
methyl
prepared
hydrogen
compound
reacting
Prior art date
Application number
IL40458A
Other languages
English (en)
Other versions
IL40458A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL40458A0 publication Critical patent/IL40458A0/xx
Publication of IL40458A publication Critical patent/IL40458A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL40458A 1971-10-29 1972-09-28 Pyrimidinones,their preparation and pharmaceutical compositions containing them IL40458A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19400671A 1971-10-29 1971-10-29

Publications (2)

Publication Number Publication Date
IL40458A0 IL40458A0 (en) 1972-11-28
IL40458A true IL40458A (en) 1976-05-31

Family

ID=22715935

Family Applications (2)

Application Number Title Priority Date Filing Date
IL40458A IL40458A (en) 1971-10-29 1972-09-28 Pyrimidinones,their preparation and pharmaceutical compositions containing them
IL48790A IL48790A (en) 1971-10-29 1976-01-05 Hydroxy-pyrimidines,their preparation and pharmaceutical compositions containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL48790A IL48790A (en) 1971-10-29 1976-01-05 Hydroxy-pyrimidines,their preparation and pharmaceutical compositions containing them

Country Status (25)

Country Link
JP (2) JPS5337870B2 (fi)
AR (2) AR198798A1 (fi)
AT (2) AT320656B (fi)
AU (1) AU467600B2 (fi)
BE (1) BE790125A (fi)
CA (1) CA980778A (fi)
CH (2) CH549579A (fi)
DE (3) DE2264657C2 (fi)
DK (1) DK131465B (fi)
EG (1) EG11013A (fi)
ES (2) ES407730A1 (fi)
FI (1) FI55503C (fi)
FR (1) FR2157865B1 (fi)
GB (2) GB1377308A (fi)
IE (1) IE37043B1 (fi)
IL (2) IL40458A (fi)
LU (1) LU66304A1 (fi)
NL (1) NL166470C (fi)
NO (1) NO136574C (fi)
PH (2) PH10129A (fi)
PL (2) PL84634B1 (fi)
SE (2) SE393376B (fi)
SU (2) SU498908A3 (fi)
YU (2) YU35125B (fi)
ZA (1) ZA727362B (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151912U (fi) * 1979-04-17 1980-11-01
JPS5752409Y2 (fi) * 1979-11-05 1982-11-15
DE3222914A1 (de) * 1982-06-18 1983-12-22 Beiersdorf Ag, 2000 Hamburg Substituierte 5-phenylthio-6-amino-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
JPH0655686B2 (ja) * 1988-08-30 1994-07-27 宇部興産株式会社 ｐ−ブロモフェノキシアセトアルデヒドジアルキルアセタール類の製造方法
US7776870B2 (en) 2005-08-22 2010-08-17 Melior Pharmaceuticals I, Inc. Methods for modulating Lyn kinase activity and treating related disorders
US8552184B2 (en) 2008-07-03 2013-10-08 Melior Pharmaceuticals I, Inc. Compounds and methods for treating disorders related to glucose metabolism
WO2011150300A1 (en) 2010-05-28 2011-12-01 Melior Pharmaceuticals I, Inc. Prevention of pancreatic beta cell degeneration
BR112019021140A2 (pt) 2017-04-10 2020-05-19 Univ Louisiana State composição, método para reduzir os níveis de glicose no sangue, ganho de peso ou níveis de depósito de gordura, ou tratamento, método de indução do bege de adipócitos ou prevenção da degeneração das células beta do pâncreas, e, ativador de lyn cinase e agonista de trpm8 para uso na redução dos níveis de glicose no sangue, ganho de peso ou níveis de depósito de gordura, ou tratamento.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2913462A (en) * 1959-11-17 Eahl h
GB951431A (en) * 1959-03-17 1964-03-04 Wellcome Found Pyrimidine derivatives and the manufacture thereof

Also Published As

Publication number Publication date
IL48790A0 (en) 1976-03-31
CH555832A (fr) 1974-11-15
AR198798A1 (es) 1974-07-24
NL7213959A (fi) 1973-05-02
PH11594A (en) 1978-03-31
ES407730A1 (es) 1976-01-16
YU36295B (en) 1982-06-18
JPS4852780A (fi) 1973-07-24
SE397090B (sv) 1977-10-17
FI55503B (fi) 1979-04-30
YU99179A (en) 1981-08-31
FI55503C (fi) 1979-08-10
AR196263A1 (es) 1973-12-10
FR2157865A1 (fi) 1973-06-08
CH549579A (fr) 1974-05-31
DK131465B (da) 1975-07-21
IE37043L (en) 1973-04-29
DE2264374A1 (de) 1973-05-24
SE393376B (sv) 1977-05-09
JPS5337870B2 (fi) 1978-10-12
NO136574C (no) 1977-09-28
YU35125B (en) 1980-09-25
ZA727362B (en) 1973-11-28
AT321308B (de) 1975-03-25
FR2157865B1 (fi) 1975-10-31
AU4722872A (en) 1974-04-04
BE790125A (fr) 1973-04-16
PH10129A (en) 1976-09-02
JPS5422995B2 (fi) 1979-08-10
YU255172A (en) 1980-03-15
DK131465C (fi) 1975-12-08
SE7505279L (sv) 1975-05-06
EG11013A (en) 1976-11-30
NL166470B (nl) 1981-03-16
SU498908A3 (ru) 1976-01-05
IE37043B1 (en) 1977-04-27
JPS53116386A (en) 1978-10-11
DE2248741A1 (de) 1973-05-03
DE2248741C3 (de) 1975-06-26
ES436624A1 (es) 1977-02-01
LU66304A1 (fi) 1973-05-03
DE2264374C3 (de) 1981-07-23
AT320656B (de) 1975-02-25
DE2264657A1 (de) 1974-06-20
NL166470C (nl) 1981-08-17
CA980778A (en) 1975-12-30
NO136574B (fi) 1977-06-20
GB1377308A (en) 1974-12-11
DE2264657C2 (de) 1982-09-16
GB1377720A (en) 1974-12-18
IL40458A0 (en) 1972-11-28
IL48790A (en) 1976-05-31
DE2248741B2 (de) 1974-11-14
DE2264374B2 (de) 1980-08-07
PL89852B1 (fi) 1976-12-31
PL84634B1 (fi) 1976-04-30
SU505362A3 (ru) 1976-02-28
AU467600B2 (en) 1975-12-04

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