WO2013020079A3 - Conjugates of an il-11 moiety and a polymer - Google Patents
Conjugates of an il-11 moiety and a polymer Download PDFInfo
- Publication number
- WO2013020079A3 WO2013020079A3 PCT/US2012/049582 US2012049582W WO2013020079A3 WO 2013020079 A3 WO2013020079 A3 WO 2013020079A3 US 2012049582 W US2012049582 W US 2012049582W WO 2013020079 A3 WO2013020079 A3 WO 2013020079A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- conjugates
- moiety
- polymer
- nonpeptidic
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Conjugates of an IL-1 1 moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to an individual.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161515113P | 2011-08-04 | 2011-08-04 | |
US61/515,113 | 2011-08-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013020079A2 WO2013020079A2 (en) | 2013-02-07 |
WO2013020079A3 true WO2013020079A3 (en) | 2013-04-18 |
Family
ID=46785781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/049582 WO2013020079A2 (en) | 2011-08-04 | 2012-08-03 | Conjugates of an il-11 moiety and a polymer |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2013020079A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA39711A (en) * | 2014-04-03 | 2015-10-08 | Nektar Therapeutics | Conjugates of an il-15 moiety and a polymer |
US10335492B2 (en) | 2015-03-03 | 2019-07-02 | Nansha Biologics (Hong Kong) Limited | Increasing serum half-life of human IL-11 variants by N-terminal branched PEGylation |
CN107405384A (en) * | 2015-03-11 | 2017-11-28 | 尼克塔治疗公司 | The parts of IL 7 and the conjugate of polymer |
CN110382524B (en) | 2017-01-16 | 2024-02-06 | 南沙生物科技(香港)公司 | Systems and methods for producing recombinant IL-11 in yeast |
CN108530636B (en) * | 2017-03-05 | 2021-05-28 | 厦门赛诺邦格生物科技股份有限公司 | Single functionalized branched polyethylene glycol |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1316436A (en) * | 2000-04-06 | 2001-10-10 | 赵剑 | Process for preparing water-soluble slow-releasing recombination protein |
US20040136952A1 (en) * | 2002-12-26 | 2004-07-15 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
US20070111240A1 (en) * | 1997-07-14 | 2007-05-17 | Bolder Biotechnology, Inc. | Cysteine variants of interleukin-11 and methods of use thereof |
WO2010024557A2 (en) * | 2008-08-25 | 2010-03-04 | Viromed Co., Ltd. | Biopolymer conjugates comprising an interleukin-11 analog |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US5371193A (en) | 1990-05-21 | 1994-12-06 | Genetics Institute, Inc. - Legal Affairs | Mammalian cytokine, IL-11 |
US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
ATE268609T1 (en) | 1998-03-12 | 2004-06-15 | Nektar Therapeutics Al Corp | POLYETHYLENE GLYCOL DERIVATIVES WITH ADJACENT REACTIVE GROUPS |
WO2001062827A2 (en) | 2000-02-22 | 2001-08-30 | Shearwater Corporation | N-maleimidyl polymer derivatives |
KR101207247B1 (en) | 2003-01-06 | 2012-12-03 | 넥타르 테라퓨틱스 | Thiol-selective water-soluble polymer derivatives |
MX2007016314A (en) | 2005-06-16 | 2008-03-10 | Nektar Therapeutics Al Corp | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. |
JP5615558B2 (en) | 2007-02-28 | 2014-10-29 | セリナ・セラピユーテイツクス・インコーポレーテツド | Active polyoxazoline and compositions containing the same |
CA2703544C (en) | 2007-10-26 | 2016-01-05 | Manuel Baca | Cytokine muteins |
-
2012
- 2012-08-03 WO PCT/US2012/049582 patent/WO2013020079A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070111240A1 (en) * | 1997-07-14 | 2007-05-17 | Bolder Biotechnology, Inc. | Cysteine variants of interleukin-11 and methods of use thereof |
CN1316436A (en) * | 2000-04-06 | 2001-10-10 | 赵剑 | Process for preparing water-soluble slow-releasing recombination protein |
US20040136952A1 (en) * | 2002-12-26 | 2004-07-15 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
WO2010024557A2 (en) * | 2008-08-25 | 2010-03-04 | Viromed Co., Ltd. | Biopolymer conjugates comprising an interleukin-11 analog |
Non-Patent Citations (2)
Title |
---|
HOWLETT M ET AL: "Cytokine signalling via gp130 in gastric cancer", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 1793, no. 11, 1 November 2009 (2009-11-01), pages 1623 - 1633, XP026696815, ISSN: 0167-4889, [retrieved on 20090807], DOI: 10.1016/J.BBAMCR.2009.07.009 * |
TAKAGI ET AL: "Enhanced pharmacological activity of recombinant human interleukin-11 (rhIL11) by chemical modification with polyethylene glycol", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 119, no. 3, 22 May 2007 (2007-05-22), pages 271 - 278, XP022087327, ISSN: 0168-3659, DOI: 10.1016/J.JCONREL.2007.03.009 * |
Also Published As
Publication number | Publication date |
---|---|
WO2013020079A2 (en) | 2013-02-07 |
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