MX391368B - Procedimiento para producir l-lisina usando microorganismos que tienen capacidad para producir l-lisina. - Google Patents

Procedimiento para producir l-lisina usando microorganismos que tienen capacidad para producir l-lisina.

Info

Publication number
MX391368B
MX391368B MX2017013971A MX2017013971A MX391368B MX 391368 B MX391368 B MX 391368B MX 2017013971 A MX2017013971 A MX 2017013971A MX 2017013971 A MX2017013971 A MX 2017013971A MX 391368 B MX391368 B MX 391368B
Authority
MX
Mexico
Prior art keywords
lysine
microorganisms
producing
procedure
capacity
Prior art date
Application number
MX2017013971A
Other languages
English (en)
Inventor
Jae Woo Jang
Kwang Ho Lee
Sang Jo Lim
Jun Ok Moon
Sang Hee Park
Su Jin Park
Original Assignee
Cj Cheiljedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Cheiljedang Corp filed Critical Cj Cheiljedang Corp
Publication of MX391368B publication Critical patent/MX391368B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01001—Transketolase (2.2.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02004—Aspartate kinase (2.7.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01001—Pyruvate carboxylase (6.4.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/101—Plasmid DNA for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a un polinucleótido modificado que codifica aspartato quinasa (EC:2.7.2.4; en lo sucesivo en el presente documento denominado LysC), transcetolasa (EC:2.2.1.1; en lo sucesivo en el presente documento denominado Tkt) o piruvato carboxilasa (EC:6.4.1 .1; en lo sucesivo en el presente documento denominado Pyc), en el que el codón de inicio está sustituido con ATG, un vector que incluye el mismo, un microorganismo transformado con el vector, y un procedimiento para producir L-lisina usando el mismo.
MX2017013971A 2011-12-21 2012-12-21 Procedimiento para producir l-lisina usando microorganismos que tienen capacidad para producir l-lisina. MX391368B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20110139527 2011-12-21
PCT/KR2012/011328 WO2013095071A2 (ko) 2011-12-21 2012-12-21 Ｌ-라이신 생산능을 갖는 미생물을 이용하여 ｌ-라이신을 생산하는 방법

Publications (1)

Publication Number Publication Date
MX391368B true MX391368B (es) 2025-03-21

Family

ID=48669667

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017013971A MX391368B (es) 2011-12-21 2012-12-21 Procedimiento para producir l-lisina usando microorganismos que tienen capacidad para producir l-lisina.
MX2014007385A MX353594B (es) 2011-12-21 2012-12-21 Procedimiento para producir l-lisina usando microorganismos que tienen capacidad para producir l-lisina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2014007385A MX353594B (es) 2011-12-21 2012-12-21 Procedimiento para producir l-lisina usando microorganismos que tienen capacidad para producir l-lisina.

Country Status (15)

Country Link
US (2) US9593354B2 (es)
EP (2) EP2796555B1 (es)
JP (2) JP6082025B2 (es)
KR (3) KR101483344B1 (es)
CN (4) CN104334728B (es)
BR (2) BR122021015693B1 (es)
CA (1) CA2860252C (es)
DK (1) DK2796555T3 (es)
ES (1) ES2696173T3 (es)
IN (1) IN2014MN01298A (es)
MX (2) MX391368B (es)
MY (1) MY171302A (es)
PL (1) PL2796555T3 (es)
RU (3) RU2616870C1 (es)
WO (1) WO2013095071A2 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2616870C1 (ru) * 2011-12-21 2017-04-18 СиДжей ЧеилДжеданг Корпорейшн Способ получения L-лизина с использованием микроорганизмов, обладающих способностью продуцировать L-лизин
KR101755767B1 (ko) * 2014-09-05 2017-07-10 씨제이제일제당 (주) L-라이신 생산능이 향상된 미생물 및 이를 이용한 l-라이신 생산방법
KR101793328B1 (ko) * 2015-07-03 2017-11-03 씨제이제일제당 (주) Ｌ-라이신 생산능을 갖는 미생물 및 이를 이용한 ｌ-라이신 생산 방법
EP3497226A4 (en) 2016-08-15 2020-07-01 Cathay Biotech Inc. CONTROL OF BIOFILM DISPERSION FOR THE PRODUCTION OF AMINO ACIDS OR PRODUCTS DERIVED FROM AMINO ACIDS
KR101863456B1 (ko) * 2016-11-15 2018-06-01 씨제이제일제당 (주) L-라이신을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-라이신의 생산방법
DE102017004751A1 (de) * 2017-05-18 2018-11-22 Forschungszentrum Jülich GmbH Pyruvatcarboxylase und für die Pyruvatcarboxylase kodierende DNA, Plasmid enthaltend die DNA, sowie Mikroorganismus zur Produktion und verfahren zur Herstellung von Produkten, deren Bioynthese Oxalacetat als Vorstufe beeinhaltet und Chromosom
EP3456833A1 (en) 2017-09-18 2019-03-20 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3467099A1 (en) 2017-10-05 2019-04-10 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3498853A1 (en) 2017-12-14 2019-06-19 Evonik Degussa GmbH Method for the fermentative production of l-lysine
KR101915433B1 (ko) * 2018-02-13 2018-11-05 씨제이제일제당 (주) 시트레이트 신타아제 (Citrate synthase)의 활성이 약화된 변이형 폴리펩타이드 및 이를 이용한 L-아미노산 생산방법
EP3594355A1 (en) 2018-07-12 2020-01-15 Evonik Operations GmbH Method for the fermentative production of l-lysine
EP3599282B1 (en) 2018-07-24 2021-03-17 Evonik Operations GmbH Method for the fermentative production of l-lysine
RU2019128538A (ru) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
EP3660158A1 (en) 2018-11-29 2020-06-03 Evonik Operations GmbH Method for the fermentative production of l-lysine
CN109554322B (zh) * 2018-12-03 2020-08-04 江南大学 一种高产l-苏氨酸的重组大肠杆菌及其构建方法
EP3670525A1 (en) 2018-12-18 2020-06-24 Evonik Operations GmbH Method for the fermentative production of l-lysine using c. glutamicum strains with a mutated kup transporter
US10829746B2 (en) 2019-01-23 2020-11-10 Evonik Operations Gmbh Method for the fermentative production of L-lysine
WO2021048353A1 (en) 2019-09-11 2021-03-18 Evonik Operations Gmbh Coryneform bacteria with a heterologous threonine transporter and their use in the production of l-threonine
CN112877269B (zh) * 2020-01-15 2021-12-24 中国科学院天津工业生物技术研究所 生产赖氨酸的微生物以及赖氨酸的生产方法
WO2022050524A1 (ko) * 2020-09-03 2022-03-10 대상 주식회사 L-라이신 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-라이신의 생산 방법
JP7683041B2 (ja) * 2021-04-30 2025-05-26 シージェイ チェイルジェダング コーポレイション Ｌ－リシン生産能が向上したコリネバクテリウム・グルタミカム変異株及びそれを用いたｌ－リシンの生産方法
BR112023022512A2 (pt) * 2021-04-30 2024-01-02 Cj Cheiljedang Corp Promotor, variante de corynebacterium glutamicum e método para produção de l-lisina
CN113308426B (zh) * 2021-05-27 2022-10-18 齐鲁工业大学 一种改造tk基因5′端序列的重组棒状杆菌及其应用
KR102703209B1 (ko) * 2021-10-14 2024-09-05 대상 주식회사 L-라이신 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-라이신의 생산 방법
CN113957073B (zh) * 2021-10-19 2023-09-01 山东寿光巨能金玉米开发有限公司 一种tkt基因启动子突变体及其在生产L-赖氨酸中的应用
EP4525842A1 (en) 2022-05-18 2025-03-26 Evonik Operations GmbH Biotechnological production of bisucaberins, desferrioxamines and analogs thereof
EP4525843A1 (en) 2022-05-18 2025-03-26 Evonik Operations GmbH Biotechnological production of monomers of bisucaberins, desferrioxamines and analogs thereof
US20250340893A1 (en) 2022-05-18 2025-11-06 Evonik Operations Gmbh Biotechnological production of desferrioxamines and analogs thereof
KR102838147B1 (ko) 2023-03-17 2025-07-28 씨제이제일제당 주식회사 5'-utr 변이 서열 및 이의 용도

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358866A (en) * 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies
KR100420743B1 (ko) * 1994-12-09 2004-05-24 아지노모토 가부시키가이샤 신규한리신데카복실라제유전자및l-리신의제조방법
HU222503B1 (hu) * 1995-06-07 2003-07-28 Ajinomoto Co., Inc. Eljárás L-lizin termelésére
KR0159812B1 (ko) 1995-12-20 1998-11-16 손경식 코리네박테리움 글루타미컴 씨에이치 77 및 이 균주를 이용한 l-라이신의 제조 방법
JP4075087B2 (ja) 1996-12-05 2008-04-16 味の素株式会社 Ｌ−リジンの製造法
AU741038B2 (en) * 1997-10-04 2001-11-22 Degussa A.G. Method for microbial production of amino acids of the aspartate and/or glutamatefamily and agents which can be used in said method
DE19831609B4 (de) * 1997-10-04 2009-11-12 Evonik Degussa Gmbh Verfahren zur Herstellung von Aminosäuren der Aspartat- und/oder Glutamatfamilie und im Verfahren einsetzbare Mittel
DE19931317A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von L-Lysin
US6171833B1 (en) * 1998-12-23 2001-01-09 Massachusetts Institute Of Technology Pyruvate carboxylase from corynebacterium glutamicum
AU2203399A (en) * 1998-12-23 2000-07-31 Massachusetts Institute Of Technology Pyruvate carboxylase from (corynebacterium glutamicum)
US20020086371A1 (en) 1999-07-07 2002-07-04 Degussa-Huls Aktiengesellschaft L-lysine-producing corynebacteria and process for the preparation of L-lysine
US6797509B1 (en) * 1999-07-09 2004-09-28 Degussa-Huls Ag Nucleotide sequences which code for the tal gene
CA2374012A1 (en) * 2000-03-17 2001-09-20 Degussa Ag Process for the fermentative preparation of l-amino acids with amplification of the tkt gene
KR100397322B1 (ko) 2000-12-30 2003-09-06 씨제이 주식회사 엘-라이신의 제조방법
US7445915B2 (en) * 2002-03-19 2008-11-04 Kyowa Hakko Kogyo Co., Ltd. Mutant isopropylmalate isomerase
DE10361268A1 (de) * 2003-12-24 2005-07-28 Degussa Ag Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae
DE102004011248A1 (de) * 2004-03-09 2005-09-22 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
AU2005321630A1 (en) * 2004-07-02 2006-07-06 Metanomics Gmbh Process for the production of fine chemicals
EP2386650B1 (en) 2006-04-07 2013-07-03 Evonik Degussa GmbH Method for producing L-amino acids using the gap promoter
JP5756259B2 (ja) 2006-09-15 2015-07-29 シージェイ チェイルジェダン コーポレイション Ｌ−リジン生産能の向上したコリネバクテリウム属およびそれを用いたｌ−リジン生産方法
EP2082044B1 (en) * 2006-10-24 2016-06-01 Basf Se Method of increasing gene expression using modified codon usage
US8133714B2 (en) * 2007-09-27 2012-03-13 Evonik Degussa Gmbh Process for the fermentative preparation of organic chemical compounds using coryneform bacteria in which the SugR gene is present in attenuated form
KR100930203B1 (ko) 2008-01-28 2009-12-07 씨제이제일제당 (주) 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법
KR100987281B1 (ko) 2008-01-31 2010-10-12 씨제이제일제당 (주) 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법
JP5395893B2 (ja) 2008-04-30 2014-01-22 ビーエーエスエフ ソシエタス・ヨーロピア 低下したイソクエン酸デヒドロゲナーゼ活性を有する微生物を使用するファインケミカルの製造方法
DE102008001874A1 (de) * 2008-05-20 2009-11-26 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren
GB0809169D0 (en) * 2008-05-20 2008-06-25 Sinvent As Method of L-lysine production
US9169502B2 (en) * 2010-06-15 2015-10-27 Paik Kwang Industrial Co., Ltd. Method of producing L-lysine using a Corynebacterium glutamicum microorganism
DE102011118019A1 (de) * 2011-06-28 2013-01-03 Evonik Degussa Gmbh Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens
RU2616870C1 (ru) * 2011-12-21 2017-04-18 СиДжей ЧеилДжеданг Корпорейшн Способ получения L-лизина с использованием микроорганизмов, обладающих способностью продуцировать L-лизин

Also Published As

Publication number Publication date
PL2796555T3 (pl) 2019-04-30
DK2796555T3 (en) 2018-12-10
EP2796555B1 (en) 2018-08-29
CA2860252A1 (en) 2013-06-27
BR112014015215B1 (pt) 2021-11-23
EP2796555A4 (en) 2015-12-09
US20170145453A1 (en) 2017-05-25
KR101483395B1 (ko) 2015-01-16
JP2017038617A (ja) 2017-02-23
MX353594B (es) 2018-01-18
MY171302A (en) 2019-10-08
JP6219481B2 (ja) 2017-10-25
US20150099281A1 (en) 2015-04-09
CN109251934B (zh) 2023-07-18
IN2014MN01298A (es) 2015-07-03
KR101483344B1 (ko) 2015-01-15
ES2696173T3 (es) 2019-01-14
RU2588665C2 (ru) 2016-07-10
KR101483396B1 (ko) 2015-01-16
KR20140093649A (ko) 2014-07-28
WO2013095071A3 (ko) 2013-08-22
KR20130072183A (ko) 2013-07-01
US9938546B2 (en) 2018-04-10
EP3404101A2 (en) 2018-11-21
CN104334728A (zh) 2015-02-04
CA2860252C (en) 2019-07-23
BR122021015693B1 (pt) 2022-05-03
CN109251934A (zh) 2019-01-22
EP2796555A2 (en) 2014-10-29
BR112014015215A2 (pt) 2018-11-06
RU2615454C1 (ru) 2017-04-04
MX2014007385A (es) 2015-08-20
JP6082025B2 (ja) 2017-02-15
RU2014127151A (ru) 2016-02-10
EP3404101A3 (en) 2018-12-26
JP2015500660A (ja) 2015-01-08
US9593354B2 (en) 2017-03-14
EP3404101B1 (en) 2025-06-11
WO2013095071A2 (ko) 2013-06-27
CN105483145A (zh) 2016-04-13
CN105483145B (zh) 2021-04-06
KR20140090130A (ko) 2014-07-16
CN104334728B (zh) 2018-09-25
CN105624175A (zh) 2016-06-01
RU2616870C1 (ru) 2017-04-18

Similar Documents

Publication Publication Date Title
MX391368B (es) Procedimiento para producir l-lisina usando microorganismos que tienen capacidad para producir l-lisina.
MY187158A (en) Method for preparing an aqueous acrylamide solution having a low acrylic acid concentration
PH12014501556A1 (en) Microorganism able to produce l-amino acid, and method for producing l-amino acid by using same
CO2017004034A2 (es) Medios y métodos para producir compuestos de amida con menor cantidad de ácido acrílico
EP4296364A3 (en) Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis
AR087956A1 (es) METODOS Y COMPOSICIONES QUE MODULAN ACETIL-CoA CARBOXILASA PARA EL CONTROL DE MALEZAS
MY188201A (en) Method and absorption medium for absorbing co2 from a gas mixture
BR112013016373A2 (pt) método para produzir uma substância alvo
MY175370A (en) Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam related thereto
MY187636A (en) Pyruvate dehydrogenase variants, a microorganism comprising the same and a method for producing l-amino acid using the same
EA201390613A1 (ru) Обогащенный дейтерием расагилин
MY181203A (en) Microorganism of corynebacterium sp. having enhanced l-lysine producibility and method for producing l-lysine using same
BR112017017071A2 (pt) nova lisina descarboxilase, e método para produzir cadaverina utilizando a mesma
EA201590788A1 (ru) Аминные соли лахинимода
BR112014013452A2 (pt) máquina elétrica
IN2015DN02381A (es)
TN2014000133A1 (en) Environmentally friendly tanning composition
MY171575A (en) Corynebacterium genus microorganism for producing l-lysine and method for producing l-lysine by using the same
PH12015502272A1 (en) Recombinant microorganism with increased productivity of 2,3-butanediol, and method for producing 2,3-butanediol using same
MX2013003581A (es) Proceso para producir granulos que comprende una o mas sales de agentes complejas.
BR112015000345A2 (pt) geração eletroquímica de derivados de ureia clorada
BR112014018985A8 (pt) Método para preparar um composto
BR112014009411A2 (pt) controle de processo de desgaseificação de polímero
MY166884A (en) Method for producing acetylenedicarboxylic acid from acetylene and carbon dioxide
MX2017004815A (es) Metodo para la polimeracion de acido (met)acrilico en solucion.