NL8204013A - Steroid en farmaceutisch preparaat alsmede werkwijze voor het bereiden daarvan. - Google Patents
Steroid en farmaceutisch preparaat alsmede werkwijze voor het bereiden daarvan. Download PDFInfo
- Publication number
- NL8204013A NL8204013A NL8204013A NL8204013A NL8204013A NL 8204013 A NL8204013 A NL 8204013A NL 8204013 A NL8204013 A NL 8204013A NL 8204013 A NL8204013 A NL 8204013A NL 8204013 A NL8204013 A NL 8204013A
- Authority
- NL
- Netherlands
- Prior art keywords
- beclomethasone dipropionate
- monohydrate
- water
- pharmaceutical preparation
- preparation according
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8131425 | 1981-10-19 | ||
GB8131425 | 1981-10-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
NL8204013A true NL8204013A (nl) | 1983-05-16 |
Family
ID=10525238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL8204013A NL8204013A (nl) | 1981-10-19 | 1982-10-18 | Steroid en farmaceutisch preparaat alsmede werkwijze voor het bereiden daarvan. |
Country Status (22)
Country | Link |
---|---|
US (1) | US4866051A (de) |
JP (1) | JPS5890599A (de) |
KR (1) | KR890000664B1 (de) |
AU (1) | AU551471B2 (de) |
BE (1) | BE894725A (de) |
CA (1) | CA1189853A (de) |
CH (1) | CH652134A5 (de) |
DE (1) | DE3238569A1 (de) |
DK (1) | DK168389B1 (de) |
DO (1) | DOP1990004774A (de) |
ES (1) | ES516611A0 (de) |
FI (1) | FI73128C (de) |
FR (1) | FR2514769B1 (de) |
HK (1) | HK100989A (de) |
IE (1) | IE54170B1 (de) |
IT (1) | IT1196553B (de) |
MY (1) | MY8700910A (de) |
NL (1) | NL8204013A (de) |
NZ (1) | NZ202212A (de) |
PT (1) | PT75692A (de) |
SE (1) | SE454356B (de) |
ZA (1) | ZA827601B (de) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225183A (en) * | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
US5766573A (en) * | 1988-12-06 | 1998-06-16 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
US5270305A (en) * | 1989-09-08 | 1993-12-14 | Glaxo Group Limited | Medicaments |
US5208226A (en) * | 1989-09-08 | 1993-05-04 | Glaxo Group Limited | Medicaments |
US5439670A (en) * | 1989-11-28 | 1995-08-08 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
SE9101090D0 (sv) * | 1991-04-11 | 1991-04-11 | Astra Ab | Process for conditioning of water-soluble substances |
GB9202519D0 (en) * | 1992-02-06 | 1992-03-25 | Glaxo Group Ltd | Medicaments |
NZ257212A (en) | 1992-09-29 | 1996-11-26 | Inhale Therapeutic Syst | Parathyroid hormone formulations comprising a biologically active n-terminal fragment of the hormone |
GB9322014D0 (en) * | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
PE44995A1 (es) * | 1994-01-27 | 1995-12-18 | Schering Corp | Furoato de mometasona para el tratamiento de las enfermedades pulmonares y de las vias respiratorias |
US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US6428771B1 (en) * | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
AU6290396A (en) * | 1995-06-29 | 1997-01-30 | Mcneil-Ppc, Inc. | The combination of topical nasal mast cell stabilizers and topical nasal steroids |
US5987746A (en) * | 1996-02-21 | 1999-11-23 | Medtronic, Inc. | Method of making medical electrical lead |
US20030203036A1 (en) | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
GB9826284D0 (en) * | 1998-12-01 | 1999-01-20 | Rhone Poulence Rorer Limited | Process |
US9006175B2 (en) * | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
PT1196430E (pt) * | 1999-06-29 | 2012-04-18 | Mannkind Corp | Purificação e estabilização de péptidos e proteínas em agentes farmacêuticos |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
DK1280520T4 (en) | 2000-05-10 | 2018-06-25 | Novartis Ag | Phospholipid based powders for drug delivery |
US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
US7575761B2 (en) | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
AU2001278115A1 (en) * | 2000-08-04 | 2002-02-18 | Longwood Pharmaceutical Research, Inc. | Formulations of mometasone and a bronchodilator for pulmonary administration |
GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
EP1446104B2 (de) * | 2001-11-01 | 2011-08-03 | Novartis AG | Sprühtrocknungsverfahren |
EP1458360B1 (de) | 2001-12-19 | 2011-05-11 | Novartis AG | Pulmonale verabreichung von aminoglykosiden |
WO2003080149A2 (en) | 2002-03-20 | 2003-10-02 | Mannkind Corporation | Inhalation apparatus |
US7582284B2 (en) | 2002-04-17 | 2009-09-01 | Nektar Therapeutics | Particulate materials |
GB0216562D0 (en) | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
KR20050084930A (ko) * | 2002-11-08 | 2005-08-29 | 가부시키가이샤 가네카 | 에르고스테롤의 분리 방법 |
US7338171B2 (en) * | 2003-10-27 | 2008-03-04 | Jen-Chuen Hsieh | Method and apparatus for visual drive control |
KR100985126B1 (ko) * | 2004-01-12 | 2010-10-05 | 맨카인드 코포레이션 | 제2형 당뇨병에서 혈청 프로인슐린 수치의 감소 방법 |
US20080090753A1 (en) * | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
DE602005024413D1 (de) | 2004-08-20 | 2010-12-09 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
ES2540886T3 (es) | 2004-08-23 | 2015-07-14 | Mannkind Corporation | Sales de dicetopiperazina para la administración de fármacos |
US20060204601A1 (en) * | 2005-03-09 | 2006-09-14 | Palu Afa K | Formulations and methods for preventing and treating substance abuse and addiction |
WO2006096906A1 (en) * | 2005-03-18 | 2006-09-21 | Nanomaterials Technology Pte Ltd | Inhalable drug |
KR101557502B1 (ko) | 2005-09-14 | 2015-10-06 | 맨카인드 코포레이션 | 결정질 미립자 표면에 대한 활성제의 친화력의 증가를기반으로 하는 약물 제제의 방법 |
US8084420B2 (en) * | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US20070086952A1 (en) * | 2005-09-29 | 2007-04-19 | Biodel, Inc. | Rapid Acting and Prolonged Acting Inhalable Insulin Preparations |
AU2007216966C1 (en) | 2006-02-22 | 2014-03-20 | Mannkind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
CA2649109A1 (en) * | 2006-04-12 | 2007-10-25 | Biodel, Inc. | Rapid acting and long acting insulin combination formulations |
UY30542A1 (es) * | 2006-08-18 | 2008-03-31 | Boehringer Ingelheim Int | Formulacion de aerosol para la inhalacion de agonistas beta |
UY30543A1 (es) * | 2006-08-18 | 2008-03-31 | Boehringer Ingelheim Int | Formulacion de aerosol para la inhalacion de beta- agonistas |
KR20150041804A (ko) | 2007-02-11 | 2015-04-17 | 맵 파마슈티컬스, 인코포레이티드 | 부작용 프로파일을 최소화하면서 편두통의 빠른 완화를 가능하게 하는 dhe의 치료적 투여 방법 |
WO2008124522A2 (en) * | 2007-04-04 | 2008-10-16 | Biodel, Inc. | Amylin formulations |
US8785396B2 (en) | 2007-10-24 | 2014-07-22 | Mannkind Corporation | Method and composition for treating migraines |
AU2009204309B2 (en) * | 2008-01-04 | 2012-11-22 | Biodel, Inc. | Insulin formulations for insulin release as a function of tissue glucose levels |
GB0806873D0 (en) * | 2008-04-16 | 2008-05-21 | Breath Ltd | Steroid nebuliser formulation |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
PL2293833T3 (pl) | 2008-06-13 | 2016-08-31 | Mannkind Corp | Inhalator proszkowy i układ do dostarczania leku |
EP2609954B1 (de) | 2008-06-20 | 2021-12-29 | MannKind Corporation | Interaktives Gerät für die Echtzeit-Profilierung von Inhalationsversuchen |
TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US9060927B2 (en) * | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
EP2405963B1 (de) | 2009-03-11 | 2013-11-06 | MannKind Corporation | Gerät, system und verfahren zur messung von widerstand in einem inhaliergerät |
KR20180079458A (ko) | 2009-06-12 | 2018-07-10 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
GB0914231D0 (en) * | 2009-08-14 | 2009-09-30 | Breath Ltd | Dry powder inhaler formulations |
US9016147B2 (en) | 2009-11-03 | 2015-04-28 | Mannkind Corporation | Apparatus and method for simulating inhalation efforts |
CA2801936C (en) | 2010-06-21 | 2021-06-01 | Mannkind Corporation | Dry powder drug delivery system and methods |
EP2694402B1 (de) | 2011-04-01 | 2017-03-22 | MannKind Corporation | Blisterverpackung für pharmakartuschen |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
EP2776053A1 (de) | 2011-10-24 | 2014-09-17 | MannKind Corporation | Verfahren und zusammensetzungen zur schmerzbehandlung |
AU2013289957B2 (en) | 2012-07-12 | 2017-02-23 | Mannkind Corporation | Dry powder drug delivery systems and methods |
EP2911690A1 (de) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalierbare influenza-impfstoffzusammensetzungen und verfahren |
KR102499439B1 (ko) | 2013-03-15 | 2023-02-13 | 맨카인드 코포레이션 | 미세결정성 디케토피페라진 조성물 및 방법 |
MX2020009878A (es) | 2013-07-18 | 2022-07-27 | Mannkind Corp | Composiciones farmaceuticas en polvo seco estables al calor y metodos. |
JP2016530930A (ja) | 2013-08-05 | 2016-10-06 | マンカインド コーポレイション | 通気装置及び方法 |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
US11756656B2 (en) | 2018-06-14 | 2023-09-12 | Astrazeneca Uk Limited | Methods for treating and preventing symptoms of asthma with a corticosteroid pharmaceutical composition |
IT201800007527A1 (it) * | 2018-07-26 | 2020-01-26 | Sofar Spa | Composizione contenente beclometasone per la prevenzione e il trattamento di prostatiti batteriche e vaginiti |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1047519A (en) * | 1963-06-11 | 1966-11-02 | Glaxo Lab Ltd | 17ª‡,21-diesters of 11,17,21-trihydroxy steroid compounds |
GB1429184A (en) * | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
DK153556C (da) * | 1974-03-27 | 1988-12-05 | Plurichemie Anstalt | Fremgangsmaade til fremstilling af estere af 9alfa-klor- eller -fluor-16alfa- eller -16beta-metyl-21-desoxyprednisoloner |
GB1571629A (en) * | 1977-11-30 | 1980-07-16 | Fisons Ltd | Pharmaceutical compositions containing beclomethasone dipropionate |
IT1121513B (it) * | 1979-05-28 | 1986-04-02 | Chiesi Farma Spa | Processo per la conversione di umo steroide antiinfiammatorio in una forma suscettibile di essere somministarta come aerosol |
EP0039369B1 (de) * | 1980-05-02 | 1983-06-15 | Schering Corporation | Beclomethason-ester-solvate, Verfahren zu ihrer Herstellung und Herstellung einer Formulierung |
FI63672C (fi) * | 1980-05-19 | 1983-08-10 | Orion Yhtymae Oy | Foerfarande foer framstaellning av en blandning av beklometasondipropionat och triklorfluormetan eller diklordifluormetan |
PT71309A (en) * | 1980-05-27 | 1980-06-01 | Hovione Sociedade Quimica Lda | Process of selective |
PT73772B (en) * | 1980-10-06 | 1983-10-14 | Glaxo Group Ltd | Topically administrable pharmaceutical compositions containing anti-inflammatory steroids |
US4391755A (en) * | 1982-01-18 | 1983-07-05 | E. R. Squibb & Sons, Inc. | Steroid monohydrates, formulations containing same and method |
IL75903A (en) * | 1984-07-25 | 1989-10-31 | Hovione Int Ltd | Di-isopropyl ether solvates of beclomethasone 17,21-dipropionate,their preparation and use |
GB8432063D0 (en) * | 1984-12-19 | 1985-01-30 | Riker Laboratories Inc | Physically modified steroids |
-
1982
- 1982-10-16 KR KR8204671A patent/KR890000664B1/ko active
- 1982-10-18 PT PT75692A patent/PT75692A/pt unknown
- 1982-10-18 AU AU89460/82A patent/AU551471B2/en not_active Expired
- 1982-10-18 CA CA000413616A patent/CA1189853A/en not_active Expired
- 1982-10-18 ES ES516611A patent/ES516611A0/es active Granted
- 1982-10-18 BE BE0/209262A patent/BE894725A/fr unknown
- 1982-10-18 CH CH6056/82A patent/CH652134A5/de not_active IP Right Cessation
- 1982-10-18 FI FI823561A patent/FI73128C/fi not_active IP Right Cessation
- 1982-10-18 FR FR8217369A patent/FR2514769B1/fr not_active Expired
- 1982-10-18 IT IT49294/82A patent/IT1196553B/it active
- 1982-10-18 SE SE8205904A patent/SE454356B/sv not_active IP Right Cessation
- 1982-10-18 NL NL8204013A patent/NL8204013A/nl active Search and Examination
- 1982-10-18 ZA ZA827601A patent/ZA827601B/xx unknown
- 1982-10-18 IE IE2514/82A patent/IE54170B1/en not_active IP Right Cessation
- 1982-10-18 DK DK461182A patent/DK168389B1/da active
- 1982-10-18 NZ NZ202212A patent/NZ202212A/en unknown
- 1982-10-18 DE DE19823238569 patent/DE3238569A1/de active Granted
- 1982-10-18 JP JP57181500A patent/JPS5890599A/ja active Granted
-
1985
- 1985-01-30 US US06/696,427 patent/US4866051A/en not_active Expired - Lifetime
-
1987
- 1987-12-30 MY MY910/87A patent/MY8700910A/xx unknown
-
1989
- 1989-12-21 HK HK1009/89A patent/HK100989A/xx not_active IP Right Cessation
-
1990
- 1990-04-17 DO DO1990004774A patent/DOP1990004774A/es unknown
Also Published As
Publication number | Publication date |
---|---|
NZ202212A (en) | 1986-01-24 |
JPS5890599A (ja) | 1983-05-30 |
PT75692A (en) | 1982-11-01 |
HK100989A (en) | 1989-12-29 |
SE8205904L (sv) | 1983-04-20 |
FI823561L (fi) | 1983-04-20 |
FR2514769A1 (fr) | 1983-04-22 |
IT8249294A0 (it) | 1982-10-18 |
MY8700910A (en) | 1987-12-31 |
ES8404374A1 (es) | 1984-05-01 |
BE894725A (fr) | 1983-04-18 |
FR2514769B1 (fr) | 1985-08-30 |
FI73128C (fi) | 1987-09-10 |
IE822514L (en) | 1983-04-19 |
KR890000664B1 (ko) | 1989-03-22 |
FI823561A0 (fi) | 1982-10-18 |
AU8946082A (en) | 1984-05-03 |
JPH0424358B2 (de) | 1992-04-24 |
IE54170B1 (en) | 1989-07-05 |
DOP1990004774A (es) | 1996-02-02 |
AU551471B2 (en) | 1986-05-01 |
SE8205904D0 (sv) | 1982-10-18 |
FI73128B (fi) | 1987-05-29 |
DE3238569C2 (de) | 1991-01-31 |
DK168389B1 (da) | 1994-03-21 |
SE454356B (sv) | 1988-04-25 |
IT1196553B (it) | 1988-11-16 |
DK461182A (da) | 1983-04-20 |
DE3238569A1 (de) | 1983-05-05 |
ES516611A0 (es) | 1984-05-01 |
ZA827601B (en) | 1983-09-28 |
CA1189853A (en) | 1985-07-02 |
KR840002007A (ko) | 1984-06-11 |
US4866051A (en) | 1989-09-12 |
CH652134A5 (de) | 1985-10-31 |
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