NL8200110A - Nieuwe verbindingen met anti-allergene effecten, werkwijze voor de bereiding daarvan, en preparaten die ze bevatten. - Google Patents
Nieuwe verbindingen met anti-allergene effecten, werkwijze voor de bereiding daarvan, en preparaten die ze bevatten. Download PDFInfo
- Publication number
- NL8200110A NL8200110A NL8200110A NL8200110A NL8200110A NL 8200110 A NL8200110 A NL 8200110A NL 8200110 A NL8200110 A NL 8200110A NL 8200110 A NL8200110 A NL 8200110A NL 8200110 A NL8200110 A NL 8200110A
- Authority
- NL
- Netherlands
- Prior art keywords
- trans
- guanidinomethyl
- hydrochloride
- formula
- mixture
- Prior art date
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- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N alpha-methyl toluene Natural products CCC1=CC=CC=C1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 150000008366 benzophenones Chemical class 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- ZNMROZJFHALUOA-UHFFFAOYSA-N bis(4-tert-butylphenyl) sulfite Chemical compound C1=CC(C(C)(C)C)=CC=C1OS(=O)OC1=CC=C(C(C)(C)C)C=C1 ZNMROZJFHALUOA-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 125000004799 bromophenyl group Chemical group 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 125000000068 chlorophenyl group Chemical group 0.000 description 1
- HLVXFWDLRHCZEI-UHFFFAOYSA-N chromotropic acid Chemical compound OS(=O)(=O)C1=CC(O)=C2C(O)=CC(S(O)(=O)=O)=CC2=C1 HLVXFWDLRHCZEI-UHFFFAOYSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 125000004802 cyanophenyl group Chemical group 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical compound [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 1
- 229960003699 evans blue Drugs 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000004013 groin Anatomy 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 229940071870 hydroiodic acid Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 125000006303 iodophenyl group Chemical group 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 150000007517 lewis acids Chemical class 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000006501 nitrophenyl group Chemical group 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 229960003540 oxyquinoline Drugs 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C07D215/32—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP728681 | 1981-01-22 | ||
| JP728481A JPS57122061A (en) | 1981-01-22 | 1981-01-22 | Novel cyclohexanecarboxylic acid derivative and its preparation |
| JP728381 | 1981-01-22 | ||
| JP728681A JPS57122060A (en) | 1981-01-22 | 1981-01-22 | Carboxylic acid ester and its preparation |
| JP728481 | 1981-01-22 | ||
| JP728381A JPS57122059A (en) | 1981-01-22 | 1981-01-22 | Novel cyclohexanecarboxylic acid derivative and its preparation |
| JP1083281A JPS57126463A (en) | 1981-01-29 | 1981-01-29 | Novel carboxylic ester and its preparation |
| JP1083281 | 1981-01-29 | ||
| JP1083181A JPS57126462A (en) | 1981-01-29 | 1981-01-29 | Novel carboxylic ester and its preparation |
| JP1083181 | 1981-01-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8200110A true NL8200110A (nl) | 1982-08-16 |
Family
ID=27518804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8200110A NL8200110A (nl) | 1981-01-22 | 1982-01-13 | Nieuwe verbindingen met anti-allergene effecten, werkwijze voor de bereiding daarvan, en preparaten die ze bevatten. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4465851A (en, 2012) |
| KR (1) | KR880001104B1 (en, 2012) |
| BE (1) | BE891790A (en, 2012) |
| BR (1) | BR8200212A (en, 2012) |
| CA (1) | CA1180716A (en, 2012) |
| CH (1) | CH652119A5 (en, 2012) |
| DE (1) | DE3201817A1 (en, 2012) |
| FR (1) | FR2498183A1 (en, 2012) |
| IT (1) | IT1191163B (en, 2012) |
| NL (1) | NL8200110A (en, 2012) |
| SE (1) | SE455789B (en, 2012) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0585130B1 (en) * | 1992-08-27 | 1998-01-28 | Shiseido Company Limited | External preparation for skin containing a depigmentation agent |
| EP0989112B1 (en) * | 1994-08-30 | 2004-04-14 | Nagase ChemteX Corporation | Intermediates for the preparation of guanidinomethyl cyclohexane carboxylic acid ester derivatives |
| AUPO227896A0 (en) * | 1996-09-13 | 1996-10-03 | Fujisawa Pharmaceutical Co., Ltd. | Novel compounds and their preparation |
| AP1224A (en) | 1998-03-19 | 2003-11-14 | Bristol Myers Squibb Co | Biphasic controlled release delivery system for high solubility pharmaceuticals and method. |
| GB9908410D0 (en) | 1999-04-13 | 1999-06-09 | Pfizer Ltd | Pyridines |
| KR101942590B1 (ko) | 2010-07-09 | 2019-01-25 | 비에이치브이 파르마, 인크. | 레모글리플로진을 포함하는 짧은 반감기 약제용의 즉시/지연 조합 방출 전달 시스템 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA929942A (en) * | 1968-10-14 | 1973-07-10 | Okano Atsuji | Esters and their production |
| JPS5339419B2 (en, 2012) * | 1972-10-19 | 1978-10-21 | ||
| JPS5140075A (en, 2012) * | 1974-09-30 | 1976-04-03 | Tokyo Shibaura Electric Co | |
| SE460667B (sv) * | 1979-09-20 | 1989-11-06 | Nippon Chemiphar Co | Cyklohexankarboxylsyraderivat, foerfarande foer framstaellning daerav samt naemnda derivat foer terapeutisk anvaendning |
| JPS5645454A (en) * | 1979-09-20 | 1981-04-25 | Nippon Chemiphar Co Ltd | Cyclohexanecarboxylic acid derivative and its preparation |
-
1982
- 1982-01-04 US US06/336,707 patent/US4465851A/en not_active Expired - Lifetime
- 1982-01-13 NL NL8200110A patent/NL8200110A/nl not_active Application Discontinuation
- 1982-01-13 BR BR8200212A patent/BR8200212A/pt unknown
- 1982-01-15 BE BE0/207062A patent/BE891790A/fr not_active IP Right Cessation
- 1982-01-20 CA CA000394507A patent/CA1180716A/en not_active Expired
- 1982-01-20 SE SE8200309A patent/SE455789B/sv not_active IP Right Cessation
- 1982-01-21 IT IT67060/82A patent/IT1191163B/it active
- 1982-01-21 CH CH380/82A patent/CH652119A5/fr not_active IP Right Cessation
- 1982-01-21 DE DE19823201817 patent/DE3201817A1/de active Granted
- 1982-01-22 KR KR8200269A patent/KR880001104B1/ko not_active Expired
- 1982-01-22 FR FR8201032A patent/FR2498183A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE3201817A1 (de) | 1982-08-19 |
| KR880001104B1 (ko) | 1988-06-29 |
| IT8267060A0 (it) | 1982-01-21 |
| SE8200309L (sv) | 1982-07-23 |
| FR2498183B1 (en, 2012) | 1985-05-10 |
| KR830009011A (ko) | 1983-12-17 |
| BR8200212A (pt) | 1982-11-09 |
| BE891790A (fr) | 1982-04-30 |
| FR2498183A1 (fr) | 1982-07-23 |
| CH652119A5 (fr) | 1985-10-31 |
| IT1191163B (it) | 1988-02-24 |
| SE455789B (sv) | 1988-08-08 |
| DE3201817C2 (en, 2012) | 1991-03-07 |
| CA1180716A (en) | 1985-01-08 |
| US4465851A (en) | 1984-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| BV | The patent application has lapsed |