WO2007050789A3 - Glycosyl-oligonucleotide conjugates and methods - Google Patents

Glycosyl-oligonucleotide conjugates and methods Download PDF

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Publication number
WO2007050789A3
WO2007050789A3 PCT/US2006/041837 US2006041837W WO2007050789A3 WO 2007050789 A3 WO2007050789 A3 WO 2007050789A3 US 2006041837 W US2006041837 W US 2006041837W WO 2007050789 A3 WO2007050789 A3 WO 2007050789A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycosyl
methods
oligonucleotide
oligonucleotide conjugates
sugar
Prior art date
Application number
PCT/US2006/041837
Other languages
French (fr)
Other versions
WO2007050789A2 (en
Inventor
Mario H Genero
Andres P Montefeltro
Gabriel G Alvarado
Original Assignee
Nedken Corp
Mario H Genero
Andres P Montefeltro
Gabriel G Alvarado
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nedken Corp, Mario H Genero, Andres P Montefeltro, Gabriel G Alvarado filed Critical Nedken Corp
Publication of WO2007050789A2 publication Critical patent/WO2007050789A2/en
Publication of WO2007050789A3 publication Critical patent/WO2007050789A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A glycosyl-oligonucleotide conjugate comprising a sugar or oligosaccharide moiety linked to an oligonucleotide by an oligonucleotide linkage between the 5' hydroxyl group of the oligonucleotide and a primary hydroxyl group of the sugar or oligosaccharide, and methods of making and using the conjugate are disclosed.
PCT/US2006/041837 2005-10-25 2006-10-25 Glycosyl-oligonucleotide conjugates and methods WO2007050789A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73049805P 2005-10-25 2005-10-25
US60/730,498 2005-10-25

Publications (2)

Publication Number Publication Date
WO2007050789A2 WO2007050789A2 (en) 2007-05-03
WO2007050789A3 true WO2007050789A3 (en) 2007-06-28

Family

ID=37890360

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/041837 WO2007050789A2 (en) 2005-10-25 2006-10-25 Glycosyl-oligonucleotide conjugates and methods

Country Status (1)

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WO (1) WO2007050789A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2638309T3 (en) * 2010-04-19 2017-10-19 Nlife Therapeutics S.L. Compositions and methods for the selective distribution of oligonucleotide molecules to specific types of neurons
CA2890112A1 (en) * 2012-10-26 2014-05-01 Nlife Therapeutics, S.L. Compositions and methods for the treatment of parkinson disease by the selective delivery of oligonucleotide molecules to specific neuron types
EP3658155A4 (en) * 2017-07-28 2021-06-30 Nogra Pharma Limited Method of preparing oligonucleotide compounds
CN114717224B (en) * 2022-04-08 2024-01-30 苏州大学 Method for enriching and identifying glycosylated ribonucleic acid glycoRNA based on solid phase
WO2023233395A1 (en) * 2022-05-30 2023-12-07 Nurexone Biologic Ltd. Compositions and methods for loading extracellular vesicles

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ADINOLFI M ET AL: "Solid Phase Glycosidation of Oligonucleotides", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 40, no. 13, 26 March 1999 (1999-03-26), pages 2607 - 2610, XP004158097, ISSN: 0040-4039 *
ADINOLFI M ET AL: "Solid-phase synthesis of glyco-oligonucleotide conjugates", SYNLETT 2001 GERMANY, no. 6, 2001, pages 745 - 748, XP002428046, ISSN: 0936-5214 *
KATAJISTO JOHANNA ET AL: "Solid-phase synthesis of oligonucleotide glycoconjugates bearing three different glycosyl groups: orthogonally protected bis(hydroxymethyl)-N,N'-bis(3-hydroxypropyl)malondiamide phosphoramidite as key building block.", THE JOURNAL OF ORGANIC CHEMISTRY 29 OCT 2004, vol. 69, no. 22, 29 October 2004 (2004-10-29), pages 7609 - 7615, XP002428045, ISSN: 0022-3263 *
MATSUURA K ET AL: "Construction of glyco-clusters by self-organization of site-specifically glycosylated oligonucleotides and their cooperative amplification of lectin-recognition", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 123, no. 2, 2001, pages 357 - 358, XP002968426, ISSN: 0002-7863 *
ZATSEPIN TIMOFEI S ET AL: "Synthesis and applications of oligonucleotide-carbohydrate conjugates.", CHEMISTRY & BIODIVERSITY OCT 2004, vol. 1, no. 10, October 2004 (2004-10-01), pages 1401 - 1417, XP002428047, ISSN: 1612-1880 *

Also Published As

Publication number Publication date
WO2007050789A2 (en) 2007-05-03

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