WO2013020079A3 - Conjugates of an il-11 moiety and a polymer - Google Patents

Conjugates of an il-11 moiety and a polymer Download PDF

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Publication number
WO2013020079A3
WO2013020079A3 PCT/US2012/049582 US2012049582W WO2013020079A3 WO 2013020079 A3 WO2013020079 A3 WO 2013020079A3 US 2012049582 W US2012049582 W US 2012049582W WO 2013020079 A3 WO2013020079 A3 WO 2013020079A3
Authority
WO
WIPO (PCT)
Prior art keywords
conjugates
moiety
polymer
nonpeptidic
methods
Prior art date
Application number
PCT/US2012/049582
Other languages
French (fr)
Other versions
WO2013020079A2 (en
Inventor
Deborah H. Charych
Sean M. Culbertson
Ping Zhang
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of WO2013020079A2 publication Critical patent/WO2013020079A2/en
Publication of WO2013020079A3 publication Critical patent/WO2013020079A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Conjugates of an IL-1 1 moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to an individual.
PCT/US2012/049582 2011-08-04 2012-08-03 Conjugates of an il-11 moiety and a polymer WO2013020079A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161515113P 2011-08-04 2011-08-04
US61/515,113 2011-08-04

Publications (2)

Publication Number Publication Date
WO2013020079A2 WO2013020079A2 (en) 2013-02-07
WO2013020079A3 true WO2013020079A3 (en) 2013-04-18

Family

ID=46785781

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/049582 WO2013020079A2 (en) 2011-08-04 2012-08-03 Conjugates of an il-11 moiety and a polymer

Country Status (1)

Country Link
WO (1) WO2013020079A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA39711A (en) * 2014-04-03 2015-10-08 Nektar Therapeutics Conjugates of an il-15 moiety and a polymer
US10335492B2 (en) 2015-03-03 2019-07-02 Nansha Biologics (Hong Kong) Limited Increasing serum half-life of human IL-11 variants by N-terminal branched PEGylation
WO2016145388A1 (en) * 2015-03-11 2016-09-15 Nektar Therapeutics Conjugates of an il-7 moiety and an polymer
WO2018132787A1 (en) 2017-01-16 2018-07-19 Nansha Biologics (Hk) Limited Systems and methods for production of recombinant il-11 in yeast
CN108530636B (en) * 2017-03-05 2021-05-28 厦门赛诺邦格生物科技股份有限公司 Single functionalized branched polyethylene glycol

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1316436A (en) * 2000-04-06 2001-10-10 赵剑 Process for preparing water-soluble slow-releasing recombination protein
US20040136952A1 (en) * 2002-12-26 2004-07-15 Mountain View Pharmaceuticals, Inc. Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
US20070111240A1 (en) * 1997-07-14 2007-05-17 Bolder Biotechnology, Inc. Cysteine variants of interleukin-11 and methods of use thereof
WO2010024557A2 (en) * 2008-08-25 2010-03-04 Viromed Co., Ltd. Biopolymer conjugates comprising an interleukin-11 analog

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5371193A (en) 1990-05-21 1994-12-06 Genetics Institute, Inc. - Legal Affairs Mammalian cytokine, IL-11
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
PT1061954E (en) 1998-03-12 2004-10-29 Nektar Therapeutics Al Corp POLY (ETHYLENE GLYCOL) DERIVATIVES WITH NEXT REACTIVE GROUPS
US6602498B2 (en) 2000-02-22 2003-08-05 Shearwater Corporation N-maleimidyl polymer derivatives
EP1581582B2 (en) 2003-01-06 2017-06-07 Nektar Therapeutics Thiol-selective water-soluble polmer derivatives
EP1896082B1 (en) 2005-06-16 2012-12-26 Nektar Therapeutics Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
JP5615558B2 (en) 2007-02-28 2014-10-29 セリナ・セラピユーテイツクス・インコーポレーテツド Active polyoxazoline and compositions containing the same
EP2215113B1 (en) 2007-10-26 2015-02-25 CSL Limited Cytokine muteins

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070111240A1 (en) * 1997-07-14 2007-05-17 Bolder Biotechnology, Inc. Cysteine variants of interleukin-11 and methods of use thereof
CN1316436A (en) * 2000-04-06 2001-10-10 赵剑 Process for preparing water-soluble slow-releasing recombination protein
US20040136952A1 (en) * 2002-12-26 2004-07-15 Mountain View Pharmaceuticals, Inc. Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
WO2010024557A2 (en) * 2008-08-25 2010-03-04 Viromed Co., Ltd. Biopolymer conjugates comprising an interleukin-11 analog

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HOWLETT M ET AL: "Cytokine signalling via gp130 in gastric cancer", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 1793, no. 11, 1 November 2009 (2009-11-01), pages 1623 - 1633, XP026696815, ISSN: 0167-4889, [retrieved on 20090807], DOI: 10.1016/J.BBAMCR.2009.07.009 *
TAKAGI ET AL: "Enhanced pharmacological activity of recombinant human interleukin-11 (rhIL11) by chemical modification with polyethylene glycol", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 119, no. 3, 22 May 2007 (2007-05-22), pages 271 - 278, XP022087327, ISSN: 0168-3659, DOI: 10.1016/J.JCONREL.2007.03.009 *

Also Published As

Publication number Publication date
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