IT201900025126A1 - Uso di derivati dell’acido ialuronico nella rigenerazione dei tessuti ossei e cartilaginei - Google Patents
Uso di derivati dell’acido ialuronico nella rigenerazione dei tessuti ossei e cartilagineiInfo
- Publication number
- IT201900025126A1 IT201900025126A1 IT102019000025126A IT201900025126A IT201900025126A1 IT 201900025126 A1 IT201900025126 A1 IT 201900025126A1 IT 102019000025126 A IT102019000025126 A IT 102019000025126A IT 201900025126 A IT201900025126 A IT 201900025126A IT 201900025126 A1 IT201900025126 A1 IT 201900025126A1
- Authority
- IT
- Italy
- Prior art keywords
- cartilage
- regeneration
- hyaluronic acid
- acid derivatives
- bone tissues
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
- 210000000988 bone and bone Anatomy 0.000 title 1
- 210000000845 cartilage Anatomy 0.000 title 1
- 230000008929 regeneration Effects 0.000 title 1
- 238000011069 regeneration method Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
- A61L2300/214—Amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102019000025126A IT201900025126A1 (it) | 2019-12-20 | 2019-12-20 | Uso di derivati dell’acido ialuronico nella rigenerazione dei tessuti ossei e cartilaginei |
| AU2020410540A AU2020410540A1 (en) | 2019-12-20 | 2020-12-18 | Use of hyaluronic acid derivatives in the regeneration of bone and cartilage tissues |
| IL294054A IL294054A (en) | 2019-12-20 | 2020-12-18 | Hyaluronic acid derivatives for use in bone and cartilage tissue regeneration |
| KR1020227025172A KR20220140712A (ko) | 2019-12-20 | 2020-12-18 | 뼈 및 연골 조직의 재생에서 히알루론산 유도체의 사용 |
| US17/786,752 US20230018851A1 (en) | 2019-12-20 | 2020-12-18 | Use of hyaluronic acid derivatives in the regeneration of bone and cartilage tissues |
| CN202080094283.4A CN115135318A (zh) | 2019-12-20 | 2020-12-18 | “透明质酸衍生物在骨和软骨组织的再生中的用途” |
| BR112022012164A BR112022012164A2 (pt) | 2019-12-20 | 2020-12-18 | Composto de ácido hialurônico e pelo menos um heterociclo derivado de purina e/ou pirimidina, composto para uso, estrutura de suporte implantável e formulação farmacêutica |
| PCT/IB2020/062186 WO2021124249A1 (en) | 2019-12-20 | 2020-12-18 | Use of hyaluronic acid derivatives in the regeneration of bone and cartilage tissues |
| EP20830336.2A EP4076428A1 (en) | 2019-12-20 | 2020-12-18 | Use of hyaluronic acid derivatives in the regeneration of bone and cartilage tissues |
| MX2022007614A MX2022007614A (es) | 2019-12-20 | 2020-12-18 | Uso de derivados de ácido hialurónico en la regeneración de tejidos óseos y cartilaginoso. |
| CA3162397A CA3162397A1 (en) | 2019-12-20 | 2020-12-18 | Use of hyaluronic acid derivatives in the regeneration of bone and cartilage tissues |
| JP2022537401A JP2023506953A (ja) | 2019-12-20 | 2020-12-18 | ヒアルロン酸誘導体の骨及び軟骨組織の再生における使用 |
| ZA2022/07058A ZA202207058B (en) | 2019-12-20 | 2022-06-24 | Use of hyaluronic acid derivatives in the regeneration of bone and cartilage tissues |
| CONC2022/0010207A CO2022010207A2 (es) | 2019-12-20 | 2022-07-18 | Uso de derivados del ácido hialurónico en la regeneración de tejidos óseos y cartilaginosos |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102019000025126A IT201900025126A1 (it) | 2019-12-20 | 2019-12-20 | Uso di derivati dell’acido ialuronico nella rigenerazione dei tessuti ossei e cartilaginei |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IT201900025126A1 true IT201900025126A1 (it) | 2021-06-20 |
Family
ID=70295628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT102019000025126A IT201900025126A1 (it) | 2019-12-20 | 2019-12-20 | Uso di derivati dell’acido ialuronico nella rigenerazione dei tessuti ossei e cartilaginei |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20230018851A1 (it) |
| EP (1) | EP4076428A1 (it) |
| JP (1) | JP2023506953A (it) |
| KR (1) | KR20220140712A (it) |
| CN (1) | CN115135318A (it) |
| AU (1) | AU2020410540A1 (it) |
| BR (1) | BR112022012164A2 (it) |
| CA (1) | CA3162397A1 (it) |
| CO (1) | CO2022010207A2 (it) |
| IL (1) | IL294054A (it) |
| IT (1) | IT201900025126A1 (it) |
| MX (1) | MX2022007614A (it) |
| WO (1) | WO2021124249A1 (it) |
| ZA (1) | ZA202207058B (it) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6761887B1 (en) * | 1998-11-16 | 2004-07-13 | Osiris Therapeutics, Inc. | Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells |
| EP1525244A1 (en) | 2002-07-22 | 2005-04-27 | Basf Corporation | Polyether polyol for foam applications |
| EP1525224A1 (en) * | 2002-07-26 | 2005-04-27 | Jasper Ltd. Liability Co. | Hyaluronic acid derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1195982A (zh) * | 1995-06-12 | 1998-10-14 | 依达研究发展有限公司 | 用作间充质骨骼祖细胞标记物的成纤维细胞生长因子受体3 |
| WO2000029552A1 (en) * | 1998-11-16 | 2000-05-25 | Osiris Therapeutics, Inc. | Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells |
| CN101622350A (zh) * | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | 作为干预治疗靶标的miR-126调控基因和通路 |
| KR101706642B1 (ko) * | 2015-02-04 | 2017-02-17 | 주식회사 엑소스템텍 | 연골세포로 분화되고 있는 줄기세포로부터 추출된 엑소좀을 포함하는 연골세포 분화 유도 또는 연골조직 재생용 조성물 |
| JP2022502379A (ja) * | 2018-09-20 | 2022-01-11 | カルティラゴ エッセ．エレ．エレ． | 細胞外マトリクスの合成を促進するグルコサミンのアミノ酸誘導体、及びこれを含む医薬組成物 |
-
2019
- 2019-12-20 IT IT102019000025126A patent/IT201900025126A1/it unknown
-
2020
- 2020-12-18 CA CA3162397A patent/CA3162397A1/en active Pending
- 2020-12-18 US US17/786,752 patent/US20230018851A1/en active Pending
- 2020-12-18 WO PCT/IB2020/062186 patent/WO2021124249A1/en unknown
- 2020-12-18 BR BR112022012164A patent/BR112022012164A2/pt unknown
- 2020-12-18 IL IL294054A patent/IL294054A/en unknown
- 2020-12-18 CN CN202080094283.4A patent/CN115135318A/zh active Pending
- 2020-12-18 JP JP2022537401A patent/JP2023506953A/ja active Pending
- 2020-12-18 MX MX2022007614A patent/MX2022007614A/es unknown
- 2020-12-18 KR KR1020227025172A patent/KR20220140712A/ko unknown
- 2020-12-18 AU AU2020410540A patent/AU2020410540A1/en active Pending
- 2020-12-18 EP EP20830336.2A patent/EP4076428A1/en active Pending
-
2022
- 2022-06-24 ZA ZA2022/07058A patent/ZA202207058B/en unknown
- 2022-07-18 CO CONC2022/0010207A patent/CO2022010207A2/es unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6761887B1 (en) * | 1998-11-16 | 2004-07-13 | Osiris Therapeutics, Inc. | Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells |
| EP1525244A1 (en) | 2002-07-22 | 2005-04-27 | Basf Corporation | Polyether polyol for foam applications |
| EP1525224A1 (en) * | 2002-07-26 | 2005-04-27 | Jasper Ltd. Liability Co. | Hyaluronic acid derivatives |
Non-Patent Citations (4)
| Title |
|---|
| ADRIANA DI BENEDETTO ET AL: "Osteogenic and Chondrogenic Potential of the Supramolecular Aggregate T-LysYal", FRONTIERS IN ENDOCRINOLOGY, vol. 11, 5 May 2020 (2020-05-05), XP055726171, DOI: 10.3389/fendo.2020.00285 * |
| M GELARDI ET AL: "Intranasal T-LysYal as adjunctive therapy for patients after functional endoscopic sinus surgery", J BIOL REGUL HOMEOST AGENTS, vol. 30, no. 1, 1 January 2016 (2016-01-01), pages 277 - 284, XP055726177 * |
| PALMER G D ET AL: "Gene-Induced Chondrogenesis of Primary Mesenchymal Stem Cells in vitro", MOLECULAR THERAPY, CELL PRESS, US, vol. 12, no. 2, 1 August 2005 (2005-08-01), pages 219 - 228, XP004991967, ISSN: 1525-0016, DOI: 10.1016/J.YMTHE.2005.03.024 * |
| STEFANO BARABINO ET AL: "Efficacy of a New Ocular Surface Modulator in Restoring Epithelial Changes in an In Vitro Model of Dry Eye Syndrome", CURRENT EYE RESEARCH, vol. 42, no. 3, 4 March 2017 (2017-03-04), US, pages 358 - 363, XP055726183, ISSN: 0271-3683, DOI: 10.1080/02713683.2016.1184282 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021124249A1 (en) | 2021-06-24 |
| MX2022007614A (es) | 2022-10-20 |
| KR20220140712A (ko) | 2022-10-18 |
| CN115135318A (zh) | 2022-09-30 |
| JP2023506953A (ja) | 2023-02-20 |
| CA3162397A1 (en) | 2021-06-24 |
| CO2022010207A2 (es) | 2022-10-21 |
| IL294054A (en) | 2022-08-01 |
| ZA202207058B (en) | 2023-05-31 |
| AU2020410540A1 (en) | 2022-07-21 |
| BR112022012164A2 (pt) | 2022-09-13 |
| EP4076428A1 (en) | 2022-10-26 |
| US20230018851A1 (en) | 2023-01-19 |
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