ES8602837A1 - Un procedimiento para la preparacion de nuevas macrolidas antibioticas - Google Patents

Un procedimiento para la preparacion de nuevas macrolidas antibioticas

Info

Publication number
ES8602837A1
ES8602837A1 ES526323A ES526323A ES8602837A1 ES 8602837 A1 ES8602837 A1 ES 8602837A1 ES 526323 A ES526323 A ES 526323A ES 526323 A ES526323 A ES 526323A ES 8602837 A1 ES8602837 A1 ES 8602837A1
Authority
ES
Spain
Prior art keywords
derivatives
antibacterial agents
hydrogen
useful antibacterial
considered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526323A
Other languages
English (en)
Other versions
ES526323A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES526323A0 publication Critical patent/ES526323A0/es
Publication of ES8602837A1 publication Critical patent/ES8602837A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVAS MACROLIDAS ANTIBIOTICAS. CONSISTE EN REDUCIR UN COMPUESTO DE FORMULA (II) MEDIANTE HIDROGENO EN PRESENCIA DE UN CATALIZADOR NIQUEL-RANEY A UNA PRESION DE 1.400 LIBRAS POR PULGADA CUADRADA PARA OBTENER UN COMPUESTO DE FORMULA (I) O SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES CONVIRTIENDO EL COMPUESTO (I) DONDE R ES ALCANOILO DE C 2 O 3 O ETILSUCCINILO, POR REACCION CON EL HALURO O ANHIDRIDO DE ACIDO APROPIADO DE FORMULA E, CL, R, BR O R2 O. SIENDO: R, H, ALCANOILO DE C 2 O 3 O ETILSUCCINILO; R1 Y R2 SON RESPECTIVAMENTE HIDROXI E HIDROGENO; R3 Y R4 INDEPENDIENTEMENTE SON H Y JUNTOS REPRESENTAN C O. SE UTILIZAN COMO SUSTANCIAS ANTIBIOTICAS SEMISINTETICAS.
ES526323A 1982-03-01 1983-10-07 Un procedimiento para la preparacion de nuevas macrolidas antibioticas Expired ES8602837A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/353,547 US4382085A (en) 1982-03-01 1982-03-01 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents

Publications (2)

Publication Number Publication Date
ES526323A0 ES526323A0 (es) 1985-11-16
ES8602837A1 true ES8602837A1 (es) 1985-11-16

Family

ID=23389603

Family Applications (2)

Application Number Title Priority Date Filing Date
ES520177A Expired ES8403928A1 (es) 1982-03-01 1983-02-28 Un procedimiento para la preparacion de nuevas macrolidas antibioticas.
ES526323A Expired ES8602837A1 (es) 1982-03-01 1983-10-07 Un procedimiento para la preparacion de nuevas macrolidas antibioticas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES520177A Expired ES8403928A1 (es) 1982-03-01 1983-02-28 Un procedimiento para la preparacion de nuevas macrolidas antibioticas.

Country Status (26)

Country Link
US (1) US4382085A (es)
EP (1) EP0087905B1 (es)
JP (1) JPS58159499A (es)
KR (1) KR850000965B1 (es)
AT (1) ATE15048T1 (es)
AU (1) AU555208B2 (es)
CA (1) CA1178596A (es)
CS (3) CS235036B2 (es)
DD (1) DD211565A5 (es)
DE (1) DE3360589D1 (es)
DK (1) DK157495C (es)
EG (1) EG16630A (es)
ES (2) ES8403928A1 (es)
FI (1) FI74287C (es)
GR (1) GR78094B (es)
GT (1) GT198301599A (es)
HU (1) HU193157B (es)
IE (1) IE56056B1 (es)
IL (1) IL68004A (es)
NO (1) NO155932C (es)
NZ (1) NZ203417A (es)
PH (1) PH17908A (es)
PL (1) PL138758B1 (es)
PT (1) PT76298B (es)
RO (1) RO86647B (es)
ZA (1) ZA831356B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526889A (en) * 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
GR80277B (en) * 1983-09-06 1985-01-04 Pfizer Azahomoerythromycin b derivatives and intermediates therefor
JPS60120895A (ja) * 1983-12-02 1985-06-28 Taisho Pharmaceut Co Ltd ６−０−メチル−２′−０，ν−ビス（ベンジルオキシカルボニル）−ν−デメチルエリスロマイシンａの製法
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
EP0184921A3 (en) * 1984-12-08 1986-10-29 Beecham Group Plc Erythromycin derivatives
US4783811A (en) * 1984-12-27 1988-11-08 Texas Instruments Incorporated Method and apparatus for determining syllable boundaries
US4681872A (en) * 1985-11-12 1987-07-21 Abbott Laboratories Erythromycin A 11,12-carbonate and method of use
US4640910A (en) * 1985-11-12 1987-02-03 Abbott Laboratories Erythromycin A silylated compounds and method of use
US4833236A (en) * 1986-05-02 1989-05-23 Taisho Pharmaceutical Co., Ltd. Erythromycin derivatives
DK0699207T3 (da) * 1993-05-19 1997-12-08 Pfizer Mellemprodukt til azithromycin
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
CA2492846C (en) * 2002-08-29 2012-09-25 Kosan Biosciences, Inc. Motilide compounds
WO2004101592A1 (ja) * 2003-05-19 2004-11-25 Taisho Pharmaceutical Co., Ltd. エリスロマイシンａ誘導体の製造方法
US7211568B2 (en) * 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3417077A (en) * 1966-05-16 1968-12-17 Lilly Co Eli Erythromycin derivative and process for the preparation thereof
US3884904A (en) * 1973-06-21 1975-05-20 Abbott Lab 11-Substituted erythromycin B derivatives
US3884903A (en) * 1973-06-21 1975-05-20 Abbott Lab 4{41 -Deoxy-4{41 -oxoerythromycin B derivatives
SE445223B (sv) * 1977-02-04 1986-06-09 Pfizer Sett att framstella 4"-amino-erytomylin-a-derivat
US4150220A (en) * 1977-02-04 1979-04-17 Pfizer Inc. Semi-synthetic 4"-erythromycin A derivatives

Also Published As

Publication number Publication date
KR840003647A (ko) 1984-09-15
AU555208B2 (en) 1986-09-18
US4382085A (en) 1983-05-03
RO86647A (ro) 1985-04-17
ES520177A0 (es) 1984-04-01
DK96783D0 (da) 1983-02-28
CS235036B2 (en) 1985-04-16
DD211565A5 (de) 1984-07-18
CS235048B2 (en) 1985-04-16
IE56056B1 (en) 1991-04-10
DK96783A (da) 1983-09-02
GT198301599A (es) 1984-09-13
PL240764A1 (en) 1985-01-02
ATE15048T1 (de) 1985-09-15
RO86647B (ro) 1985-05-01
PL138758B1 (en) 1986-10-31
IL68004A0 (en) 1983-06-15
ZA831356B (en) 1983-11-30
PH17908A (en) 1985-01-25
GR78094B (es) 1984-09-26
DK157495C (da) 1990-06-11
FI74287C (fi) 1988-01-11
CS235049B2 (en) 1985-04-16
PT76298A (en) 1983-03-01
EP0087905B1 (en) 1985-08-21
EG16630A (en) 1991-03-30
ES526323A0 (es) 1985-11-16
IE830411L (en) 1983-09-01
CA1178596A (en) 1984-11-27
ES8403928A1 (es) 1984-04-01
EP0087905A1 (en) 1983-09-07
NO830686L (no) 1983-09-02
AU1189883A (en) 1983-09-08
IL68004A (en) 1986-11-30
FI830654A0 (fi) 1983-02-28
FI74287B (fi) 1987-09-30
PT76298B (en) 1986-01-27
JPS58159499A (ja) 1983-09-21
NZ203417A (en) 1985-10-11
FI830654L (fi) 1983-09-02
NO155932C (no) 1987-06-24
DE3360589D1 (en) 1985-09-26
DK157495B (da) 1990-01-15
KR850000965B1 (ko) 1985-07-02
HU193157B (en) 1987-08-28
NO155932B (no) 1987-03-16
JPH0140039B2 (es) 1989-08-24

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