MX336191B - Derivados de carbamato de hexafluoroisopropilo, su preparacion y su uso en terapeutica. - Google Patents
Derivados de carbamato de hexafluoroisopropilo, su preparacion y su uso en terapeutica.Info
- Publication number
- MX336191B MX336191B MX2012014153A MX2012014153A MX336191B MX 336191 B MX336191 B MX 336191B MX 2012014153 A MX2012014153 A MX 2012014153A MX 2012014153 A MX2012014153 A MX 2012014153A MX 336191 B MX336191 B MX 336191B
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- carbamate derivatives
- therapeutic application
- hexafluoroisopropyl
- hexafluoroisopropyl carbamate
- Prior art date
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D249/18—Benzotriazoles
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- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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Abstract
La invención se refiere a los derivados de carbamatos de hexafluoroisopropilo, de fórmula general (I): en donde R, Z, A, m y n son como se definen en la memoria descriptiva, en forma de base o de una sal de adición con un ácido. Los compuestos se pueden usar como inhibidores de la enzima MGL (monoacil glicerol lipasa).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1054411A FR2960875B1 (fr) | 2010-06-04 | 2010-06-04 | Derives de carbamates d'hexafluoroisopropyle, leur preparation et leur application en therapeutique |
PCT/IB2011/052458 WO2011151808A1 (en) | 2010-06-04 | 2011-06-06 | Hexafluoroisopropyl carbamate derivatives, their preparation and their therapeutic application |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012014153A MX2012014153A (es) | 2013-02-07 |
MX336191B true MX336191B (es) | 2016-01-11 |
Family
ID=43402192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012014153A MX336191B (es) | 2010-06-04 | 2011-06-06 | Derivados de carbamato de hexafluoroisopropilo, su preparacion y su uso en terapeutica. |
Country Status (35)
Country | Link |
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US (1) | US8835418B2 (es) |
EP (1) | EP2576507B1 (es) |
JP (1) | JP5913296B2 (es) |
KR (1) | KR101753939B1 (es) |
CN (1) | CN103068797B (es) |
AR (1) | AR081578A1 (es) |
AU (1) | AU2011262222B2 (es) |
BR (1) | BR112012030906A2 (es) |
CA (1) | CA2801405C (es) |
CL (1) | CL2012003401A1 (es) |
CO (1) | CO6640299A2 (es) |
CR (1) | CR20120602A (es) |
DK (1) | DK2576507T3 (es) |
DO (1) | DOP2012000301A (es) |
EA (1) | EA022076B1 (es) |
EC (1) | ECSP12012323A (es) |
ES (1) | ES2632136T3 (es) |
FR (1) | FR2960875B1 (es) |
GT (1) | GT201200322A (es) |
IL (1) | IL223384A (es) |
MA (1) | MA34359B1 (es) |
MX (1) | MX336191B (es) |
MY (1) | MY156938A (es) |
NI (1) | NI201200174A (es) |
NZ (1) | NZ603985A (es) |
PE (1) | PE20130684A1 (es) |
PL (1) | PL2576507T3 (es) |
PT (1) | PT2576507T (es) |
SG (1) | SG186145A1 (es) |
TN (1) | TN2012000543A1 (es) |
TW (1) | TWI531564B (es) |
UA (1) | UA108240C2 (es) |
UY (1) | UY33427A (es) |
WO (1) | WO2011151808A1 (es) |
ZA (1) | ZA201209145B (es) |
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PT2800565T (pt) * | 2012-01-06 | 2020-04-29 | Scripps Research Inst | Compostos de carbamato e processos para a sua preparação e utilização |
US10539870B2 (en) * | 2013-05-31 | 2020-01-21 | Rohm And Haas Electronic Materials Llc | Photoresists comprising carbamate component |
JP2018513119A (ja) | 2015-03-18 | 2018-05-24 | アビデ セラピューティクス,インク. | ピペラジンカルバメート、およびピペラジンカルバメートを製造ならびに使用する方法 |
KR20180004263A (ko) | 2015-05-11 | 2018-01-10 | 어바이드 테라퓨틱스, 인크. | 염증 또는 신경병성 통증의 치료 방법 |
EP3328849B9 (en) | 2015-07-31 | 2021-01-06 | Pfizer Inc. | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors |
WO2017143283A1 (en) | 2016-02-19 | 2017-08-24 | Abide Therapeutics, Inc. | Radiolabeled monoacylglycerol lipase occupancy probe |
CN109496213B (zh) | 2016-05-12 | 2022-03-04 | H.隆德贝克有限公司 | 螺环化合物及其制备和使用方法 |
ES2892952T3 (es) | 2016-09-19 | 2022-02-07 | H Lundbeck As | Carbamatos de piperazina como moduladores del MAGL y/o ABHD6 y su uso |
WO2018068296A1 (en) | 2016-10-14 | 2018-04-19 | Merck Sharp & Dohme Corp. | PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE |
WO2018068295A1 (en) | 2016-10-14 | 2018-04-19 | Merck Sharp & Dohme Corp. | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE |
JOP20190105A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
JOP20190107A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
JOP20190106A1 (ar) * | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
JP2020506899A (ja) | 2017-01-20 | 2020-03-05 | ファイザー・インク | Magl阻害薬としての1,1,1−トリフルオロ−3−ヒドロキシプロパン−2−イルカルバマート誘導体 |
SG11201906427QA (en) | 2017-01-23 | 2019-08-27 | Pfizer | Heterocyclic spiro compounds as magl inhibitors |
KR20200046061A (ko) | 2017-08-29 | 2020-05-06 | 룬드벡 라 졸라 리서치 센터 인코포레이티드 | 스피로사이클 화합물 및 이를 제조하고 사용하는 방법 |
PE20200665A1 (es) * | 2017-08-29 | 2020-06-11 | Lundbeck La Jolla Research Center Inc | Compuestos espirociclicos y sus metodos de preparacion y uso |
EP3717477B1 (en) | 2017-11-28 | 2022-07-20 | F. Hoffmann-La Roche AG | New heterocyclic compounds |
TW201930300A (zh) * | 2017-12-15 | 2019-08-01 | 瑞士商赫孚孟拉羅股份公司 | 新雜環化合物 |
US10570106B2 (en) | 2018-05-15 | 2020-02-25 | Lundbeck La Jolla Research Center, Inc. | MAGL inhibitors |
AU2019304198A1 (en) * | 2018-07-19 | 2021-02-04 | Pfizer Inc. | Heterocyclic spiro compounds as MAGL inhibitors |
BR112021025516A2 (pt) | 2020-04-21 | 2022-11-01 | H Lundbeck As | Processos para a fabricação de 4-(2-(pirrolidin-1-il)-4-(trifluorometil)benzil)piperazina-1-carboxilato de 1,1,1,3,3,3-hexafluoropropan-2-ila e da forma 2 do sal monocloridrato do mesmo |
CN114787206A (zh) * | 2020-09-16 | 2022-07-22 | 株式会社Lg化学 | 化合物、包含其的抗菌除臭组合物以及用于制备其的方法 |
US11141404B1 (en) | 2020-11-18 | 2021-10-12 | Anebulo Pharmaceuticals, Inc. | Formulations and methods for treating acute cannabinoid overdose |
AU2022362107A1 (en) | 2021-10-11 | 2024-05-02 | Anebulo Pharmaceuticals, Inc. | Crystalline forms of a cannabinoid receptor type 1 (cb1) modulator and methods of use and preparation thereof |
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JPH09506920A (ja) | 1993-12-22 | 1997-07-08 | シエル・インターナシヨナル・リサーチ・マートスハツペイ・ベー・ヴエー | カルバメートの製造法 |
KR20010013407A (ko) | 1997-06-05 | 2001-02-26 | 스윈넨 앤 마리 | 카르바메이트의 제조 방법 |
EP1803453A1 (en) | 2005-12-21 | 2007-07-04 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Carbamate antibiotics |
WO2008106047A2 (en) | 2007-02-26 | 2008-09-04 | Kosan Biosciences Incorporated | Carbamate compounds |
WO2009052320A1 (en) * | 2007-10-16 | 2009-04-23 | Northeastern University | Methods and compounds for modulating cannabinoid activity |
US8188098B2 (en) * | 2008-05-19 | 2012-05-29 | Hoffmann-La Roche Inc. | GPR119 receptor agonists |
CA2730610A1 (en) * | 2008-07-16 | 2010-01-21 | Schering Corporation | Bicyclic heterocycle derivatives and their use as gpcr modulators |
FR2938537B1 (fr) | 2008-11-14 | 2012-10-26 | Sanofi Aventis | Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique. |
JP2011132138A (ja) * | 2009-12-22 | 2011-07-07 | Dainippon Sumitomo Pharma Co Ltd | カルバメート誘導体またはその薬理学的に許容される塩 |
WO2011127051A1 (en) * | 2010-04-06 | 2011-10-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
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