IN2014MN01298A - - Google Patents

Info

Publication number
IN2014MN01298A
IN2014MN01298A IN1298MUN2014A IN2014MN01298A IN 2014MN01298 A IN2014MN01298 A IN 2014MN01298A IN 1298MUN2014 A IN1298MUN2014 A IN 1298MUN2014A IN 2014MN01298 A IN2014MN01298 A IN 2014MN01298A
Authority
IN
India
Prior art keywords
hereinafter
vector
relates
present
microorganisms
Prior art date
Application number
Inventor
Kwang Ho Lee
Sang Jo Lim
Jun Ok Moon
Jae Woo Jang
Su Jin Park
Sang Hee Park
Original Assignee
Cj Cheiljedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Cheiljedang Corp filed Critical Cj Cheiljedang Corp
Publication of IN2014MN01298A publication Critical patent/IN2014MN01298A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01001—Transketolase (2.2.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02004—Aspartate kinase (2.7.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01001—Pyruvate carboxylase (6.4.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/101—Plasmid DNA for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present invention relates to variant polynucleotides in which an initiation codon of each polynucleotide coding aspartate kinase; EC:2.7.2.4 (hereinafter LysC) transketolase; EC:2.2.1.1 (hereinafter Tkt) or pyruvate carboxylase; EC:6.4.1.1 (hereinafter Pyc) is substituted by ATG. The present invention also relates to a vector comprising the variant polynucleotides microorganisms transformed by the vector and to a method for producing L lysine using the microorganisms.
IN1298MUN2014 2011-12-21 2012-12-21 IN2014MN01298A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20110139527 2011-12-21
PCT/KR2012/011328 WO2013095071A2 (en) 2011-12-21 2012-12-21 Method for producing l-lysine using microorganisms having ability to produce l-lysine

Publications (1)

Publication Number Publication Date
IN2014MN01298A true IN2014MN01298A (en) 2015-07-03

Family

ID=48669667

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1298MUN2014 IN2014MN01298A (en) 2011-12-21 2012-12-21

Country Status (15)

Country Link
US (2) US9593354B2 (en)
EP (2) EP2796555B1 (en)
JP (2) JP6082025B2 (en)
KR (3) KR101483344B1 (en)
CN (4) CN104334728B (en)
BR (2) BR122021015693B1 (en)
CA (1) CA2860252C (en)
DK (1) DK2796555T3 (en)
ES (1) ES2696173T3 (en)
IN (1) IN2014MN01298A (en)
MX (2) MX391368B (en)
MY (1) MY171302A (en)
PL (1) PL2796555T3 (en)
RU (3) RU2616870C1 (en)
WO (1) WO2013095071A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2616870C1 (en) * 2011-12-21 2017-04-18 СиДжей ЧеилДжеданг Корпорейшн Method for l-lysine production using microorganisms capable of l-lysine production
KR101755767B1 (en) * 2014-09-05 2017-07-10 씨제이제일제당 (주) A microorganism having enhanced L-lysine productivity and a method of producing L-lysine using the same
KR101793328B1 (en) * 2015-07-03 2017-11-03 씨제이제일제당 (주) A microorganism having enhanced L-lysine productivity and a method of producing L-lysine using the same
EP3497226A4 (en) 2016-08-15 2020-07-01 Cathay Biotech Inc. CONTROL OF THE DISTRIBUTION OF A BIOFILM FOR THE PRODUCTION OF AMINO ACIDS OR PRODUCTS FROM AMINO ACIDS
KR101863456B1 (en) * 2016-11-15 2018-06-01 씨제이제일제당 (주) A microorganism of the genus Corynebacterium and a method for producing L-lysine using the same
DE102017004751A1 (en) * 2017-05-18 2018-11-22 Forschungszentrum Jülich GmbH Pyruvate carboxylase and DNA encoding the pyruvate carboxylase, plasmid containing the DNA, and microorganism for production, and methods for producing products whose biosynthesis involves oxaloacetate as a precursor and chromosome
EP3456833A1 (en) 2017-09-18 2019-03-20 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3467099A1 (en) 2017-10-05 2019-04-10 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3498853A1 (en) 2017-12-14 2019-06-19 Evonik Degussa GmbH Method for the fermentative production of l-lysine
KR101915433B1 (en) * 2018-02-13 2018-11-05 씨제이제일제당 (주) Modified polypeptide with attenuated activity of citrate synthase and a method for producing L-amino acid using the same
EP3594355A1 (en) 2018-07-12 2020-01-15 Evonik Operations GmbH Method for the fermentative production of l-lysine
EP3599282B1 (en) 2018-07-24 2021-03-17 Evonik Operations GmbH Method for the fermentative production of l-lysine
RU2019128538A (en) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ METHOD FOR ENZYMATIC PRODUCTION OF L-LYSINE
EP3660158A1 (en) 2018-11-29 2020-06-03 Evonik Operations GmbH Method for the fermentative production of l-lysine
CN109554322B (en) * 2018-12-03 2020-08-04 江南大学 Recombinant Escherichia coli with high L-threonine yield and construction method thereof
EP3670525A1 (en) 2018-12-18 2020-06-24 Evonik Operations GmbH Method for the fermentative production of l-lysine using c. glutamicum strains with a mutated kup transporter
US10829746B2 (en) 2019-01-23 2020-11-10 Evonik Operations Gmbh Method for the fermentative production of L-lysine
WO2021048353A1 (en) 2019-09-11 2021-03-18 Evonik Operations Gmbh Coryneform bacteria with a heterologous threonine transporter and their use in the production of l-threonine
CN112877269B (en) * 2020-01-15 2021-12-24 中国科学院天津工业生物技术研究所 Microorganism producing lysine and method for producing lysine
WO2022050524A1 (en) * 2020-09-03 2022-03-10 대상 주식회사 Corynebacterium glutamicum variant having improved l-lysine production ability, and method for producing l-lysine using same
JP7683041B2 (en) * 2021-04-30 2025-05-26 シージェイ チェイルジェダング コーポレイション Corynebacterium glutamicum mutant with improved L-lysine production ability and method for producing L-lysine using the same
BR112023022512A2 (en) * 2021-04-30 2024-01-02 Cj Cheiljedang Corp PROMOTER, CORYNEBACTERIUM GLUTAMICUM VARIANT AND METHOD FOR L-LYSINE PRODUCTION
CN113308426B (en) * 2021-05-27 2022-10-18 齐鲁工业大学 A recombinant coryneform bacterium with modified TK gene 5'-end sequence and its application
KR102703209B1 (en) * 2021-10-14 2024-09-05 대상 주식회사 Mutant of Corynebacterium glutamicum with enhanced L-lysine productivity and method for preparing L-lysine using the same
CN113957073B (en) * 2021-10-19 2023-09-01 山东寿光巨能金玉米开发有限公司 Tkt gene promoter mutant and application thereof in L-lysine production
EP4525842A1 (en) 2022-05-18 2025-03-26 Evonik Operations GmbH Biotechnological production of bisucaberins, desferrioxamines and analogs thereof
EP4525843A1 (en) 2022-05-18 2025-03-26 Evonik Operations GmbH Biotechnological production of monomers of bisucaberins, desferrioxamines and analogs thereof
US20250340893A1 (en) 2022-05-18 2025-11-06 Evonik Operations Gmbh Biotechnological production of desferrioxamines and analogs thereof
KR102838147B1 (en) 2023-03-17 2025-07-28 씨제이제일제당 주식회사 5' Untranslated Region mutation sequence and uses thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358866A (en) * 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies
KR100420743B1 (en) * 1994-12-09 2004-05-24 아지노모토 가부시키가이샤 Methods for the preparation of novel lysine decarboxylase genes and L-lysine
HU222503B1 (en) * 1995-06-07 2003-07-28 Ajinomoto Co., Inc. Process for producing l-lysine
KR0159812B1 (en) 1995-12-20 1998-11-16 손경식 Corynebacterium glutamicum ch77 and method for producing l-lysine
JP4075087B2 (en) 1996-12-05 2008-04-16 味の素株式会社 Method for producing L-lysine
AU741038B2 (en) * 1997-10-04 2001-11-22 Degussa A.G. Method for microbial production of amino acids of the aspartate and/or glutamatefamily and agents which can be used in said method
DE19831609B4 (en) * 1997-10-04 2009-11-12 Evonik Degussa Gmbh Process for the preparation of amino acids of the aspartate and / or glutamate family and agents which can be used in the process
DE19931317A1 (en) * 1999-07-07 2001-01-11 Degussa L-lysine-producing coryneform bacteria and method for producing L-lysine
US6171833B1 (en) * 1998-12-23 2001-01-09 Massachusetts Institute Of Technology Pyruvate carboxylase from corynebacterium glutamicum
AU2203399A (en) * 1998-12-23 2000-07-31 Massachusetts Institute Of Technology Pyruvate carboxylase from (corynebacterium glutamicum)
US20020086371A1 (en) 1999-07-07 2002-07-04 Degussa-Huls Aktiengesellschaft L-lysine-producing corynebacteria and process for the preparation of L-lysine
US6797509B1 (en) * 1999-07-09 2004-09-28 Degussa-Huls Ag Nucleotide sequences which code for the tal gene
CA2374012A1 (en) * 2000-03-17 2001-09-20 Degussa Ag Process for the fermentative preparation of l-amino acids with amplification of the tkt gene
KR100397322B1 (en) 2000-12-30 2003-09-06 씨제이 주식회사 Process for preparing L-lycine
US7445915B2 (en) * 2002-03-19 2008-11-04 Kyowa Hakko Kogyo Co., Ltd. Mutant isopropylmalate isomerase
DE10361268A1 (en) * 2003-12-24 2005-07-28 Degussa Ag Process for the fermentative production of L-amino acids using strains of the family Enterobacteriaceae
DE102004011248A1 (en) * 2004-03-09 2005-09-22 Degussa Ag Process for producing L-amino acids using coryneform bacteria
AU2005321630A1 (en) * 2004-07-02 2006-07-06 Metanomics Gmbh Process for the production of fine chemicals
EP2386650B1 (en) 2006-04-07 2013-07-03 Evonik Degussa GmbH Method for producing L-amino acids using the gap promoter
JP5756259B2 (en) 2006-09-15 2015-07-29 シージェイ チェイルジェダン コーポレイション Corynebacterium genus having improved L-lysine production ability and method for producing L-lysine using the same
EP2082044B1 (en) * 2006-10-24 2016-06-01 Basf Se Method of increasing gene expression using modified codon usage
US8133714B2 (en) * 2007-09-27 2012-03-13 Evonik Degussa Gmbh Process for the fermentative preparation of organic chemical compounds using coryneform bacteria in which the SugR gene is present in attenuated form
KR100930203B1 (en) 2008-01-28 2009-12-07 씨제이제일제당 (주) Improved promoter and method for producing L-lysine using the same
KR100987281B1 (en) 2008-01-31 2010-10-12 씨제이제일제당 (주) Improved promoter and method for producing L-lysine using the same
JP5395893B2 (en) 2008-04-30 2014-01-22 ビーエーエスエフ ソシエタス・ヨーロピア Method for producing fine chemicals using microorganisms having reduced isocitrate dehydrogenase activity
DE102008001874A1 (en) * 2008-05-20 2009-11-26 Evonik Degussa Gmbh Process for the preparation of L-amino acids
GB0809169D0 (en) * 2008-05-20 2008-06-25 Sinvent As Method of L-lysine production
US9169502B2 (en) * 2010-06-15 2015-10-27 Paik Kwang Industrial Co., Ltd. Method of producing L-lysine using a Corynebacterium glutamicum microorganism
DE102011118019A1 (en) * 2011-06-28 2013-01-03 Evonik Degussa Gmbh Variants of the promoter of the glyceraldehyde-3-phosphate dehydrogenase-encoding gap gene
RU2616870C1 (en) * 2011-12-21 2017-04-18 СиДжей ЧеилДжеданг Корпорейшн Method for l-lysine production using microorganisms capable of l-lysine production

Also Published As

Publication number Publication date
PL2796555T3 (en) 2019-04-30
DK2796555T3 (en) 2018-12-10
EP2796555B1 (en) 2018-08-29
CA2860252A1 (en) 2013-06-27
BR112014015215B1 (en) 2021-11-23
EP2796555A4 (en) 2015-12-09
US20170145453A1 (en) 2017-05-25
KR101483395B1 (en) 2015-01-16
JP2017038617A (en) 2017-02-23
MX353594B (en) 2018-01-18
MY171302A (en) 2019-10-08
JP6219481B2 (en) 2017-10-25
US20150099281A1 (en) 2015-04-09
CN109251934B (en) 2023-07-18
KR101483344B1 (en) 2015-01-15
ES2696173T3 (en) 2019-01-14
RU2588665C2 (en) 2016-07-10
KR101483396B1 (en) 2015-01-16
KR20140093649A (en) 2014-07-28
WO2013095071A3 (en) 2013-08-22
KR20130072183A (en) 2013-07-01
US9938546B2 (en) 2018-04-10
EP3404101A2 (en) 2018-11-21
CN104334728A (en) 2015-02-04
CA2860252C (en) 2019-07-23
MX391368B (en) 2025-03-21
BR122021015693B1 (en) 2022-05-03
CN109251934A (en) 2019-01-22
EP2796555A2 (en) 2014-10-29
BR112014015215A2 (en) 2018-11-06
RU2615454C1 (en) 2017-04-04
MX2014007385A (en) 2015-08-20
JP6082025B2 (en) 2017-02-15
RU2014127151A (en) 2016-02-10
EP3404101A3 (en) 2018-12-26
JP2015500660A (en) 2015-01-08
US9593354B2 (en) 2017-03-14
EP3404101B1 (en) 2025-06-11
WO2013095071A2 (en) 2013-06-27
CN105483145A (en) 2016-04-13
CN105483145B (en) 2021-04-06
KR20140090130A (en) 2014-07-16
CN104334728B (en) 2018-09-25
CN105624175A (en) 2016-06-01
RU2616870C1 (en) 2017-04-18

Similar Documents

Publication Publication Date Title
IN2014MN01298A (en)
MY175370A (en) Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam related thereto
PH12014501556A1 (en) Microorganism able to produce l-amino acid, and method for producing l-amino acid by using same
MY187158A (en) Method for preparing an aqueous acrylamide solution having a low acrylic acid concentration
EP4296364A3 (en) Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis
PH12014500266B1 (en) Microorganism having enhanced l-valine productivity and method for producing l-valine using the same
MX367578B (en) Production method for diazabicyclooctane derivative and intermediary body thereof.
MX353111B (en) Remote control of a first user's gameplay by a second user.
MY175678A (en) Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto
IN2015DN03133A (en)
MY187636A (en) Pyruvate dehydrogenase variants, a microorganism comprising the same and a method for producing l-amino acid using the same
MX2021002854A (en) Enzymatic cyclization of homofarnesylic acid.
MY166660A (en) Polynucleotides encoding enzymes from the jute lignin biosynthetic pathway
MY181203A (en) Microorganism of corynebacterium sp. having enhanced l-lysine producibility and method for producing l-lysine using same
MY164371A (en) Method for preparing cysteine or a derivative thereof using a novel o-phosphoserine sulfhydrylase
TN2014000133A1 (en) Environmentally friendly tanning composition
PH12015502272A1 (en) Recombinant microorganism with increased productivity of 2,3-butanediol, and method for producing 2,3-butanediol using same
MX2010005015A (en) Methods for preparing capecitabine and beta-anomer-rich trialkyl carbonate compound used therein.
MY171575A (en) Corynebacterium genus microorganism for producing l-lysine and method for producing l-lysine by using the same
AU2014370874A1 (en) Improved beta-fructofuranosidase
IN2014MN01621A (en)
IN2014DN03469A (en)
MY166884A (en) Method for producing acetylenedicarboxylic acid from acetylene and carbon dioxide
MX2015003308A (en) An improved process for the preparation of 2-amino-5,8-dimethoxy[ 1,2,4]triazolo[1,5-c]pyrimidine from 4-amino-2,5-dimethoxypyrimid ine.
PH12015501540B1 (en) Microorganism for production of chemicals derived from acetyl-coa