MX376178B - Espirocicloheptanos como inhibidores de la cinasa rho (rock). - Google Patents

Espirocicloheptanos como inhibidores de la cinasa rho (rock).

Info

Publication number
MX376178B
MX376178B MX2017000485A MX2017000485A MX376178B MX 376178 B MX376178 B MX 376178B MX 2017000485 A MX2017000485 A MX 2017000485A MX 2017000485 A MX2017000485 A MX 2017000485A MX 376178 B MX376178 B MX 376178B
Authority
MX
Mexico
Prior art keywords
spirocycloheptanes
rock
kinase inhibitors
rho kinase
compounds
Prior art date
Application number
MX2017000485A
Other languages
English (en)
Other versions
MX2017000485A (es
Inventor
Peter W Glunz
Vladimir Ladziata
Yufeng Wang
Zilun Hu
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2017000485A publication Critical patent/MX2017000485A/es
Publication of MX376178B publication Critical patent/MX376178B/es

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    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

La presente invención se refiere a compuestos de la Fórmula (I): (ver Fórmula) o estereoisómeros, tautómeros o sales de los mismos farmacéuticamente aceptables, en donde todas las variables son como se definen en la presente. Estos compuestos son inhibidores de ROCK selectivos. La presente invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos y a métodos para tratar trastornos cardiovasculares, trastornos relacionados con el músculo liso, trastornos oncológicos, trastornos neuropatológicos, trastornos autoinmunitarios, trastornos fibróticos y/o trastornos inflamatorios mediante su uso.
MX2017000485A 2014-07-15 2015-07-14 Espirocicloheptanos como inhibidores de la cinasa rho (rock). MX376178B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462024555P 2014-07-15 2014-07-15
US14/797,414 US9902702B2 (en) 2014-07-15 2015-07-13 Spirocycloheptanes as inhibitors of rock
PCT/US2015/040254 WO2016010950A1 (en) 2014-07-15 2015-07-14 Spirocycloheptanes as inhibitors of rock

Publications (2)

Publication Number Publication Date
MX2017000485A MX2017000485A (es) 2017-04-27
MX376178B true MX376178B (es) 2025-03-07

Family

ID=55073996

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017000485A MX376178B (es) 2014-07-15 2015-07-14 Espirocicloheptanos como inhibidores de la cinasa rho (rock).

Country Status (24)

Country Link
US (2) US9902702B2 (es)
EP (1) EP3169682B1 (es)
JP (2) JP6499749B2 (es)
KR (1) KR102420938B1 (es)
CN (1) CN106817899B (es)
AR (1) AR101208A1 (es)
AU (1) AU2015289897B2 (es)
BR (1) BR112017000808A2 (es)
CA (1) CA2954976A1 (es)
CL (1) CL2017000089A1 (es)
CO (1) CO2017001152A2 (es)
EA (1) EA033061B1 (es)
ES (1) ES2716415T3 (es)
IL (1) IL250046B (es)
MA (1) MA39554B1 (es)
MX (1) MX376178B (es)
PE (1) PE20170672A1 (es)
PH (1) PH12017500072A1 (es)
SG (1) SG11201700251PA (es)
TN (1) TN2017000009A1 (es)
TW (1) TW201607933A (es)
UY (1) UY36215A (es)
WO (1) WO2016010950A1 (es)
ZA (1) ZA201700304B (es)

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US10857157B2 (en) 2015-01-26 2020-12-08 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US10112929B2 (en) 2015-03-09 2018-10-30 Bristol-Myers Squibb Company Lactams as inhibitors of rock
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AR107354A1 (es) * 2016-01-13 2018-04-18 Bristol Myers Squibb Co Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock
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