NL160805C - Werkwijze ter bereiding van een geneesmiddel met stimule- rende werking op beta-andrenergische receptoren onder toepassing van een hydroxyfenyl-aminoethanol-derivaat, waarvan de aminogroep slechts een substituent draagt. - Google Patents

Werkwijze ter bereiding van een geneesmiddel met stimule- rende werking op beta-andrenergische receptoren onder toepassing van een hydroxyfenyl-aminoethanol-derivaat, waarvan de aminogroep slechts een substituent draagt.

Info

Publication number
NL160805C
NL160805C NL6713016.A NL6713016A NL160805C NL 160805 C NL160805 C NL 160805C NL 6713016 A NL6713016 A NL 6713016A NL 160805 C NL160805 C NL 160805C
Authority
NL
Netherlands
Prior art keywords
hydroxyphenyl
substituent
preparing
amino group
medicinal product
Prior art date
Application number
NL6713016.A
Other languages
English (en)
Dutch (nl)
Other versions
NL6713016A (cs
NL160805B (nl
Original Assignee
Allen & Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26253347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL160805(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allen & Hanburys Ltd filed Critical Allen & Hanburys Ltd
Publication of NL6713016A publication Critical patent/NL6713016A/xx
Priority to NLAANVRAGE7811843,A priority Critical patent/NL173164C/xx
Publication of NL160805B publication Critical patent/NL160805B/xx
Application granted granted Critical
Publication of NL160805C publication Critical patent/NL160805C/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NL6713016.A 1966-09-23 1967-09-22 Werkwijze ter bereiding van een geneesmiddel met stimule- rende werking op beta-andrenergische receptoren onder toepassing van een hydroxyfenyl-aminoethanol-derivaat, waarvan de aminogroep slechts een substituent draagt. NL160805C (nl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NLAANVRAGE7811843,A NL173164C (nl) 1966-09-23 1978-12-04 Werkwijze voor het bereiden van een hydroxyfenylaminoethanolderivaat met stimulerende werking op beta-adrenergische receptoren.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB18383/67A GB1200886A (en) 1966-09-23 1966-09-23 Phenylaminoethanol derivatives
GB1838367 1967-04-21

Publications (3)

Publication Number Publication Date
NL6713016A NL6713016A (cs) 1968-03-25
NL160805B NL160805B (nl) 1979-07-16
NL160805C true NL160805C (nl) 1979-12-17

Family

ID=26253347

Family Applications (2)

Application Number Title Priority Date Filing Date
NL6713016.A NL160805C (nl) 1966-09-23 1967-09-22 Werkwijze ter bereiding van een geneesmiddel met stimule- rende werking op beta-andrenergische receptoren onder toepassing van een hydroxyfenyl-aminoethanol-derivaat, waarvan de aminogroep slechts een substituent draagt.
NL7809942A NL7809942A (nl) 1966-09-23 1978-10-02 Werkwijze voor het bereiden van een geneesmiddel met blokkerende werking op beta-adrenergische receptoren onder toepassing van een fenylaminoethanolderivaat.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL7809942A NL7809942A (nl) 1966-09-23 1978-10-02 Werkwijze voor het bereiden van een geneesmiddel met blokkerende werking op beta-adrenergische receptoren onder toepassing van een fenylaminoethanolderivaat.

Country Status (15)

Country Link
US (3) US3644353A (cs)
AT (1) AT280996B (cs)
BE (1) BE704037A (cs)
CH (1) CH492676A (cs)
CS (1) CS167874B2 (cs)
CY (1) CY713A (cs)
DE (1) DE1643224C3 (cs)
DK (1) DK133618B (cs)
FR (2) FR8010M (cs)
GB (1) GB1200886A (cs)
IL (1) IL28643A (cs)
NL (2) NL160805C (cs)
NO (1) NO126014B (cs)
PL (1) PL70430B1 (cs)
SE (1) SE354061B (cs)

Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE741762A (cs) * 1968-11-18 1970-05-19
US4101579A (en) * 1969-02-06 1978-07-18 Allen & Hanburys Limited Phenethanolamine ethers
US4012444A (en) * 1969-07-08 1977-03-15 Allen & Hanburys Limited 5-[1-Hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl] salicylamide and physiologically acceptable acid addition salts thereof
GB1266058A (cs) * 1969-07-08 1972-03-08
GB1298494A (en) * 1970-06-17 1972-12-06 Allen & Hanburys Ltd Phenylethanolamine derivatives
AT310146B (de) * 1971-04-26 1973-09-25 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen N,N'-Bis-(β-hydroxyaryläthyl)-diaminoalkanen und deren Säureadditionssalzen
BE794414A (fr) * 1972-01-25 1973-07-23 Sandoz Sa Nouveaux amino-alcools, leur preparation et leur application comme medicament
US4018825A (en) * 1972-07-27 1977-04-19 Warner-Lambert Company 5-Hydroxy-α-(substituted aminomethyl)-m-xylene-α,α'-diols
US4024255A (en) * 1973-04-05 1977-05-17 Allen & Hanburys Limited Tetrazole containing naphthyridine-3-carboxamides
US4000192A (en) * 1973-05-07 1976-12-28 Allen & Hanburys Limited Pharmacologically active compounds
GB1468673A (en) * 1973-05-07 1977-03-30 Allen & Hanburys Ltd Substituted benzamides
US3883560A (en) * 1973-07-05 1975-05-13 Colgate Palmolive Co Salicylamidophenethanolamines
US4046913A (en) * 1973-08-18 1977-09-06 Boehringer Ingelheim Gmbh 1-(M-alkanoyloxy-phenyl)-1-hydroxy-2-(N-lower alkyl-amino)-ethanes and salts thereof
US4022776A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxycarbostyril derivatives
US4093628A (en) * 1974-04-18 1978-06-06 American Home Products Corporation Thiophene ethanolamines
US4012528A (en) * 1974-06-03 1977-03-15 Smithkline Corporation α-AMINOALKYL-3-(1,2-DIHYDROXYETHYL)-4-HYDROXY-BENZYL ALCOHOLS HAVING β-ADRENERGIC STIMULANT ACTIVITY
US4173583A (en) * 1975-04-17 1979-11-06 Schering Corporation Diastereoisomers of 5-(1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide
GB1529972A (en) * 1975-07-29 1978-10-25 Allen & Hanburys Ltd Basic alcohols
US4160036A (en) * 1975-07-29 1979-07-03 Allen & Hanburys Limited 4-Hydroxy-1,3-benzenedimethanol derivatives
US4154761A (en) * 1976-02-09 1979-05-15 Allen & Hanburys Limited Pharmacologically active compounds
JPS52113934A (en) * 1976-03-19 1977-09-24 Eisai Co Ltd Phenethylamine derivatives and bronchodilator containing the same
US4055658A (en) * 1976-05-17 1977-10-25 Mead Johnson & Company Cyanomethylphenethanolamines
US4127674A (en) * 1977-03-21 1978-11-28 Allergan Pharmaceuticals, Inc. Method of treatment for glaucoma
US4163053A (en) * 1977-12-27 1979-07-31 Schering Corporation Anti-hypertensive 5-[2-(substituted anilinoalkylamino)-1-hydroxyalkyl]salicylamides
DK160936C (da) * 1978-07-03 1991-10-21 Lilly Co Eli Analogifremgangsmaade til fremstilling af optisk aktive phenethanolaminer
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
DE2935062A1 (de) * 1978-09-06 1980-03-20 Degussa Substituierte aminoalkylguanidine, deren herstellung und arzneimittel
US4950783A (en) * 1978-09-20 1990-08-21 Schering Corporation Treatment of hypertension
US4275074A (en) * 1979-03-09 1981-06-23 Graham J. Dobbie Catecholamine treatment of ocular hypertension
US4590210A (en) * 1979-03-09 1986-05-20 Langham Maurice E Compositions for treatment of ocular hypertension
IT1148741B (it) * 1980-11-28 1986-12-03 Zambeletti Spa L Procedimento per la preparazione dell'1-(3,5-dimetossi-4-idrossifenil)-2-(n-metilammino)etanolo cloridrato
US4358455A (en) * 1980-12-23 1982-11-09 Merck & Co., Inc. Aralkylamindethanol heterocyclic compounds
US4348398A (en) * 1980-12-23 1982-09-07 Merck Sharp & Dohme (I.A.) Corp. Quinolinyl ethanolamines
US4486446A (en) * 1980-12-23 1984-12-04 Merck & Co., Inc. Aralkylaminoethanol heterocyclic compounds
US4379166A (en) * 1981-08-03 1983-04-05 Schering Corporation Arylmethoxy-, arylmethylthio-, heteroarylmethoxy-, and heteroarylmethylthio-alkylaminoalcohols
CA1219865A (en) * 1982-05-14 1987-03-31 Leo Alig Aziridine phenethanolamine derivatives
GB2120942B (en) * 1982-05-27 1985-10-30 Glaxo Group Ltd Salbutamol compositions
CH656308A5 (fr) * 1982-05-27 1986-06-30 Glaxo Group Ltd Compositions pharmaceutiques contenant du salbutamol.
US4594359B1 (en) * 1982-05-27 1994-07-26 Glaxo Group Ltd Pharmaceutical compositions
CA1258454A (en) * 1982-08-10 1989-08-15 Leo Alig Phenethanolamines
EP0103830A3 (de) * 1982-09-22 1985-07-31 Bayer Ag Wachstumsfördernde Phenylethylamin-Derivate
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
US4499108A (en) * 1983-06-08 1985-02-12 Schering Corporation Stable pleasant-tasting albuterol sulfate pharmaceutical formulations
US4851229A (en) * 1983-12-01 1989-07-25 Alza Corporation Composition comprising a therapeutic agent and a modulating agent
US4751071A (en) * 1983-12-01 1988-06-14 Alza Corporation Composition comprising salbutamol
US4777049A (en) * 1983-12-01 1988-10-11 Alza Corporation Constant release system with pulsed release
US4853381A (en) * 1984-04-17 1989-08-01 Glaxo Group Limited Ethanolamine compounds
FI851523L (fi) * 1984-04-17 1985-10-18 Glaxo Group Ltd Fenetanolaminderivat.
US5250546A (en) * 1984-09-28 1993-10-05 Nippon Chemiphar Co., Ltd. Amino-alcohol derivatives and processes for their preparation
JPS6183147A (ja) * 1984-09-28 1986-04-26 Nippon Chemiphar Co Ltd 新規なアミノアルコール誘導体およびその製造法並びにそれを有効成分とするグルタミン酸遮断剤
EP0259159A3 (en) * 1986-09-05 1989-08-09 Schering Corporation Method for the preparation of alpha1- [[(1,1-Dimethylethyl) amino] methyl]-4-hydroxy-1,3-benzenedimethanol, and intermediates used in its preparation
US5011993A (en) * 1986-09-05 1991-04-30 Schering Corporation Method for the preparation of α1 [[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol
US4952729A (en) * 1986-09-05 1990-08-28 Schering-Plough Corp. Intermediates in the preparation of alpha1(((1,1-dimethylethyl) amino) methyl)-4-hydroxy-1,3-benzenedimethanol
US5453418A (en) * 1988-03-07 1995-09-26 Eli Lilly And Company Ractopamine and growth hormone combinations
US5030640A (en) * 1989-01-05 1991-07-09 Merck & Co., Inc. Novel β-adrenergic agonists and pharmaceutical compositions thereof
US5166437A (en) * 1989-03-03 1992-11-24 Orion-Yhtyma Oy Process for the preparation of fluoxetine
GB8909273D0 (en) * 1989-04-24 1989-06-07 Glaxo Group Ltd Chemical compounds
SK280968B6 (sk) 1990-03-02 2000-10-09 Glaxo Group Limited Balenie medikamentu na použite v inhalačnom prístroji
US6536427B2 (en) 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
UA26230A (uk) 1990-03-02 1999-07-19 Глексо Груп Лімітед Іhгалятор для спільhого використаhhя з лікувальhим блоком і лікувальhий блок
WO1991019693A1 (en) * 1990-06-13 1991-12-26 Schering Corporation Esters and cyclic diesters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds
US5011845A (en) * 1990-06-13 1991-04-30 Schering Corporation Cyclic diesters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds
US5118683A (en) * 1990-06-13 1992-06-02 Schering Corporation Esters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds
DE69105277T2 (de) * 1990-09-11 1995-04-06 Schering Corp Verfahren zur herstellung von albuterol, sowie von arylglyoxal-, acetal-, hemiacetal- und hydrat-zwischenprodukten.
US5182097A (en) * 1991-02-14 1993-01-26 Virginia Commonwealth University Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
ZA924163B (en) 1991-06-10 1993-02-24 Schering Corp Non-chlorofluorocarbon aerosol formulations
YU59092A (sh) * 1991-06-10 1994-12-28 Schering Corporation Formulacije aerosola koji ne sadrže hlorofluorougljenična jedinjenja
NO179246C (no) * 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
ES2099415T3 (es) * 1991-12-18 1997-05-16 Minnesota Mining & Mfg Formulaciones de aerosol en suspension.
US7105152B1 (en) 1991-12-18 2006-09-12 3M Innovative Properties Company Suspension aerosol formulations
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
US5776983A (en) * 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
US5475138A (en) * 1994-07-07 1995-12-12 Pharm-Eco Laboratories Incorporated Method preparing amino acid-derived diaminopropanols
EP0820279B1 (en) * 1995-04-14 2002-07-03 Smithkline Beecham Corporation Metered dose inhaler for albuterol
DK0820323T3 (da) 1995-04-14 2003-11-24 Smithkline Beecham Corp Inhalator til afmålte doser af salmeterol
JPH11503352A (ja) 1995-04-14 1999-03-26 グラクソ、ウェルカム、インコーポレーテッド プロピオン酸フルチカゾン用計量投与用吸入器
US5603918A (en) * 1995-06-09 1997-02-18 Boehringer Ingelheim Pharmaceuticals, Inc. Aerosol composition of a salt of ipratropium and a salt of albuterol
US5770615A (en) * 1996-04-04 1998-06-23 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
EP0801060A1 (en) * 1996-04-09 1997-10-15 Pfizer Inc. Heterocyclic Beta-3 Adrenergenic Agonists
US20030103906A1 (en) * 1997-10-14 2003-06-05 Smithkline Beecham Corporation Metered dose inhaler having internal surfaces coated with fluorocarbon polymer
ZA994264B (en) * 1998-07-01 2000-01-25 Warner Lambert Co Stereoisomers with high affinity for adrenergic receptors.
US7232837B2 (en) * 1999-06-29 2007-06-19 Mcneil-Ppc, Inc. Stereoisomers with high affinity for adrenergic receptors
GB0030171D0 (en) 2000-12-11 2001-01-24 Cipla Ltd Process for preparing isomers of salbutamol
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US20030203930A1 (en) * 2001-10-26 2003-10-30 Imtiaz Chaudry Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease
JP2003221335A (ja) 2001-10-26 2003-08-05 Dey Lp 慢性閉塞性肺疾患の症状を緩和するためのアルブテロールおよびイプラトロピウム吸入溶液、システム、キットおよび方法
US6702997B2 (en) 2001-10-26 2004-03-09 Dey, L.P. Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma
US20030191151A1 (en) * 2001-10-26 2003-10-09 Imtiaz Chaudry Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease
US20030140920A1 (en) * 2001-10-26 2003-07-31 Dey L.P. Albuterol inhalation soultion, system, kit and method for relieving symptoms of pediatric asthma
US7582284B2 (en) * 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
CN1675180A (zh) * 2002-06-12 2005-09-28 住友制药株式会社 吲哚、吲唑和氮茚衍生物
DE10249576B3 (de) * 2002-10-24 2004-04-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von (R)-Salbutamol
US20040127733A1 (en) 2002-10-31 2004-07-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg New beta-agonists, processes for preparing them and their use as pharmaceutical compositions
DE10251170A1 (de) * 2002-10-31 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
ATE324364T1 (de) * 2002-12-10 2006-05-15 Sepracor Inc Verwendung vom l-tartrat levalbuterolsalz in der herstellung eines dosierinhalators
US7098241B2 (en) * 2002-12-16 2006-08-29 Hoffmann-La Roche Inc. Thiophene hydroxamic acid derivatives
EP1658283A2 (en) * 2003-05-30 2006-05-24 Ranbaxy Laboratories, Ltd. Substituted pyrrole derivatives and their use as hmg-co inhibitors
BRPI0413330A (pt) * 2003-08-29 2006-10-10 Ranbaxy Lab Ltd inibidores de fosfodiesterase do tipo iv, composição farmacêutica contendo os mesmos e processo para sua preparação
EP1663159A4 (en) * 2003-09-10 2010-06-09 Map Pharmaceuticals Inc AEROSOL FORMULATIONS FOR THE DELIVERY OF DIHYDROERGOTAMINE TO THE SYSTEMIC CIRCULATION BY PULMONARY INHALATION
AU2004285447A1 (en) * 2003-10-20 2005-05-12 Schering Corporation Pharmaceutical compositions
EP1694655A2 (en) * 2003-11-26 2006-08-30 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
EP1577292A1 (en) * 2004-03-17 2005-09-21 Pfizer Limited Phenylaminoethanol derivatives as beta2 receptor agonists
DE102004021779A1 (de) 2004-04-30 2005-11-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
WO2007008427A2 (en) * 2005-07-08 2007-01-18 Xemplar Pharmaceuticals, Llc Aerosol compositions and methods
EP1934219A1 (en) 2005-09-16 2008-06-25 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
AU2006305619A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
US20090054382A1 (en) * 2005-10-19 2009-02-26 Abhijit Ray Compositions of phosphodiesterase type iv inhibitors
DE102005052127A1 (de) 2005-10-28 2007-05-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue indol-haltige Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
BRPI0618379A2 (pt) * 2005-11-08 2011-08-30 Ranbaxy Lab Ltd processo para preparação do hemi-sal de cálcio do ácido (3r,5r) -7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroxime tilfenilamino) carbonil]-pirrol-1-il] -3, 5-diidroxi heptanóico
AR059838A1 (es) * 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulaciones para dosis estabilizantes de estatina
CN100398512C (zh) * 2006-04-21 2008-07-02 华南农业大学 （±）α-[（取代胺基）甲基]-苯环取代基-苯甲醇类化合物的制备方法
US20070286814A1 (en) * 2006-06-12 2007-12-13 Medispray Laboratories Pvt. Ltd. Stable aerosol pharmaceutical formulations
US20080153896A1 (en) * 2006-07-14 2008-06-26 Gyan Chand Yadav Polymorphic Forms of an HMG-CoA Reductase Inhibitor and Uses Thereof
EA016567B1 (ru) * 2006-08-22 2012-05-30 Ранбакси Лабораториз Лимитед Ингибиторы матриксных металлопротеиназ
WO2008035316A2 (en) * 2006-09-22 2008-03-27 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
EA200900472A1 (ru) * 2006-09-22 2009-10-30 Ранбакси Лабораторис Лимитед Ингибиторы фосфодиэстеразы iv типа
ES2306595B1 (es) 2007-02-09 2009-09-11 Laboratorios Almirall S.A. Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
CN101677954A (zh) * 2007-02-11 2010-03-24 Map药物公司 治疗性施用dhe用于快速减轻偏头痛而使副作用分布最小化的方法
US20080207659A1 (en) * 2007-02-15 2008-08-28 Asit Kumar Chakraborti Inhibitors of phosphodiesterase type 4
WO2008111009A1 (en) * 2007-03-14 2008-09-18 Ranbaxy Laboratories Limited Pyrazolo [3, 4-b] pyridine derivatives as phosphodiesterase inhibitors
KR101568884B1 (ko) * 2007-03-14 2015-11-12 랜박시 래보러터리스 리미티드 포스포디에스테라제 저해제로서 피라졸로 (３,４-ｂ) 피리딘 유도체
EP3210966B1 (en) 2007-10-05 2020-01-08 Acucela, Inc. Alkoxyphenylpropylamines for the treatment of age-related macular degeneration
ES2320961B1 (es) 2007-11-28 2010-03-17 Laboratorios Almirall, S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2.
EP2111861A1 (en) 2008-04-21 2009-10-28 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type IV inhibitors
UY32297A (es) 2008-12-22 2010-05-31 Almirall Sa Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
CN101575298B (zh) * 2008-12-31 2013-03-06 上海予利化学科技有限公司 一种制备手性医药中间体2-氨基-1-苯乙醇的方法
EP2228368A1 (en) 2009-03-12 2010-09-15 Almirall, S.A. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
US20110171141A1 (en) * 2009-06-26 2011-07-14 Kellerman Donald J Administration of dihydroergotamine mesylate particles using a metered dose inhaler
ES2897527T3 (es) * 2009-07-02 2022-03-01 Acucela Inc Farmacología de moduladores del ciclo visual
CA2807097A1 (en) 2010-07-30 2012-02-02 Ranbaxy Laboratories Limited Matrix metalloproteinase inhibitors
EP2619185A1 (en) 2010-09-24 2013-07-31 Ranbaxy Laboratories Limited Matrix metalloproteinase inhibitors
CN102584609B (zh) * 2011-01-06 2015-05-27 上海医药工业研究院 一种沙美特罗的制备方法
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
WO2013109991A1 (en) 2012-01-20 2013-07-25 Acucela Inc. Substituted heterocyclic compounds for disease treatment
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
CN103086916B (zh) * 2012-10-10 2015-06-24 淮海工学院 席夫碱功能化的双子离子液体
CN102924382B (zh) * 2012-10-10 2014-11-19 淮海工学院 双水杨醛功能化的咪唑型双子离子液体及其制备方法
BR112015011897B1 (pt) 2012-12-03 2021-11-03 Pfizer Inc Compostos moduladores seletivos do receptor de andrógeno e seu uso
EP3042892A1 (en) 2015-01-09 2016-07-13 Deva Holding Anonim Sirketi Amorphisation of levosalbutamol tartrate
CN108947831A (zh) * 2018-07-13 2018-12-07 重庆康刻尔制药有限公司 一种沙丁胺醇中间体ⅲ的纯化方法
CN108623486A (zh) * 2018-07-13 2018-10-09 重庆康刻尔制药有限公司 一种沙丁胺醇中间体ⅴ盐酸盐的制备方法
CN112479908B (zh) * 2020-11-26 2025-05-27 江西天戌药业有限公司 一种硫酸沙丁胺醇杂质d的制备方法
CN112920064A (zh) * 2021-05-11 2021-06-08 仁合诚益医药技术(天津)有限公司 一种沙丁胺醇杂质化合物及其制备方法、检测方法和用途
HUE067547T2 (hu) 2021-07-09 2024-10-28 Astrazeneca Pharmaceuticals Lp Készítmények, eljárások és rendszerek aeroszol gyógyszerbevitelre
CN114159385A (zh) * 2021-09-27 2022-03-11 北京四环科宝制药股份有限公司 含有硫酸沙丁胺醇的药物组合物及其制备方法
US20250057764A1 (en) 2021-12-20 2025-02-20 Astrazeneca Ab Compositions, methods and systems for aerosol drug delivery
GB202304652D0 (en) * 2023-03-29 2023-05-10 Atrogi Ab New compounds and medical uses thereof
CN116283619A (zh) * 2023-03-30 2023-06-23 河北广祥制药有限公司 一种硫酸沙丁胺醇杂质及其制备方法

Also Published As

Publication number Publication date
US3642896A (en) 1972-02-15
SE354061B (cs) 1973-02-26
BE704037A (cs) 1968-02-01
NL6713016A (cs) 1968-03-25
DE1643224B2 (de) 1978-11-23
CY713A (en) 1973-11-26
US3644353A (en) 1972-02-22
NL7809942A (nl) 1979-01-31
NO126014B (cs) 1972-12-11
DK133618C (cs) 1976-11-08
NL160805B (nl) 1979-07-16
US3705233A (en) 1972-12-05
PL70430B1 (en) 1974-02-28
DK133618B (da) 1976-06-21
DE1643224A1 (de) 1972-03-02
DE1643224C3 (de) 1979-08-09
IL28643A (en) 1971-12-29
CH492676A (de) 1970-06-30
FR8010M (cs) 1970-07-27
AT280996B (de) 1970-05-11
GB1200886A (en) 1970-08-05
FR1557677A (cs) 1969-02-21
CS167874B2 (cs) 1976-05-28

Similar Documents

Publication Publication Date Title
NL160805C (nl) Werkwijze ter bereiding van een geneesmiddel met stimule- rende werking op beta-andrenergische receptoren onder toepassing van een hydroxyfenyl-aminoethanol-derivaat, waarvan de aminogroep slechts een substituent draagt.
NL154508B (nl) Werkwijze ter bereiding van een therapeutisch preparaat met een bloeddrukverlagende werking en het aldus verkregen voortbrengsel, alsmede werkwijze ter bereiding van een 2,4,6-triaminopyrimidinederivaat.
NL151630B (nl) Werkwijze ter bereiding van een farmaceutisch preparaat met anti-inflammatoire werking.
NL143795B (nl) Werkwijze ter bereiding van een preparaat met herbicide eigenschappen.
FI48845C (fi) Menetelmä kationaktiivisten vesiliukoisten polyamidien valmistamiseksi .
NL155795B (nl) Werkwijze voor de bereiding van een gemalen molybdeendisulfideprodukt.
NL141783B (nl) Werkwijze ter bereiding van een geneesmiddel met antihypertensieve werking.
NL7501792A (nl) Werkwijze ter bereiding van een geneesmiddel met (beta)-adrenolytische werking, de door toepassing van deze werkwijze verkregen voorwerpen, alsmede een werkwijze ter bereiding van (beta)-adrenolytisch werk- zame 1-fenoxy 2-hydroxy 3-alkylaminopropaanderi- vaten.
NL140408B (nl) Werkwijze voor het bereiden van een therapeutische pasta, alsmede wondcompres voorzien van deze pasta.
FI49716C (fi) Menetelmä 2,4-diamino-5-bentsyyli-pyrimidiinien valmistamiseksi.
NL160166C (nl) Werkwijze voor de bereiding van een therapeutisch preparaat met werking tegen ontstekingen, alsmede gevormd preparaat, verkregen onder toepassing van deze werkwijze.
NL169172B (nl) Werkwijze ter bereiding van een geneesmiddel voor hartaandoeningen.
NL158791B (nl) Werkwijze voor de bereiding van een morfinanderivaat.
NL153543B (nl) Werkwijze ter bereiding van een therapeutisch preparaat met een bloeddrukverlagende werking en het verkregen gevormde voortbrengsel, alsmede werkwijze ter bereiding van een alkyldiaminopyrimidinederivaat.
NL162897C (nl) Werkwijze ter bereiding van een geneesmiddel met blok- kerende werking op beta-adrenergische receptoren, gevormd geneesmiddel en werkwijze ter bereiding van de werkzame verbinding.
NL146819B (nl) Werkwijze ter bereiding van een geneesmiddel met antibacteriele werking, alsmede werkwijze ter bereiding van geneeskrachtige verbindingen.
NL145552B (nl) Werkwijze ter bereiding van 3-(5-nitro-2-thiazolyl)-2-oxo-1,3-diazacycloalkaanverbindingen met antiparasitaire werking, werkwijze ter bereiding van farmaceutische perparaten, alsmede de verkregen gevormde preparaten.
NL157900B (nl) Werkwijze voor het bereiden van een farmaceutisch preparaat met antibacteriele werking op basis van een functioneel derivaat van 2-methyl-3-carboxylchinoxaline-1,4-dioxyde, aldus gevormde preparaten, alsmede een werkwijze ter bereiding van de actieve verbindingen.
NL148904B (nl) Werkwijze ter bereiding van 3-oxo-5554,9,11-19-nor-androstatrienen met anabole en androgene werking, werkwijze ter bereiding van farmaceutische preparaten, alsmede de aldus verkregen gevormde voortbrengselen.
NL139873B (nl) Werkwijze voor de bereiding van een voeder voor roofdieren.
NL152278B (nl) Werkwijze voor het bereiden van een transparante polyamide.
NL159282B (nl) Werkwijze voor het bereiden van een farmaceutisch preparaat, alsmede door toepassing daarvan verkregen gevormde voortbrengselen.
NL154218B (nl) Werkwijze ter bereiding van een geneesmiddel met progestatieve werking, onder toepassing hiervan gevormde geneesmiddelen en werkwijze ter bereiding van de hiertoe geschikte geneeskrachtige 16-methyleen-progesteronderivaten.
NL158802B (nl) Werkwijze ter bereiding van een therapeutisch preparaat met maagsapsecretieremmende werking op basis van een quaternair isopropylatropiniumderivaat, alsmede werkwijze voor de bereiding van de actieve verbinding.
NL143928B (nl) Werkwijze ter bereiding van een farmaceutisch preparaat met anthelmintische werking.

Legal Events

Date Code Title Description
NL80 Abbreviated name of patent owner mentioned of already nullified patent

Owner name: ALLEN HANBURY

V4 Lapsed because of reaching the maximum lifetime of a patent