MX9702351A - Glicociltransferasas para biosintesis de oligosacaridos, y genes que las codifican. - Google Patents

Glicociltransferasas para biosintesis de oligosacaridos, y genes que las codifican.

Info

Publication number
MX9702351A
MX9702351A MX9702351A MX9702351A MX9702351A MX 9702351 A MX9702351 A MX 9702351A MX 9702351 A MX9702351 A MX 9702351A MX 9702351 A MX9702351 A MX 9702351A MX 9702351 A MX9702351 A MX 9702351A
Authority
MX
Mexico
Prior art keywords
beta
glycosyltransferases
gal
oligosaccharides
4glc
Prior art date
Application number
MX9702351A
Other languages
English (en)
Inventor
Emil C Gotschlich
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Publication of MX9702351A publication Critical patent/MX9702351A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invencion está dirigida a ácidos nucleicos que codifican glicociltransferasas, las proteínas codificadas por los mismos y a métodos para sintetizar oligosacáridos usando las glicociltransferasas de la invencion; en una modalidad específica, un locus de glicociltransferasa de Neisseria gonorrhoeae que contiene cinco marcos de lectura abierta para cinco glicociltransferasas diferentes; las glicociltransferasas funcionalmente activas de la invencion se caracterizan por catalizar reacciones tales como añadir Gal beta1-->4 a GlcNAc o Glc; añadir GalNAc o GlcNAc beta1-->3 a Gal; y añadir Gal alfal-->4 a Gal; las glicociltransferasas de la invencion son particularmente adecuadas para la síntesis de los oligosacáridos Gal betal-->4GlcNAc betal-->3Gal betal-->4Glc (una imitacion de lacto-N-neotetraosa), GalNAc betal-->3Gal betal-->4GlcNAc betal-->3Gal betal-->4Glc betal4 (una imitacion de gangliosido), y Galalfal-->4Gal betal-->4Glc betal-->4Hep-->R (una imitacion de la porcion de sacárido de globoglicolípidos).
MX9702351A 1994-09-26 1995-09-25 Glicociltransferasas para biosintesis de oligosacaridos, y genes que las codifican. MX9702351A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/312,387 US5545553A (en) 1994-09-26 1994-09-26 Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
PCT/US1995/012317 WO1996010086A1 (en) 1994-09-26 1995-09-25 Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them

Publications (1)

Publication Number Publication Date
MX9702351A true MX9702351A (es) 1997-10-31

Family

ID=23211210

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9702351A MX9702351A (es) 1994-09-26 1995-09-25 Glicociltransferasas para biosintesis de oligosacaridos, y genes que las codifican.

Country Status (10)

Country Link
US (9) US5545553A (es)
EP (2) EP0784688B1 (es)
JP (2) JP3756182B2 (es)
KR (1) KR100465892B1 (es)
AT (2) ATE435290T1 (es)
CA (2) CA2502785C (es)
DE (1) DE69535975D1 (es)
ES (1) ES2371440T3 (es)
MX (1) MX9702351A (es)
WO (1) WO1996010086A1 (es)

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