FI823561A0 - Foerbaettringar vid en steroidfoerening och denna innehaollande farmaceutiska produkter - Google Patents

Foerbaettringar vid en steroidfoerening och denna innehaollande farmaceutiska produkter

Info

Publication number
FI823561A0
FI823561A0 FI823561A FI823561A FI823561A0 FI 823561 A0 FI823561 A0 FI 823561A0 FI 823561 A FI823561 A FI 823561A FI 823561 A FI823561 A FI 823561A FI 823561 A0 FI823561 A0 FI 823561A0
Authority
FI
Finland
Prior art keywords
pharmaceutical products
pharmaceutical
products
Prior art date
Application number
FI823561A
Other languages
English (en)
Other versions
FI823561L (fi
FI73128C (fi
FI73128B (fi
Inventor
John Harold Hunt
John Malcolm Padfield
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FI823561A0 publication Critical patent/FI823561A0/fi
Publication of FI823561L publication Critical patent/FI823561L/fi
Application granted granted Critical
Publication of FI73128B publication Critical patent/FI73128B/fi
Publication of FI73128C publication Critical patent/FI73128C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
FI823561A 1981-10-19 1982-10-18 Foerfarande foer framstaellning av finmalt beklometason-dipropionat-monohydrat. FI73128C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8131425 1981-10-19
GB8131425 1981-10-19

Publications (4)

Publication Number Publication Date
FI823561A0 true FI823561A0 (fi) 1982-10-18
FI823561L FI823561L (fi) 1983-04-20
FI73128B FI73128B (fi) 1987-05-29
FI73128C FI73128C (fi) 1987-09-10

Family

ID=10525238

Family Applications (1)

Application Number Title Priority Date Filing Date
FI823561A FI73128C (fi) 1981-10-19 1982-10-18 Foerfarande foer framstaellning av finmalt beklometason-dipropionat-monohydrat.

Country Status (22)

Country Link
US (1) US4866051A (fi)
JP (1) JPS5890599A (fi)
KR (1) KR890000664B1 (fi)
AU (1) AU551471B2 (fi)
BE (1) BE894725A (fi)
CA (1) CA1189853A (fi)
CH (1) CH652134A5 (fi)
DE (1) DE3238569A1 (fi)
DK (1) DK168389B1 (fi)
DO (1) DOP1990004774A (fi)
ES (1) ES516611A0 (fi)
FI (1) FI73128C (fi)
FR (1) FR2514769B1 (fi)
HK (1) HK100989A (fi)
IE (1) IE54170B1 (fi)
IT (1) IT1196553B (fi)
MY (1) MY8700910A (fi)
NL (1) NL8204013A (fi)
NZ (1) NZ202212A (fi)
PT (1) PT75692A (fi)
SE (1) SE454356B (fi)
ZA (1) ZA827601B (fi)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225183A (en) * 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
US5766573A (en) * 1988-12-06 1998-06-16 Riker Laboratories, Inc. Medicinal aerosol formulations
US5270305A (en) * 1989-09-08 1993-12-14 Glaxo Group Limited Medicaments
US5208226A (en) * 1989-09-08 1993-05-04 Glaxo Group Limited Medicaments
US5439670A (en) * 1989-11-28 1995-08-08 Riker Laboratories, Inc. Medicinal aerosol formulations
SE9101090D0 (sv) * 1991-04-11 1991-04-11 Astra Ab Process for conditioning of water-soluble substances
GB9202519D0 (en) * 1992-02-06 1992-03-25 Glaxo Group Ltd Medicaments
PT679088E (pt) 1992-09-29 2002-12-31 Inhale Therapeutic Syst Administracao pulmonar de fragmentos activos de hormona paratiroide
GB9322014D0 (en) * 1993-10-26 1993-12-15 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
PE44995A1 (es) * 1994-01-27 1995-12-18 Schering Corp Furoato de mometasona para el tratamiento de las enfermedades pulmonares y de las vias respiratorias
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US6428771B1 (en) * 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
AU6290396A (en) * 1995-06-29 1997-01-30 Mcneil-Ppc, Inc. The combination of topical nasal mast cell stabilizers and topical nasal steroids
US5987746A (en) * 1996-02-21 1999-11-23 Medtronic, Inc. Method of making medical electrical lead
US20030203036A1 (en) * 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
GB9826284D0 (en) * 1998-12-01 1999-01-20 Rhone Poulence Rorer Limited Process
US9006175B2 (en) * 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
PT1808438E (pt) 1999-06-29 2015-01-14 Mannkind Corp Purificação e estabilização de péptidos e proteínas em agentes farmacêuticos
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
WO2001085136A2 (en) 2000-05-10 2001-11-15 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
WO2002011711A2 (en) * 2000-08-04 2002-02-14 Longwood Pharmaceutical Research, Inc. Formulations of mometasone and a bronchodilator for pulmonary administration
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
EP1446104B2 (en) 2001-11-01 2011-08-03 Novartis AG Spray drying methods
JP2005514393A (ja) 2001-12-19 2005-05-19 ネクター セラピューティクス アミノグリコシドの肺への供給
WO2003080149A2 (en) 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US7884221B2 (en) * 2002-11-08 2011-02-08 Kaneka Corporation Method of separating ergosterol
US7338171B2 (en) * 2003-10-27 2008-03-04 Jen-Chuen Hsieh Method and apparatus for visual drive control
EP1708738B1 (en) * 2004-01-12 2016-05-04 MannKind Corporation A method of reducing serum proinsulin levels in type 2 diabetics
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US20080248999A1 (en) * 2007-04-04 2008-10-09 Biodel Inc. Amylin formulations
JP5078014B2 (ja) 2004-08-20 2012-11-21 マンカインド コーポレイション ジケトピペラジン合成の触媒反応
HUE026797T2 (en) 2004-08-23 2016-07-28 Mannkind Corp Diceto-piperazine salts for drug delivery
US20060204601A1 (en) * 2005-03-09 2006-09-14 Palu Afa K Formulations and methods for preventing and treating substance abuse and addiction
EP1871344A4 (en) * 2005-03-18 2012-05-02 Nanomaterials Tech Pte Ltd INHIBITABLE MEDICINAL PRODUCT
KR20120060245A (ko) 2005-09-14 2012-06-11 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
US20070086952A1 (en) * 2005-09-29 2007-04-19 Biodel, Inc. Rapid Acting and Prolonged Acting Inhalable Insulin Preparations
US8084420B2 (en) * 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
EP2497484A3 (en) 2006-02-22 2012-11-07 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US7718609B2 (en) * 2006-04-12 2010-05-18 Biodel Inc. Rapid acting and long acting insulin combination formulations
UY30543A1 (es) * 2006-08-18 2008-03-31 Boehringer Ingelheim Int Formulacion de aerosol para la inhalacion de beta- agonistas
UY30542A1 (es) * 2006-08-18 2008-03-31 Boehringer Ingelheim Int Formulacion de aerosol para la inhalacion de agonistas beta
EP2425819A1 (en) 2007-02-11 2012-03-07 MAP Pharmaceuticals Inc Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
MX2010007342A (es) * 2008-01-04 2010-08-26 Biodel Inc Formulaciones de insulina para la liberacion de insulina como una funcion de los niveles de glucosa en el tejido.
GB0806873D0 (en) * 2008-04-16 2008-05-21 Breath Ltd Steroid nebuliser formulation
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP3281663B8 (en) 2008-06-13 2022-09-21 MannKind Corporation Breath powered dry powder inhaler for drug delivery
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9060927B2 (en) * 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
WO2010144789A2 (en) 2009-06-12 2010-12-16 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
GB0914231D0 (en) * 2009-08-14 2009-09-30 Breath Ltd Dry powder inhaler formulations
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
AU2011271097B2 (en) 2010-06-21 2014-11-27 Mannkind Corporation Dry powder drug delivery system and methods
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
KR20140095483A (ko) 2011-10-24 2014-08-01 맨카인드 코포레이션 통증을 치료하기 위한 방법 및 조성물
DK2872205T3 (en) 2012-07-12 2017-02-27 Mannkind Corp DRY POWDER FORMAL ADMINISTRATION SYSTEM
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
KR102499439B1 (ko) 2013-03-15 2023-02-13 맨카인드 코포레이션 미세결정성 디케토피페라진 조성물 및 방법
WO2015010092A1 (en) 2013-07-18 2015-01-22 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
CA3103679A1 (en) 2018-06-14 2019-12-19 Astrazeneca Uk Limited Methods for treating and preventing symptoms of asthma with a corticosteroid pharmaceutical composition
IT201800007527A1 (it) * 2018-07-26 2020-01-26 Sofar Spa Composizione contenente beclometasone per la prevenzione e il trattamento di prostatiti batteriche e vaginiti

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1047519A (en) * 1963-06-11 1966-11-02 Glaxo Lab Ltd 17ª‡,21-diesters of 11,17,21-trihydroxy steroid compounds
GB1429184A (en) * 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
CH622811A5 (fi) * 1974-03-27 1981-04-30 Plurichemie Anstalt
GB1571629A (en) * 1977-11-30 1980-07-16 Fisons Ltd Pharmaceutical compositions containing beclomethasone dipropionate
IT1121513B (it) * 1979-05-28 1986-04-02 Chiesi Farma Spa Processo per la conversione di umo steroide antiinfiammatorio in una forma suscettibile di essere somministarta come aerosol
EP0039369B1 (en) * 1980-05-02 1983-06-15 Schering Corporation Beclomethasone ester solvates, process for their preparation, and preparation of a formulation
FI63672C (fi) * 1980-05-19 1983-08-10 Orion Yhtymae Oy Foerfarande foer framstaellning av en blandning av beklometasondipropionat och triklorfluormetan eller diklordifluormetan
PT71309A (en) * 1980-05-27 1980-06-01 Hovione Sociedade Quimica Lda Process of selective
PT73772B (en) * 1980-10-06 1983-10-14 Glaxo Group Ltd Topically administrable pharmaceutical compositions containing anti-inflammatory steroids
US4391755A (en) * 1982-01-18 1983-07-05 E. R. Squibb & Sons, Inc. Steroid monohydrates, formulations containing same and method
US4913892A (en) * 1984-07-25 1990-04-03 Hovione Inter Ltd. Preparation and use of new solvates of beclomethasone 17,21-dipropionate
GB8432063D0 (en) * 1984-12-19 1985-01-30 Riker Laboratories Inc Physically modified steroids

Also Published As

Publication number Publication date
FR2514769B1 (fr) 1985-08-30
SE8205904D0 (sv) 1982-10-18
NL8204013A (nl) 1983-05-16
DK168389B1 (da) 1994-03-21
MY8700910A (en) 1987-12-31
JPS5890599A (ja) 1983-05-30
DE3238569C2 (fi) 1991-01-31
IT1196553B (it) 1988-11-16
FI823561L (fi) 1983-04-20
FR2514769A1 (fr) 1983-04-22
PT75692A (en) 1982-11-01
IE54170B1 (en) 1989-07-05
AU8946082A (en) 1984-05-03
ZA827601B (en) 1983-09-28
CH652134A5 (de) 1985-10-31
BE894725A (fr) 1983-04-18
HK100989A (en) 1989-12-29
DOP1990004774A (es) 1996-02-02
KR840002007A (ko) 1984-06-11
FI73128C (fi) 1987-09-10
ES8404374A1 (es) 1984-05-01
IE822514L (en) 1983-04-19
AU551471B2 (en) 1986-05-01
SE8205904L (sv) 1983-04-20
NZ202212A (en) 1986-01-24
IT8249294A0 (it) 1982-10-18
KR890000664B1 (ko) 1989-03-22
FI73128B (fi) 1987-05-29
DE3238569A1 (de) 1983-05-05
DK461182A (da) 1983-04-20
ES516611A0 (es) 1984-05-01
US4866051A (en) 1989-09-12
CA1189853A (en) 1985-07-02
JPH0424358B2 (fi) 1992-04-24
SE454356B (sv) 1988-04-25

Similar Documents

Publication Publication Date Title
FI823561L (fi) Foerbaettringar vid en steroidfoerening och denna innehaollande farmaceutiska produkter
FI821123A0 (fi) Lokalt anvaendbara farmaceutiska produkter
FI871826A0 (fi) Fotokromisia tuotteita ja yhdisteitä
DK82982A (da) Bandage til indgift af et gavnligt laegemiddel
IT8050314A0 (it) Dispositivo per la somministrazione di medicamenti in polvere
FI802329A (fi) Med uv-straolning haerdbara silikonbelaeggningsblandningar och deras anvaendningsmetoder
DE3483713D1 (de) Hydroxypyridon-derivate und sie enthaltende pharmazeutische zubereitungen.
FI830299A0 (fi) Difosfonsyra-derivat och dessa innehaollande farmaceutiska produkter
DK51493A (da) Laegemiddel indeholdende humant interleukin-1alfa og anvendelse af interleukin-1alfa til fremstilling af et saadant laegemiddel
DK345682A (da) Pharmaceutiske expienser
DK475684D0 (da) Phenothiazinderivater og farmaceutiske praeparater indeholdende phenothiazinderivaterne
FI810558L (fi) 2(1h)-pyridinonderivat deras framstaellning och dessa innehaollande farmaceutiska produkter
BE894376A (fr) Preparation pharmaceutique
IT8248677A0 (it) Formulazioni farmaceutiche
DK327983A (da) Farmaceutiske praeparater og produkter
DK114584A (da) Fast farmaceutisk praeparat samt fremgangsmaade til fremstilling deraf
FI813412L (fi) 3-aminopropoxifenylderivat deras framstaellning och dessa innehaollande farmaceutiska produkter
FI810934L (fi) Farmaceutiska produkter
DK314283D0 (da) Farmaceutiske praeparater
FI803846L (fi) Farmaceutiska produkter
MC1372A1 (fr) Preparations pharmaceutiques
FI830399A0 (fi) Mjoeldryge-alkaloider, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska produkter
FI822980A0 (fi) Furanokromonderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska produkter
FI812253L (fi) Ergolinderivat foerfarande foer deras framstaellning dessa innehaollande farmaceutiska foereningar och deras anvaendning vid terapeutisk behandling
BE890817A (fr) Medicaments pschycotropes

Legal Events

Date Code Title Description
MA Patent expired

Owner name: GLAXO GROUP LIMITED