GR1000714B - (2r, cis)-1,2 εποξυπροπυλο-φωσφονικη μονο (2-αμμωνιο-2-υδροφυμεθυλο-1,3-προπανοδιολη) εχουσα βελτιωμενα χαρακτηριστικα σταθεροτητος και επεξεργασιας - Google Patents

(2r, cis)-1,2 εποξυπροπυλο-φωσφονικη μονο (2-αμμωνιο-2-υδροφυμεθυλο-1,3-προπανοδιολη) εχουσα βελτιωμενα χαρακτηριστικα σταθεροτητος και επεξεργασιας

Info

Publication number
GR1000714B
GR1000714B GR900100570A GR900100570A GR1000714B GR 1000714 B GR1000714 B GR 1000714B GR 900100570 A GR900100570 A GR 900100570A GR 900100570 A GR900100570 A GR 900100570A GR 1000714 B GR1000714 B GR 1000714B
Authority
GR
Greece
Prior art keywords
oxipropyl
amnonium
phosphonate
propanediol
hydroxymethyl
Prior art date
Application number
GR900100570A
Other languages
English (en)
Other versions
GR900100570A (en
Inventor
Graziano Castaldi
Claudio Giordano
Franco Pozzi
Dario Tentorio
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of GR900100570A publication Critical patent/GR900100570A/el
Publication of GR1000714B publication Critical patent/GR1000714B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
    • C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
GR900100570A 1989-07-27 1990-07-25 (2r, cis)-1,2 εποξυπροπυλο-φωσφονικη μονο (2-αμμωνιο-2-υδροφυμεθυλο-1,3-προπανοδιολη) εχουσα βελτιωμενα χαρακτηριστικα σταθεροτητος και επεξεργασιας GR1000714B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8921340A IT1231013B (it) 1989-07-27 1989-07-27 Mono (2 ammonio 2 idrossimetil 1,3 propandiolo)(2r,cis) 1,2 epossipropil fosfonato avente migliorate caratteristiche di stabilita' e lavorabilita'.

Publications (2)

Publication Number Publication Date
GR900100570A GR900100570A (en) 1991-12-10
GR1000714B true GR1000714B (el) 1992-11-23

Family

ID=11180349

Family Applications (1)

Application Number Title Priority Date Filing Date
GR900100570A GR1000714B (el) 1989-07-27 1990-07-25 (2r, cis)-1,2 εποξυπροπυλο-φωσφονικη μονο (2-αμμωνιο-2-υδροφυμεθυλο-1,3-προπανοδιολη) εχουσα βελτιωμενα χαρακτηριστικα σταθεροτητος και επεξεργασιας

Country Status (19)

Country Link
US (1) US5162309A (el)
JP (1) JP2821803B2 (el)
AT (1) AT398204B (el)
BE (1) BE1002775A3 (el)
CA (1) CA2021809A1 (el)
CH (1) CH679669A5 (el)
DE (1) DE4023775C2 (el)
DK (1) DK170777B1 (el)
ES (1) ES2020790A6 (el)
FI (1) FI97232C (el)
FR (1) FR2650280B1 (el)
GB (1) GB2234245B (el)
GR (1) GR1000714B (el)
IE (1) IE63984B1 (el)
IT (1) IT1231013B (el)
LU (1) LU87774A1 (el)
NL (1) NL194504C (el)
PT (1) PT94816B (el)
SE (1) SE468769B (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20021725A1 (it) 2002-08-01 2002-10-31 Zambon Spa Composizioni farmaceutiche ad attivita' antibiotica.
ES2244333B1 (es) * 2004-05-18 2006-08-01 Simbec Iberica, Sl Preparado farmaceutico oral de fosfomicina estable y apto para diabeticos.
EP1762573A1 (en) 2005-09-08 2007-03-14 Interquim, S.A. De C.V. A process for the preparation of fosfomycin salts
ES2385158B1 (es) * 2010-12-24 2013-05-28 Arafarma Group, S.A. Composición farmacéutica de fosfomicina
CN102351902A (zh) * 2011-08-12 2012-02-15 山西仟源制药股份有限公司 磷霉素单氨丁三醇的制备方法
CN102807586B (zh) 2012-08-31 2015-05-13 东北制药集团股份有限公司 磷霉素氨盐的制备方法
ITTO20130839A1 (it) * 2013-10-16 2015-04-17 C & G Farmaceutici S R L Composizione a base di fosfomicina trometamolo
DE102014218913A1 (de) * 2014-09-19 2016-03-24 Heraeus Medical Gmbh Verfahren zur Herstellung eines antibiotischen Polymehtylmethacrylat-Knochenzementpulvers und ein antibiotisches Polymethtylmethacrylat-Knochenzementpulver
WO2017111718A1 (en) 2015-12-25 2017-06-29 Yusuf Toktamiş Öğün The formulation comprising phosphomycine and ascorbic acid for the treatment of bacterial urinary system infections
CN108997425B (zh) * 2017-06-06 2020-11-13 湖南华纳大药厂手性药物有限公司 一种制备高含量磷霉素氨丁三醇的方法
CN108997424B (zh) * 2017-06-06 2020-11-13 湖南华纳大药厂手性药物有限公司 一种简捷制备磷霉素氨丁三醇的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641063A (en) * 1968-01-22 1972-02-08 Merck & Co Inc Antibiotic purification process
US3914231A (en) * 1970-09-04 1975-10-21 Merck & Co Inc ({31 )(Cis-1,2-epoxypropyl)-phosphonic acid and salts thereof
IT1112282B (it) * 1978-07-19 1986-01-13 Zambon Spa Bis-(2-ammonio-2-idrossimetil-1,3-propandiolo)(2r-cis)-(3-metilossiranil)fosfonato
IT1124610B (it) * 1979-10-18 1986-05-07 Zambo Spa Mono(2-ammonio-2-idrossimetil-1,3-propandiolo) (2r-cis)-(o-metilossiranil)fosfonato

Also Published As

Publication number Publication date
ES2020790A6 (es) 1991-09-16
IE902628A1 (en) 1991-02-27
FI97232B (fi) 1996-07-31
SE9002501L (sv) 1991-01-28
US5162309A (en) 1992-11-10
BE1002775A3 (fr) 1991-06-04
GB2234245A (en) 1991-01-30
SE9002501D0 (sv) 1990-07-26
LU87774A1 (fr) 1990-12-11
IT8921340A0 (it) 1989-07-27
FR2650280A1 (fr) 1991-02-01
NL9001712A (nl) 1991-02-18
IT1231013B (it) 1991-11-08
GR900100570A (en) 1991-12-10
ATA156590A (de) 1994-02-15
FI97232C (fi) 1996-11-11
PT94816A (pt) 1991-04-18
PT94816B (pt) 1997-03-31
SE468769B (sv) 1993-03-15
DK177990D0 (da) 1990-07-26
GB2234245B (en) 1992-10-14
DE4023775A1 (de) 1991-01-31
FI903760A0 (fi) 1990-07-27
CA2021809A1 (en) 1991-01-28
CH679669A5 (el) 1992-03-31
AT398204B (de) 1994-10-25
DK177990A (da) 1991-01-28
IE63984B1 (en) 1995-06-28
GB9016253D0 (en) 1990-09-12
DK170777B1 (da) 1996-01-15
JPH03101683A (ja) 1991-04-26
NL194504B (nl) 2002-02-01
FR2650280B1 (fr) 1992-02-07
NL194504C (nl) 2002-06-04
DE4023775C2 (de) 1999-07-22
JP2821803B2 (ja) 1998-11-05

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