NL194504B - Werkwijze voor de bereiding van mono(2-ammonium-2-hydroxymethyl-1,3- propaandiol)(2R,cis)-1,2-epoxypropyl-fosfonaat met verbeterde eigenschappen van stabiliteit en verwerking. - Google Patents

Werkwijze voor de bereiding van mono(2-ammonium-2-hydroxymethyl-1,3- propaandiol)(2R,cis)-1,2-epoxypropyl-fosfonaat met verbeterde eigenschappen van stabiliteit en verwerking.

Info

Publication number
NL194504B
NL194504B NL9001712A NL9001712A NL194504B NL 194504 B NL194504 B NL 194504B NL 9001712 A NL9001712 A NL 9001712A NL 9001712 A NL9001712 A NL 9001712A NL 194504 B NL194504 B NL 194504B
Authority
NL
Netherlands
Prior art keywords
propanediol
hydroxymethyl
cis
mono
ammonium
Prior art date
Application number
NL9001712A
Other languages
English (en)
Other versions
NL9001712A (nl
NL194504C (nl
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of NL9001712A publication Critical patent/NL9001712A/nl
Publication of NL194504B publication Critical patent/NL194504B/nl
Application granted granted Critical
Publication of NL194504C publication Critical patent/NL194504C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
    • C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
NL9001712A 1989-07-27 1990-07-27 Werkwijze voor de bereiding van mono(2-ammonium-2-hydroxymethyl-1,3- propaandiol)(2R,cis)-1,2-epoxypropyl-fosfonaat met verbeterde eigenschappen van stabiliteit en verwerking. NL194504C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8921340A IT1231013B (it) 1989-07-27 1989-07-27 Mono (2 ammonio 2 idrossimetil 1,3 propandiolo)(2r,cis) 1,2 epossipropil fosfonato avente migliorate caratteristiche di stabilita' e lavorabilita'.
IT2134089 1989-07-27

Publications (3)

Publication Number Publication Date
NL9001712A NL9001712A (nl) 1991-02-18
NL194504B true NL194504B (nl) 2002-02-01
NL194504C NL194504C (nl) 2002-06-04

Family

ID=11180349

Family Applications (1)

Application Number Title Priority Date Filing Date
NL9001712A NL194504C (nl) 1989-07-27 1990-07-27 Werkwijze voor de bereiding van mono(2-ammonium-2-hydroxymethyl-1,3- propaandiol)(2R,cis)-1,2-epoxypropyl-fosfonaat met verbeterde eigenschappen van stabiliteit en verwerking.

Country Status (19)

Country Link
US (1) US5162309A (nl)
JP (1) JP2821803B2 (nl)
AT (1) AT398204B (nl)
BE (1) BE1002775A3 (nl)
CA (1) CA2021809A1 (nl)
CH (1) CH679669A5 (nl)
DE (1) DE4023775C2 (nl)
DK (1) DK170777B1 (nl)
ES (1) ES2020790A6 (nl)
FI (1) FI97232C (nl)
FR (1) FR2650280B1 (nl)
GB (1) GB2234245B (nl)
GR (1) GR1000714B (nl)
IE (1) IE63984B1 (nl)
IT (1) IT1231013B (nl)
LU (1) LU87774A1 (nl)
NL (1) NL194504C (nl)
PT (1) PT94816B (nl)
SE (1) SE468769B (nl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20021725A1 (it) 2002-08-01 2002-10-31 Zambon Spa Composizioni farmaceutiche ad attivita' antibiotica.
ES2244333B1 (es) * 2004-05-18 2006-08-01 Simbec Iberica, Sl Preparado farmaceutico oral de fosfomicina estable y apto para diabeticos.
EP1762573A1 (en) 2005-09-08 2007-03-14 Interquim, S.A. De C.V. A process for the preparation of fosfomycin salts
ES2385158B1 (es) * 2010-12-24 2013-05-28 Arafarma Group, S.A. Composición farmacéutica de fosfomicina
CN102351902A (zh) * 2011-08-12 2012-02-15 山西仟源制药股份有限公司 磷霉素单氨丁三醇的制备方法
CN102807586B (zh) * 2012-08-31 2015-05-13 东北制药集团股份有限公司 磷霉素氨盐的制备方法
ITTO20130839A1 (it) * 2013-10-16 2015-04-17 C & G Farmaceutici S R L Composizione a base di fosfomicina trometamolo
DE102014218913A1 (de) * 2014-09-19 2016-03-24 Heraeus Medical Gmbh Verfahren zur Herstellung eines antibiotischen Polymehtylmethacrylat-Knochenzementpulvers und ein antibiotisches Polymethtylmethacrylat-Knochenzementpulver
WO2017111718A1 (en) 2015-12-25 2017-06-29 Yusuf Toktamiş Öğün The formulation comprising phosphomycine and ascorbic acid for the treatment of bacterial urinary system infections
CN108997424B (zh) * 2017-06-06 2020-11-13 湖南华纳大药厂手性药物有限公司 一种简捷制备磷霉素氨丁三醇的方法
CN108997425B (zh) * 2017-06-06 2020-11-13 湖南华纳大药厂手性药物有限公司 一种制备高含量磷霉素氨丁三醇的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641063A (en) * 1968-01-22 1972-02-08 Merck & Co Inc Antibiotic purification process
US3914231A (en) * 1970-09-04 1975-10-21 Merck & Co Inc ({31 )(Cis-1,2-epoxypropyl)-phosphonic acid and salts thereof
IT1112282B (it) * 1978-07-19 1986-01-13 Zambon Spa Bis-(2-ammonio-2-idrossimetil-1,3-propandiolo)(2r-cis)-(3-metilossiranil)fosfonato
IT1124610B (it) * 1979-10-18 1986-05-07 Zambo Spa Mono(2-ammonio-2-idrossimetil-1,3-propandiolo) (2r-cis)-(o-metilossiranil)fosfonato

Also Published As

Publication number Publication date
GB2234245B (en) 1992-10-14
DK170777B1 (da) 1996-01-15
GB9016253D0 (en) 1990-09-12
FR2650280B1 (fr) 1992-02-07
FI903760A0 (fi) 1990-07-27
GB2234245A (en) 1991-01-30
US5162309A (en) 1992-11-10
IE63984B1 (en) 1995-06-28
LU87774A1 (fr) 1990-12-11
GR1000714B (el) 1992-11-23
DK177990D0 (da) 1990-07-26
PT94816B (pt) 1997-03-31
CH679669A5 (nl) 1992-03-31
ES2020790A6 (es) 1991-09-16
NL9001712A (nl) 1991-02-18
JP2821803B2 (ja) 1998-11-05
SE9002501D0 (sv) 1990-07-26
FR2650280A1 (fr) 1991-02-01
BE1002775A3 (fr) 1991-06-04
CA2021809A1 (en) 1991-01-28
DE4023775A1 (de) 1991-01-31
SE9002501L (sv) 1991-01-28
IE902628A1 (en) 1991-02-27
GR900100570A (en) 1991-12-10
DE4023775C2 (de) 1999-07-22
DK177990A (da) 1991-01-28
AT398204B (de) 1994-10-25
JPH03101683A (ja) 1991-04-26
IT8921340A0 (it) 1989-07-27
FI97232B (fi) 1996-07-31
NL194504C (nl) 2002-06-04
IT1231013B (it) 1991-11-08
FI97232C (fi) 1996-11-11
PT94816A (pt) 1991-04-18
SE468769B (sv) 1993-03-15
ATA156590A (de) 1994-02-15

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Legal Events

Date Code Title Description
BB A search report has been drawn up
BC A request for examination has been filed
V1 Lapsed because of non-payment of the annual fee

Effective date: 20060201