MX2020009237A - Composiciones inyectables de reparacion de cartilagos, tendones y ligamentos fuera del estante y metodos de uso. - Google Patents

Composiciones inyectables de reparacion de cartilagos, tendones y ligamentos fuera del estante y metodos de uso.

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Publication number
MX2020009237A
MX2020009237A MX2020009237A MX2020009237A MX2020009237A MX 2020009237 A MX2020009237 A MX 2020009237A MX 2020009237 A MX2020009237 A MX 2020009237A MX 2020009237 A MX2020009237 A MX 2020009237A MX 2020009237 A MX2020009237 A MX 2020009237A
Authority
MX
Mexico
Prior art keywords
cartilage
methods
tendon
injectable
shelf
Prior art date
Application number
MX2020009237A
Other languages
English (en)
Inventor
Terri-Ann Kelly
Eric Meade Jeffries
Olivia Spencer Beane
Angela Hai Huang
Sarindr Bhumiratana
Original Assignee
Epibone Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epibone Inc filed Critical Epibone Inc
Publication of MX2020009237A publication Critical patent/MX2020009237A/es

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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Abstract

Se proporcionan composiciones que comprenden un cuerpo de células mesenquimales condensadas y un hidrogel. Las composiciones pueden incluir además fármacos o factores de crecimiento. El cuerpo de células mesenquimales condensadas puede incluir una célula de tejido conectivo, o incluso una célula progenitora capaz de producir matrices extracelulares de tejido conectivo, tales como colágeno y glicosaminoglicano. También se proporcionan métodos para tratar defectos de tejido conectivo, lesión de cartílago y degradación de cartílago.
MX2020009237A 2018-03-06 2019-03-06 Composiciones inyectables de reparacion de cartilagos, tendones y ligamentos fuera del estante y metodos de uso. MX2020009237A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862639322P 2018-03-06 2018-03-06
PCT/US2019/020893 WO2019173435A1 (en) 2018-03-06 2019-03-06 Injectable off-the- shelf cartilage, tendon, and ligament repair compositions and methods of use

Publications (1)

Publication Number Publication Date
MX2020009237A true MX2020009237A (es) 2021-04-28

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Application Number Title Priority Date Filing Date
MX2020009237A MX2020009237A (es) 2018-03-06 2019-03-06 Composiciones inyectables de reparacion de cartilagos, tendones y ligamentos fuera del estante y metodos de uso.

Country Status (10)

Country Link
US (2) US20210047612A1 (es)
EP (1) EP3762480A4 (es)
JP (1) JP2021517121A (es)
KR (1) KR20210035776A (es)
CN (1) CN112567020A (es)
AU (1) AU2019231273A1 (es)
CA (1) CA3093069A1 (es)
MX (1) MX2020009237A (es)
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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110423721B (zh) * 2018-05-01 2024-02-27 云南济慈再生医学研究院有限公司 一种年轻化的修复型成纤维细胞的制备方法及其应用
CN111419874B (zh) * 2020-04-17 2021-08-13 南京鼓楼医院 一种负载MSCs来源外泌体的口服微球的制备方法及应用
CN111454901B (zh) * 2020-05-09 2022-07-12 山东兴瑞生物科技有限公司 一种脂肪干细胞诱导分化成软骨细胞的方法
EP4251175A1 (en) * 2020-11-25 2023-10-04 Flagship Pioneering, Inc. Adipogenic cell compositions and methods
KR102500398B1 (ko) * 2020-12-10 2023-02-16 (주)인벤티지랩 조직 수복용 주사제 조성물 및 이의 제조 방법
CN115007177B (zh) * 2022-06-17 2023-06-23 四川大学 一种CdSeS幻数纳米团簇及其作为光催化剂的用途
CN115487358B (zh) * 2022-08-05 2023-05-30 核工业四一六医院 一种用于软骨组织修复的凝胶复合支架及制备方法
PL442580A1 (pl) * 2022-10-19 2024-04-22 Alvanaeko Spółka Z Ograniczoną Odpowiedzialnością Sposób wytwarzania mączki ze skorupy i membrany jaja ptasiego
CN115671396A (zh) * 2022-11-02 2023-02-03 安徽科门生物科技有限公司 一种富含间充质干细胞的关节修复材料

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080822A1 (fr) * 2002-03-27 2003-10-02 Nipro Corporation Cellules mesenchymales placentaires et leur utilisation medicale
US20050069572A1 (en) * 2002-10-09 2005-03-31 Jennifer Elisseeff Multi-layered polymerizing hydrogels for tissue regeneration
BRPI0512831A (pt) * 2004-06-30 2008-04-08 Univ Illinois construção de tecido liso, método para preparação de uma construção de tecido liso, uso da construção de tecido liso, e composição
WO2008078157A2 (en) * 2006-04-28 2008-07-03 The University Of Hong Kong Bioengineered intervertebral discs and methods for their preparation
US8679809B2 (en) * 2006-05-19 2014-03-25 The University Of Hong Kong Cell-matrix microspheres, methods for preparation and applications
CN101011600A (zh) * 2006-11-30 2007-08-08 中国人民解放军第三军医大学第一附属医院 具有应力控释作用复合微球的脱钙骨支架及其制备方法
CN101020082B (zh) * 2007-03-09 2010-06-30 高心 一种骨修复材料及其制备方法和用途
KR101091084B1 (ko) * 2008-11-07 2011-12-09 한국과학기술연구원 연골 손상의 치료를 위한 세포군집체-하이드로겔-고분자 지지체 복합체, 이의 제조방법 및 이를 유효성분으로 함유하는 연골 손상 치료용 조성물
WO2010111278A1 (en) * 2009-03-23 2010-09-30 The Texas A&M University System Compositions of mesenchymal stem cells to regenerate bone
AU2010258356B2 (en) * 2009-06-12 2017-01-19 Generex Pharmaceuticals, Inc. Compositions and methods for prevention and treatment of brain diseases and conditions
EP3620185A1 (en) * 2010-10-06 2020-03-11 President and Fellows of Harvard College Injectable, pore-forming hydrogels for materials-based cell therapies
US9814802B2 (en) * 2012-04-30 2017-11-14 The University Of Kansas Method for promoting hair growth comprising implanting a tissue scaffold comprising CK-19 positive cells derived from Wharton's jelly mesenchymal stromal cells
CN102690436B (zh) * 2012-06-11 2013-12-25 北京大学 一种能够定向调控软骨细胞积聚的活性微球及其制备方法
KR101613478B1 (ko) * 2014-09-22 2016-04-19 (주)안트로젠 중간엽줄기세포-하이드로겔을 함유하는 조성물 및 이의 제조방법
CN104307046B (zh) * 2014-10-27 2016-06-08 南京医科大学附属南京医院 一种可注射骨髓间充质干细胞外基质/琼脂糖复合水凝胶及其制备方法和应用
US20160129155A1 (en) * 2014-11-07 2016-05-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Musculoskeletal tissue fabrication
SG11201705249XA (en) * 2015-01-23 2017-08-30 Univ Columbia Engineering mechanically functional human cartilage and method of making same
CN104651300B (zh) * 2015-02-11 2018-10-12 南开大学 一种三维复合细胞聚集体模型及其制备方法与应用
EP3090764A1 (en) * 2015-05-08 2016-11-09 Université Catholique De Louvain Compositions comprising mesenchymal stem cells and uses thereof
GB201509264D0 (en) * 2015-05-29 2015-07-15 Univ Leuven Kath Novel ATMP's
US10632230B2 (en) * 2015-07-10 2020-04-28 Warsaw Orthopedic, Inc. Implants having a high drug load of an oxysterol and methods of use

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