MX366426B - Compuestos de heterociclilo como inhibidores de mek. - Google Patents

Compuestos de heterociclilo como inhibidores de mek.

Info

Publication number
MX366426B
MX366426B MX2018003665A MX2018003665A MX366426B MX 366426 B MX366426 B MX 366426B MX 2018003665 A MX2018003665 A MX 2018003665A MX 2018003665 A MX2018003665 A MX 2018003665A MX 366426 B MX366426 B MX 366426B
Authority
MX
Mexico
Prior art keywords
compounds
mek inhibitors
heterocyclyl compounds
formula
present disclosure
Prior art date
Application number
MX2018003665A
Other languages
English (en)
Inventor
Kumar Kamboj Rajender
P Palle Venkata
Dave Bhavesh
Kumar Banerjee Rakesh
Phukan Samiron
Datta Khoje Abhijit
Hangarge Rajkumar
Sambhaji Jadhav Jitendra
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47997632&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX366426(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of MX366426B publication Critical patent/MX366426B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La presente divulgación se relaciona con compuestos de heteroarilo como inhibidores de MEK. Estos compuestos incluyen compuestos de heteroarilo de Fórmula (I), sus sales farmacéuticamente aceptables, combinaciones con composiciones de medicamentos y farmacéuticas adecuadas de los mismos. La presente divulgación también incluye procesos para la preparación de los compuestos y su uso en métodos de tratamiento. Los compuestos tal como se divulgan en la presente son de la Fórmula (I) que figura a continuación: (ver Fórmula).
MX2018003665A 2012-03-14 2013-03-11 Compuestos de heterociclilo como inhibidores de mek. MX366426B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN288KO2012 2012-03-14
PCT/IB2013/051908 WO2013136249A1 (en) 2012-03-14 2013-03-11 Heterocyclyl compounds as mek inhibitors

Publications (1)

Publication Number Publication Date
MX366426B true MX366426B (es) 2019-07-08

Family

ID=47997632

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2014010928A MX355474B (es) 2012-03-14 2013-03-11 Compuestos de heterociclilo como inhibidores de mek.
MX2018003665A MX366426B (es) 2012-03-14 2013-03-11 Compuestos de heterociclilo como inhibidores de mek.
MX2014010925A MX355526B (es) 2012-03-14 2013-03-11 Compuesto de heterociclilo.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2014010928A MX355474B (es) 2012-03-14 2013-03-11 Compuestos de heterociclilo como inhibidores de mek.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2014010925A MX355526B (es) 2012-03-14 2013-03-11 Compuesto de heterociclilo.

Country Status (36)

Country Link
US (5) US9573944B2 (es)
EP (2) EP2834237B1 (es)
JP (3) JP6093384B2 (es)
KR (4) KR20140138910A (es)
CN (4) CN104271577A (es)
AP (2) AP3834A (es)
AU (4) AU2013234014B2 (es)
BR (1) BR112014022713B1 (es)
CA (2) CA2865167C (es)
CL (2) CL2014002412A1 (es)
CO (2) CO7160029A2 (es)
CR (2) CR20140464A (es)
CU (2) CU24272B1 (es)
DK (2) DK2834237T3 (es)
DO (2) DOP2014000203A (es)
EA (2) EA028232B1 (es)
ES (2) ES2741896T3 (es)
GE (2) GEP201706774B (es)
GT (2) GT201400196A (es)
HK (2) HK1202538A1 (es)
IL (2) IL234560A (es)
IN (2) IN2014MN01755A (es)
MA (2) MA37400B1 (es)
MX (3) MX355474B (es)
MY (2) MY174188A (es)
NI (2) NI201400108A (es)
NZ (2) NZ629432A (es)
PE (2) PE20141974A1 (es)
PH (2) PH12014502040B1 (es)
PL (1) PL2834237T3 (es)
SG (2) SG11201405007QA (es)
TN (2) TN2014000357A1 (es)
TR (1) TR201811976T4 (es)
UA (2) UA114906C2 (es)
WO (2) WO2013136249A1 (es)
ZA (1) ZA201406186B (es)

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NI201400107A (es) 2014-11-26
CA2865164A1 (en) 2013-09-19
AU2013234009B2 (en) 2016-10-27
MX2014010928A (es) 2015-04-10
CN108383836B (zh) 2021-11-12
JP6093384B2 (ja) 2017-03-08
CL2014002411A1 (es) 2015-04-06
MX2014010925A (es) 2015-04-10
AU2017200493A1 (en) 2017-02-16
MY174188A (en) 2020-03-12
SG11201405007QA (en) 2014-10-30
GEP201706671B (en) 2017-05-25
AU2013234014B2 (en) 2017-02-02
UA114907C2 (uk) 2017-08-28
MA37400A1 (fr) 2016-05-31
DK2834237T3 (en) 2018-08-27
DK2834236T3 (da) 2019-08-26
CN107698585A (zh) 2018-02-16
KR102240101B1 (ko) 2021-04-14
AP3834A (en) 2016-09-30
PH12014502041B1 (en) 2014-11-24
ZA201406186B (en) 2016-06-29
CO7170131A2 (es) 2015-01-28
EP2834237B1 (en) 2018-06-06
IN2014MN01755A (es) 2015-07-03
JP2018115215A (ja) 2018-07-26
CL2014002412A1 (es) 2015-03-06
GT201400195A (es) 2017-11-09
IL234560A (en) 2017-06-29
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KR102241111B1 (ko) 2021-04-15
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US9428499B2 (en) 2016-08-30
BR112014022713A2 (es) 2017-06-20
UA114906C2 (uk) 2017-08-28
MX355474B (es) 2018-04-16
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GT201400196A (es) 2017-09-28
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US9573944B2 (en) 2017-02-21
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CU20140109A7 (es) 2014-11-27

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