MX9606541A - Aminoeteres aromaticos como agentes para aliviar el dolor. - Google Patents
Aminoeteres aromaticos como agentes para aliviar el dolor.Info
- Publication number
- MX9606541A MX9606541A MX9606541A MX9606541A MX9606541A MX 9606541 A MX9606541 A MX 9606541A MX 9606541 A MX9606541 A MX 9606541A MX 9606541 A MX9606541 A MX 9606541A MX 9606541 A MX9606541 A MX 9606541A
- Authority
- MX
- Mexico
- Prior art keywords
- hydrogen
- optionally substituted
- ring system
- 3alkyl
- 4alkyl
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
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- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
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- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
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- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
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- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
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- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
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- Pain & Pain Management (AREA)
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- General Health & Medical Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invencion se relaciona con compuestos de la formula (I), en la que A es fenilo, naftilo, piridilo, pirazinilo, piridazinilo, pirimidilo, tienilo, tiazolilo, oxazolilo, tiadiazolilo sustituidos opcionalmente que tienen por lo menos dos átomos de carbono en el anillo adyacente o un sistema de anillo bicíclico, con la condicion de que los grupos de enlace -CH(R3)N(R2)BR1 Y -OCH(R4)-D se colocan en una relacion 1.2 entre sí en los átomos de carbono del anillo y el átomo en el anillo colocado en otro para el grupo de enlace -CHR4 (y por lo tanto en la posicion 3 relativa al grupo de enlace -CHR3NR2) no está sustituido, B es un sistema de anillo sustituido opcionalmente; D es un sistema de anillo sustituido opcionalmente, R1 es una variedad del grupo como se definio en la descripcion; R2 es hidrogeno, alquilo de C1-6, alquenilo de C2-6, alquinilo de C2-6, fenilalquilo de C1-3, o heteroarilalquilo de C1-3 de 5 o 6 miembros, R3 es hidrogeno o alquilo de C1-4; R4 es hidrogeno o alquilo de c1-4, y N-oxidos de NR2 donde sea químicamente posible,; y S-oxidos de azufre que contienen anillos donde sea químicamente posible; y sales farmacéuticamente aceptables y ésteres y amidas de los mismos hidrolizables in vivo. El proceso para su preparacion, intermediarios y su preparacion, su uso como agentes terapéuticos y composiciones farmacéuticas que los contienen.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9414924A GB9414924D0 (en) | 1994-07-25 | 1994-07-25 | Aromatic compounds |
GBGB9501288.6A GB9501288D0 (en) | 1995-01-24 | 1995-01-24 | Aromatic compounds |
PCT/GB1995/001728 WO1996003380A1 (en) | 1994-07-25 | 1995-07-21 | Aromatic amino ethers as pain relieving agents |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9606541A true MX9606541A (es) | 1997-12-31 |
Family
ID=26305334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MX9606541A MX9606541A (es) | 1994-07-25 | 1995-07-21 | Aminoeteres aromaticos como agentes para aliviar el dolor. |
Country Status (28)
Country | Link |
---|---|
US (1) | US5843942A (es) |
EP (1) | EP0773930B1 (es) |
JP (1) | JPH10503487A (es) |
KR (1) | KR970704690A (es) |
CN (2) | CN1085663C (es) |
AT (1) | ATE196898T1 (es) |
AU (1) | AU688541B2 (es) |
BG (1) | BG101259A (es) |
BR (1) | BR9508335A (es) |
CA (1) | CA2192088A1 (es) |
CZ (1) | CZ22097A3 (es) |
DE (1) | DE69519099T2 (es) |
DK (1) | DK0773930T3 (es) |
EE (1) | EE9700016A (es) |
ES (1) | ES2150577T3 (es) |
FI (1) | FI116219B (es) |
GB (1) | GB9514160D0 (es) |
GR (1) | GR3034603T3 (es) |
HU (1) | HUT76606A (es) |
IL (1) | IL114705A0 (es) |
MX (1) | MX9606541A (es) |
NO (1) | NO308032B1 (es) |
NZ (1) | NZ289905A (es) |
PL (1) | PL318283A1 (es) |
PT (1) | PT773930E (es) |
SK (1) | SK10197A3 (es) |
TW (1) | TW411328B (es) |
WO (1) | WO1996003380A1 (es) |
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-
1995
- 1995-07-11 GB GBGB9514160.2A patent/GB9514160D0/en active Pending
- 1995-07-21 CA CA002192088A patent/CA2192088A1/en not_active Abandoned
- 1995-07-21 PT PT95925943T patent/PT773930E/pt unknown
- 1995-07-21 DK DK95925943T patent/DK0773930T3/da active
- 1995-07-21 AU AU29883/95A patent/AU688541B2/en not_active Ceased
- 1995-07-21 MX MX9606541A patent/MX9606541A/es not_active IP Right Cessation
- 1995-07-21 JP JP8505573A patent/JPH10503487A/ja not_active Ceased
- 1995-07-21 EE EE9700016A patent/EE9700016A/xx unknown
- 1995-07-21 DE DE69519099T patent/DE69519099T2/de not_active Expired - Fee Related
- 1995-07-21 US US08/776,275 patent/US5843942A/en not_active Expired - Fee Related
- 1995-07-21 SK SK101-97A patent/SK10197A3/sk unknown
- 1995-07-21 HU HU9603338A patent/HUT76606A/hu unknown
- 1995-07-21 CZ CZ97220A patent/CZ22097A3/cs unknown
- 1995-07-21 NZ NZ289905A patent/NZ289905A/en unknown
- 1995-07-21 ES ES95925943T patent/ES2150577T3/es not_active Expired - Lifetime
- 1995-07-21 BR BR9508335A patent/BR9508335A/pt not_active Application Discontinuation
- 1995-07-21 WO PCT/GB1995/001728 patent/WO1996003380A1/en active IP Right Grant
- 1995-07-21 CN CN95194340A patent/CN1085663C/zh not_active Expired - Fee Related
- 1995-07-21 KR KR1019970700434A patent/KR970704690A/ko not_active Application Discontinuation
- 1995-07-21 EP EP95925943A patent/EP0773930B1/en not_active Expired - Lifetime
- 1995-07-21 AT AT95925943T patent/ATE196898T1/de not_active IP Right Cessation
- 1995-07-21 PL PL95318283A patent/PL318283A1/xx unknown
- 1995-07-22 TW TW084107606A patent/TW411328B/zh not_active IP Right Cessation
- 1995-07-24 IL IL11470595A patent/IL114705A0/xx unknown
-
1997
- 1997-01-22 FI FI970261A patent/FI116219B/fi not_active IP Right Cessation
- 1997-01-24 NO NO970314A patent/NO308032B1/no unknown
- 1997-02-25 BG BG101259A patent/BG101259A/xx unknown
-
2000
- 2000-03-10 CN CN00104017A patent/CN1286254A/zh active Pending
- 2000-10-12 GR GR20000402119T patent/GR3034603T3/el not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
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FG | Grant or registration | ||
HC | Change of company name or juridical status |
Owner name: THE LUBRIZOL CORPORATION.* |
|
PD | Change of proprietorship |
Owner name: ASTRAZENECA UK LIMITED |
|
MM | Annulment or lapse due to non-payment of fees |