MX2023000053A - Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso. - Google Patents

Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.

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Publication number
MX2023000053A
MX2023000053A MX2023000053A MX2023000053A MX2023000053A MX 2023000053 A MX2023000053 A MX 2023000053A MX 2023000053 A MX2023000053 A MX 2023000053A MX 2023000053 A MX2023000053 A MX 2023000053A MX 2023000053 A MX2023000053 A MX 2023000053A
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MX
Mexico
Prior art keywords
suffering
subject
irna
methods
angptl3
Prior art date
Application number
MX2023000053A
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English (en)
Inventor
Kevin Fitzgerald
Stuart Milstein
Brian Bettencourt
William Querbes
Maria Frank-Kamenetsky
Svetlana Shulga-Morskaya
Original Assignee
Alnylam Pharmaceuticals Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47423191&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2023000053(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2023000053A publication Critical patent/MX2023000053A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
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    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

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  • Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Diabetes (AREA)
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  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención se relaciona con composiciones de ácido ribonucleico de doble hebra (ARNds) que tiene como objetivo el gen para ANGPTL3 así como métodos para inhibir la expresión de ANGPTL3 y métodos para tratar a sujetos que presentar un trastorno de metabolismo de lípidos tal como hiperlipidemia o hipertrigliceridemia, utilizando las composiciones de ARNds.
MX2023000053A 2011-06-21 2013-12-06 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso. MX2023000053A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161499620P 2011-06-21 2011-06-21
US201261638288P 2012-04-25 2012-04-25

Publications (1)

Publication Number Publication Date
MX2023000053A true MX2023000053A (es) 2023-04-10

Family

ID=47423191

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2017000476A MX360782B (es) 2011-06-21 2012-06-20 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.
MX2013014364A MX345095B (es) 2011-06-21 2012-06-20 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.
MX2023000053A MX2023000053A (es) 2011-06-21 2013-12-06 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.
MX2022012087A MX2022012087A (es) 2011-06-21 2013-12-06 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2017000476A MX360782B (es) 2011-06-21 2012-06-20 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.
MX2013014364A MX345095B (es) 2011-06-21 2012-06-20 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022012087A MX2022012087A (es) 2011-06-21 2013-12-06 Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso.

Country Status (14)

Country Link
US (16) US9322018B2 (es)
EP (4) EP3656860B1 (es)
JP (5) JP6110372B2 (es)
KR (4) KR102232287B1 (es)
CN (3) CN112961855A (es)
AU (5) AU2012272970A1 (es)
BR (2) BR122019026068B8 (es)
CA (1) CA2839573A1 (es)
ES (1) ES2923573T3 (es)
HK (1) HK1199457A1 (es)
MX (4) MX360782B (es)
RU (1) RU2711799C2 (es)
SG (2) SG10201913683WA (es)
WO (1) WO2012177784A2 (es)

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