NL1016012C1 - Tosylaatzouten van 4-(p-fluorfenyl)-piperidine-3-carbinols. - Google Patents

Tosylaatzouten van 4-(p-fluorfenyl)-piperidine-3-carbinols. Download PDF

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Publication number
NL1016012C1
NL1016012C1 NL1016012A NL1016012A NL1016012C1 NL 1016012 C1 NL1016012 C1 NL 1016012C1 NL 1016012 A NL1016012 A NL 1016012A NL 1016012 A NL1016012 A NL 1016012A NL 1016012 C1 NL1016012 C1 NL 1016012C1
Authority
NL
Netherlands
Prior art keywords
compound
formula
group
methyl
impurity
Prior art date
Application number
NL1016012A
Other languages
English (en)
Dutch (nl)
Inventor
Jacobus Maria Lemmens
Theodorus Hendricus Ant Peters
Pavel Slanina
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Application granted granted Critical
Publication of NL1016012C1 publication Critical patent/NL1016012C1/nl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NL1016012A 2000-05-12 2000-08-24 Tosylaatzouten van 4-(p-fluorfenyl)-piperidine-3-carbinols. NL1016012C1 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL0000320 2000-05-12
PCT/NL2000/000320 WO2001085688A1 (en) 2000-05-12 2000-05-12 TOSYLATE SALTS OF 4-(p-FLUOROPHENYL)-PIPERIDINE-3-CARBINOLS

Publications (1)

Publication Number Publication Date
NL1016012C1 true NL1016012C1 (nl) 2001-01-30

Family

ID=19760688

Family Applications (1)

Application Number Title Priority Date Filing Date
NL1016012A NL1016012C1 (nl) 2000-05-12 2000-08-24 Tosylaatzouten van 4-(p-fluorfenyl)-piperidine-3-carbinols.

Country Status (6)

Country Link
US (1) US6521758B2 (cs)
EP (1) EP1280775A1 (cs)
AU (1) AU2000246280A1 (cs)
CZ (1) CZ20023694A3 (cs)
NL (1) NL1016012C1 (cs)
WO (1) WO2001085688A1 (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9930577D0 (en) * 1999-12-23 2000-02-16 Smithkline Beecham Plc Novel process
CN101205211B (zh) * 2006-12-19 2011-12-14 北京德众万全药物技术开发有限公司 一种盐酸帕罗西汀重要中间体的制备方法
CA2709774C (en) 2008-05-22 2012-10-02 Teva Pharmaceutical Industries Ltd. Varenicline tosylate, an intermediate in the preparation process of varenicline l-tartrate
EP2438054A1 (en) 2009-06-22 2012-04-11 Teva Pharmaceutical Industries Ltd. Solid states forms of varenicline salts and processes for preparation thereof
CN104402800A (zh) * 2014-12-02 2015-03-11 千辉药业（安徽）有限责任公司 一种反式-4-(4-氟苯基)-3-羟甲基-1-甲基哌啶的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US4585777A (en) 1984-02-07 1986-04-29 A/S Ferrosan (-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT
EP0190496A3 (en) * 1984-12-13 1987-05-27 Beecham Group Plc Piperidine derivatives having a gastro-intestinal activity
DE3680184D1 (de) * 1985-08-10 1991-08-14 Beecham Group Plc Verfahren zur herstellung von arylpiperidincarbinol.
GB8714707D0 (en) 1987-06-23 1987-07-29 Beecham Group Plc Chemical process
GB9209687D0 (en) 1992-05-06 1992-06-17 Smithkline Beecham Plc Novel process
US5258517A (en) 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
AU721257B2 (en) 1995-05-17 2000-06-29 Novo Nordisk A/S Process for preparing 4-aryl-piperidine derivatives
JP3446468B2 (ja) 1996-04-15 2003-09-16 旭硝子株式会社 ピペリジンカルビノール類の製造方法
JP3882224B2 (ja) 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
EP1384720A1 (en) 1996-06-13 2004-01-28 SUMIKA FINE CHEMICALS Co., Ltd. Process for drying paroxetine hydrochloride
HU221921B1 (hu) 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
GB9710004D0 (en) * 1997-05-17 1997-07-09 Knoll Ag Chemical process
EP1078925A1 (en) * 1997-06-10 2001-02-28 Synthon B.V. 4-Phenylpiperidine compounds
WO2000026187A1 (en) * 1998-11-02 2000-05-11 Synthon B.V. Process for producing 4-arylpiperidine-3-carbinols and related compounds
DK1286965T3 (da) * 2000-05-12 2004-05-03 Synthon Bv Piperidin-forbindelser og fremgangsmåder til fremstilling af sådanne

Also Published As

Publication number Publication date
AU2000246280A1 (en) 2001-11-20
EP1280775A1 (en) 2003-02-05
CZ20023694A3 (cs) 2003-05-14
US6521758B2 (en) 2003-02-18
US20020082277A1 (en) 2002-06-27
WO2001085688A1 (en) 2001-11-15

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Effective date: 20060301