MX2020010184A - Compuesto heterociclico. - Google Patents
Compuesto heterociclico.Info
- Publication number
- MX2020010184A MX2020010184A MX2020010184A MX2020010184A MX2020010184A MX 2020010184 A MX2020010184 A MX 2020010184A MX 2020010184 A MX2020010184 A MX 2020010184A MX 2020010184 A MX2020010184 A MX 2020010184A MX 2020010184 A MX2020010184 A MX 2020010184A
- Authority
- MX
- Mexico
- Prior art keywords
- heterocyclic compound
- cardiomyocyte
- maturation
- enhance
- activity
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 210000004413 cardiac myocyte Anatomy 0.000 abstract 3
- 230000035800 maturation Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cardiology (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
La presente invención proporciona un compuesto heterocíclico que tiene actividad para promover la maduración de un cardiomiocito. Un compuesto representado por la fórmula (I): (ver Fórmula) en donde cada símbolo es el definido en la descripción, o una sal del mismo tiene actividad para promover la maduración de un cardiomiocito y es útil como promotor de la maduración de cardiomiocitos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018069872 | 2018-03-30 | ||
PCT/JP2019/013529 WO2019189553A1 (ja) | 2018-03-30 | 2019-03-28 | 複素環化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020010184A true MX2020010184A (es) | 2020-10-28 |
Family
ID=68059192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020010184A MX2020010184A (es) | 2018-03-30 | 2019-03-28 | Compuesto heterociclico. |
Country Status (15)
Country | Link |
---|---|
US (1) | US11401264B2 (es) |
EP (1) | EP3778587B1 (es) |
JP (1) | JP7257698B2 (es) |
KR (1) | KR20200139210A (es) |
CN (1) | CN111918866B (es) |
AU (1) | AU2019241702B2 (es) |
BR (1) | BR112020019579A8 (es) |
CA (1) | CA3095717A1 (es) |
CO (1) | CO2020012101A2 (es) |
ES (1) | ES2966207T3 (es) |
IL (1) | IL277340B1 (es) |
MX (1) | MX2020010184A (es) |
SG (1) | SG11202009314XA (es) |
TW (1) | TWI820104B (es) |
WO (1) | WO2019189553A1 (es) |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI9210098B (sl) * | 1991-02-06 | 2000-06-30 | Dr. Karl Thomae | Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo |
US5602127A (en) | 1991-02-06 | 1997-02-11 | Karl Thomae Gmbh | (Alkanesultam-1-yl)-benzimidazol-1-yl)-1yl)-methyl-biphenyls useful as angiotensin-II antagonists |
US5594003A (en) | 1991-02-06 | 1997-01-14 | Dr. Karl Thomae Gmbh | Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biphenyls useful as angiotensin-II antagonists |
US5591762A (en) * | 1991-02-06 | 1997-01-07 | Dr. Karl Thomae Gmbh | Benzimidazoles useful as angiotensin-11 antagonists |
DE4212748A1 (de) | 1992-04-16 | 1993-10-21 | Thomae Gmbh Dr K | Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
CA2540135C (en) | 2003-10-03 | 2012-12-04 | Keiichi Fukuda | Method of inducing the differentiation of stem cells into cardiomyocytes |
BRPI0418732A (pt) | 2004-04-10 | 2007-09-11 | Henkel Kgaa | dispositivo para enrolar cabelos |
KR101529317B1 (ko) | 2005-06-22 | 2015-06-16 | 아스테리아스 바이오세라퓨틱스, 인크. | 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화 |
US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
AU2006325975B2 (en) | 2005-12-13 | 2011-12-08 | Kyoto University | Nuclear reprogramming factor |
CA2650685C (en) | 2006-04-28 | 2014-02-04 | Asubio Pharma Co., Ltd. | Method for inducing differentiation of pluripotent stem cells into cardiomyocytes |
US7661738B2 (en) | 2006-11-28 | 2010-02-16 | Veritainer Corporation | Radiation detection unit for mounting a radiation sensor to a container crane |
EP2626416A3 (en) | 2007-04-07 | 2013-12-18 | The Whitehead Institute for Biomedical Research | Reprogramming of somatic cells |
EP2164951A2 (en) | 2007-05-30 | 2010-03-24 | The General Hospital Corporation | Methods of generating pluripotent cells from somatic cells |
JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
US8765465B2 (en) | 2008-03-26 | 2014-07-01 | Kyoto University | Efficient production and use of highly cardiogenic progenitors and cardiomyocytes from embryonic and induced pluripotent stem cells |
US9499790B2 (en) | 2010-08-26 | 2016-11-22 | Kyoto University | Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells |
WO2012026491A1 (ja) | 2010-08-26 | 2012-03-01 | 国立大学法人京都大学 | 多能性幹細胞の心筋分化促進剤 |
JP5840855B2 (ja) | 2011-03-30 | 2016-01-06 | 学校法人東京女子医科大学 | 胚性幹細胞から心筋シートを製造する方法 |
EP2826855B1 (en) | 2012-03-15 | 2018-08-29 | iHeart Japan Corporation | Myocardial sheet |
WO2014192909A1 (ja) | 2013-05-31 | 2014-12-04 | iHeart Japan株式会社 | ハイドロゲルを組み込んだ積層化細胞シート |
EP3708655A1 (en) * | 2013-06-11 | 2020-09-16 | Ncardia B.V. | Culture medium compositions for maturating cardiomyocytes derived from pluripotent mammalian stem cells |
JP6651218B2 (ja) | 2014-05-30 | 2020-02-19 | 国立大学法人京都大学 | 低分子化合物を用いた多能性幹細胞の心筋分化誘導法 |
WO2016076368A1 (ja) | 2014-11-12 | 2016-05-19 | テルモ株式会社 | 心筋細胞シート |
JP2017060422A (ja) * | 2015-09-24 | 2017-03-30 | 国立大学法人 東京大学 | 成熟した心筋細胞を分化誘導させる方法 |
JP6702134B2 (ja) | 2016-10-27 | 2020-05-27 | トヨタ自動車株式会社 | 電動車両 |
-
2019
- 2019-03-28 WO PCT/JP2019/013529 patent/WO2019189553A1/ja active Application Filing
- 2019-03-28 TW TW108110970A patent/TWI820104B/zh active
- 2019-03-28 BR BR112020019579A patent/BR112020019579A8/pt unknown
- 2019-03-28 JP JP2020509307A patent/JP7257698B2/ja active Active
- 2019-03-28 IL IL277340A patent/IL277340B1/en unknown
- 2019-03-28 US US17/043,162 patent/US11401264B2/en active Active
- 2019-03-28 CA CA3095717A patent/CA3095717A1/en active Pending
- 2019-03-28 MX MX2020010184A patent/MX2020010184A/es unknown
- 2019-03-28 EP EP19774392.5A patent/EP3778587B1/en active Active
- 2019-03-28 CN CN201980022883.7A patent/CN111918866B/zh active Active
- 2019-03-28 KR KR1020207031404A patent/KR20200139210A/ko not_active Application Discontinuation
- 2019-03-28 AU AU2019241702A patent/AU2019241702B2/en active Active
- 2019-03-28 SG SG11202009314XA patent/SG11202009314XA/en unknown
- 2019-03-28 ES ES19774392T patent/ES2966207T3/es active Active
-
2020
- 2020-09-29 CO CONC2020/0012101A patent/CO2020012101A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
BR112020019579A2 (pt) | 2021-01-12 |
WO2019189553A1 (ja) | 2019-10-03 |
SG11202009314XA (en) | 2020-10-29 |
BR112020019579A8 (pt) | 2022-10-18 |
EP3778587A4 (en) | 2021-10-06 |
CN111918866B (zh) | 2023-07-04 |
CO2020012101A2 (es) | 2020-12-10 |
RU2020135574A (ru) | 2022-05-04 |
JP7257698B2 (ja) | 2023-04-14 |
IL277340B1 (en) | 2024-03-01 |
US20210024512A1 (en) | 2021-01-28 |
JPWO2019189553A1 (ja) | 2021-03-25 |
EP3778587A1 (en) | 2021-02-17 |
AU2019241702B2 (en) | 2023-07-27 |
IL277340A (en) | 2020-10-29 |
KR20200139210A (ko) | 2020-12-11 |
EP3778587C0 (en) | 2023-10-04 |
CN111918866A (zh) | 2020-11-10 |
US11401264B2 (en) | 2022-08-02 |
EP3778587B1 (en) | 2023-10-04 |
ES2966207T3 (es) | 2024-04-18 |
AU2019241702A1 (en) | 2020-10-08 |
TWI820104B (zh) | 2023-11-01 |
CA3095717A1 (en) | 2019-10-03 |
TW201942354A (zh) | 2019-11-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB | Transfer or rights |
Owner name: ORIZURU THERAPEUTICS, INC. |