MY8700179A - Indoles - Google Patents

Indoles

Info

Publication number
MY8700179A
MY8700179A MY179/87A MY8700179A MY8700179A MY 8700179 A MY8700179 A MY 8700179A MY 179/87 A MY179/87 A MY 179/87A MY 8700179 A MY8700179 A MY 8700179A MY 8700179 A MY8700179 A MY 8700179A
Authority
MY
Malaysia
Prior art keywords
indoles
Prior art date
Application number
MY179/87A
Other languages
English (en)
Inventor
Michael Dennis Dowle
Ian Harold Coates
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10530876&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MY8700179(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MY8700179A publication Critical patent/MY8700179A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
MY179/87A 1982-06-07 1987-12-30 Indoles MY8700179A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8216526 1982-06-07

Publications (1)

Publication Number Publication Date
MY8700179A true MY8700179A (en) 1987-12-31

Family

ID=10530876

Family Applications (1)

Application Number Title Priority Date Filing Date
MY179/87A MY8700179A (en) 1982-06-07 1987-12-30 Indoles

Country Status (33)

Country Link
US (1) US4816470A (OSRAM)
JP (1) JPS5942366A (OSRAM)
KR (1) KR900006681B1 (OSRAM)
AT (1) AT381933B (OSRAM)
AU (1) AU566149B2 (OSRAM)
BE (1) BE896986A (OSRAM)
CA (1) CA1199643A (OSRAM)
CH (1) CH657359A5 (OSRAM)
CY (1) CY1458A (OSRAM)
CZ (1) CZ280529B6 (OSRAM)
DE (2) DE3320521A1 (OSRAM)
DK (1) DK260183D0 (OSRAM)
DO (1) DOP1989476000A (OSRAM)
ES (3) ES523039A0 (OSRAM)
FI (1) FI79530C (OSRAM)
FR (1) FR2530625B1 (OSRAM)
GB (1) GB2124210B (OSRAM)
GR (1) GR79215B (OSRAM)
HK (1) HK14789A (OSRAM)
IE (1) IE55358B1 (OSRAM)
IL (1) IL68913A (OSRAM)
IT (1) IT1170387B (OSRAM)
KE (1) KE3833A (OSRAM)
LU (1) LU84852A1 (OSRAM)
MX (1) MX9202623A (OSRAM)
MY (1) MY8700179A (OSRAM)
NL (1) NL193694C (OSRAM)
NZ (1) NZ204482A (OSRAM)
PH (1) PH19908A (OSRAM)
PT (1) PT76830B (OSRAM)
SE (1) SE452459B (OSRAM)
SK (1) SK404091A3 (OSRAM)
ZA (1) ZA834110B (OSRAM)

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GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
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US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8601959D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Indole derivatives
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GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
ES2058292T3 (es) * 1987-08-13 1994-11-01 Glaxo Group Ltd Derivados de indol.
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
HUT57185A (en) * 1990-03-21 1991-11-28 Merrell Dow Pharma Process for producing 8-sulfamil-methylen-2-amino-tetraline derivatives and pharmaceutical compositions containing them
US5155218A (en) 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
US5935925A (en) * 1990-05-08 1999-08-10 Synaptic Pharmaceutical Corporation Methods of treating migraine and compounds useful for such methods
ATE156823T1 (de) * 1990-06-07 1997-08-15 Zeneca Ltd Therapeutische heterocyclische verbindungen
GB9013845D0 (en) * 1990-06-21 1990-08-15 Glaxo Group Ltd Process
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
GB9022250D0 (en) * 1990-10-12 1990-11-28 Glaxo Group Ltd Medicaments
GB9103770D0 (en) * 1991-02-22 1991-04-10 Glaxo Group Ltd Chemical compounds
GB9104890D0 (en) * 1991-03-08 1991-04-24 Glaxo Group Ltd Compositions
CA2084531A1 (en) * 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211276D0 (en) * 1992-05-28 1992-07-15 Glaxo Lab Sa Pharmaceutical compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
GB9216009D0 (en) * 1992-07-28 1992-09-09 Almirall Lab New indol derivatives
ES2056025B1 (es) * 1992-10-08 1995-05-01 Almirall Lab Nuevos derivados de indol.
RU2108326C1 (ru) * 1993-02-26 1998-04-10 Вита-Инвест С.А. Способ получения 2-карбокси-3-[2-(диметиламино)этил]-n-метил-1h-индол-5-метансульфонамида или его сложных эфиров
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US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
ES2079323B1 (es) * 1994-06-21 1996-10-16 Vita Invest Sa Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
US5618816A (en) * 1995-03-02 1997-04-08 Bristol-Myers Squibb Company Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
FR2731224B1 (fr) * 1995-03-02 1997-05-30 Pf Medicament Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5872145A (en) * 1996-08-16 1999-02-16 Pozen, Inc. Formulation of 5-HT agonist and NSAID for treatment of migraine
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US6416472B1 (en) 1997-11-06 2002-07-09 Edus Inc. Method and device for measuring cognitive efficiency
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
WO2002015899A1 (en) * 2000-08-23 2002-02-28 Bristol-Myers Squibb Company Combination therapy for the treatment of migraine
IL157771A0 (en) * 2001-03-27 2004-03-28 Galen Chemicals Ltd Intravaginal drug delivery devices for the administration of an antimicrobial agent
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
DE60228294D1 (en) * 2001-06-05 2008-09-25 Ronald Aung-Din Topische migränetherapie
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
AU2003243605A1 (en) * 2002-06-13 2003-12-31 Dr. Reddy's Laboratories Limited 3-'2-(dimethylamino) ethyl!-n-methyl-1h-indole-5-methanesulfonamide and the succinate thereof
US20040068000A1 (en) * 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
EP1572647B1 (en) 2002-12-20 2016-09-21 Basf Se Synthesis of amines and intermediates for the synthesis thereof
PT1575566E (pt) 2002-12-26 2012-03-29 Pozen Inc Formas de dosagem em multicamada contendo naproxeno e triptanos
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
WO2004076403A1 (en) * 2003-02-24 2004-09-10 Transform Pharmaceuticals, Inc. Sumatriptan crystalline forms, pharmaceutical compositions and methods
JP2006527195A (ja) * 2003-06-06 2006-11-30 グラクソ　グループ　リミテッド トリプタンおよびｎｓａｉｄを含む組成物
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ATE504288T1 (de) * 2003-09-26 2011-04-15 Alza Corp Oros-push-stick für die kontrollierte abgabe von wirkstoffen
US20070259033A1 (en) * 2003-09-26 2007-11-08 Evangeline Cruz Controlled release formulations exhibiting an ascending rate of release
MXPA06003450A (es) * 2003-09-26 2006-08-31 Johnson & Johnson Recubrimiento de farmaco que proporciona alta carga del farmaco y metodos para proporcionar el mismo.
US20060002989A1 (en) * 2004-06-10 2006-01-05 Ahmed Salah U Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
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CN101466709B (zh) * 2006-04-13 2013-03-20 轴突公司 具有nos抑制活性的1,5和3,6-取代的吲哚化合物
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US20090252791A1 (en) * 2008-04-02 2009-10-08 Venkata Nookaraju Sreedharala Pharmaceutical compositions comprising a triptan and a nonsteroidal anti-inflammatory drug
CA2725618C (en) 2008-05-27 2016-04-12 Biota Scientific Management Pty Ltd Antiviral salts
AU2009260166B2 (en) * 2008-06-20 2014-10-09 Alphapharm Pty Ltd Pharmaceutical formulation
US8592424B2 (en) * 2008-06-30 2013-11-26 Afgin Pharma Llc Topical regional neuro-affective therapy
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
DK2480197T3 (en) 2009-09-25 2016-01-25 Reddys Lab Ltd Dr Compositions containing triptanforbindelser
HK1248564A1 (zh) 2015-03-02 2018-10-19 阿福金制药有限责任公司 用大麻素的局部区域神经影响性疗法
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
US10537554B2 (en) 2015-08-05 2020-01-21 Upsher-Smith Laboratories, Llc Pharmaceutical composition for treating migraine
BR112018015367A2 (pt) 2016-01-27 2018-12-18 Instar Tech A S carreadores oromucosais de nanofibra para tratamento terapêutico
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan

Family Cites Families (5)

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ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
SE454880B (sv) * 1980-08-12 1988-06-06 Glaxo Group Ltd 3-aminoalkyl-1h-indol-5-acetamider, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren
GB2082175B (en) * 1980-08-12 1984-05-02 Glaxo Group Ltd Heterocyclic compounds
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
NZ197998A (en) * 1980-08-12 1985-08-16 Glaxo Group Ltd 5-amino(methyl)-1h-indol-3-ylalkaneamines

Also Published As

Publication number Publication date
AT381933B (de) 1986-12-10
DE19375045I2 (de) 2002-09-05
KR900006681B1 (ko) 1990-09-17
NL8302031A (nl) 1984-01-02
ES8609247A1 (es) 1986-07-16
AU566149B2 (en) 1987-10-08
SK277877B6 (en) 1995-06-07
AU1544183A (en) 1983-12-15
NL193694B (nl) 2000-03-01
GB2124210B (en) 1985-11-13
FI79530B (fi) 1989-09-29
DE3320521A1 (de) 1983-12-08
CA1199643A (en) 1986-01-21
NL193694C (nl) 2000-07-04
DE3320521C2 (OSRAM) 1992-06-25
IT1170387B (it) 1987-06-03
GR79215B (OSRAM) 1984-10-22
IE831335L (en) 1983-12-07
CH657359A5 (fr) 1986-08-29
ES8407473A1 (es) 1984-10-01
LU84852A1 (fr) 1985-03-29
PT76830A (en) 1983-07-01
FI832035L (fi) 1983-12-08
FI79530C (fi) 1990-01-10
GB8315564D0 (en) 1983-07-13
HK14789A (en) 1989-02-24
CY1458A (en) 1989-07-21
BE896986A (fr) 1983-12-07
MX9202623A (es) 1992-06-30
IE55358B1 (en) 1990-08-29
FR2530625A1 (fr) 1984-01-27
PH19908A (en) 1986-08-13
IL68913A (en) 1987-08-31
US4816470A (en) 1989-03-28
ES529802A0 (es) 1985-11-16
SK404091A3 (en) 1995-06-07
JPH0329069B2 (OSRAM) 1991-04-23
JPS5942366A (ja) 1984-03-08
ES544281A0 (es) 1986-07-16
SE8303208D0 (sv) 1983-06-07
PT76830B (en) 1986-04-21
KR840005095A (ko) 1984-11-03
CZ404091A3 (en) 1993-04-14
FI832035A0 (fi) 1983-06-07
GB2124210A (en) 1984-02-15
IT8348422A0 (it) 1983-06-03
FR2530625B1 (fr) 1986-04-18
CZ280529B6 (cs) 1996-02-14
KE3833A (en) 1988-11-18
DK260183D0 (da) 1983-06-06
SE8303208L (sv) 1983-12-08
DOP1989476000A (es) 1996-02-03
ES523039A0 (es) 1984-10-01
ES8601880A1 (es) 1985-11-16
IL68913A0 (en) 1983-10-31
ATA208483A (de) 1986-05-15
ZA834110B (en) 1985-01-30
NZ204482A (en) 1986-09-10
SE452459B (sv) 1987-11-30

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