GB0220198D0 - Modified saccharides,conjugates thereof and their manufacture - Google Patents

Modified saccharides,conjugates thereof and their manufacture

Info

Publication number
GB0220198D0
GB0220198D0 GBGB0220198.6A GB0220198A GB0220198D0 GB 0220198 D0 GB0220198 D0 GB 0220198D0 GB 0220198 A GB0220198 A GB 0220198A GB 0220198 D0 GB0220198 D0 GB 0220198D0
Authority
GB
United Kingdom
Prior art keywords
conjugates
linker
new
manufacture
modified saccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0220198.6A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GSK Vaccines SRL
Original Assignee
Chiron SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron SRL filed Critical Chiron SRL
Priority to GBGB0220198.6A priority Critical patent/GB0220198D0/en
Publication of GB0220198D0 publication Critical patent/GB0220198D0/en
Priority to AT03791149T priority patent/ATE319481T1/de
Priority to DE60303961T priority patent/DE60303961T2/de
Priority to RU2005108992/04A priority patent/RU2005108992A/ru
Priority to US10/526,124 priority patent/US8895516B2/en
Priority to ES03791149T priority patent/ES2260682T3/es
Priority to MXPA05002315A priority patent/MXPA05002315A/es
Priority to CN2010101825535A priority patent/CN101863998B/zh
Priority to CA2497167A priority patent/CA2497167C/en
Priority to AU2003260921A priority patent/AU2003260921B2/en
Priority to JP2004532625A priority patent/JP5268222B2/ja
Priority to NZ538703A priority patent/NZ538703A/en
Priority to DK03791149T priority patent/DK1534342T3/da
Priority to EP03791149A priority patent/EP1534342B1/en
Priority to CN038237245A priority patent/CN1688343B/zh
Priority to PCT/IB2003/004194 priority patent/WO2004019992A1/en
Priority to BR0314089-0A priority patent/BR0314089A/pt
Priority to RU2008150551/13A priority patent/RU2531909C2/ru
Priority to JP2011228229A priority patent/JP5314745B2/ja
Priority to US14/521,761 priority patent/US20150166593A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GBGB0220198.6A 2002-08-30 2002-08-30 Modified saccharides,conjugates thereof and their manufacture Ceased GB0220198D0 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
GBGB0220198.6A GB0220198D0 (en) 2002-08-30 2002-08-30 Modified saccharides,conjugates thereof and their manufacture
BR0314089-0A BR0314089A (pt) 2002-08-30 2003-09-01 Sacarìdeos modificados, conjugados do mesmo e sua fabricação
CA2497167A CA2497167C (en) 2002-08-30 2003-09-01 Modified saccharides, conjugates thereof, and their manufacture
JP2004532625A JP5268222B2 (ja) 2002-08-30 2003-09-01 改変された糖類、それらの結合体、およびそられの製造
RU2005108992/04A RU2005108992A (ru) 2002-08-30 2003-09-01 Модифицированные сахариды, их конъюгаты и их изготовление
US10/526,124 US8895516B2 (en) 2002-08-30 2003-09-01 Modified saccharides, conjugates thereof, and their manufacture
ES03791149T ES2260682T3 (es) 2002-08-30 2003-09-01 Sacaridos modificados, sus conjugados y su produccion.
MXPA05002315A MXPA05002315A (es) 2002-08-30 2003-09-01 Sacaridos modificados, conjugados del mismo y su produccion.
CN2010101825535A CN101863998B (zh) 2002-08-30 2003-09-01 修饰糖、其缀合物及其制备方法
AT03791149T ATE319481T1 (de) 2002-08-30 2003-09-01 Modifizierte saccharide, deren konjugate sowie deren herstellung
AU2003260921A AU2003260921B2 (en) 2002-08-30 2003-09-01 Modified saccharides, conjugates thereof, and their manufacture
DE60303961T DE60303961T2 (de) 2002-08-30 2003-09-01 Modifizierte saccharide, deren konjugate sowie deren herstellung
NZ538703A NZ538703A (en) 2002-08-30 2003-09-01 Modified saccharides, having a linker moiety and a masked aldehyde group, to prevent and treat diseases caused by capsulate bacteria
DK03791149T DK1534342T3 (da) 2002-08-30 2003-09-01 Modificerede saccharider, konjugater deraf og fremstilling deraf
EP03791149A EP1534342B1 (en) 2002-08-30 2003-09-01 Modified saccharides, conjugates thereof, and their manufacture
CN038237245A CN1688343B (zh) 2002-08-30 2003-09-01 修饰糖、其缀合物及其制备方法
PCT/IB2003/004194 WO2004019992A1 (en) 2002-08-30 2003-09-01 Modified saccharides, conjugates thereof, and their manufacture
RU2008150551/13A RU2531909C2 (ru) 2002-08-30 2008-12-19 Модифицированные сахариды, их конъюгаты и их изготовление
JP2011228229A JP5314745B2 (ja) 2002-08-30 2011-10-17 改変された糖類、それらの結合体、およびそられの製造
US14/521,761 US20150166593A1 (en) 2002-08-30 2014-10-23 Modified saccharides, conjugates thereof, and their manufacture

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0220198.6A GB0220198D0 (en) 2002-08-30 2002-08-30 Modified saccharides,conjugates thereof and their manufacture

Publications (1)

Publication Number Publication Date
GB0220198D0 true GB0220198D0 (en) 2002-10-09

Family

ID=9943241

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0220198.6A Ceased GB0220198D0 (en) 2002-08-30 2002-08-30 Modified saccharides,conjugates thereof and their manufacture

Country Status (16)

Country Link
US (2) US8895516B2 (enExample)
EP (1) EP1534342B1 (enExample)
JP (2) JP5268222B2 (enExample)
CN (2) CN101863998B (enExample)
AT (1) ATE319481T1 (enExample)
AU (1) AU2003260921B2 (enExample)
BR (1) BR0314089A (enExample)
CA (1) CA2497167C (enExample)
DE (1) DE60303961T2 (enExample)
DK (1) DK1534342T3 (enExample)
ES (1) ES2260682T3 (enExample)
GB (1) GB0220198D0 (enExample)
MX (1) MXPA05002315A (enExample)
NZ (1) NZ538703A (enExample)
RU (2) RU2005108992A (enExample)
WO (1) WO2004019992A1 (enExample)

Families Citing this family (32)

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Publication number Priority date Publication date Assignee Title
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
GB0220198D0 (en) * 2002-08-30 2002-10-09 Chiron Spa Modified saccharides,conjugates thereof and their manufacture
EP2172213B1 (en) 2003-01-30 2013-04-03 Novartis AG Injectable vaccines against multiple meningococcal serogroups
WO2005051429A2 (en) * 2003-11-19 2005-06-09 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Targeted conjugates with a modified saccharide linker
MX2007013881A (es) 2005-05-06 2008-10-22 Novartis Vaccines & Diagnostic Inmunogenos para vacunas de meningitides-a.
KR101515078B1 (ko) * 2005-12-22 2015-04-24 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
GB0700562D0 (en) * 2007-01-11 2007-02-21 Novartis Vaccines & Diagnostic Modified Saccharides
AU2014200640B2 (en) * 2007-01-11 2016-06-16 Glaxosmithkline Biologicals Sa Modified saccharides
WO2010027499A2 (en) 2008-09-05 2010-03-11 University Of Massachusetts Medical School Methods, compositions and vaccines relating to neisseria meningitidis antibodies
SA110310528B1 (ar) 2009-06-22 2014-07-02 Wyeth Llc التركيبات المولدة للمناعة لأنتيجينات ستافيلوكوكس أوريس
SG10201406432RA (en) 2009-06-22 2014-11-27 Wyeth Llc Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions
HUE034251T2 (en) * 2009-10-30 2018-02-28 Glaxosmithkline Biologicals Sa Purification of staphylococcus aureus type 5 and type 8 capsular saccharides
CN107913396B (zh) 2010-08-23 2022-03-08 惠氏有限责任公司 脑膜炎萘瑟氏菌rLP2086抗原的稳定制剂
AU2011300409B2 (en) 2010-09-10 2015-03-26 Wyeth Llc Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
MY198910A (en) 2012-03-09 2023-10-02 Pfizer Neisseria meningitidis compositions and methods thereof
CN102861326A (zh) * 2012-09-19 2013-01-09 天津康希诺生物技术有限公司 流脑多糖-蛋白质缀合疫苗及制备方法
WO2014136064A2 (en) 2013-03-08 2014-09-12 Pfizer Inc. Immunogenic fusion polypeptides
RU2662968C2 (ru) 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
ES2701169T3 (es) * 2014-02-14 2019-02-21 Pfizer Conjugados glucoproteicos inmunogénicos
WO2016132294A1 (en) 2015-02-19 2016-08-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
WO2016170186A1 (en) * 2015-04-23 2016-10-27 Synaffix B.V. PROCESS FOR THE MODIFICATION OF A GLYCOPROTEIN USING A GLYCOSYLTRANSFERASE THAT IS OR IS DERIVED FROM A β(1,4)-N-ACETYLGALACTOSAMINYLTRANSFERASE
JP2019508468A (ja) * 2016-03-15 2019-03-28 エムエスディー ウェルカム トラスト ヒルマン ラボラトリーズ プライベート リミテッドＭｓｄ Ｗｅｌｌｃｏｍｅ Ｔｒｕｓｔ Ｈｉｌｌｅｍａｎ Ｌａｂｏｒａｔｏｒｉｅｓ Ｐｖｔ．Ｌｔｄ． 新規の多糖体−タンパク質コンジュゲート及びそれを得る方法
BR112019003992A2 (pt) 2016-09-02 2019-05-28 Sanofi Pasteur Inc vacina contra neisseria meningitidis
AU2018215585B2 (en) 2017-01-31 2022-03-17 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
JP7680185B2 (ja) * 2017-02-24 2025-05-20 メルク・シャープ・アンド・ドーム・エルエルシー 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強
MX394768B (es) 2017-09-07 2025-03-21 Merck Sharp & Dohme Llc Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina.
MX394767B (es) 2017-09-07 2025-03-24 Merck Sharp & Dohme Llc Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina transportadora.
WO2020182635A1 (en) * 2019-03-08 2020-09-17 Glaxosmithkline Biologicals Sa Carbocyclic derivatives and conjugated derivatives thereof, and their use in vaccines
WO2021059181A1 (en) 2019-09-27 2021-04-01 Pfizer Inc. Neisseria meningitidis compositions and methods thereof

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
FR2427341A1 (fr) * 1978-06-02 1979-12-28 Delalande Sa Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique
DK0447171T3 (da) * 1990-03-15 1994-12-12 Tanabe Seiyaku Co Polysulfat af cyclodextrinderivat og fremgangsmåde til fremstilling deraf
US5698526A (en) * 1993-12-28 1997-12-16 Pfizer Inc. Steroidal glycosides
WO1995029927A2 (en) * 1994-05-02 1995-11-09 Biomira, Inc. Process for preparation of glycosides of tumor-associated carbohydrate antigens
US6472506B1 (en) * 1997-01-21 2002-10-29 Aventis Pasteur S.A. Polysaccharide-peptide-conjugates
US5929049A (en) 1997-08-08 1999-07-27 Dade Behring Marburg Gmbh Polysaccharide conjugates of biomolecules
JP4182269B2 (ja) * 1997-08-08 2008-11-19 ベーリングウエルケ、アクティエンゲゼルシャフト 生体分子のポリサッカライド接合体
US5952454A (en) * 1997-12-12 1999-09-14 The United States Of America As Represented By The Department Of Health And Human Services Linking compounds useful for coupling carbohydrates to amine-containing carriers
ES2616180T3 (es) 2002-03-26 2017-06-09 Glaxosmithkline Biologicals Sa Sacáridos modificados con estabilidad mejorada en agua para su uso como medicamento
GB0220198D0 (en) * 2002-08-30 2002-10-09 Chiron Spa Modified saccharides,conjugates thereof and their manufacture

Also Published As

Publication number Publication date
BR0314089A (pt) 2005-11-16
WO2004019992A1 (en) 2004-03-11
CA2497167A1 (en) 2004-03-11
CN101863998A (zh) 2010-10-20
EP1534342B1 (en) 2006-03-08
CN1688343A (zh) 2005-10-26
NZ538703A (en) 2006-09-29
JP5268222B2 (ja) 2013-08-21
JP5314745B2 (ja) 2013-10-16
EP1534342A1 (en) 2005-06-01
AU2003260921A1 (en) 2004-03-19
MXPA05002315A (es) 2005-06-08
CA2497167C (en) 2011-07-12
DK1534342T3 (da) 2006-07-10
CN1688343B (zh) 2010-09-08
DE60303961D1 (de) 2006-05-04
CN101863998B (zh) 2012-08-29
DE60303961T2 (de) 2006-10-26
JP2006511465A (ja) 2006-04-06
AU2003260921B2 (en) 2008-03-06
US8895516B2 (en) 2014-11-25
RU2008150551A (ru) 2010-06-27
ES2260682T3 (es) 2006-11-01
US20150166593A1 (en) 2015-06-18
US20060263390A1 (en) 2006-11-23
ATE319481T1 (de) 2006-03-15
RU2005108992A (ru) 2005-11-10
RU2531909C2 (ru) 2014-10-27
JP2012017342A (ja) 2012-01-26

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)