FR2559773B1 - Procede pour la fabrication de l'ester methylique d'a-l-aspartyl-l-phenylalanine ou son halohydrate - Google Patents

Procede pour la fabrication de l'ester methylique d'a-l-aspartyl-l-phenylalanine ou son halohydrate

Info

Publication number
FR2559773B1
FR2559773B1 FR8502523A FR8502523A FR2559773B1 FR 2559773 B1 FR2559773 B1 FR 2559773B1 FR 8502523 A FR8502523 A FR 8502523A FR 8502523 A FR8502523 A FR 8502523A FR 2559773 B1 FR2559773 B1 FR 2559773B1
Authority
FR
France
Prior art keywords
halohydrate
aspartyl
manufacture
methyl ester
phenylalanine methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8502523A
Other languages
English (en)
Other versions
FR2559773A1 (fr
Inventor
Katsumi Sugiyama Masanao Ozaki Et Keizo Matsuda Emiko Shinohara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of FR2559773A1 publication Critical patent/FR2559773A1/fr
Application granted granted Critical
Publication of FR2559773B1 publication Critical patent/FR2559773B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
FR8502523A 1984-02-21 1985-02-21 Procede pour la fabrication de l'ester methylique d'a-l-aspartyl-l-phenylalanine ou son halohydrate Expired - Lifetime FR2559773B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59030987A JPS60174799A (ja) 1984-02-21 1984-02-21 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法

Publications (2)

Publication Number Publication Date
FR2559773A1 FR2559773A1 (fr) 1985-08-23
FR2559773B1 true FR2559773B1 (fr) 1994-01-14

Family

ID=12318969

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8502523A Expired - Lifetime FR2559773B1 (fr) 1984-02-21 1985-02-21 Procede pour la fabrication de l'ester methylique d'a-l-aspartyl-l-phenylalanine ou son halohydrate

Country Status (5)

Country Link
US (1) US4634790A (fr)
JP (1) JPS60174799A (fr)
FR (1) FR2559773B1 (fr)
IT (1) IT1183336B (fr)
NL (1) NL193542C (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8703487A1 (es) * 1984-12-27 1987-03-01 Mitsui Toatsu Chemicals Procedimiento para la preparacion de a-l-aspartil-l-fenila- lanina metil ester
AU561384B2 (en) * 1985-03-26 1987-05-07 Mitsui Toatsu Chemicals Inc. Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof
AU586669B2 (en) * 1985-03-29 1989-07-20 Mitsui Toatsu Chemicals Inc. Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
JPH0751596B2 (ja) * 1985-04-01 1995-06-05 三井東圧化学株式会社 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製造方法
DE3668910D1 (de) * 1985-10-11 1990-03-15 Ajinomoto Kk Verfahren zur herstellung von l-aspartyl-l-phenylalanin und dessen diketopiperazin.
DE3780585T2 (de) * 1986-12-05 1993-03-18 Mitsui Toatsu Chemicals Herstellung von alpha-l-aspartyl-l-phenylalanin-methylester oder deren hydrohalide.
JPH0832719B2 (ja) * 1986-12-19 1996-03-29 三井東圧化学株式会社 吸湿性の小さいα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
US4892820A (en) * 1987-06-10 1990-01-09 The Nutrasweet Company Solvent system for enzymatic coupling process
JP2508803B2 (ja) * 1987-07-22 1996-06-19 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニン誘導体の製造法
US4897507A (en) * 1987-07-22 1990-01-30 Ajinomoto Co., Inc. Method for producing α-L-aspartyl-L-phenylalanine derivatives
US4992552A (en) * 1988-08-31 1991-02-12 Eastman Kodak Company Process for preparation of amino acids
US5144073A (en) * 1988-08-31 1992-09-01 Hubbs John C Process for preparation of dipeptides
US5214145A (en) * 1988-08-31 1993-05-25 Eastman Kodak Company Trisubstituted piperazin-2,5-diones
DK0478729T3 (da) * 1990-03-15 1996-09-16 Nutrasweet Co Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil
JPH05117246A (ja) * 1991-10-23 1993-05-14 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法
JPH05194587A (ja) * 1992-01-14 1993-08-03 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの精製法
JP3208874B2 (ja) * 1992-12-07 2001-09-17 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンの製造法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2261926C3 (de) * 1972-12-18 1978-11-30 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Verfahren zur Herstellung von DL-Methionyl-DL-methionin
JPS5113737A (en) * 1974-07-23 1976-02-03 Ajinomoto Kk Arufua ll asuparuchiru ll fueniruaraninteikyuarukiruesuteruno seizoho
US4173562A (en) * 1976-12-27 1979-11-06 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
JPS59219258A (ja) * 1983-05-28 1984-12-10 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル又はその塩酸塩の製法
US4618695A (en) * 1983-06-02 1986-10-21 Ajinomoto Co., Inc. Method of preparing methyl ester and its hydrochloride
JPS59227849A (ja) * 1983-06-08 1984-12-21 Ajinomoto Co Inc Ｌ―α―アスパルチル―Ｌ―フェニルアラニンメチルエステル束状晶の晶析分離法

Also Published As

Publication number Publication date
JPS60174799A (ja) 1985-09-09
NL193542B (nl) 1999-09-01
US4634790A (en) 1987-01-06
NL193542C (nl) 2000-01-04
JPH0564159B2 (fr) 1993-09-14
IT8519484A0 (it) 1985-02-13
NL8500325A (nl) 1985-09-16
FR2559773A1 (fr) 1985-08-23
IT1183336B (it) 1987-10-22

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