MX358399B - Conjugados de un resto de interleucina-2 y un polímero. - Google Patents

Conjugados de un resto de interleucina-2 y un polímero.

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Publication number
MX358399B
MX358399B MX2013005363A MX2013005363A MX358399B MX 358399 B MX358399 B MX 358399B MX 2013005363 A MX2013005363 A MX 2013005363A MX 2013005363 A MX2013005363 A MX 2013005363A MX 358399 B MX358399 B MX 358399B
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Mexico
Prior art keywords
conjugates
methods
moiety
polymer
nonpeptidic
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MX2013005363A
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English (en)
Other versions
MX2013005363A (es
Inventor
Mary J Bossard
Harold Zappe
Yujun Wang
Xiaofeng Liu
Cherie F Ali
Deborah H Charych
Jicai Huang
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Nektar Therapeutics
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Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of MX2013005363A publication Critical patent/MX2013005363A/es
Publication of MX358399B publication Critical patent/MX358399B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P37/02—Immunomodulators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
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  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a un conjugado de un resto de interleucina-2 (IL-2) que tiene la secuencia de aminoácidos de la SEQ ID NO: 3, el conjugado caracterizado porque comprende de uno a siete polímeros hidrosolubles unidos covalentemente mediante un conector liberable a grupos amino dentro del reto de IL-2, en donde cualquier grupo amino dado dentro de restos de IL-2 tiene como máximo un polímero hidrosoluble unido covalentemente mediante el conector liberable al mismo, y en donde adicionalmente: (i) cada polímero hidrosoluble tiene un peso molecular promedio en el rango de aproximadamente 20,000 Daltons a aproximadamente 85,000 Daltons; y (ii) al menos un polímero hidrosoluble es liberablemente unido covalentemente a un grupo amino de una lisina dentro del resto de IL-2.
MX2013005363A 2010-11-12 2011-11-11 Conjugados de un resto de interleucina-2 y un polímero. MX358399B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41323610P 2010-11-12 2010-11-12
PCT/US2011/060408 WO2012065086A1 (en) 2010-11-12 2011-11-11 Conjugates of an il-2 moiety and a polymer

Publications (2)

Publication Number Publication Date
MX2013005363A MX2013005363A (es) 2013-11-04
MX358399B true MX358399B (es) 2018-08-16

Family

ID=46051324

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2013005363A MX358399B (es) 2010-11-12 2011-11-11 Conjugados de un resto de interleucina-2 y un polímero.
MX2018009979A MX388465B (es) 2010-11-12 2011-11-11 Conjugados de un resto de interleucina-2 y un polímero.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2018009979A MX388465B (es) 2010-11-12 2011-11-11 Conjugados de un resto de interleucina-2 y un polímero.

Country Status (22)

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US (6) US9861705B2 (es)
EP (2) EP3895735A1 (es)
JP (7) JP2014506116A (es)
KR (5) KR102472497B1 (es)
CN (2) CN103517718A (es)
AU (7) AU2011325990C1 (es)
CA (2) CA3144697C (es)
CY (1) CY1124659T1 (es)
DK (1) DK2637694T3 (es)
EA (2) EA202092025A1 (es)
ES (1) ES2866674T3 (es)
HR (1) HRP20210642T1 (es)
HU (1) HUE054318T2 (es)
IL (2) IL295201A (es)
LT (1) LT2637694T (es)
MX (2) MX358399B (es)
PL (1) PL2637694T3 (es)
PT (1) PT2637694T (es)
RS (1) RS61854B1 (es)
SI (1) SI2637694T1 (es)
SM (1) SMT202100314T1 (es)
WO (1) WO2012065086A1 (es)

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