NL193136C - Kristallijn hydraat van een oraal cefalosporine derivaat, werkwijze voor het bereiden daarvan en farmaceutisch product daaruit. - Google Patents

Kristallijn hydraat van een oraal cefalosporine derivaat, werkwijze voor het bereiden daarvan en farmaceutisch product daaruit. Download PDF

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Publication number
NL193136C
NL193136C NL8701507A NL8701507A NL193136C NL 193136 C NL193136 C NL 193136C NL 8701507 A NL8701507 A NL 8701507A NL 8701507 A NL8701507 A NL 8701507A NL 193136 C NL193136 C NL 193136C
Authority
NL
Netherlands
Prior art keywords
solution
crystalline hydrate
derivative
water
hydrate
Prior art date
Application number
NL8701507A
Other languages
English (en)
Dutch (nl)
Other versions
NL193136B (nl
NL8701507A (nl
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61156954A external-priority patent/JP2544113B2/ja
Priority claimed from JP21626086A external-priority patent/JPH0717651B2/ja
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of NL8701507A publication Critical patent/NL8701507A/nl
Publication of NL193136B publication Critical patent/NL193136B/xx
Application granted granted Critical
Publication of NL193136C publication Critical patent/NL193136C/nl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
NL8701507A 1986-07-02 1987-06-26 Kristallijn hydraat van een oraal cefalosporine derivaat, werkwijze voor het bereiden daarvan en farmaceutisch product daaruit. NL193136C (nl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP15695486 1986-07-02
JP61156954A JP2544113B2 (ja) 1986-07-02 1986-07-02 安定なカプセル製剤
JP21626086A JPH0717651B2 (ja) 1986-09-12 1986-09-12 経口投与用セフアロスポリン水和物結晶
JP21626086 1986-09-12

Publications (3)

Publication Number Publication Date
NL8701507A NL8701507A (nl) 1988-02-01
NL193136B NL193136B (nl) 1998-08-03
NL193136C true NL193136C (nl) 1998-12-04

Family

ID=26484565

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8701507A NL193136C (nl) 1986-07-02 1987-06-26 Kristallijn hydraat van een oraal cefalosporine derivaat, werkwijze voor het bereiden daarvan en farmaceutisch product daaruit.

Country Status (27)

Country Link
US (2) US4812561A (zh)
KR (1) KR950005302B1 (zh)
CN (1) CN1015106B (zh)
AR (1) AR243893A1 (zh)
AT (1) AT392472B (zh)
AU (1) AU594167B2 (zh)
BE (1) BE1001691A4 (zh)
CA (1) CA1283405C (zh)
CH (1) CH672788A5 (zh)
DE (1) DE3721913A1 (zh)
DK (1) DK161080C (zh)
ES (2) ES2004952A6 (zh)
FI (1) FI89052C (zh)
FR (1) FR2601014B1 (zh)
GB (1) GB2192183B (zh)
GR (1) GR871014B (zh)
HK (1) HK47893A (zh)
HU (1) HU200777B (zh)
IE (1) IE59613B1 (zh)
IL (1) IL83059A (zh)
IT (1) IT1211469B (zh)
NL (1) NL193136C (zh)
NO (1) NO170889C (zh)
NZ (1) NZ220764A (zh)
PL (1) PL159180B1 (zh)
RU (1) RU1829932C (zh)
SE (1) SE466257B (zh)

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RU2009127855A (ru) 2006-12-22 2011-01-27 Шеринг Корпорейшн (US) 4,5 циклоаннелированные производные индола для лечения или предотвращения вируса гепатита с (hcv) и родственных вирусных инфекций
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ES2447543T3 (es) 2007-08-29 2014-03-12 Merck Sharp & Dohme Corp. Derivados de indol sustituidos y métodos de utilización de los mismos
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JP5619743B2 (ja) 2008-08-20 2014-11-05 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． エテニル置換ピリジンおよびピリミジン誘導体およびウイルス感染の治療におけるそれらの使用
EP2331511A1 (en) 2008-08-20 2011-06-15 Schering Corporation Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
AU2009282567B2 (en) 2008-08-20 2014-10-02 Merck Sharp & Dohme Corp. Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
US8470834B2 (en) 2008-08-20 2013-06-25 Merck Sharp & Dohme Corp. AZO-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
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KR20130008040A (ko) 2010-03-09 2013-01-21 머크 샤프 앤드 돔 코포레이션 융합된 트리시클릭 실릴 화합물 및 바이러스성 질환의 치료를 위한 그의 사용 방법
WO2011139253A2 (en) 2010-05-04 2011-11-10 Mahmut Bilgic Pharmaceutical compositions comprising ceftibuten
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EP2696681B1 (en) 2011-04-13 2018-10-03 Merck Sharp & Dohme Corp. 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
EP2697242B1 (en) 2011-04-13 2018-10-03 Merck Sharp & Dohme Corp. 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2013033901A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
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WO2013033900A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
EP2755981A4 (en) 2011-09-14 2015-03-25 Merck Sharp & Dohme HETEROCYCLIC COMPOUNDS CONTAINING SILYL AND METHODS OF USING THE SAME FOR TREATING VIRAL DISEASES
EP2833874A1 (en) * 2012-04-04 2015-02-11 Mahmut Bilgic Capsule formulations comprising ceftibuten
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CN106432270A (zh) * 2016-09-21 2017-02-22 临沂草之美医药科技有限公司 一种制备治疗外科手术感染的药物头孢布烯晶体化合物的方法
JP2024524372A (ja) * 2021-07-01 2024-07-05 キューペックス バイオファーマ， インコーポレイテッド セフチブテンの結晶形態

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Also Published As

Publication number Publication date
BE1001691A4 (fr) 1990-02-13
FI89052B (fi) 1993-04-30
US4812561A (en) 1989-03-14
NO170889B (no) 1992-09-14
NO872729D0 (no) 1987-06-30
GR871014B (en) 1987-11-02
GB2192183A (en) 1988-01-06
NO170889C (no) 1992-12-23
DK161080B (da) 1991-05-27
FR2601014A1 (fr) 1988-01-08
GB8715064D0 (en) 1987-08-05
NO872729L (no) 1988-01-04
KR880001670A (ko) 1988-04-26
CN87105009A (zh) 1988-03-23
HUT44257A (en) 1988-02-29
GB2192183B (en) 1990-05-16
SE8702705L (sv) 1988-01-03
IT8767566A0 (it) 1987-07-01
IT1211469B (it) 1989-11-03
NL193136B (nl) 1998-08-03
AR243893A1 (es) 1993-09-30
SE466257B (sv) 1992-01-20
CN1015106B (zh) 1991-12-18
RU1829932C (ru) 1993-07-23
KR950005302B1 (ko) 1995-05-23
IL83059A0 (en) 1987-12-31
DE3721913A1 (de) 1988-01-07
AU594167B2 (en) 1990-03-01
FI872903A0 (fi) 1987-07-01
AU7504087A (en) 1988-01-07
SE8702705D0 (sv) 1987-06-30
HK47893A (en) 1993-05-27
FI89052C (fi) 1993-08-10
FR2601014B1 (fr) 1990-09-14
ES2004952A6 (es) 1989-02-16
NZ220764A (en) 1989-09-27
DK161080C (da) 1991-11-11
FI872903A (fi) 1988-01-03
ATA165887A (de) 1990-09-15
DK336487D0 (da) 1987-06-30
CH672788A5 (zh) 1989-12-29
IE871738L (en) 1988-01-02
DK336487A (da) 1988-01-03
PL266567A1 (en) 1988-07-21
ES2008759A6 (es) 1989-08-01
US4933443A (en) 1990-06-12
IE59613B1 (en) 1994-03-09
IL83059A (en) 1992-03-29
HU200777B (en) 1990-08-28
CA1283405C (en) 1991-04-23
NL8701507A (nl) 1988-02-01
AT392472B (de) 1991-04-10
PL159180B1 (pl) 1992-11-30

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Effective date: 20070626