MXPA05002315A - Sacaridos modificados, conjugados del mismo y su produccion. - Google Patents
Sacaridos modificados, conjugados del mismo y su produccion.Info
- Publication number
- MXPA05002315A MXPA05002315A MXPA05002315A MXPA05002315A MXPA05002315A MX PA05002315 A MXPA05002315 A MX PA05002315A MX PA05002315 A MXPA05002315 A MX PA05002315A MX PA05002315 A MXPA05002315 A MX PA05002315A MX PA05002315 A MXPA05002315 A MX PA05002315A
- Authority
- MX
- Mexico
- Prior art keywords
- saccharide
- carbon atoms
- formula
- group
- modified
- Prior art date
Links
- 150000001720 carbohydrates Chemical class 0.000 title claims abstract description 131
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- 125000003172 aldehyde group Chemical group 0.000 claims abstract description 13
- 125000004432 carbon atom Chemical group C* 0.000 claims description 76
- 238000000034 method Methods 0.000 claims description 41
- 239000000203 mixture Substances 0.000 claims description 31
- 125000000217 alkyl group Chemical group 0.000 claims description 28
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- 125000003118 aryl group Chemical group 0.000 claims description 21
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 21
- PFKFTWBEEFSNDU-UHFFFAOYSA-N 1,1'-Carbonyldiimidazole Substances C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims description 20
- -1 amino compound Chemical class 0.000 claims description 16
- 238000006268 reductive amination reaction Methods 0.000 claims description 16
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 13
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 12
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- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 claims description 2
- SNTWKPAKVQFCCF-UHFFFAOYSA-N 2,3-dihydro-1h-triazole Chemical compound N1NC=CN1 SNTWKPAKVQFCCF-UHFFFAOYSA-N 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0220198.6A GB0220198D0 (en) | 2002-08-30 | 2002-08-30 | Modified saccharides,conjugates thereof and their manufacture |
| PCT/IB2003/004194 WO2004019992A1 (en) | 2002-08-30 | 2003-09-01 | Modified saccharides, conjugates thereof, and their manufacture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05002315A true MXPA05002315A (es) | 2005-06-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05002315A MXPA05002315A (es) | 2002-08-30 | 2003-09-01 | Sacaridos modificados, conjugados del mismo y su produccion. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8895516B2 (enExample) |
| EP (1) | EP1534342B1 (enExample) |
| JP (2) | JP5268222B2 (enExample) |
| CN (2) | CN101863998B (enExample) |
| AT (1) | ATE319481T1 (enExample) |
| AU (1) | AU2003260921B2 (enExample) |
| BR (1) | BR0314089A (enExample) |
| CA (1) | CA2497167C (enExample) |
| DE (1) | DE60303961T2 (enExample) |
| DK (1) | DK1534342T3 (enExample) |
| ES (1) | ES2260682T3 (enExample) |
| GB (1) | GB0220198D0 (enExample) |
| MX (1) | MXPA05002315A (enExample) |
| NZ (1) | NZ538703A (enExample) |
| RU (2) | RU2005108992A (enExample) |
| WO (1) | WO2004019992A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| PT2191844E (pt) | 2003-01-30 | 2014-06-04 | Novartis Ag | Vacinas injetáveis contra múltiplos serogrupos meningocócicos |
| WO2005051429A2 (en) * | 2003-11-19 | 2005-06-09 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Targeted conjugates with a modified saccharide linker |
| EP1885734B1 (en) * | 2005-05-06 | 2015-01-14 | Novartis AG | Immunogens for meningitidis-a vaccines |
| HUE032903T2 (hu) * | 2005-12-22 | 2017-11-28 | Glaxosmithkline Biologicals Sa | Streptococcus pneumoniae kapszulárispoliszacharid-konjugátumok |
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| FR2427341A1 (fr) * | 1978-06-02 | 1979-12-28 | Delalande Sa | Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique |
| DE69104877T2 (de) * | 1990-03-15 | 1995-03-16 | Tanabe Seiyaku Co | Polysulfat eines Cyclodextrinderivates und Verfahren zu dessen Herstellung. |
| WO1995018144A1 (en) * | 1993-12-28 | 1995-07-06 | Pfizer Inc. | Steroidal glycosides |
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| DK0959905T3 (da) * | 1997-01-21 | 2010-04-06 | Sanofi Pasteur | Polysaccharid-peptid-konjugater |
| CA2266718C (en) * | 1997-08-08 | 2007-05-22 | Behringwerke Aktiengesellschaft | Polysaccharide conjugates of biomolecules |
| US5929049A (en) * | 1997-08-08 | 1999-07-27 | Dade Behring Marburg Gmbh | Polysaccharide conjugates of biomolecules |
| US5952454A (en) * | 1997-12-12 | 1999-09-14 | The United States Of America As Represented By The Department Of Health And Human Services | Linking compounds useful for coupling carbohydrates to amine-containing carriers |
| BR0308768A (pt) | 2002-03-26 | 2005-02-15 | Chiron Srl | Sacarìdeos modificados possuindo estabilidade melhorada em água |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
-
2002
- 2002-08-30 GB GBGB0220198.6A patent/GB0220198D0/en not_active Ceased
-
2003
- 2003-09-01 JP JP2004532625A patent/JP5268222B2/ja not_active Expired - Fee Related
- 2003-09-01 ES ES03791149T patent/ES2260682T3/es not_active Expired - Lifetime
- 2003-09-01 BR BR0314089-0A patent/BR0314089A/pt not_active Application Discontinuation
- 2003-09-01 AT AT03791149T patent/ATE319481T1/de active
- 2003-09-01 EP EP03791149A patent/EP1534342B1/en not_active Expired - Lifetime
- 2003-09-01 MX MXPA05002315A patent/MXPA05002315A/es active IP Right Grant
- 2003-09-01 NZ NZ538703A patent/NZ538703A/en not_active IP Right Cessation
- 2003-09-01 CA CA2497167A patent/CA2497167C/en not_active Expired - Fee Related
- 2003-09-01 CN CN2010101825535A patent/CN101863998B/zh not_active Expired - Fee Related
- 2003-09-01 US US10/526,124 patent/US8895516B2/en not_active Expired - Fee Related
- 2003-09-01 DE DE60303961T patent/DE60303961T2/de not_active Expired - Lifetime
- 2003-09-01 CN CN038237245A patent/CN1688343B/zh not_active Expired - Fee Related
- 2003-09-01 RU RU2005108992/04A patent/RU2005108992A/ru unknown
- 2003-09-01 DK DK03791149T patent/DK1534342T3/da active
- 2003-09-01 AU AU2003260921A patent/AU2003260921B2/en not_active Ceased
- 2003-09-01 WO PCT/IB2003/004194 patent/WO2004019992A1/en not_active Ceased
-
2008
- 2008-12-19 RU RU2008150551/13A patent/RU2531909C2/ru not_active IP Right Cessation
-
2011
- 2011-10-17 JP JP2011228229A patent/JP5314745B2/ja not_active Expired - Fee Related
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2014
- 2014-10-23 US US14/521,761 patent/US20150166593A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2260682T3 (es) | 2006-11-01 |
| CA2497167C (en) | 2011-07-12 |
| NZ538703A (en) | 2006-09-29 |
| RU2531909C2 (ru) | 2014-10-27 |
| RU2005108992A (ru) | 2005-11-10 |
| US20060263390A1 (en) | 2006-11-23 |
| JP2012017342A (ja) | 2012-01-26 |
| BR0314089A (pt) | 2005-11-16 |
| ATE319481T1 (de) | 2006-03-15 |
| JP5268222B2 (ja) | 2013-08-21 |
| JP2006511465A (ja) | 2006-04-06 |
| JP5314745B2 (ja) | 2013-10-16 |
| CN1688343A (zh) | 2005-10-26 |
| DE60303961D1 (de) | 2006-05-04 |
| EP1534342A1 (en) | 2005-06-01 |
| DK1534342T3 (da) | 2006-07-10 |
| RU2008150551A (ru) | 2010-06-27 |
| CN101863998B (zh) | 2012-08-29 |
| US20150166593A1 (en) | 2015-06-18 |
| CN1688343B (zh) | 2010-09-08 |
| WO2004019992A1 (en) | 2004-03-11 |
| CA2497167A1 (en) | 2004-03-11 |
| GB0220198D0 (en) | 2002-10-09 |
| AU2003260921B2 (en) | 2008-03-06 |
| AU2003260921A1 (en) | 2004-03-19 |
| EP1534342B1 (en) | 2006-03-08 |
| US8895516B2 (en) | 2014-11-25 |
| CN101863998A (zh) | 2010-10-20 |
| DE60303961T2 (de) | 2006-10-26 |
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