MXPA01011227A - Glicosidas androgenas y su actividad androgenica. - Google Patents
Glicosidas androgenas y su actividad androgenica.Info
- Publication number
- MXPA01011227A MXPA01011227A MXPA01011227A MXPA01011227A MXPA01011227A MX PA01011227 A MXPA01011227 A MX PA01011227A MX PA01011227 A MXPA01011227 A MX PA01011227A MX PA01011227 A MXPA01011227 A MX PA01011227A MX PA01011227 A MXPA01011227 A MX PA01011227A
- Authority
- MX
- Mexico
- Prior art keywords
- hydrogen
- further characterized
- methyl
- compound according
- compound
- Prior art date
Links
- 229930182470 glycoside Natural products 0.000 title claims abstract description 29
- 150000002338 glycosides Chemical class 0.000 title claims abstract description 22
- 239000003098 androgen Substances 0.000 title abstract description 22
- 230000001548 androgenic effect Effects 0.000 title description 7
- 150000001875 compounds Chemical class 0.000 claims description 99
- 239000001257 hydrogen Substances 0.000 claims description 85
- 229910052739 hydrogen Inorganic materials 0.000 claims description 85
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 58
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 52
- 125000004432 carbon atom Chemical group C* 0.000 claims description 46
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 33
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 33
- -1 orthoester glycoside Chemical group 0.000 claims description 28
- 241001465754 Metazoa Species 0.000 claims description 26
- 125000000217 alkyl group Chemical group 0.000 claims description 22
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- 101100243950 Arabidopsis thaliana PIE1 gene Proteins 0.000 claims description 8
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- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 230000024898 regulation of gonadotropin secretion Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000004706 scrotum Anatomy 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000036299 sexual function Effects 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 229930002534 steroid glycoside Natural products 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 229960000312 trenbolone Drugs 0.000 description 1
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- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 150000003738 xylenes Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0057—Nitrogen and oxygen
- C07J71/0063—Nitrogen and oxygen at position 2(3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- C07J71/0047—Nitrogen only at position 2(3)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13250099P | 1999-05-04 | 1999-05-04 | |
| US19529400P | 2000-04-07 | 2000-04-07 | |
| PCT/GB2000/001700 WO2000066612A1 (en) | 1999-05-04 | 2000-05-04 | Androgen glycosides and androgenic activity thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA01011227A true MXPA01011227A (es) | 2002-07-02 |
Family
ID=26830416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA01011227A MXPA01011227A (es) | 1999-05-04 | 2000-05-04 | Glicosidas androgenas y su actividad androgenica. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6630453B1 (enExample) |
| EP (1) | EP1175433B1 (enExample) |
| JP (1) | JP5005127B2 (enExample) |
| KR (1) | KR20020013533A (enExample) |
| CN (1) | CN1250563C (enExample) |
| AT (1) | ATE301129T1 (enExample) |
| AU (1) | AU777770C (enExample) |
| BR (1) | BR0010708A (enExample) |
| CA (1) | CA2372720C (enExample) |
| CZ (1) | CZ20013912A3 (enExample) |
| DE (1) | DE60021720T2 (enExample) |
| DK (1) | DK1175433T3 (enExample) |
| ES (1) | ES2246234T3 (enExample) |
| HU (1) | HUP0200871A3 (enExample) |
| IL (2) | IL146284A0 (enExample) |
| MX (1) | MXPA01011227A (enExample) |
| NO (1) | NO321296B1 (enExample) |
| NZ (1) | NZ515134A (enExample) |
| PT (1) | PT1175433E (enExample) |
| WO (1) | WO2000066612A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE60021720T2 (de) | 1999-05-04 | 2006-06-01 | Strakan International Ltd. | Androgen glykoside und die androgenische aktivität davon |
| EP1441724B8 (en) * | 2001-09-27 | 2007-10-17 | Laboratoires Serono SA | Methods of increasing endogenous testosterone levels |
| US7217696B2 (en) * | 2002-02-28 | 2007-05-15 | A & D Bioscience, Inc. | Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof |
| US20050107310A1 (en) * | 2002-03-19 | 2005-05-19 | Holick Michael F. | Carboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof |
| WO2003086475A1 (en) * | 2002-04-12 | 2003-10-23 | A & D Bioscience, Inc. | Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof |
| EP1549323A2 (en) * | 2002-05-07 | 2005-07-06 | A & D Bioscience, Inc. | Conjugates comprising central nervous system active drug |
| US20050215487A1 (en) * | 2002-06-27 | 2005-09-29 | Holick Michael F | Conjugates comprising an nsaid and a sugar and uses thereof |
| US20070225354A1 (en) * | 2006-03-21 | 2007-09-27 | Eric Marchewitz | Use of dihydrolipoamide for enhancing physical performance |
| US10966916B2 (en) | 2014-11-10 | 2021-04-06 | The Procter And Gamble Company | Personal care compositions |
| EP3217948B1 (en) | 2014-11-10 | 2020-09-16 | The Procter and Gamble Company | Personal care compositions with two benefit phases |
| EP3217949B1 (en) | 2014-11-10 | 2020-06-17 | The Procter and Gamble Company | Personal care compositions with two benefit phases |
| CN105388245A (zh) * | 2015-12-25 | 2016-03-09 | 浙江省水产技术推广总站 | 适用于水产品中46种药物的筛查方法 |
| CN111212625B (zh) | 2017-10-20 | 2023-05-23 | 宝洁公司 | 气溶胶泡沫洁肤剂 |
| WO2019079405A1 (en) | 2017-10-20 | 2019-04-25 | The Procter & Gamble Company | AEROSOL FOAMING CLEANSER FOR THE SKIN |
| CN113015904B (zh) | 2018-11-29 | 2024-06-18 | 宝洁公司 | 用于筛选个人护理产品的方法 |
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-
2000
- 2000-05-04 DE DE60021720T patent/DE60021720T2/de not_active Expired - Lifetime
- 2000-05-04 DK DK00927493T patent/DK1175433T3/da active
- 2000-05-04 CZ CZ20013912A patent/CZ20013912A3/cs unknown
- 2000-05-04 NZ NZ515134A patent/NZ515134A/en unknown
- 2000-05-04 US US09/565,122 patent/US6630453B1/en not_active Expired - Fee Related
- 2000-05-04 AU AU45893/00A patent/AU777770C/en not_active Ceased
- 2000-05-04 KR KR1020017014072A patent/KR20020013533A/ko not_active Ceased
- 2000-05-04 EP EP00927493A patent/EP1175433B1/en not_active Expired - Lifetime
- 2000-05-04 AT AT00927493T patent/ATE301129T1/de active
- 2000-05-04 PT PT00927493T patent/PT1175433E/pt unknown
- 2000-05-04 CN CNB008096910A patent/CN1250563C/zh not_active Expired - Fee Related
- 2000-05-04 HU HU0200871A patent/HUP0200871A3/hu unknown
- 2000-05-04 WO PCT/GB2000/001700 patent/WO2000066612A1/en not_active Ceased
- 2000-05-04 CA CA002372720A patent/CA2372720C/en not_active Expired - Fee Related
- 2000-05-04 MX MXPA01011227A patent/MXPA01011227A/es active IP Right Grant
- 2000-05-04 BR BR0010708-5A patent/BR0010708A/pt not_active IP Right Cessation
- 2000-05-04 JP JP2000615641A patent/JP5005127B2/ja not_active Expired - Fee Related
- 2000-05-04 IL IL14628400A patent/IL146284A0/xx active IP Right Grant
- 2000-05-04 ES ES00927493T patent/ES2246234T3/es not_active Expired - Lifetime
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2001
- 2001-11-01 IL IL146284A patent/IL146284A/en unknown
- 2001-11-01 NO NO20015338A patent/NO321296B1/no not_active IP Right Cessation
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Also Published As
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|---|---|
| CA2372720C (en) | 2007-09-11 |
| AU777770C (en) | 2005-11-10 |
| EP1175433B1 (en) | 2005-08-03 |
| KR20020013533A (ko) | 2002-02-20 |
| HUP0200871A2 (en) | 2002-08-28 |
| US6916791B2 (en) | 2005-07-12 |
| PT1175433E (pt) | 2005-11-30 |
| NO20015338D0 (no) | 2001-11-01 |
| IL146284A (en) | 2006-07-05 |
| CN1360590A (zh) | 2002-07-24 |
| NZ515134A (en) | 2004-01-30 |
| AU4589300A (en) | 2000-11-17 |
| NO20015338L (no) | 2001-11-19 |
| BR0010708A (pt) | 2002-02-19 |
| JP5005127B2 (ja) | 2012-08-22 |
| ATE301129T1 (de) | 2005-08-15 |
| US20030216328A1 (en) | 2003-11-20 |
| CN1250563C (zh) | 2006-04-12 |
| DK1175433T3 (da) | 2005-09-19 |
| CA2372720A1 (en) | 2000-11-09 |
| US6630453B1 (en) | 2003-10-07 |
| JP2002543217A (ja) | 2002-12-17 |
| EP1175433A1 (en) | 2002-01-30 |
| DE60021720D1 (de) | 2005-09-08 |
| HUP0200871A3 (en) | 2004-04-28 |
| AU777770B2 (en) | 2004-10-28 |
| ES2246234T3 (es) | 2006-02-16 |
| WO2000066612A1 (en) | 2000-11-09 |
| NO321296B1 (no) | 2006-04-18 |
| IL146284A0 (en) | 2002-07-25 |
| DE60021720T2 (de) | 2006-06-01 |
| CZ20013912A3 (cs) | 2002-05-15 |
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