MX9710218A - Compuestos aromaticos y composiciones farmaceuticas que los contienen. - Google Patents

Compuestos aromaticos y composiciones farmaceuticas que los contienen.

Info

Publication number
MX9710218A
MX9710218A MX9710218A MX9710218A MX9710218A MX 9710218 A MX9710218 A MX 9710218A MX 9710218 A MX9710218 A MX 9710218A MX 9710218 A MX9710218 A MX 9710218A MX 9710218 A MX9710218 A MX 9710218A
Authority
MX
Mexico
Prior art keywords
optionally substituted
3alkyl
linking group
ring
pharmaceutical compositions
Prior art date
Application number
MX9710218A
Other languages
English (en)
Spanish (es)
Inventor
Gloria Anne Breault
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9512476.4A external-priority patent/GB9512476D0/en
Priority claimed from GBGB9601462.6A external-priority patent/GB9601462D0/en
Priority claimed from GBGB9606831.7A external-priority patent/GB9606831D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of MX9710218A publication Critical patent/MX9710218A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • C07D213/80Acids; Esters in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyridine Compounds (AREA)
MX9710218A 1995-06-20 1996-06-17 Compuestos aromaticos y composiciones farmaceuticas que los contienen. MX9710218A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9512476.4A GB9512476D0 (en) 1995-06-20 1995-06-20 Aromatic compounds
GBGB9601462.6A GB9601462D0 (en) 1996-01-25 1996-01-25 Aromatic compounds
GBGB9606831.7A GB9606831D0 (en) 1996-03-30 1996-03-30 Aromatic compounds
PCT/GB1996/001442 WO1997000863A1 (en) 1995-06-20 1996-06-17 Aromatic compounds and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
MX9710218A true MX9710218A (es) 1998-03-31

Family

ID=27267781

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9710218A MX9710218A (es) 1995-06-20 1996-06-17 Compuestos aromaticos y composiciones farmaceuticas que los contienen.

Country Status (29)

Country Link
US (2) US5994353A (no)
EP (1) EP0835246B1 (no)
JP (1) JP3949166B2 (no)
KR (1) KR19990023006A (no)
CN (1) CN1193963A (no)
AR (1) AR004495A1 (no)
AT (1) ATE207468T1 (no)
AU (1) AU700337B2 (no)
BG (1) BG63777B1 (no)
BR (1) BR9608956A (no)
CA (1) CA2220925A1 (no)
CZ (1) CZ290923B6 (no)
DE (1) DE69616323T2 (no)
DK (1) DK0835246T3 (no)
EE (1) EE9700341A (no)
ES (1) ES2165505T3 (no)
HR (1) HRP960288B1 (no)
HU (1) HUP9802317A3 (no)
IL (1) IL118664A (no)
MX (1) MX9710218A (no)
MY (1) MY116531A (no)
NO (1) NO311129B1 (no)
NZ (1) NZ311082A (no)
PL (1) PL324205A1 (no)
PT (1) PT835246E (no)
RO (1) RO119945B1 (no)
SK (1) SK282450B6 (no)
TW (1) TW434240B (no)
WO (1) WO1997000863A1 (no)

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TW434240B (en) 1995-06-20 2001-05-16 Zeneca Ltd Aromatic compounds, preparation thereof and pharmaceutical composition comprising same
TW502026B (en) * 1995-06-20 2002-09-11 Zeneca Ltd Aromatic compounds useful as antagonists of e-type prostaglandins, processes for the preparation thereof, pharmaceutical compositions comprising the compounds, and intermediates
EP0752421B1 (en) * 1995-07-07 2005-10-12 AstraZeneca AB Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists
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WO2003035064A1 (en) 2001-10-23 2003-05-01 Applied Research Systems Ars Holding N.V. Pyrazolidinone compounds as ligands of the prostaglandin ep2 and/or ep4 receptors
WO2003043655A1 (fr) * 2001-11-19 2003-05-30 Ono Pharmaceutical Co., Ltd. Remedes pour la frequence urinaire
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WO2013102145A1 (en) 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
CN104135859B (zh) 2011-12-28 2017-06-27 全球血液疗法公司 取代的苯甲醛化合物及其用于增加组织氧合的方法
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
SG11201507453VA (en) 2013-03-15 2015-10-29 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
JP6426694B2 (ja) 2013-03-15 2018-11-21 グローバル ブラッド セラピューティクス インコーポレイテッド ヘモグロビンの修飾のための化合物及びその使用
JP6463327B2 (ja) 2013-03-15 2019-01-30 グローバル ブラッド セラピューティクス インコーポレイテッド ヘモグロビンの修飾のための化合物及びその使用
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
DK3102208T4 (da) 2014-02-07 2024-08-26 Global Blood Therapeutics Inc Krystallinsk polymorph af den frie base af 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyd
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
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TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
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GB9417532D0 (en) * 1994-08-31 1994-10-19 Zeneca Ltd Aromatic compounds
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TW502026B (en) * 1995-06-20 2002-09-11 Zeneca Ltd Aromatic compounds useful as antagonists of e-type prostaglandins, processes for the preparation thereof, pharmaceutical compositions comprising the compounds, and intermediates
EP0752421B1 (en) * 1995-07-07 2005-10-12 AstraZeneca AB Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists
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Also Published As

Publication number Publication date
SK173297A3 (en) 1998-07-08
HRP960288A2 (en) 1998-02-28
BR9608956A (pt) 1999-03-02
ES2165505T3 (es) 2002-03-16
PT835246E (pt) 2002-04-29
NO311129B1 (no) 2001-10-15
AR004495A1 (es) 1998-12-16
IL118664A0 (en) 1996-10-31
BG102173A (en) 1998-09-30
NZ311082A (en) 2000-01-28
NO975985D0 (no) 1997-12-19
HUP9802317A3 (en) 2001-11-28
IL118664A (en) 2001-12-23
HRP960288B1 (en) 2003-02-28
EE9700341A (et) 1998-06-15
CN1193963A (zh) 1998-09-23
CZ410997A3 (cs) 1998-03-18
AU700337B2 (en) 1998-12-24
TW434240B (en) 2001-05-16
BG63777B1 (bg) 2002-12-29
AU6232096A (en) 1997-01-22
US6365603B1 (en) 2002-04-02
US5994353A (en) 1999-11-30
WO1997000863A1 (en) 1997-01-09
HUP9802317A2 (hu) 1999-03-29
NO975985L (no) 1997-12-19
EP0835246B1 (en) 2001-10-24
DE69616323D1 (de) 2001-11-29
CZ290923B6 (cs) 2002-11-13
EP0835246A1 (en) 1998-04-15
RO119945B1 (ro) 2005-06-30
DE69616323T2 (de) 2002-07-25
SK282450B6 (sk) 2002-02-05
JPH11508878A (ja) 1999-08-03
KR19990023006A (ko) 1999-03-25
CA2220925A1 (en) 1997-01-09
ATE207468T1 (de) 2001-11-15
MY116531A (en) 2004-02-28
JP3949166B2 (ja) 2007-07-25
DK0835246T3 (da) 2002-01-21
PL324205A1 (en) 1998-05-11

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