NL193542C - Werkwijze voor het bereiden van een zout van de methylester van Ó-L-aspartyl-L-fenylalanine. - Google Patents

Werkwijze voor het bereiden van een zout van de methylester van Ó-L-aspartyl-L-fenylalanine. Download PDF

Info

Publication number
NL193542C
NL193542C NL8500325A NL8500325A NL193542C NL 193542 C NL193542 C NL 193542C NL 8500325 A NL8500325 A NL 8500325A NL 8500325 A NL8500325 A NL 8500325A NL 193542 C NL193542 C NL 193542C
Authority
NL
Netherlands
Prior art keywords
afm
crystals
dkp
phenylalanine
concentration
Prior art date
Application number
NL8500325A
Other languages
English (en)
Dutch (nl)
Other versions
NL193542B (nl
NL8500325A (nl
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of NL8500325A publication Critical patent/NL8500325A/nl
Publication of NL193542B publication Critical patent/NL193542B/xx
Application granted granted Critical
Publication of NL193542C publication Critical patent/NL193542C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
NL8500325A 1984-02-21 1985-02-06 Werkwijze voor het bereiden van een zout van de methylester van Ó-L-aspartyl-L-fenylalanine. NL193542C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3098784 1984-02-21
JP59030987A JPS60174799A (ja) 1984-02-21 1984-02-21 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法

Publications (3)

Publication Number Publication Date
NL8500325A NL8500325A (nl) 1985-09-16
NL193542B NL193542B (nl) 1999-09-01
NL193542C true NL193542C (nl) 2000-01-04

Family

ID=12318969

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8500325A NL193542C (nl) 1984-02-21 1985-02-06 Werkwijze voor het bereiden van een zout van de methylester van Ó-L-aspartyl-L-fenylalanine.

Country Status (5)

Country Link
US (1) US4634790A (ja)
JP (1) JPS60174799A (ja)
FR (1) FR2559773B1 (ja)
IT (1) IT1183336B (ja)
NL (1) NL193542C (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8703487A1 (es) * 1984-12-27 1987-03-01 Mitsui Toatsu Chemicals Procedimiento para la preparacion de a-l-aspartil-l-fenila- lanina metil ester
AU561384B2 (en) * 1985-03-26 1987-05-07 Mitsui Toatsu Chemicals Inc. Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof
JPH0751596B2 (ja) * 1985-04-01 1995-06-05 三井東圧化学株式会社 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製造方法
AU586669B2 (en) * 1985-03-29 1989-07-20 Mitsui Toatsu Chemicals Inc. Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
DE3668910D1 (de) * 1985-10-11 1990-03-15 Ajinomoto Kk Verfahren zur herstellung von l-aspartyl-l-phenylalanin und dessen diketopiperazin.
DE3780585T2 (de) * 1986-12-05 1993-03-18 Mitsui Toatsu Chemicals Herstellung von alpha-l-aspartyl-l-phenylalanin-methylester oder deren hydrohalide.
JPH0832719B2 (ja) * 1986-12-19 1996-03-29 三井東圧化学株式会社 吸湿性の小さいα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
US4892820A (en) * 1987-06-10 1990-01-09 The Nutrasweet Company Solvent system for enzymatic coupling process
US4897507A (en) * 1987-07-22 1990-01-30 Ajinomoto Co., Inc. Method for producing α-L-aspartyl-L-phenylalanine derivatives
JP2508803B2 (ja) * 1987-07-22 1996-06-19 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニン誘導体の製造法
US4992552A (en) * 1988-08-31 1991-02-12 Eastman Kodak Company Process for preparation of amino acids
US5144073A (en) * 1988-08-31 1992-09-01 Hubbs John C Process for preparation of dipeptides
US5214145A (en) * 1988-08-31 1993-05-25 Eastman Kodak Company Trisubstituted piperazin-2,5-diones
ES2091324T3 (es) * 1990-03-15 1996-11-01 Nutrasweet Co Proceso para la preparacion de aspartama a partir de una dicetopiperazina y nuevos compuestos intermedios y derivados para dicho proceso.
JPH05117246A (ja) * 1991-10-23 1993-05-14 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法
JPH05194587A (ja) * 1992-01-14 1993-08-03 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの精製法
JP3208874B2 (ja) * 1992-12-07 2001-09-17 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンの製造法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2261926C3 (de) * 1972-12-18 1978-11-30 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Verfahren zur Herstellung von DL-Methionyl-DL-methionin
JPS5113737A (en) * 1974-07-23 1976-02-03 Ajinomoto Kk Arufua ll asuparuchiru ll fueniruaraninteikyuarukiruesuteruno seizoho
US4173562A (en) * 1976-12-27 1979-11-06 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
JPS59219258A (ja) * 1983-05-28 1984-12-10 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル又はその塩酸塩の製法
US4618695A (en) * 1983-06-02 1986-10-21 Ajinomoto Co., Inc. Method of preparing methyl ester and its hydrochloride
JPS59227849A (ja) * 1983-06-08 1984-12-21 Ajinomoto Co Inc Ｌ―α―アスパルチル―Ｌ―フェニルアラニンメチルエステル束状晶の晶析分離法

Also Published As

Publication number Publication date
FR2559773B1 (fr) 1994-01-14
FR2559773A1 (fr) 1985-08-23
NL193542B (nl) 1999-09-01
IT8519484A0 (it) 1985-02-13
US4634790A (en) 1987-01-06
JPH0564159B2 (ja) 1993-09-14
JPS60174799A (ja) 1985-09-09
IT1183336B (it) 1987-10-22
NL8500325A (nl) 1985-09-16

Similar Documents

Publication Publication Date Title
NL193542C (nl) Werkwijze voor het bereiden van een zout van de methylester van Ó-L-aspartyl-L-fenylalanine.
AU681523B2 (en) Improved method for the preparation of an aspartame-derived compound useful as a sweetener
US4436925A (en) Addition compound of dipeptide derivative and amino acid derivative
US4606854A (en) Method of preparing α-L-aspartyl-L-phenylalanine methyl ester and its hydrochloride
JPS62106100A (ja) タンパク質アミノ末端残基の選択的化学的除去法
EP0092933B1 (en) Process for producing alpha-l-aspartyl-l-phenylalanine methyl ester or its hydrochloride
US3833554A (en) Method of purifying alpha-l-aspartyl-l-phenylalanine lower alkyl esters of peptide impurities
US4021418A (en) Method of removing formyl groups from N-formyl-amino acid and N-formyl-peptide esters
EP0466963B1 (en) A process for the preparation of alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl-aspartic anhydride
US4897507A (en) Method for producing α-L-aspartyl-L-phenylalanine derivatives
US4212945A (en) Process for recovering protease
US3985723A (en) Trifluoroacetylation process
EP0127108A1 (en) Process for preparing polypeptides
EP0300450B1 (en) Method for producing alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride
US5693485A (en) Enzymatic coupling reaction of N-protected-L-aspartic acid and phenylalanine methyl ester
KR920006560B1 (ko) α-L-아스파르틸-L-페닐알라닌 메틸 에스테르의 제조방법
KR930008088B1 (ko) N-보호된-L-α-아스파틸-L-페닐알라닌의 제조방법
US4942255A (en) Method for producing α-aspartylphenylalanine derivatives
JP2910228B2 (ja) α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステル塩酸塩の製法
JP2541622B2 (ja) Ｎ―ホルミルアスパルチルフェニルアラニンメチルエステルからアスパルチルフェニルアラニンメチルエステルを製造する方法及びアスパルチルフェニルアラニンメチルエステルの蓚酸塩
US4321391A (en) Preparation of L-aspartic acid N-thiocarboxyanhydride
DE69027318T2 (de) Eintopfverfahren zur Herstellung des alpha-L-Aspartyl-L-Phenylalaninmethylesters
CA2101870A1 (en) Method for the production of .alpha.-l-aspartyl-l- phenylalanine methyl ester hydrochloride
Lundgren et al. Crystalline Complexes of Amino Acids with Alkyl Titanates
JPH05202094A (ja) α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステル又はその塩酸塩の製造法

Legal Events

Date Code Title Description
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
V4 Discontinued because of reaching the maximum lifetime of a patent

Effective date: 20050206