MX362339B - Forma de sal de un inhibidor de histona metiltransferasa humana ezh2. - Google Patents
Forma de sal de un inhibidor de histona metiltransferasa humana ezh2.Info
- Publication number
- MX362339B MX362339B MX2014012380A MX2014012380A MX362339B MX 362339 B MX362339 B MX 362339B MX 2014012380 A MX2014012380 A MX 2014012380A MX 2014012380 A MX2014012380 A MX 2014012380A MX 362339 B MX362339 B MX 362339B
- Authority
- MX
- Mexico
- Prior art keywords
- methyltranspherase
- histan
- ezh2
- histone
- inhibitor
- Prior art date
Links
- JXYWFNAQESKDNC-BTJKTKAUSA-N (z)-4-hydroxy-4-oxobut-2-enoate;2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethyl-dimethylazanium Chemical class OC(=O)\C=C/C(O)=O.C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 JXYWFNAQESKDNC-BTJKTKAUSA-N 0.000 title 1
- 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 title 1
- 108010033040 Histones Proteins 0.000 title 1
- 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000003839 salts Chemical group 0.000 title 1
- -1 (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl) methyl Chemical group 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261624215P | 2012-04-13 | 2012-04-13 | |
| PCT/US2013/036193 WO2013155317A1 (en) | 2012-04-13 | 2013-04-11 | Salt form of a human hi stone methyltransf erase ezh2 inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014012380A MX2014012380A (es) | 2015-07-23 |
| MX362339B true MX362339B (es) | 2019-01-11 |
Family
ID=49328166
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014012380A MX362339B (es) | 2012-04-13 | 2013-04-11 | Forma de sal de un inhibidor de histona metiltransferasa humana ezh2. |
| MX2019000449A MX384641B (es) | 2012-04-13 | 2013-04-11 | Forma de sal de un inhibidor de histona metiltransferasa humana ezh2. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019000449A MX384641B (es) | 2012-04-13 | 2013-04-11 | Forma de sal de un inhibidor de histona metiltransferasa humana ezh2. |
Country Status (26)
| Country | Link |
|---|---|
| US (7) | US9394283B2 (esLanguage) |
| EP (4) | EP3628670B1 (esLanguage) |
| JP (3) | JP6255382B2 (esLanguage) |
| KR (4) | KR20250005505A (esLanguage) |
| CN (2) | CN104603130B (esLanguage) |
| AU (2) | AU2013245878B2 (esLanguage) |
| BR (1) | BR112014025508B1 (esLanguage) |
| CA (1) | CA2870005C (esLanguage) |
| CY (2) | CY1119383T1 (esLanguage) |
| DK (3) | DK3628670T3 (esLanguage) |
| ES (3) | ES2745016T3 (esLanguage) |
| HR (2) | HRP20170295T1 (esLanguage) |
| HU (3) | HUE045353T2 (esLanguage) |
| IL (4) | IL296199B2 (esLanguage) |
| IN (1) | IN2014DN09068A (esLanguage) |
| LT (2) | LT2836491T (esLanguage) |
| MX (2) | MX362339B (esLanguage) |
| NZ (1) | NZ700761A (esLanguage) |
| PL (3) | PL2836491T3 (esLanguage) |
| PT (3) | PT3184523T (esLanguage) |
| RS (2) | RS55690B1 (esLanguage) |
| RU (1) | RU2658911C2 (esLanguage) |
| SG (3) | SG10201608577RA (esLanguage) |
| SI (2) | SI3184523T1 (esLanguage) |
| SM (2) | SMT201700132T1 (esLanguage) |
| WO (1) | WO2013155317A1 (esLanguage) |
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| WO2013173441A2 (en) | 2012-05-16 | 2013-11-21 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
| KR102057366B1 (ko) | 2012-10-15 | 2019-12-18 | 에피자임, 인코포레이티드 | 치환된 벤젠 화합물 |
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