NL193752C - 1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat. - Google Patents
1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat. Download PDFInfo
- Publication number
- NL193752C NL193752C NL8003498A NL8003498A NL193752C NL 193752 C NL193752 C NL 193752C NL 8003498 A NL8003498 A NL 8003498A NL 8003498 A NL8003498 A NL 8003498A NL 193752 C NL193752 C NL 193752C
- Authority
- NL
- Netherlands
- Prior art keywords
- dihydro
- imidazol
- methyl
- branched
- straight
- Prior art date
Links
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- 230000003276 anti-hypertensive effect Effects 0.000 title claims description 8
- 230000003177 cardiotonic effect Effects 0.000 title claims description 6
- 230000002785 anti-thrombosis Effects 0.000 title claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 3
- 239000003146 anticoagulant agent Substances 0.000 title description 7
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- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
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- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 description 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
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- PUGUQINMNYINPK-UHFFFAOYSA-N tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCN(C(=O)CCl)CC1 PUGUQINMNYINPK-UHFFFAOYSA-N 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
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- UBZYKBZMAMTNKW-UHFFFAOYSA-J titanium tetrabromide Chemical compound Br[Ti](Br)(Br)Br UBZYKBZMAMTNKW-UHFFFAOYSA-J 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4980879A | 1979-06-18 | 1979-06-18 | |
| US4980879 | 1979-06-18 | ||
| US11920780A | 1980-02-07 | 1980-02-07 | |
| US11920780 | 1980-02-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NL8003498A NL8003498A (nl) | 1980-12-22 |
| NL193752B NL193752B (nl) | 2000-05-01 |
| NL193752C true NL193752C (nl) | 2000-09-04 |
Family
ID=26727558
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8003498A NL193752C (nl) | 1979-06-18 | 1980-06-17 | 1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat. |
| NL300015C NL300015I1 (nl) | 1979-06-18 | 2000-09-04 | 1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL300015C NL300015I1 (nl) | 1979-06-18 | 2000-09-04 | 1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat. |
Country Status (20)
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH18106A (en) * | 1981-02-18 | 1985-03-21 | Merrell Dow Pharma | Novel-4-aroylimidazol-2-ones |
| US4405628A (en) * | 1981-03-05 | 1983-09-20 | Merrell Dow Pharmaceuticals Inc. | 4-Pyridylimidazolones and method of use |
| US4329470A (en) * | 1981-05-04 | 1982-05-11 | Merrell Dow Pharmaceuticals Inc. | 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives |
| US4371737A (en) * | 1981-05-04 | 1983-02-01 | Merrell Dow Pharmaceuticals Inc. | 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives |
| US4381393A (en) * | 1981-05-04 | 1983-04-26 | Merrell Dow Pharmaceuticals Inc. | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones |
| US4329471A (en) * | 1981-05-04 | 1982-05-11 | Merrell Dow Pharmaceuticals Inc. | 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones |
| US4526981A (en) * | 1981-05-04 | 1985-07-02 | Merrell Dow Pharmaceuticals Inc. | [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates |
| AU549872B2 (en) * | 1981-05-04 | 1986-02-20 | Merrell Dow Pharmaceuticals Inc. | 4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazol-2-ones |
| US4410540A (en) * | 1981-11-04 | 1983-10-18 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic 4-aroylimidazolidin-2-ones |
| US4367236A (en) * | 1981-11-04 | 1983-01-04 | Merrell Dow Pharmaceuticals Inc. | Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| JP2007530563A (ja) * | 2004-03-22 | 2007-11-01 | ミオゲン インコーポレイティッド | （ｓ）−エノキシモンスルホキシドおよびｐｄｅ−ｉｉｉ媒介疾患の治療におけるその使用 |
| WO2005092333A1 (en) * | 2004-03-22 | 2005-10-06 | Myogen, Inc. | (r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
| US8067433B2 (en) | 2005-11-09 | 2011-11-29 | Zalicus Inc. | Methods, compositions, and kits for the treatment of ophthalmic disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
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| EA201592263A1 (ru) | 2013-06-05 | 2016-05-31 | Синерджи Фармасьютикалз, Инк. | Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования |
| KR102456567B1 (ko) | 2013-08-09 | 2022-10-19 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
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| CN114539157B (zh) * | 2022-03-03 | 2023-12-22 | 曲靖师范学院 | 一种碘促进氧化法制备4-碘代n-芳基吡唑类化合物的方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2441933A (en) * | 1945-07-30 | 1948-05-18 | Hoffmann La Roche | Substituted imidazolones and process of making them |
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1985
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1986
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2000
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