BR112020019579A8 - Composto, promotor de maturação de cardiomiócito, método para preparação de um cardiomiócito maduro, e, cardiomiócito maduro - Google Patents

Composto, promotor de maturação de cardiomiócito, método para preparação de um cardiomiócito maduro, e, cardiomiócito maduro

Info

Publication number
BR112020019579A8
BR112020019579A8 BR112020019579A BR112020019579A BR112020019579A8 BR 112020019579 A8 BR112020019579 A8 BR 112020019579A8 BR 112020019579 A BR112020019579 A BR 112020019579A BR 112020019579 A BR112020019579 A BR 112020019579A BR 112020019579 A8 BR112020019579 A8 BR 112020019579A8
Authority
BR
Brazil
Prior art keywords
cardiomyocyte
mature
maturation
compound
promoter
Prior art date
Application number
BR112020019579A
Other languages
English (en)
Other versions
BR112020019579A2 (pt
Inventor
Yoshida Yoshinori
Miki Kenji
Kaieda Akira
Kondo Shigeru
Nara Hiroshi
Ikeura Yoshinori
Original Assignee
Takeda Pharmaceuticals Co
Univ Kyoto
Orizuru Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co, Univ Kyoto, Orizuru Therapeutics Inc filed Critical Takeda Pharmaceuticals Co
Publication of BR112020019579A2 publication Critical patent/BR112020019579A2/pt
Publication of BR112020019579A8 publication Critical patent/BR112020019579A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

A presente invenção fornece um composto heterocíclico tendo uma atividade para intensificar a maturação de um cardiomiócito. Um composto representado pela fórmula (I) [em que cada símbolo é como definido na descrição] ou um sal do mesmo tem uma atividade para intensificar a maturação de um cardiomiócito e é, portanto, útil como um intensificador da maturação de cardiomiócito.
BR112020019579A 2018-03-30 2019-03-28 Composto, promotor de maturação de cardiomiócito, método para preparação de um cardiomiócito maduro, e, cardiomiócito maduro BR112020019579A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018-069872 2018-03-30
JP2018069872 2018-03-30
PCT/JP2019/013529 WO2019189553A1 (ja) 2018-03-30 2019-03-28 複素環化合物

Publications (2)

Publication Number Publication Date
BR112020019579A2 BR112020019579A2 (pt) 2021-01-12
BR112020019579A8 true BR112020019579A8 (pt) 2022-10-18

Family

ID=68059192

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020019579A BR112020019579A8 (pt) 2018-03-30 2019-03-28 Composto, promotor de maturação de cardiomiócito, método para preparação de um cardiomiócito maduro, e, cardiomiócito maduro

Country Status (15)

Country Link
US (1) US11401264B2 (pt)
EP (1) EP3778587B1 (pt)
JP (1) JP7257698B2 (pt)
KR (1) KR102708268B1 (pt)
CN (1) CN111918866B (pt)
AU (1) AU2019241702B2 (pt)
BR (1) BR112020019579A8 (pt)
CA (1) CA3095717A1 (pt)
CO (1) CO2020012101A2 (pt)
ES (1) ES2966207T3 (pt)
IL (1) IL277340B2 (pt)
MX (1) MX2020010184A (pt)
SG (1) SG11202009314XA (pt)
TW (1) TWI820104B (pt)
WO (1) WO2019189553A1 (pt)

Family Cites Families (27)

* Cited by examiner, † Cited by third party
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US5602127A (en) 1991-02-06 1997-02-11 Karl Thomae Gmbh (Alkanesultam-1-yl)-benzimidazol-1-yl)-1yl)-methyl-biphenyls useful as angiotensin-II antagonists
US5614519A (en) 1991-02-06 1997-03-25 Karl Thomae Gmbh (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
US5594003A (en) 1991-02-06 1997-01-14 Dr. Karl Thomae Gmbh Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biphenyls useful as angiotensin-II antagonists
DE4212748A1 (de) 1992-04-16 1993-10-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
CN1863904B (zh) 2003-10-03 2014-05-28 福田惠一 由干细胞分化诱导心肌细胞的方法
PL1610642T3 (pl) 2004-04-10 2007-01-31 Henkel Kgaa Wałek do włosów
KR101529317B1 (ko) 2005-06-22 2015-06-16 아스테리아스 바이오세라퓨틱스, 인크. 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US8048999B2 (en) 2005-12-13 2011-11-01 Kyoto University Nuclear reprogramming factor
AU2007244226B2 (en) 2006-04-28 2012-09-20 Daiichi Sankyo Company, Limited Method for inducing differentiation of pluripotent stem cells into cardiomyocytes
US7661738B2 (en) 2006-11-28 2010-02-16 Veritainer Corporation Radiation detection unit for mounting a radiation sensor to a container crane
JP2010523117A (ja) 2007-04-07 2010-07-15 ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ 体細胞の再プログラミング
JP2010528622A (ja) 2007-05-30 2010-08-26 ザ ジェネラル ホスピタル コーポレイション 体細胞から多能性細胞を生成する方法
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US8765465B2 (en) 2008-03-26 2014-07-01 Kyoto University Efficient production and use of highly cardiogenic progenitors and cardiomyocytes from embryonic and induced pluripotent stem cells
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
WO2012026491A1 (ja) 2010-08-26 2012-03-01 国立大学法人京都大学 多能性幹細胞の心筋分化促進剤
JP5840855B2 (ja) 2011-03-30 2016-01-06 学校法人東京女子医科大学 胚性幹細胞から心筋シートを製造する方法
US9764063B2 (en) 2012-03-15 2017-09-19 Iheart Japan Corporation Method for producing mixed cell population of cardiomyocytes and vascular cells from induced pluripotent stem cell
US10159766B2 (en) 2013-05-31 2018-12-25 Iheart Japan Corporation Layered cell sheet incorporating hydrogel
PT3008172T (pt) * 2013-06-11 2020-07-21 Pluriomics B V Composições de meio de cultura para maturar cardiomicóticos derivados de células estaminais pluripotentes de mamíferos
WO2015182765A1 (ja) * 2014-05-30 2015-12-03 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
JP7180965B2 (ja) 2014-11-12 2022-11-30 テルモ株式会社 心筋細胞シート
JP2017060422A (ja) * 2015-09-24 2017-03-30 国立大学法人 東京大学 成熟した心筋細胞を分化誘導させる方法
JP6702134B2 (ja) 2016-10-27 2020-05-27 トヨタ自動車株式会社 電動車両

Also Published As

Publication number Publication date
BR112020019579A2 (pt) 2021-01-12
US20210024512A1 (en) 2021-01-28
JPWO2019189553A1 (ja) 2021-03-25
EP3778587C0 (en) 2023-10-04
SG11202009314XA (en) 2020-10-29
EP3778587A1 (en) 2021-02-17
US11401264B2 (en) 2022-08-02
IL277340B2 (en) 2024-07-01
CA3095717A1 (en) 2019-10-03
IL277340B1 (en) 2024-03-01
WO2019189553A1 (ja) 2019-10-03
AU2019241702A1 (en) 2020-10-08
IL277340A (en) 2020-10-29
KR20200139210A (ko) 2020-12-11
CN111918866B (zh) 2023-07-04
AU2019241702B2 (en) 2023-07-27
MX2020010184A (es) 2020-10-28
EP3778587B1 (en) 2023-10-04
KR102708268B1 (ko) 2024-09-20
CN111918866A (zh) 2020-11-10
RU2020135574A (ru) 2022-05-04
CO2020012101A2 (es) 2020-12-10
EP3778587A4 (en) 2021-10-06
JP7257698B2 (ja) 2023-04-14
TW201942354A (zh) 2019-11-01
TWI820104B (zh) 2023-11-01
ES2966207T3 (es) 2024-04-18

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B25A Requested transfer of rights approved

Owner name: ORIZURU THERAPEUTICS, INC. (JP)

B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]