ES2260682T3 - Sacaridos modificados, sus conjugados y su produccion. - Google Patents
Sacaridos modificados, sus conjugados y su produccion.Info
- Publication number
- ES2260682T3 ES2260682T3 ES03791149T ES03791149T ES2260682T3 ES 2260682 T3 ES2260682 T3 ES 2260682T3 ES 03791149 T ES03791149 T ES 03791149T ES 03791149 T ES03791149 T ES 03791149T ES 2260682 T3 ES2260682 T3 ES 2260682T3
- Authority
- ES
- Spain
- Prior art keywords
- saccharide
- formula
- group
- alkyl
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 125000000217 alkyl group Chemical group 0.000 claims description 30
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- 229960005486 vaccine Drugs 0.000 claims description 22
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- -1 amine compound Chemical class 0.000 claims description 16
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 15
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
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- Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Epidemiology (AREA)
- Virology (AREA)
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- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0220198 | 2002-08-30 | ||
| GBGB0220198.6A GB0220198D0 (en) | 2002-08-30 | 2002-08-30 | Modified saccharides,conjugates thereof and their manufacture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2260682T3 true ES2260682T3 (es) | 2006-11-01 |
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ID=9943241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03791149T Expired - Lifetime ES2260682T3 (es) | 2002-08-30 | 2003-09-01 | Sacaridos modificados, sus conjugados y su produccion. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8895516B2 (enExample) |
| EP (1) | EP1534342B1 (enExample) |
| JP (2) | JP5268222B2 (enExample) |
| CN (2) | CN101863998B (enExample) |
| AT (1) | ATE319481T1 (enExample) |
| AU (1) | AU2003260921B2 (enExample) |
| BR (1) | BR0314089A (enExample) |
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| ES (1) | ES2260682T3 (enExample) |
| GB (1) | GB0220198D0 (enExample) |
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| NZ (1) | NZ538703A (enExample) |
| RU (2) | RU2005108992A (enExample) |
| WO (1) | WO2004019992A1 (enExample) |
Families Citing this family (31)
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| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| JP4827726B2 (ja) | 2003-01-30 | 2011-11-30 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | 複数の髄膜炎菌血清群に対する注射可能ワクチン |
| WO2005051429A2 (en) * | 2003-11-19 | 2005-06-09 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Targeted conjugates with a modified saccharide linker |
| AU2006245440B2 (en) * | 2005-05-06 | 2012-04-19 | Novartis Vaccines And Diagnostics Srl | Immunogens for meningitidis-A vaccines |
| TW201350129A (zh) * | 2005-12-22 | 2013-12-16 | Glaxosmithkline Biolog Sa | 包含莢膜醣結合物之肺炎鏈球菌免疫原組合物、包含其之疫苗及套組及其用途 |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| AU2014200640B2 (en) * | 2007-01-11 | 2016-06-16 | Glaxosmithkline Biologicals Sa | Modified saccharides |
| GB0700562D0 (en) * | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| US9475864B2 (en) | 2008-09-05 | 2016-10-25 | University Of Massachusetts | Methods, compositions and vaccines relating to Neisseria meningitidis antibodies |
| SG177310A1 (en) * | 2009-06-22 | 2012-02-28 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| KR101486122B1 (ko) | 2009-06-22 | 2015-01-23 | 와이어쓰 엘엘씨 | 스타필로코커스 아우레우스 항원의 면역원성 조성물 |
| CN102971009A (zh) * | 2009-10-30 | 2013-03-13 | 诺华有限公司 | 金黄色葡萄球菌5型和8型荚膜多糖的纯化 |
| MX350142B (es) | 2010-08-23 | 2017-08-28 | Wyeth Llc * | Formulaciones estables de antigenos rlp2086 de neisseria meningitidis. |
| SG187912A1 (en) | 2010-09-10 | 2013-04-30 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| US8986710B2 (en) | 2012-03-09 | 2015-03-24 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CN102861326A (zh) * | 2012-09-19 | 2013-01-09 | 天津康希诺生物技术有限公司 | 流脑多糖-蛋白质缀合疫苗及制备方法 |
| WO2014136064A2 (en) | 2013-03-08 | 2014-09-12 | Pfizer Inc. | Immunogenic fusion polypeptides |
| CN105492021B (zh) | 2013-09-08 | 2018-12-04 | 辉瑞公司 | 脑膜炎奈瑟氏球菌组合物及其方法 |
| ES2701169T3 (es) * | 2014-02-14 | 2019-02-21 | Pfizer | Conjugados glucoproteicos inmunogénicos |
| US10888611B2 (en) | 2015-02-19 | 2021-01-12 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CN108883192A (zh) * | 2016-03-15 | 2018-11-23 | 默沙东和惠康基金会合资的希勒曼实验室私人有限公司 | 新型多糖-蛋白质结合物及其获取工艺 |
| CN118236477B (zh) | 2016-09-02 | 2025-04-25 | 赛诺菲巴斯德股份有限公司 | 脑膜炎奈瑟氏菌疫苗 |
| MX372587B (es) | 2017-01-31 | 2020-04-17 | Pfizer | Composiciones de neisseria meningitidis y metodos respectivos |
| MX2019009867A (es) | 2017-02-24 | 2019-10-02 | Merck Sharp & Dohme | Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae. |
| WO2019050816A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
| US11395849B2 (en) | 2017-09-07 | 2022-07-26 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| MX2021010555A (es) * | 2019-03-08 | 2022-04-06 | Glaxosmithkline Biologicals Sa | Derivados carbocíclicos y derivados conjugados de los mismos y su uso en vacunas. |
| CN115605222A (zh) | 2019-09-27 | 2023-01-13 | 辉瑞公司（Us） | 脑膜炎奈瑟氏菌组合物及其方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2427341A1 (fr) * | 1978-06-02 | 1979-12-28 | Delalande Sa | Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique |
| DK0447171T3 (da) * | 1990-03-15 | 1994-12-12 | Tanabe Seiyaku Co | Polysulfat af cyclodextrinderivat og fremgangsmåde til fremstilling deraf |
| US5698526A (en) * | 1993-12-28 | 1997-12-16 | Pfizer Inc. | Steroidal glycosides |
| CA2189356A1 (en) * | 1994-05-02 | 1995-11-09 | Ting Chi Wong | Process for preparation of glycosides of tumor-associated carbohydrate antigens |
| DK0959905T3 (da) * | 1997-01-21 | 2010-04-06 | Sanofi Pasteur | Polysaccharid-peptid-konjugater |
| US5929049A (en) * | 1997-08-08 | 1999-07-27 | Dade Behring Marburg Gmbh | Polysaccharide conjugates of biomolecules |
| DE69737298T2 (de) * | 1997-08-08 | 2007-06-28 | Dade Behring Marburg Gmbh | Konjugate von polysacchariden und biomolekülen |
| US5952454A (en) * | 1997-12-12 | 1999-09-14 | The United States Of America As Represented By The Department Of Health And Human Services | Linking compounds useful for coupling carbohydrates to amine-containing carriers |
| PT1490409E (pt) | 2002-03-26 | 2009-04-03 | Novartis Vaccines & Diagnostic | Sacáridos modificados possuindo uma estabilidade melhorada em água |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
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2002
- 2002-08-30 GB GBGB0220198.6A patent/GB0220198D0/en not_active Ceased
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2003
- 2003-09-01 CA CA2497167A patent/CA2497167C/en not_active Expired - Fee Related
- 2003-09-01 AU AU2003260921A patent/AU2003260921B2/en not_active Ceased
- 2003-09-01 BR BR0314089-0A patent/BR0314089A/pt not_active Application Discontinuation
- 2003-09-01 NZ NZ538703A patent/NZ538703A/en not_active IP Right Cessation
- 2003-09-01 RU RU2005108992/04A patent/RU2005108992A/ru unknown
- 2003-09-01 AT AT03791149T patent/ATE319481T1/de active
- 2003-09-01 DK DK03791149T patent/DK1534342T3/da active
- 2003-09-01 JP JP2004532625A patent/JP5268222B2/ja not_active Expired - Fee Related
- 2003-09-01 CN CN2010101825535A patent/CN101863998B/zh not_active Expired - Fee Related
- 2003-09-01 DE DE60303961T patent/DE60303961T2/de not_active Expired - Lifetime
- 2003-09-01 MX MXPA05002315A patent/MXPA05002315A/es active IP Right Grant
- 2003-09-01 US US10/526,124 patent/US8895516B2/en not_active Expired - Fee Related
- 2003-09-01 WO PCT/IB2003/004194 patent/WO2004019992A1/en not_active Ceased
- 2003-09-01 EP EP03791149A patent/EP1534342B1/en not_active Expired - Lifetime
- 2003-09-01 ES ES03791149T patent/ES2260682T3/es not_active Expired - Lifetime
- 2003-09-01 CN CN038237245A patent/CN1688343B/zh not_active Expired - Fee Related
-
2008
- 2008-12-19 RU RU2008150551/13A patent/RU2531909C2/ru not_active IP Right Cessation
-
2011
- 2011-10-17 JP JP2011228229A patent/JP5314745B2/ja not_active Expired - Fee Related
-
2014
- 2014-10-23 US US14/521,761 patent/US20150166593A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003260921A1 (en) | 2004-03-19 |
| US20060263390A1 (en) | 2006-11-23 |
| EP1534342A1 (en) | 2005-06-01 |
| CA2497167A1 (en) | 2004-03-11 |
| RU2008150551A (ru) | 2010-06-27 |
| BR0314089A (pt) | 2005-11-16 |
| JP2006511465A (ja) | 2006-04-06 |
| DE60303961T2 (de) | 2006-10-26 |
| DK1534342T3 (da) | 2006-07-10 |
| DE60303961D1 (de) | 2006-05-04 |
| MXPA05002315A (es) | 2005-06-08 |
| AU2003260921B2 (en) | 2008-03-06 |
| US8895516B2 (en) | 2014-11-25 |
| RU2531909C2 (ru) | 2014-10-27 |
| CN101863998B (zh) | 2012-08-29 |
| ATE319481T1 (de) | 2006-03-15 |
| CA2497167C (en) | 2011-07-12 |
| US20150166593A1 (en) | 2015-06-18 |
| JP2012017342A (ja) | 2012-01-26 |
| WO2004019992A1 (en) | 2004-03-11 |
| GB0220198D0 (en) | 2002-10-09 |
| JP5314745B2 (ja) | 2013-10-16 |
| NZ538703A (en) | 2006-09-29 |
| EP1534342B1 (en) | 2006-03-08 |
| RU2005108992A (ru) | 2005-11-10 |
| CN1688343B (zh) | 2010-09-08 |
| CN1688343A (zh) | 2005-10-26 |
| JP5268222B2 (ja) | 2013-08-21 |
| CN101863998A (zh) | 2010-10-20 |
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