NL8005133A - Fenylpiperazinederivaten met antiagressieve werking. - Google Patents

Fenylpiperazinederivaten met antiagressieve werking. Download PDF

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Publication number
NL8005133A
NL8005133A NL8005133A NL8005133A NL8005133A NL 8005133 A NL8005133 A NL 8005133A NL 8005133 A NL8005133 A NL 8005133A NL 8005133 A NL8005133 A NL 8005133A NL 8005133 A NL8005133 A NL 8005133A
Authority
NL
Netherlands
Prior art keywords
formula
compound
group
process according
meaning
Prior art date
Application number
NL8005133A
Other languages
English (en)
Dutch (nl)
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Priority to NL8005133A priority Critical patent/NL8005133A/nl
Priority to EP81200929A priority patent/EP0048045A1/fr
Priority to AU75029/81A priority patent/AU7502981A/en
Priority to GR66001A priority patent/GR75079B/el
Priority to HU812582A priority patent/HU184966B/hu
Priority to PL23296581A priority patent/PL232965A1/xx
Priority to JP56141150A priority patent/JPS5781464A/ja
Priority to YU02173/81A priority patent/YU217381A/xx
Priority to CS816656A priority patent/CS228532B2/cs
Priority to FI812808A priority patent/FI812808L/fi
Priority to ZA816256A priority patent/ZA816256B/xx
Priority to DK400081A priority patent/DK400081A/da
Priority to DD81233166A priority patent/DD202152A5/de
Priority to IL63784A priority patent/IL63784A0/xx
Priority to ES505373A priority patent/ES8302681A1/es
Priority to CA000385649A priority patent/CA1155116A/fr
Publication of NL8005133A publication Critical patent/NL8005133A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
NL8005133A 1980-09-12 1980-09-12 Fenylpiperazinederivaten met antiagressieve werking. NL8005133A (nl)

Priority Applications (16)

Application Number Priority Date Filing Date Title
NL8005133A NL8005133A (nl) 1980-09-12 1980-09-12 Fenylpiperazinederivaten met antiagressieve werking.
EP81200929A EP0048045A1 (fr) 1980-09-12 1981-08-25 Dérivés de phényl-pipérazine ayant une activité antiagressive
AU75029/81A AU7502981A (en) 1980-09-12 1981-09-08 Phenyl piperazine derivatives having antiagresive activity
GR66001A GR75079B (fr) 1980-09-12 1981-09-08
HU812582A HU184966B (en) 1980-09-12 1981-09-08 Process for producing phenyl-piperazine derivatives of anti-agression activity
PL23296581A PL232965A1 (fr) 1980-09-12 1981-09-09
JP56141150A JPS5781464A (en) 1980-09-12 1981-09-09 Phenylpiperazine derivative and attack inhibitor thereof as effective ingredient
YU02173/81A YU217381A (en) 1980-09-12 1981-09-09 Process for preparing derivatives of phenyl piperazine of antiaggressive activity
CS816656A CS228532B2 (en) 1980-09-12 1981-09-09 Production method of phenylpiperazine derivative
FI812808A FI812808L (fi) 1980-09-12 1981-09-09 Fenylpiperazinderivat med antiagressiv aktivitet
ZA816256A ZA816256B (en) 1980-09-12 1981-09-09 Phenyl piperazine derivatives having anti-aggressive activity
DK400081A DK400081A (da) 1980-09-12 1981-09-09 Fremgangsmaade til fremstilling af phenylpiperazinderivater
DD81233166A DD202152A5 (de) 1980-09-12 1981-09-09 Verfahren zur herstellung von phenylpiperazinderivaten
IL63784A IL63784A0 (en) 1980-09-12 1981-09-09 Phenyl piperazine derivatives,their preparation and pharmaceutical compositions containing them
ES505373A ES8302681A1 (es) 1980-09-12 1981-09-10 Un metodo para preparar derivados de fenilpiperazina
CA000385649A CA1155116A (fr) 1980-09-12 1981-09-11 Derives de la phenyl piperazine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8005133A NL8005133A (nl) 1980-09-12 1980-09-12 Fenylpiperazinederivaten met antiagressieve werking.
NL8005133 1980-09-12

Publications (1)

Publication Number Publication Date
NL8005133A true NL8005133A (nl) 1982-04-01

Family

ID=19835870

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8005133A NL8005133A (nl) 1980-09-12 1980-09-12 Fenylpiperazinederivaten met antiagressieve werking.

Country Status (16)

Country Link
EP (1) EP0048045A1 (fr)
JP (1) JPS5781464A (fr)
AU (1) AU7502981A (fr)
CA (1) CA1155116A (fr)
CS (1) CS228532B2 (fr)
DD (1) DD202152A5 (fr)
DK (1) DK400081A (fr)
ES (1) ES8302681A1 (fr)
FI (1) FI812808L (fr)
GR (1) GR75079B (fr)
HU (1) HU184966B (fr)
IL (1) IL63784A0 (fr)
NL (1) NL8005133A (fr)
PL (1) PL232965A1 (fr)
YU (1) YU217381A (fr)
ZA (1) ZA816256B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK169601B1 (da) * 1983-10-17 1994-12-19 Duphar Int Res Piperazinderivater og farmaceutisk præparat indeholdende et sådant derivat, samt piperazinderivater med mellemproduktanvendelse
DE3571436D1 (en) * 1984-12-21 1989-08-17 Duphar Int Res New pharmaceutical compositions having anti-psychotic properties
US4778796A (en) * 1985-07-19 1988-10-18 Dainippon Pharmaceutical Co., Ltd. ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same
US5010078A (en) * 1988-05-24 1991-04-23 American Home Products Corporation Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity
US5254552A (en) * 1988-05-24 1993-10-19 American Home Products Corporation Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
US5192779A (en) * 1989-02-14 1993-03-09 Fujisawa Pharmaceutical Co., Ltd. Substituted-acetamide compound and a process for the preparation thereof
US5066680A (en) * 1989-02-14 1991-11-19 Fujisawa Pharmaceutical Co., Ltd. Novel substituted-acetamide compound and a process for the preparation thereof
FI102175B1 (fi) * 1989-04-22 1998-10-30 Wyeth John & Brother Ltd Menetelmä terapeuttisesti käyttökelpoisten piperatsiinijohdannaisten valmistamiseksi
US5382583A (en) * 1989-04-22 1995-01-17 John Wyeth & Brother, Limited Piperazine derivatives
US5340812A (en) * 1989-04-22 1994-08-23 John Wyeth & Brother, Limited Piperazine derivatives
DK0395313T3 (da) * 1989-04-22 2000-06-19 American Home Prod Tertiære alkyl-funktionaliserede piperazin-derivater
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
ZA924760B (en) * 1991-06-28 1993-03-31 Smithkline Beecham Corp Bicyclic fibrinogen antagonists
GB9200293D0 (en) * 1992-01-08 1992-02-26 Wyeth John & Brother Ltd Piperazine derivatives
SE9201138D0 (sv) * 1992-04-09 1992-04-09 Astra Ab Novel phthalimidoalkylpiperazines
JPH0771521B2 (ja) * 1992-07-08 1995-08-02 功司 後藤 靴の製法
DE69332860T2 (de) * 1992-12-21 2004-03-11 Smithkline Beecham Corp. Bicyklische fibrinogen antagoniste
IT1266582B1 (it) * 1993-07-30 1997-01-09 Recordati Chem Pharm Derivati (di)azacicloesanici e diazacicloeptanici
US6403578B1 (en) 1993-12-21 2002-06-11 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
MA23420A1 (fr) * 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US6458784B1 (en) 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
US5661163A (en) 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
US5807856A (en) * 1995-11-15 1998-09-15 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonist
CZ315098A3 (cs) * 1996-04-05 1999-04-14 Société De Conseils De Recherches Et D'applications Scientifiques (S. C. R. A. S.) Antagonisté alfa1-adrenergických receptorů
DE19624659A1 (de) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide
US6451816B1 (en) 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
DE19624704A1 (de) * 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalkansäureamide
DE19756235A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
DE19756236A1 (de) * 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue piperazinylsubstituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
DE19756261A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
DE19756212A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
US6903118B1 (en) 1997-12-17 2005-06-07 Klinge Pharma Gmbh Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
EP1031564A1 (fr) 1999-02-26 2000-08-30 Klinge Pharma GmbH Inhibiteurs de la formation du nicotinamide mononucléotide et leur utilisation dans le traitement du cancer
US7030122B2 (en) 2002-04-12 2006-04-18 Sepracor Inc. 1,4-disubstituted piperazine ligands for neurotransmitter receptors
RU2320656C2 (ru) * 2002-07-04 2008-03-27 Шварц Фарма Аг Производные гетероаренкарбоксамида, способ их получения, фармацевтическая композиция на их основе и применение

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1088058B (de) * 1956-08-21 1960-09-01 Davis & Company Verfahren zur Herstellung von sympatholytisch wirkenden N-o-Halogenphenyl-N'-acylamino-alkylpiperazinen und deren Saeuresalzen
GB1166364A (en) * 1966-11-25 1969-10-08 American Cyanamid Co N-(Tert-Aminoalkyl) Amide Derivatives and Process for Preparing the Same
BE788280A (fr) * 1971-09-04 1973-02-28 Pfizer Nouvelles 1-(3-trifluoro-methyl-phenyl)-4-((amido cyclique)- alkyl) piperazines et composition pharmaceutique les contenant
AU532411B2 (en) * 1979-03-01 1983-09-29 Duphar International Research B.V. Phenyl piperazine derivatives

Also Published As

Publication number Publication date
JPS5781464A (en) 1982-05-21
IL63784A0 (en) 1981-12-31
AU7502981A (en) 1982-03-18
FI812808L (fi) 1982-03-13
DD202152A5 (de) 1983-08-31
PL232965A1 (fr) 1982-10-25
CA1155116A (fr) 1983-10-11
YU217381A (en) 1983-09-30
ZA816256B (en) 1982-08-25
HU184966B (en) 1984-11-28
GR75079B (fr) 1984-07-13
ES505373A0 (es) 1982-12-01
CS228532B2 (en) 1984-05-14
EP0048045A1 (fr) 1982-03-24
ES8302681A1 (es) 1982-12-01
DK400081A (da) 1982-03-13

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Legal Events

Date Code Title Description
A1B A search report has been drawn up
A85 Still pending on 85-01-01
BV The patent application has lapsed