NL8501766A - Gesubstitueerde 3,4-diamino-1,2,5-thiadiazolen met histamine h2-receptorantagonistaktiviteit. - Google Patents

Gesubstitueerde 3,4-diamino-1,2,5-thiadiazolen met histamine h2-receptorantagonistaktiviteit. Download PDF

Info

Publication number
NL8501766A
NL8501766A NL8501766A NL8501766A NL8501766A NL 8501766 A NL8501766 A NL 8501766A NL 8501766 A NL8501766 A NL 8501766A NL 8501766 A NL8501766 A NL 8501766A NL 8501766 A NL8501766 A NL 8501766A
Authority
NL
Netherlands
Prior art keywords
formula
compound
lower alkyl
halogen
represents hydrogen
Prior art date
Application number
NL8501766A
Other languages
English (en)
Dutch (nl)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of NL8501766A publication Critical patent/NL8501766A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NL8501766A 1984-06-22 1985-06-19 Gesubstitueerde 3,4-diamino-1,2,5-thiadiazolen met histamine h2-receptorantagonistaktiviteit. NL8501766A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62358884 1984-06-22
US06/623,588 US4644006A (en) 1984-06-22 1984-06-22 Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity

Publications (1)

Publication Number Publication Date
NL8501766A true NL8501766A (nl) 1986-01-16

Family

ID=24498651

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8501766A NL8501766A (nl) 1984-06-22 1985-06-19 Gesubstitueerde 3,4-diamino-1,2,5-thiadiazolen met histamine h2-receptorantagonistaktiviteit.

Country Status (33)

Country Link
US (1) US4644006A (es)
JP (2) JPS6118775A (es)
KR (1) KR900004321B1 (es)
AR (1) AR240935A1 (es)
AT (1) AT390790B (es)
AU (2) AU580605B2 (es)
BE (1) BE902724A (es)
CA (2) CA1267412A (es)
CH (1) CH665210A5 (es)
CS (1) CS257276B2 (es)
DD (1) DD240889A5 (es)
DE (1) DE3522101A1 (es)
DK (1) DK282885A (es)
ES (2) ES8702902A1 (es)
FI (1) FI852405L (es)
FR (1) FR2566406B1 (es)
GB (2) GB2161157B (es)
GR (1) GR851514B (es)
HU (1) HU193992B (es)
IE (2) IE58261B1 (es)
IL (1) IL75567A0 (es)
IT (1) IT1190372B (es)
LU (1) LU85969A1 (es)
NL (1) NL8501766A (es)
NO (1) NO161856C (es)
NZ (1) NZ212403A (es)
OA (1) OA08039A (es)
PT (1) PT80684B (es)
SE (1) SE464305B (es)
SU (1) SU1537136A3 (es)
YU (2) YU45725B (es)
ZA (1) ZA854710B (es)
ZW (1) ZW10385A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0535227A4 (en) * 1990-05-29 1993-08-18 Nippon Soda Co., Ltd. N-substituted heterocyclic amidine derivative
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3657237A (en) * 1968-05-22 1972-04-18 Frosst & Co Charles E Process for making 1 2 5-thiadiazoles in the sinister configuration
DK160611C (da) * 1979-09-04 1991-09-16 Bristol Myers Squibb Co Analogifremgangsmaade til fremstilling af 3,4-disubstituerede 1,2,5-thiadiazol-1-oxider og -1,1-dioxider
EP0040696B1 (en) * 1980-04-30 1986-08-27 Merck & Co. Inc. Aminothiadiazoles as gastric secretion inhibitors
US4394508A (en) * 1980-06-07 1983-07-19 Bristol-Myers Company Chemical compounds
DE3168031D1 (en) * 1980-07-30 1985-02-14 Ici Plc Guanidine derivatives
EP0060730A3 (en) * 1981-03-18 1982-12-08 Imperial Chemical Industries Plc Bicyclic derivatives
EP0065823A1 (en) * 1981-05-13 1982-12-01 Imperial Chemical Industries Plc Heterocyclic guanidines as histamine H-2 antagonists
US4528375A (en) * 1982-03-29 1985-07-09 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
ZW7683A1 (en) * 1982-03-29 1984-01-04 Bristol Myers Co Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine h2 receptor antagonist activity
US4528377A (en) * 1982-03-29 1985-07-09 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
US4517366A (en) * 1982-03-29 1985-05-14 Bristol-Myers Company Intermediates for preparing 3,4-diamino-1,2,5-thiadiazoles
US4528378A (en) * 1982-03-29 1985-07-09 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
US4588826A (en) * 1982-03-29 1986-05-13 Bristol-Myers Company Ethanediimidamide intermediates
FI832519L (fi) * 1982-07-12 1984-01-13 Bristol Myers Co Farmaceutiska foerfaranden och sammansaettningar
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
JPS5978171A (ja) * 1982-10-26 1984-05-04 Ikeda Mohandou:Kk 複素環式化合物
US4440933A (en) * 1983-03-16 1984-04-03 Bristol-Myers Company Process for preparing 1,2,5-thiadiazoles

Also Published As

Publication number Publication date
AU2977589A (en) 1989-06-01
CA1267412A (en) 1990-04-03
OA08039A (fr) 1987-01-31
IT8521217A0 (it) 1985-06-20
SE8503110D0 (sv) 1985-06-20
GB8716149D0 (en) 1987-08-12
CS424785A2 (en) 1987-09-17
GR851514B (es) 1985-11-25
IL75567A0 (en) 1985-10-31
DK282885D0 (da) 1985-06-21
SU1537136A3 (ru) 1990-01-15
YU105185A (en) 1987-12-31
HUT42087A (en) 1987-06-29
AT390790B (de) 1990-06-25
YU102587A (en) 1988-02-29
SE464305B (sv) 1991-04-08
IE58261B1 (en) 1993-08-25
LU85969A1 (fr) 1986-01-24
GB2192884A (en) 1988-01-27
CH665210A5 (de) 1988-04-29
FR2566406B1 (fr) 1988-01-29
NO161856C (no) 1989-10-04
AU4392085A (en) 1986-01-02
NO852519L (no) 1985-12-23
YU45822B (sh) 1992-07-20
IE851557L (en) 1985-12-22
JPS6118775A (ja) 1986-01-27
FI852405A0 (fi) 1985-06-17
ES544409A0 (es) 1987-01-16
FI852405L (fi) 1985-12-23
ES8702902A1 (es) 1987-01-16
KR860000275A (ko) 1986-01-27
CS257276B2 (en) 1988-04-15
GB2161157A (en) 1986-01-08
BE902724A (fr) 1985-12-23
GB2192884B (en) 1988-08-10
US4644006A (en) 1987-02-17
JPS61186369A (ja) 1986-08-20
ZW10385A1 (en) 1986-02-05
AR240935A2 (es) 1991-03-27
KR900004321B1 (ko) 1990-06-22
NZ212403A (en) 1989-04-26
AU614331B2 (en) 1991-08-29
CA1297875C (en) 1992-03-24
IT1190372B (it) 1988-02-16
ATA185885A (de) 1989-12-15
ZA854710B (en) 1986-02-26
AU580605B2 (en) 1989-01-19
DE3522101A1 (de) 1986-01-02
SE8503110L (sv) 1985-12-23
AR240935A1 (es) 1991-03-27
GB8515749D0 (en) 1985-07-24
YU45725B (sh) 1992-07-20
FR2566406A1 (fr) 1985-12-27
IE57937B1 (en) 1993-05-19
NO161856B (no) 1989-06-26
PT80684A (en) 1985-07-01
HU193992B (en) 1987-12-28
ES551506A0 (es) 1987-01-16
DK282885A (da) 1985-12-23
DD240889A5 (de) 1986-11-19
GB2161157B (en) 1988-08-10
PT80684B (en) 1987-05-08
ES8702881A1 (es) 1987-01-16

Similar Documents

Publication Publication Date Title
US4639523A (en) Aminoalkylphenoxy derivatives
US4101548A (en) 1,2,3-Thiadiazole amides
US4390701A (en) 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione
US4171363A (en) 1,2,3-Thiadiazole process
SU1400508A3 (ru) Способ получени производных арилтиазолов
EP2676955B1 (en) Thiazole Derivative and use thereof as VAP-1 Inhibitor
JPS6028819B2 (ja) 新規なるグアニジン誘導体の製造方法
HU184259B (en) Process for producing 2-imidazoline derivatives
HU182461B (en) Process for producing new h-2 down-receptore antagonistic thiazole derivatives
CS241072B2 (en) Method of 3-/(amino or subst,amino/)-4-/(subst.amino/)-1,2,5-thiadizoles production
US4692531A (en) Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
KR900000370B1 (ko) 티아졸론 및 이의 제조방법
EP0010893A1 (en) Antisecretory branched-chain heterocyclic guanidine derivatives, processes for their manufacture, intermediates, and pharmaceutical compositions containing said derivatives
NL8501766A (nl) Gesubstitueerde 3,4-diamino-1,2,5-thiadiazolen met histamine h2-receptorantagonistaktiviteit.
US4395553A (en) Chemical compounds
CH643849A5 (en) 3,7-Disubstituted 3-cephem-4-carboxylic acid compounds, processes for their preparation and pharmaceuticals containing them
US4595683A (en) 3- and 5-[bicyclic ether or bicyclic alkylene thioether]alkylene amino thiatriazines, and their pharmaceutical uses
HU187877B (en) Process for preparing guanidino-heterocyclyl-phenyl-amidines and pharmaceutical compositions containing thereof
US5240918A (en) 2-(substituted imino)-thiazolidines and process for the preparation thereof
EP0744402B1 (en) Potassium salt of biphenylmethane derivative and medicine containing the same
DK160821B (da) 1,3-dihydro-4-benzoyl-2h-imidazol-2-oner samt middel til behandling af hjertesvigt
EP0877026B1 (en) Substituted 6-r-1,3,4-thiadiazine-2-amines, the use thereof as anaesthetising, cardiovascular and hypometabolic agents, and a pharmaceutical composition containing them
RU2141480C1 (ru) Моно- или дикалий 2-[[5-этил-3-[2'-(1н-тетразол-5-ил)бифенил-4-ил]метил-1,3,4-тиадиазолин-2- илиден]аминокарбонил]-1-циклопентенкарбоксилат, фармацевтическая композиция и способ терапевтического лечения гипертензии
KR810000600B1 (ko) 헤테로 사이클 유도체의 제법
NO129577B (es)

Legal Events

Date Code Title Description
A1A A request for search or an international-type search has been filed
BB A search report has been drawn up
DNT Communications of changes of names of applicants whose applications have been laid open to public inspection

Free format text: BRISTOL-MYERS SQUIBB COMPANY

BC A request for examination has been filed
BV The patent application has lapsed