DK1534342T3 - Modificerede saccharider, konjugater deraf og fremstilling deraf - Google Patents
Modificerede saccharider, konjugater deraf og fremstilling derafInfo
- Publication number
- DK1534342T3 DK1534342T3 DK03791149T DK03791149T DK1534342T3 DK 1534342 T3 DK1534342 T3 DK 1534342T3 DK 03791149 T DK03791149 T DK 03791149T DK 03791149 T DK03791149 T DK 03791149T DK 1534342 T3 DK1534342 T3 DK 1534342T3
- Authority
- DK
- Denmark
- Prior art keywords
- conjugates
- linker
- new
- preparation
- modified saccharides
- Prior art date
Links
- 150000001720 carbohydrates Chemical class 0.000 title abstract 3
- 125000005647 linker group Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 abstract 1
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0220198.6A GB0220198D0 (en) | 2002-08-30 | 2002-08-30 | Modified saccharides,conjugates thereof and their manufacture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1534342T3 true DK1534342T3 (da) | 2006-07-10 |
Family
ID=9943241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03791149T DK1534342T3 (da) | 2002-08-30 | 2003-09-01 | Modificerede saccharider, konjugater deraf og fremstilling deraf |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8895516B2 (enExample) |
| EP (1) | EP1534342B1 (enExample) |
| JP (2) | JP5268222B2 (enExample) |
| CN (2) | CN101863998B (enExample) |
| AT (1) | ATE319481T1 (enExample) |
| AU (1) | AU2003260921B2 (enExample) |
| BR (1) | BR0314089A (enExample) |
| CA (1) | CA2497167C (enExample) |
| DE (1) | DE60303961T2 (enExample) |
| DK (1) | DK1534342T3 (enExample) |
| ES (1) | ES2260682T3 (enExample) |
| GB (1) | GB0220198D0 (enExample) |
| MX (1) | MXPA05002315A (enExample) |
| NZ (1) | NZ538703A (enExample) |
| RU (2) | RU2005108992A (enExample) |
| WO (1) | WO2004019992A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| DK1587537T3 (da) * | 2003-01-30 | 2012-07-16 | Novartis Ag | Injicerbare vacciner mod multiple meningococ-serogrupper |
| US20070258986A1 (en) * | 2003-11-19 | 2007-11-08 | Govt of the US as represented by the secretary, | Targeted Delivery System for Bioactive Agents |
| NZ563940A (en) | 2005-05-06 | 2010-11-26 | Novartis Vaccines & Diagnostic | Immunogens for meningitidis-A vaccines comprising oligosaccharides linked by a phosphonate |
| CN103251940A (zh) | 2005-12-22 | 2013-08-21 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗 |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700562D0 (en) * | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| AU2014200640B2 (en) * | 2007-01-11 | 2016-06-16 | Glaxosmithkline Biologicals Sa | Modified saccharides |
| WO2010027499A2 (en) | 2008-09-05 | 2010-03-11 | University Of Massachusetts Medical School | Methods, compositions and vaccines relating to neisseria meningitidis antibodies |
| TWI505834B (zh) * | 2009-06-22 | 2015-11-01 | Wyeth Llc | 組合物及製備金黃色葡萄球菌血清型５及８莢膜多醣結合物之免疫原性組合物之方法 |
| BRPI1015567A2 (pt) | 2009-06-22 | 2021-08-31 | Wyeth Llc | Composições imunogênicas de antígenos de staphylococcus aureus |
| MX345967B (es) * | 2009-10-30 | 2017-02-28 | Novartis Ag | Purificacion de sacaridos capsulares de staphylococcus aureus tipo 5 y tipo 8. |
| PL3831406T3 (pl) | 2010-08-23 | 2024-09-09 | Wyeth Llc | Stabilne preparaty antygenów rLP2086 Neisseria meningitidis |
| RU2546873C2 (ru) | 2010-09-10 | 2015-04-10 | УАЙТ ЭлЭлСи | Нелипидизированные варианты антигенов neisseria meningitidis orf2086 |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| MY167723A (en) | 2012-03-09 | 2018-09-21 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| CN102861326A (zh) * | 2012-09-19 | 2013-01-09 | 天津康希诺生物技术有限公司 | 流脑多糖-蛋白质缀合疫苗及制备方法 |
| US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
| EP4098276A1 (en) | 2013-09-08 | 2022-12-07 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| ES2930318T3 (es) | 2014-02-14 | 2022-12-09 | Pfizer | Conjugados glucoproteicos inmunogénicos |
| US10888611B2 (en) | 2015-02-19 | 2021-01-12 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| WO2017158480A1 (en) * | 2016-03-15 | 2017-09-21 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Novel polysaccharide-protein conjugates and process to obtain thereof |
| AU2017321863B2 (en) | 2016-09-02 | 2024-07-11 | Sanofi Vaccines US Inc. | Neisseria meningitidis vaccine |
| PE20191107A1 (es) | 2017-01-31 | 2019-08-26 | Pfizer | Composiciones de neisseria meningitidis y metodos respectivos |
| CA3050120A1 (en) * | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
| US11395849B2 (en) | 2017-09-07 | 2022-07-26 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| US11389540B2 (en) | 2017-09-07 | 2022-07-19 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| WO2020182635A1 (en) * | 2019-03-08 | 2020-09-17 | Glaxosmithkline Biologicals Sa | Carbocyclic derivatives and conjugated derivatives thereof, and their use in vaccines |
| WO2021059181A1 (en) | 2019-09-27 | 2021-04-01 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2427341A1 (fr) * | 1978-06-02 | 1979-12-28 | Delalande Sa | Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique |
| DK0447171T3 (da) * | 1990-03-15 | 1994-12-12 | Tanabe Seiyaku Co | Polysulfat af cyclodextrinderivat og fremgangsmåde til fremstilling deraf |
| AU7948494A (en) * | 1993-12-28 | 1995-07-17 | Pfizer Inc. | Steroidal glycosides |
| WO1995029927A2 (en) * | 1994-05-02 | 1995-11-09 | Biomira, Inc. | Process for preparation of glycosides of tumor-associated carbohydrate antigens |
| ATE451124T1 (de) * | 1997-01-21 | 2009-12-15 | Sanofi Pasteur | Polysaccharid-peptid-konjugate |
| CA2266718C (en) * | 1997-08-08 | 2007-05-22 | Behringwerke Aktiengesellschaft | Polysaccharide conjugates of biomolecules |
| US5929049A (en) * | 1997-08-08 | 1999-07-27 | Dade Behring Marburg Gmbh | Polysaccharide conjugates of biomolecules |
| US5952454A (en) * | 1997-12-12 | 1999-09-14 | The United States Of America As Represented By The Department Of Health And Human Services | Linking compounds useful for coupling carbohydrates to amine-containing carriers |
| WO2003080678A1 (en) * | 2002-03-26 | 2003-10-02 | Chiron Srl | Modified saccharides having improved stability in water |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
-
2002
- 2002-08-30 GB GBGB0220198.6A patent/GB0220198D0/en not_active Ceased
-
2003
- 2003-09-01 AU AU2003260921A patent/AU2003260921B2/en not_active Ceased
- 2003-09-01 NZ NZ538703A patent/NZ538703A/en not_active IP Right Cessation
- 2003-09-01 RU RU2005108992/04A patent/RU2005108992A/ru unknown
- 2003-09-01 BR BR0314089-0A patent/BR0314089A/pt not_active Application Discontinuation
- 2003-09-01 EP EP03791149A patent/EP1534342B1/en not_active Expired - Lifetime
- 2003-09-01 DE DE60303961T patent/DE60303961T2/de not_active Expired - Lifetime
- 2003-09-01 AT AT03791149T patent/ATE319481T1/de active
- 2003-09-01 JP JP2004532625A patent/JP5268222B2/ja not_active Expired - Fee Related
- 2003-09-01 CN CN2010101825535A patent/CN101863998B/zh not_active Expired - Fee Related
- 2003-09-01 CN CN038237245A patent/CN1688343B/zh not_active Expired - Fee Related
- 2003-09-01 ES ES03791149T patent/ES2260682T3/es not_active Expired - Lifetime
- 2003-09-01 WO PCT/IB2003/004194 patent/WO2004019992A1/en not_active Ceased
- 2003-09-01 DK DK03791149T patent/DK1534342T3/da active
- 2003-09-01 MX MXPA05002315A patent/MXPA05002315A/es active IP Right Grant
- 2003-09-01 US US10/526,124 patent/US8895516B2/en not_active Expired - Fee Related
- 2003-09-01 CA CA2497167A patent/CA2497167C/en not_active Expired - Fee Related
-
2008
- 2008-12-19 RU RU2008150551/13A patent/RU2531909C2/ru not_active IP Right Cessation
-
2011
- 2011-10-17 JP JP2011228229A patent/JP5314745B2/ja not_active Expired - Fee Related
-
2014
- 2014-10-23 US US14/521,761 patent/US20150166593A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150166593A1 (en) | 2015-06-18 |
| EP1534342A1 (en) | 2005-06-01 |
| CA2497167A1 (en) | 2004-03-11 |
| AU2003260921B2 (en) | 2008-03-06 |
| JP5268222B2 (ja) | 2013-08-21 |
| RU2005108992A (ru) | 2005-11-10 |
| DE60303961T2 (de) | 2006-10-26 |
| GB0220198D0 (en) | 2002-10-09 |
| BR0314089A (pt) | 2005-11-16 |
| NZ538703A (en) | 2006-09-29 |
| EP1534342B1 (en) | 2006-03-08 |
| JP5314745B2 (ja) | 2013-10-16 |
| MXPA05002315A (es) | 2005-06-08 |
| RU2008150551A (ru) | 2010-06-27 |
| US20060263390A1 (en) | 2006-11-23 |
| DE60303961D1 (de) | 2006-05-04 |
| JP2006511465A (ja) | 2006-04-06 |
| RU2531909C2 (ru) | 2014-10-27 |
| ES2260682T3 (es) | 2006-11-01 |
| WO2004019992A1 (en) | 2004-03-11 |
| ATE319481T1 (de) | 2006-03-15 |
| CN1688343A (zh) | 2005-10-26 |
| CN101863998A (zh) | 2010-10-20 |
| US8895516B2 (en) | 2014-11-25 |
| CA2497167C (en) | 2011-07-12 |
| JP2012017342A (ja) | 2012-01-26 |
| AU2003260921A1 (en) | 2004-03-19 |
| CN1688343B (zh) | 2010-09-08 |
| CN101863998B (zh) | 2012-08-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1534342T3 (da) | Modificerede saccharider, konjugater deraf og fremstilling deraf | |
| RU2412944C2 (ru) | Иммуногены для вакцин против менингита а | |
| ATE409048T1 (de) | Pharmazeutisch aktive oligosaccharid-conjugate | |
| WO2005030258A3 (en) | Small molecule compositions and methods for increasing drug efficiency using compositions thereof | |
| JP2005532287A5 (enExample) | ||
| MXPA03002779A (es) | Derivados de glucopiranosiloxibencilbenceno y composiciones medicinales conteniendo los mismos. | |
| NO20100579L (no) | Fremgangsmater for behandling av reumatoid artritt ved anvendelse av opploselig mutant CTLA4 molekyl | |
| PL410219A1 (pl) | Kompozycja zawierająca koniugat leku obejmujący pochodne kalicheamycyny i przeciwciało, oraz kompozycja farmaceutyczna ją zawierająca | |
| DK1327146T3 (da) | Forbindelse med et forgrenet linkermolekyle | |
| DK1748791T3 (da) | Neisseria Meningitidis IgtB LOS som hjælpestof | |
| DK0751144T3 (da) | Nye antracyclin-pro-drugs, fremgangsmåde til fremstilling deraf samt antitumorsammensætninger og et komponentkit indeholdende disse pro-drugs | |
| EP1775289A4 (en) | NEW IMIDAZOLIDINE DERIVATIVES | |
| CA2423007A1 (en) | Spiro derivatives and adhesion molecule inhibitors containing the same as effective ingredients | |
| IL183655A0 (en) | Vitamin d receptor modulators | |
| ATE308540T1 (de) | Antithrombosemittel | |
| GB0501964D0 (en) | Chemical compounds | |
| EA200201024A1 (ru) | Фармацевтические композиции, содержащие олигосахариды, и их получение | |
| WO2024238872A3 (en) | Isoindolinone-glutarimide antibody conjugates, and uses thereof | |
| WO2010079499A3 (en) | Novel hydrazide containing taxane conjugates | |
| DK1250335T3 (da) | Fremgangsmåde og mellemprodukter til fremstilling af imidazopyridiner | |
| WO2007050789A3 (en) | Glycosyl-oligonucleotide conjugates and methods | |
| DE60131769D1 (de) | Derivatisierte kohlenhydrate und ihre verwendung in feste verabreichungssysteme | |
| WO2023150667A3 (en) | Ribose linkers and conjugates thereof | |
| WO2006079719A3 (fr) | Nouveaux derives d'oximes heterocycliques, leur procede de preparation, les compositions pharmaceutiques qui les contiennent et leur utilisation pour le traitement de l’obesite | |
| CY1116593T1 (el) | Συζευγματα που φερουν μια αποδομησιμη συνδεση και πολυμερικα αντιδραστηρια χρησιμα στην παρασκευη τετοιων συζευγματων |