BR112021017336A2 - Inibidores de rad51 - Google Patents
Inibidores de rad51Info
- Publication number
- BR112021017336A2 BR112021017336A2 BR112021017336A BR112021017336A BR112021017336A2 BR 112021017336 A2 BR112021017336 A2 BR 112021017336A2 BR 112021017336 A BR112021017336 A BR 112021017336A BR 112021017336 A BR112021017336 A BR 112021017336A BR 112021017336 A2 BR112021017336 A2 BR 112021017336A2
- Authority
- BR
- Brazil
- Prior art keywords
- rad51 inhibitors
- rad51
- inhibitors
- methods
- structural formula
- Prior art date
Links
- 101100355586 Schizosaccharomyces pombe (strain 972 / ATCC 24843) rhp51 gene Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
nibidores de rad51. a presente invenção refere-se a inibidores de rad51 representados pela seguinte fórmula estrutural (i), (i), e métodos para seu uso, tal como, para tratar câncer, doenças autoimunes, deficiências imunes ou doenças neurodegenerativas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962816998P | 2019-03-12 | 2019-03-12 | |
| PCT/US2020/022293 WO2020186006A1 (en) | 2019-03-12 | 2020-03-12 | Rad51 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021017336A2 true BR112021017336A2 (pt) | 2021-11-09 |
Family
ID=72422797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021017336A BR112021017336A2 (pt) | 2019-03-12 | 2020-03-12 | Inibidores de rad51 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11247988B2 (pt) |
| EP (1) | EP3938358B1 (pt) |
| JP (1) | JP7460649B2 (pt) |
| KR (1) | KR20210127790A (pt) |
| CN (1) | CN114072390B (pt) |
| AU (1) | AU2020235089A1 (pt) |
| BR (1) | BR112021017336A2 (pt) |
| CA (1) | CA3132987A1 (pt) |
| IL (1) | IL285889B2 (pt) |
| MX (1) | MX2021010916A (pt) |
| SG (1) | SG11202109399SA (pt) |
| TW (1) | TW202104198A (pt) |
| WO (1) | WO2020186006A1 (pt) |
| ZA (1) | ZA202106284B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3652159B1 (en) | 2017-07-11 | 2023-01-18 | Cyteir Therapeutics, Inc. | Substituted thiazole derivatives as rad51 inhibitors for the treatment of cancer diseases, autoimmune and neurodegenerative conditions |
| EP4112616A1 (en) | 2017-09-11 | 2023-01-04 | Cyteir Therapeutics, Inc. | Rad51 inhibitors |
| TW202104198A (zh) | 2019-03-12 | 2021-02-01 | 美商賽堤爾醫療公司 | Ｒａｄ５１抑制劑 |
| CN114173781A (zh) | 2019-03-25 | 2022-03-11 | 赛泰尔治疗公司 | Rad51和parp抑制剂的组合 |
| BR112021025491A2 (pt) | 2019-06-21 | 2022-04-26 | Cyteir Therapeutics Inc | Métodos para uso de inibidores de rad51 para tratamento de câncer pancreático |
| EP4108663A1 (en) * | 2020-02-19 | 2022-12-28 | Simcere Pharmaceutical Co., Ltd. | Substituted aryl compound |
| WO2023078271A1 (zh) * | 2021-11-02 | 2023-05-11 | 上海旭成医药科技有限公司 | 芳香化合物、其制备方法、中间体、药物组合物和应用 |
| WO2023185831A1 (zh) * | 2022-03-29 | 2023-10-05 | 正大天晴药业集团股份有限公司 | 含有噻唑环的化合物 |
| CN114736173B (zh) * | 2022-05-24 | 2024-06-11 | 无锡捷化医药科技有限公司 | 一种3-（二氟甲基）氧杂环丁烷-3-胺盐酸盐的制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| JPS6230780A (ja) | 1985-04-17 | 1987-02-09 | Ss Pharmaceut Co Ltd | １，７−ナフチリジン誘導体及びこれを含有する薬剤 |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| WO1992010588A1 (en) | 1990-12-06 | 1992-06-25 | Affymax Technologies N.V. | Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US6309823B1 (en) | 1993-10-26 | 2001-10-30 | Affymetrix, Inc. | Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same |
| GB9507238D0 (en) | 1995-04-07 | 1995-05-31 | Isis Innovation | Detecting dna sequence variations |
| WO2012113774A1 (en) | 2011-02-24 | 2012-08-30 | Nerviano Medical Sciences S.R.L. | Thiazolylphenyl-benzenesulfonamido derivatives as kinase inhibitors |
| UA117913C2 (uk) * | 2012-05-31 | 2018-10-25 | Фінекс Фармас'Ютікалс Аг | КАРБОКСАМІД- АБО СУЛЬФОНАМІДЗАМІЩЕНІ ТІАЗОЛИ ТА СПОРІДНЕНІ ПОХІДНІ ЯК МОДУЛЯТОРИ ОРФАНОВОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ |
| JP2017100949A (ja) | 2014-04-01 | 2017-06-08 | 大日本住友製薬株式会社 | ５員環ヘテロアリール誘導体 |
| TW201702218A (zh) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
| WO2016140971A1 (en) | 2015-03-02 | 2016-09-09 | The Regents Of The University Of California | Novel rad51 inhibitors and uses thereof |
| WO2016196955A1 (en) | 2015-06-04 | 2016-12-08 | Drexel University | Inhibitors of RAD52 Recombination Protein and Methods Using Same |
| EP3652159B1 (en) * | 2017-07-11 | 2023-01-18 | Cyteir Therapeutics, Inc. | Substituted thiazole derivatives as rad51 inhibitors for the treatment of cancer diseases, autoimmune and neurodegenerative conditions |
| EP4112616A1 (en) * | 2017-09-11 | 2023-01-04 | Cyteir Therapeutics, Inc. | Rad51 inhibitors |
| TW202104198A (zh) | 2019-03-12 | 2021-02-01 | 美商賽堤爾醫療公司 | Ｒａｄ５１抑制劑 |
| CN114173781A (zh) | 2019-03-25 | 2022-03-11 | 赛泰尔治疗公司 | Rad51和parp抑制剂的组合 |
-
2020
- 2020-03-12 TW TW109108203A patent/TW202104198A/zh unknown
- 2020-03-12 CN CN202080035279.0A patent/CN114072390B/zh active Active
- 2020-03-12 KR KR1020217032591A patent/KR20210127790A/ko unknown
- 2020-03-12 WO PCT/US2020/022293 patent/WO2020186006A1/en unknown
- 2020-03-12 IL IL285889A patent/IL285889B2/en unknown
- 2020-03-12 MX MX2021010916A patent/MX2021010916A/es unknown
- 2020-03-12 EP EP20768883.9A patent/EP3938358B1/en active Active
- 2020-03-12 BR BR112021017336A patent/BR112021017336A2/pt unknown
- 2020-03-12 AU AU2020235089A patent/AU2020235089A1/en active Pending
- 2020-03-12 US US16/816,393 patent/US11247988B2/en active Active
- 2020-03-12 SG SG11202109399SA patent/SG11202109399SA/en unknown
- 2020-03-12 JP JP2021553834A patent/JP7460649B2/ja active Active
- 2020-03-12 CA CA3132987A patent/CA3132987A1/en active Pending
-
2021
- 2021-08-30 ZA ZA2021/06284A patent/ZA202106284B/en unknown
- 2021-12-16 US US17/552,577 patent/US11932636B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020186006A1 (en) | 2020-09-17 |
| AU2020235089A1 (en) | 2021-09-23 |
| US20220259198A1 (en) | 2022-08-18 |
| CA3132987A1 (en) | 2020-09-17 |
| SG11202109399SA (en) | 2021-09-29 |
| JP7460649B2 (ja) | 2024-04-02 |
| ZA202106284B (en) | 2023-02-22 |
| US20200291014A1 (en) | 2020-09-17 |
| CN114072390B (zh) | 2024-06-11 |
| TW202104198A (zh) | 2021-02-01 |
| KR20210127790A (ko) | 2021-10-22 |
| EP3938358B1 (en) | 2024-10-02 |
| IL285889A (en) | 2021-10-31 |
| IL285889B2 (en) | 2024-09-01 |
| MX2021010916A (es) | 2021-10-01 |
| IL285889B1 (en) | 2024-05-01 |
| EP3938358A1 (en) | 2022-01-19 |
| US11932636B2 (en) | 2024-03-19 |
| JP2022525069A (ja) | 2022-05-11 |
| US11247988B2 (en) | 2022-02-15 |
| EP3938358A4 (en) | 2022-12-21 |
| CN114072390A (zh) | 2022-02-18 |
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