MX343324B - Ensayos para detectar auto anticuerpos neutralizadores de la terapia biologica con tnf alpha. - Google Patents
Ensayos para detectar auto anticuerpos neutralizadores de la terapia biologica con tnf alpha.Info
- Publication number
- MX343324B MX343324B MX2013015420A MX2013015420A MX343324B MX 343324 B MX343324 B MX 343324B MX 2013015420 A MX2013015420 A MX 2013015420A MX 2013015420 A MX2013015420 A MX 2013015420A MX 343324 B MX343324 B MX 343324B
- Authority
- MX
- Mexico
- Prior art keywords
- neutralizing
- therapy
- biologic
- present
- assays
- Prior art date
Links
- 230000003472 neutralizing effect Effects 0.000 title abstract 6
- 238000001815 biotherapy Methods 0.000 title abstract 4
- 238000003556 assay Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 3
- 238000012544 monitoring process Methods 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 239000003124 biologic agent Substances 0.000 abstract 1
- 229960000074 biopharmaceutical Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000009260 cross reactivity Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
- G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/34—Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/525—Tumor necrosis factor [TNF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rehabilitation Therapy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161505031P | 2011-07-06 | 2011-07-06 | |
| US201161528072P | 2011-08-26 | 2011-08-26 | |
| US201161535884P | 2011-09-16 | 2011-09-16 | |
| PCT/US2012/045794 WO2013006810A1 (en) | 2011-07-06 | 2012-07-06 | Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013015420A MX2013015420A (es) | 2015-01-22 |
| MX343324B true MX343324B (es) | 2016-11-01 |
Family
ID=46551894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013015420A MX343324B (es) | 2011-07-06 | 2012-07-06 | Ensayos para detectar auto anticuerpos neutralizadores de la terapia biologica con tnf alpha. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9465027B2 (https=) |
| EP (2) | EP3130921B1 (https=) |
| JP (1) | JP6181646B2 (https=) |
| KR (1) | KR20140047628A (https=) |
| CN (1) | CN103782172A (https=) |
| AU (2) | AU2012278802B2 (https=) |
| CA (1) | CA2840232A1 (https=) |
| MX (1) | MX343324B (https=) |
| RU (1) | RU2013158256A (https=) |
| SG (1) | SG10201605516YA (https=) |
| WO (1) | WO2013006810A1 (https=) |
| ZA (1) | ZA201309703B (https=) |
Families Citing this family (18)
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| US10365224B2 (en) | 2007-12-06 | 2019-07-30 | Genalyte, Inc. | Label-free optical sensors |
| US9846126B2 (en) | 2008-10-27 | 2017-12-19 | Genalyte, Inc. | Biosensors based on optical probing and sensing |
| NZ621655A (en) | 2009-10-26 | 2015-08-28 | Nestec Sa | Assays for the detection of anti-tnf drugs and autoantibodies |
| NZ609363A (en) | 2010-10-18 | 2015-04-24 | Nestec Sa | Methods for determining anti-drug antibody isotypes |
| MX343324B (es) | 2011-07-06 | 2016-11-01 | Nestec Sa | Ensayos para detectar auto anticuerpos neutralizadores de la terapia biologica con tnf alpha. |
| JP2015532425A (ja) | 2012-10-05 | 2015-11-09 | ネステク ソシエテ アノニム | 粘膜治癒を予測及びモニタリングするための方法 |
| BR112015012482A2 (pt) * | 2012-11-30 | 2017-07-11 | Nestec Sa | ensaios para detecção de autoanticorpos neutralizantes à terapia com produtos biológicos |
| WO2014122600A1 (en) | 2013-02-05 | 2014-08-14 | Nestec S.A. | Methods of selecting combination therapy for colorectal cancer patients |
| WO2015010108A1 (en) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| CA2932571A1 (en) | 2013-12-03 | 2015-06-11 | Nestec S.A. | Methods for predicting post-operative recurrence of crohn's disease |
| WO2015110989A1 (en) | 2014-01-23 | 2015-07-30 | Nestec S.A. | Biomarker panel for assessment of mucosal healing |
| WO2016088104A2 (en) * | 2014-12-05 | 2016-06-09 | Nestec S.A. | Indirect homogeneous mobility shift assays for the detection of biologics in patient samples |
| CN105277682A (zh) * | 2015-11-17 | 2016-01-27 | 苏州浩欧博生物医药有限公司 | 一种抗TNF-α单抗药物抗体检测试剂盒 |
| EP3482199A1 (en) * | 2016-07-08 | 2019-05-15 | Atonomics A/S | A universal assay for determining the quantity of therapeutic monoclonal antibodies and their corresponding anti-drug-antibodies in samples |
| EP3990922A1 (en) * | 2019-06-25 | 2022-05-04 | ProciseDx Inc. | Detection of anti-tnf alpha drug biologics and anti-drug antibodies |
| KR102626197B1 (ko) * | 2020-11-19 | 2024-01-18 | 바디텍메드(주) | 항 약물 항체의 수준을 정확하게 정량화하는 방법 |
| CN112730846B (zh) * | 2020-12-18 | 2023-12-15 | 安渡生物医药(杭州)有限公司 | 一种用于小鼠血样检测免疫复合物的方法 |
| CN114236139A (zh) * | 2021-12-30 | 2022-03-25 | 苏州和锐生物科技有限公司 | 一种TNF-α生物制剂的抗体检测试剂盒、制备方法 |
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| MX343324B (es) | 2011-07-06 | 2016-11-01 | Nestec Sa | Ensayos para detectar auto anticuerpos neutralizadores de la terapia biologica con tnf alpha. |
| US20130266963A1 (en) | 2011-07-06 | 2013-10-10 | Nestec S.A. | Assay for detecting neutralizing autoantibodies to biologic therapy |
| US20140051184A1 (en) | 2012-08-15 | 2014-02-20 | Nestec S.A. | Mobility shift assays for detecting anti-tnf alpha drugs and autoantibodies thereto |
| US20130295685A1 (en) | 2012-04-10 | 2013-11-07 | Nestec S.A. | Mobility shift assays for detecting anti-tnf alpha drugs and autoantibodies |
| BR112015012482A2 (pt) | 2012-11-30 | 2017-07-11 | Nestec Sa | ensaios para detecção de autoanticorpos neutralizantes à terapia com produtos biológicos |
| MX388027B (es) | 2013-11-13 | 2025-03-19 | Pfizer | Anticuerpos específicos para el ligando 1a tipo factor de necrosis tumoral y composiciones y usos de los mismos. |
| WO2016088104A2 (en) | 2014-12-05 | 2016-06-09 | Nestec S.A. | Indirect homogeneous mobility shift assays for the detection of biologics in patient samples |
| KR102423893B1 (ko) | 2015-03-31 | 2022-07-21 | 삼성디스플레이 주식회사 | 플렉서블 표시 장치 |
| EP3554342B1 (en) | 2016-12-14 | 2024-07-24 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a tnf inhibitor |
-
2012
- 2012-07-06 MX MX2013015420A patent/MX343324B/es active IP Right Grant
- 2012-07-06 EP EP16177029.2A patent/EP3130921B1/en not_active Not-in-force
- 2012-07-06 EP EP12738310.7A patent/EP2729807B1/en active Active
- 2012-07-06 WO PCT/US2012/045794 patent/WO2013006810A1/en not_active Ceased
- 2012-07-06 AU AU2012278802A patent/AU2012278802B2/en not_active Ceased
- 2012-07-06 CN CN201280043142.5A patent/CN103782172A/zh active Pending
- 2012-07-06 RU RU2013158256/15A patent/RU2013158256A/ru not_active Application Discontinuation
- 2012-07-06 CA CA2840232A patent/CA2840232A1/en not_active Abandoned
- 2012-07-06 KR KR1020137034951A patent/KR20140047628A/ko not_active Withdrawn
- 2012-07-06 SG SG10201605516YA patent/SG10201605516YA/en unknown
- 2012-07-06 JP JP2014519077A patent/JP6181646B2/ja not_active Expired - Fee Related
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2013
- 2013-12-20 ZA ZA2013/09703A patent/ZA201309703B/en unknown
- 2013-12-30 US US14/144,261 patent/US9465027B2/en active Active
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2016
- 2016-02-25 AU AU2016201196A patent/AU2016201196B2/en not_active Ceased
- 2016-09-01 US US15/254,934 patent/US10794906B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013006810A1 (en) | 2013-01-10 |
| US10794906B2 (en) | 2020-10-06 |
| AU2012278802B2 (en) | 2015-11-26 |
| US20140186973A1 (en) | 2014-07-03 |
| HK1194467A1 (zh) | 2014-10-17 |
| NZ619172A (en) | 2016-01-29 |
| SG10201605516YA (en) | 2016-08-30 |
| AU2016201196B2 (en) | 2018-01-25 |
| US20170176433A1 (en) | 2017-06-22 |
| EP2729807A1 (en) | 2014-05-14 |
| MX2013015420A (es) | 2015-01-22 |
| ZA201309703B (en) | 2019-09-25 |
| JP2014525036A (ja) | 2014-09-25 |
| AU2016201196A1 (en) | 2016-03-17 |
| JP6181646B2 (ja) | 2017-08-16 |
| AU2012278802A1 (en) | 2013-05-02 |
| RU2013158256A (ru) | 2015-07-10 |
| EP3130921B1 (en) | 2018-09-12 |
| US9465027B2 (en) | 2016-10-11 |
| KR20140047628A (ko) | 2014-04-22 |
| CA2840232A1 (en) | 2013-01-10 |
| CN103782172A (zh) | 2014-05-07 |
| EP3130921A1 (en) | 2017-02-15 |
| EP2729807B1 (en) | 2016-08-17 |
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