SG132683A1
(en)
*
|
2003-10-15 |
2007-06-28 |
Osi Pharm Inc |
Imidazopyrazine tyrosine kinase inhibitors
|
WO2005047289A1
(en)
*
|
2003-11-17 |
2005-05-26 |
Pfizer Products Inc. |
Pyrrolopyrimidine compounds useful in treatment of cancer
|
DK1740591T3
(da)
|
2004-04-02 |
2009-10-26 |
Osi Pharm Inc |
Heterobicykliske proteinkinaseinhibitorer substitueret med en 6,6-biocyclisk ring
|
JP4842929B2
(ja)
*
|
2004-05-27 |
2011-12-21 |
ファイザー・プロダクツ・インク |
癌治療に有用なピロロピリミジン誘導体
|
TW200613306A
(en)
*
|
2004-07-20 |
2006-05-01 |
Osi Pharm Inc |
Imidazotriazines as protein kinase inhibitors
|
PT1858877E
(pt)
|
2005-01-14 |
2014-06-05 |
Gilead Connecticut Inc |
Ureias substituídas 1,3 diarilo, moduladoras da atividade de quinase
|
US20070287719A1
(en)
*
|
2005-03-11 |
2007-12-13 |
Pfizer Inc |
Salts, Prodrugs and Formulations of 1-[5-(4-Amino-7-Isopropyl-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonyl)-2-Methoxy-Phenyl]-3-(2,4-Dichloro-Phenyl)-Urea
|
US7777040B2
(en)
|
2005-05-03 |
2010-08-17 |
Cgi Pharmaceuticals, Inc. |
Certain substituted ureas, as modulators of kinase activity
|
US7795248B2
(en)
*
|
2005-05-18 |
2010-09-14 |
Abbott Laboratories, Inc. |
Substituted 7,8-dihydro-1H-pyrimido[4,5-B][1,4]diazepin-4-amines are novel kinase inhibitors
|
DE102005037499A1
(de)
*
|
2005-08-09 |
2007-02-15 |
Merck Patent Gmbh |
Pyrazolderivate
|
US20070049592A1
(en)
*
|
2005-08-22 |
2007-03-01 |
Geuns-Meyer Stephanie D |
Bis-aryl urea compounds and methods of use
|
RU2008120850A
(ru)
*
|
2005-10-28 |
2009-12-10 |
Айрм Ллк (Bm) |
Соединения и композиции в качестве ингибиторов протеинкиназ
|
PT1951724E
(pt)
*
|
2005-11-17 |
2011-08-02 |
Osi Pharm Inc |
Inibidores mtor fundidos bicíclicos
|
EP1968979A2
(en)
*
|
2005-12-08 |
2008-09-17 |
Abbott Laboratories |
9-membered heterobicyclic compounds as inhibitors of protein kinases
|
WO2007066189A2
(en)
*
|
2005-12-09 |
2007-06-14 |
Pfizer Products Inc. |
Salts, prodrugs and formulations of 1-[5-(4-amino-7-isopropyl-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-urea
|
US8575164B2
(en)
*
|
2005-12-19 |
2013-11-05 |
OSI Pharmaceuticals, LLC |
Combination cancer therapy
|
US20080299113A1
(en)
*
|
2005-12-19 |
2008-12-04 |
Arnold Lee D |
Combined treatment with and composition of 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents
|
JP5512975B2
(ja)
*
|
2005-12-29 |
2014-06-04 |
アッヴィ・インコーポレイテッド |
タンパク質キナーゼ阻害薬
|
KR101532256B1
(ko)
|
2006-11-22 |
2015-06-29 |
인사이트 코포레이션 |
키나제 억제제로서의 이미다조트리아진 및 이미다조피리미딘
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
WO2008076143A1
(en)
*
|
2006-12-18 |
2008-06-26 |
Osi Pharmaceuticals, Inc. |
Combination of igfr inhibitor and anti-cancer agent
|
CA2695004C
(en)
|
2007-07-17 |
2016-01-19 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
WO2009046448A1
(en)
|
2007-10-04 |
2009-04-09 |
Intellikine, Inc. |
Chemical entities and therapeutic uses thereof
|
CA2705303A1
(en)
*
|
2007-11-07 |
2009-05-14 |
Foldrx Pharmaceuticals, Inc. |
Modulation of protein trafficking
|
WO2009091939A1
(en)
*
|
2008-01-18 |
2009-07-23 |
Osi Pharmaceuticals, Inc. |
Imidazopyrazinol derivatives for the treatment of cancers
|
JP5547099B2
(ja)
*
|
2008-03-14 |
2014-07-09 |
インテリカイン, エルエルシー |
キナーゼ阻害剤および使用方法
|
WO2009114874A2
(en)
*
|
2008-03-14 |
2009-09-17 |
Intellikine, Inc. |
Benzothiazole kinase inhibitors and methods of use
|
PE20091846A1
(es)
|
2008-05-19 |
2009-12-16 |
Plexxikon Inc |
DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
|
US8158636B2
(en)
|
2008-05-19 |
2012-04-17 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
ES2396613T3
(es)
*
|
2008-05-19 |
2013-02-22 |
OSI Pharmaceuticals, LLC |
Imidazopirazinas e imidazotriazinas sustituidas
|
AU2009257635A1
(en)
*
|
2008-06-10 |
2009-12-17 |
Plexxikon, Inc. |
5H-Pyrrolo [2,3-b] pyrazine derivatives for kinase modulation, and indications therefor
|
US8110576B2
(en)
*
|
2008-06-10 |
2012-02-07 |
Plexxikon Inc. |
Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications
|
AU2009262199B2
(en)
|
2008-06-27 |
2012-08-09 |
Amgen Inc. |
Ang-2 inhibition to treat multiple sclerosis
|
JP5788316B2
(ja)
|
2008-07-08 |
2015-09-30 |
インテリカイン, エルエルシー |
キナーゼインヒビターおよび使用方法
|
WO2010045542A2
(en)
*
|
2008-10-16 |
2010-04-22 |
The Regents Of The University Of California |
Fused ring heteroaryl kinase inhibitors
|
US8476282B2
(en)
|
2008-11-03 |
2013-07-02 |
Intellikine Llc |
Benzoxazole kinase inhibitors and methods of use
|
US20120064072A1
(en)
|
2009-03-18 |
2012-03-15 |
Maryland Franklin |
Combination Cancer Therapy Comprising Administration of an EGFR Inhibitor and an IGF-1R Inhibitor
|
NZ594398A
(en)
|
2009-04-03 |
2014-03-28 |
Plexxikon Inc |
Propane-1-sulfonic acid (3-[5-(4-chloro-phenyl)-1h-pyrrol [2, 3-b] pyridine-3-carbonyl]-2,4-difluoro-phenyl} -amide compositions and uses thereof
|
CA2752826A1
(en)
|
2009-04-20 |
2010-10-28 |
OSI Pharmaceuticals, LLC |
Preparation of c-pyrazine-methylamines
|
JP2012526138A
(ja)
*
|
2009-05-07 |
2012-10-25 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
副腎皮質癌を治療するためのosi−906の使用
|
US8329724B2
(en)
|
2009-08-03 |
2012-12-11 |
Hoffmann-La Roche Inc. |
Process for the manufacture of pharmaceutically active compounds
|
CN105078978A
(zh)
|
2009-08-17 |
2015-11-25 |
因特利凯公司 |
杂环化合物及其用途
|
CA2769151A1
(en)
|
2009-08-24 |
2011-03-03 |
Ascepion Pharmaceuticals, Inc. |
5,6-bicyclic heteroaryl-containing urea compounds as kinase inhibitors
|
US20110112127A1
(en)
|
2009-11-06 |
2011-05-12 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
CA2781287C
(en)
*
|
2009-11-18 |
2018-07-31 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
US20110130711A1
(en)
*
|
2009-11-19 |
2011-06-02 |
Follica, Inc. |
Hair growth treatment
|
CN102892768A
(zh)
|
2009-12-30 |
2013-01-23 |
艾科尔公司 |
被取代的吡咯并氨基嘧啶化合物
|
WO2011153553A2
(en)
*
|
2010-06-04 |
2011-12-08 |
The Regents Of The University Of California |
Methods and compositions for kinase inhibition
|
US10010439B2
(en)
|
2010-06-13 |
2018-07-03 |
Synerz Medical, Inc. |
Intragastric device for treating obesity
|
US9526648B2
(en)
|
2010-06-13 |
2016-12-27 |
Synerz Medical, Inc. |
Intragastric device for treating obesity
|
US8628554B2
(en)
|
2010-06-13 |
2014-01-14 |
Virender K. Sharma |
Intragastric device for treating obesity
|
US10420665B2
(en)
|
2010-06-13 |
2019-09-24 |
W. L. Gore & Associates, Inc. |
Intragastric device for treating obesity
|
WO2012064744A2
(en)
*
|
2010-11-08 |
2012-05-18 |
Lycera Corporation |
Tetrahydroquinoline and related bicyclic compounds for inhibition of rorϒ activity and the treatment of disease
|
US8754114B2
(en)
|
2010-12-22 |
2014-06-17 |
Incyte Corporation |
Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
|
ES2696023T3
(es)
|
2011-02-07 |
2019-01-11 |
Plexxikon Inc |
Compuestos y métodos para la modulación de quinasas e indicaciones para ello
|
AR085397A1
(es)
|
2011-02-23 |
2013-09-25 |
Intellikine Inc |
Combinacion de inhibidores de quinasa y sus usos
|
WO2012129145A1
(en)
|
2011-03-18 |
2012-09-27 |
OSI Pharmaceuticals, LLC |
Nscle combination therapy
|
WO2012137089A1
(en)
|
2011-04-05 |
2012-10-11 |
Pfizer Limited |
Pyrrolo [2, 3 -d] pyrimidine derivatives as inhibitors of tropomyosin- related kinases
|
KR20140048968A
(ko)
*
|
2011-07-13 |
2014-04-24 |
파마시클릭스, 인코포레이티드 |
브루톤형 티로신 키나제의 억제제
|
CN107245056A
(zh)
|
2011-08-26 |
2017-10-13 |
润新生物公司 |
化学实体、组合物及方法
|
JP6342805B2
(ja)
|
2011-09-02 |
2018-06-13 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
置換ピラゾロ[3,4−d]ピリミジンおよびその用途
|
WO2013040515A1
(en)
*
|
2011-09-14 |
2013-03-21 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
KR20140117582A
(ko)
*
|
2012-01-25 |
2014-10-07 |
바이엘 파마 악티엔게젤샤프트 |
치환된 페닐이미다조피라졸 및 그의 용도
|
WO2013112950A2
(en)
|
2012-01-25 |
2013-08-01 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
WO2013169864A2
(en)
|
2012-05-08 |
2013-11-14 |
Lycera Corporation |
TETRAHYDRO[1,8]NAPHTHYRIDINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORƴ AND THE TREATMENT OF DISEASE
|
EP2846804B1
(en)
|
2012-05-08 |
2017-11-29 |
Merck Sharp & Dohme Corp. |
TETRAHYDRONAPHTHYRIDINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
EP3822273B1
(en)
|
2012-06-13 |
2024-04-10 |
Incyte Holdings Corporation |
Substituted tricyclic compounds as fgfr inhibitors
|
WO2014026125A1
(en)
|
2012-08-10 |
2014-02-13 |
Incyte Corporation |
Pyrazine derivatives as fgfr inhibitors
|
WO2014047648A1
(en)
|
2012-09-24 |
2014-03-27 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
RU2015115631A
(ru)
|
2012-09-26 |
2016-11-20 |
Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния |
Модулирование ire1
|
EP2912036A1
(en)
|
2012-10-04 |
2015-09-02 |
Pfizer Limited |
Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors
|
US20150250785A1
(en)
|
2012-10-04 |
2015-09-10 |
Pfizer Limited |
Tropomyosin-Related Kinase Inhibitors
|
JP2015531394A
(ja)
|
2012-10-04 |
2015-11-02 |
ファイザー・リミテッドPfizer Limited |
ピロロ[2,3−d]ピリミジントロポミオシン関連キナーゼ阻害剤
|
US9725421B2
(en)
|
2012-11-12 |
2017-08-08 |
Neupharma, Inc. |
Substituted quinoxalines as B-raf kinase inhibitors
|
US9266892B2
(en)
|
2012-12-19 |
2016-02-23 |
Incyte Holdings Corporation |
Fused pyrazoles as FGFR inhibitors
|
CN105209042B
(zh)
|
2013-03-22 |
2019-03-08 |
米伦纽姆医药公司 |
催化性mtorc 1/2抑制剂与选择性极光a激酶抑制剂的组合
|
SG10201708520YA
(en)
|
2013-04-19 |
2017-12-28 |
Incyte Corp |
Bicyclic heterocycles as fgfr inhibitors
|
US9783511B2
(en)
|
2013-12-20 |
2017-10-10 |
Lycera Corporation |
Carbamate benzoxazine propionic acids and acid derivatives for modulation of RORgamma activity and the treatment of disease
|
EP3083602A1
(en)
|
2013-12-20 |
2016-10-26 |
Pfizer Limited |
N-acylpiperidine ether tropomyosin-related kinase inhibitors
|
WO2015095795A1
(en)
|
2013-12-20 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE, AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE
|
WO2015095788A1
(en)
|
2013-12-20 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE
|
WO2015131035A1
(en)
|
2014-02-27 |
2015-09-03 |
Lycera Corporation |
Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma & related therapeutic methods
|
WO2015159175A1
(en)
|
2014-04-15 |
2015-10-22 |
Pfizer Inc. |
Tropomyosin-related kinase inhibitors containing both a 1h-pyrazole and a pyrimidine moiety
|
US10189777B2
(en)
|
2014-05-05 |
2019-01-29 |
Lycera Corporation |
Benzenesulfonamido and related compounds for use as agonists of RORγ and the treatment of disease
|
EP3140291A4
(en)
|
2014-05-05 |
2018-01-10 |
Lycera Corporation |
Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease
|
EP3140298A1
(en)
|
2014-05-07 |
2017-03-15 |
Pfizer Inc. |
Tropomyosin-related kinase inhibitors
|
WO2016009296A1
(en)
|
2014-07-16 |
2016-01-21 |
Pfizer Inc. |
N-acylpiperidine ether tropomyosin-related kinase inhibitors
|
WO2016020784A1
(en)
|
2014-08-05 |
2016-02-11 |
Pfizer Inc. |
N-acylpyrrolidine ether tropomyosin-related kinase inhibitors
|
US10851105B2
(en)
|
2014-10-22 |
2020-12-01 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
ES2792036T3
(es)
|
2014-11-14 |
2020-11-06 |
Nerviano Medical Sciences Srl |
Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de cinasa
|
CA2975997A1
(en)
|
2015-02-11 |
2016-08-18 |
Merck Sharp & Dohme Corp. |
Substituted pyrazole compounds as rorgammat inhibitors and uses thereof
|
WO2016134294A1
(en)
|
2015-02-20 |
2016-08-25 |
Incyte Corporation |
Bicyclic heterocycles as fgfr4 inhibitors
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
MX2017010673A
(es)
|
2015-02-20 |
2018-03-21 |
Incyte Corp |
Heterociclos biciclicos como inhibidores de receptores del factor de crecimiento fibroblastico (fgfr).
|
ES2827523T3
(es)
*
|
2015-03-11 |
2021-05-21 |
Riken |
Agente terapéutico para la leucemia intratable
|
CA2982847A1
(en)
|
2015-05-05 |
2016-11-10 |
Lycera Corporation |
Dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of ror.gamma. and the treatment of disease
|
CA2987289A1
(en)
|
2015-06-11 |
2016-12-15 |
Lycera Corporation |
Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of ror.gamma. and the treatment of disease
|
MA41559A
(fr)
|
2015-09-08 |
2017-12-26 |
Taiho Pharmaceutical Co Ltd |
Composé de pyrimidine condensé ou un sel de celui-ci
|
CA3002853A1
(en)
|
2015-10-27 |
2017-05-04 |
Merck Sharp & Dohme Corp. |
Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof
|
US10344000B2
(en)
|
2015-10-27 |
2019-07-09 |
Merck Sharp & Dohme Corp. |
Substituted bicyclic pyrazole compounds as RORgammaT inhibitors and uses thereof
|
CA3002850A1
(en)
|
2015-10-27 |
2017-05-04 |
Merck Sharp & Dohme Corp. |
Substituted indazole compounds as rorgammat inhibitors and uses thereof
|
US10112924B2
(en)
|
2015-12-02 |
2018-10-30 |
Astraea Therapeutics, Inc. |
Piperdinyl nociceptin receptor compounds
|
KR20180094940A
(ko)
*
|
2015-12-02 |
2018-08-24 |
아스트레아 테라퓨틱스 엘엘씨 |
피페리디닐 노시셉틴 수용체 화합물
|
US9630968B1
(en)
|
2015-12-23 |
2017-04-25 |
Arqule, Inc. |
Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof
|
WO2017133669A1
(en)
*
|
2016-02-05 |
2017-08-10 |
Savira Pharmaceuticals Gmbh |
5, 7-diazaindole and 5, 7-diazaindazole derivatives and their use in the treatment, amelioration or prevention of influenza
|
MD3269370T2
(ro)
|
2016-02-23 |
2020-05-31 |
Taiho Pharmaceutical Co Ltd |
Compus pirimidinic condensat nou sau sare a acestuia
|
US10779980B2
(en)
|
2016-04-27 |
2020-09-22 |
Synerz Medical, Inc. |
Intragastric device for treating obesity
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
WO2018233526A1
(zh)
*
|
2017-06-19 |
2018-12-27 |
上海和誉生物医药科技有限公司 |
一种csf1r抑制剂及其制备方法和应用
|
TW201920184A
(zh)
*
|
2017-08-17 |
2019-06-01 |
美國華盛頓大學 |
Cdpk1抑制劑、組合物及與其相關之方法
|
CN112867716A
(zh)
|
2018-05-04 |
2021-05-28 |
因赛特公司 |
Fgfr抑制剂的固体形式和其制备方法
|
CN112566912A
(zh)
|
2018-05-04 |
2021-03-26 |
因赛特公司 |
Fgfr抑制剂的盐
|
WO2020185532A1
(en)
|
2019-03-08 |
2020-09-17 |
Incyte Corporation |
Methods of treating cancer with an fgfr inhibitor
|
WO2021007269A1
(en)
|
2019-07-09 |
2021-01-14 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
AU2020366006A1
(en)
|
2019-10-14 |
2022-04-21 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
US11566028B2
(en)
|
2019-10-16 |
2023-01-31 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
EP4069696A1
(en)
|
2019-12-04 |
2022-10-12 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
KR20220131900A
(ko)
|
2019-12-04 |
2022-09-29 |
인사이트 코포레이션 |
Fgfr 억제제의 유도체
|
CN112574200B
(zh)
|
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