MX2018013341A - Analisis de macromoleculas que emplea la codificacion de acido nucleico. - Google Patents

Analisis de macromoleculas que emplea la codificacion de acido nucleico.

Info

Publication number
MX2018013341A
MX2018013341A MX2018013341A MX2018013341A MX2018013341A MX 2018013341 A MX2018013341 A MX 2018013341A MX 2018013341 A MX2018013341 A MX 2018013341A MX 2018013341 A MX2018013341 A MX 2018013341A MX 2018013341 A MX2018013341 A MX 2018013341A
Authority
MX
Mexico
Prior art keywords
nucleic acid
analysis
acid coding
macromolecules used
macromolecules
Prior art date
Application number
MX2018013341A
Other languages
English (en)
Spanish (es)
Inventor
Gunderson Kevin
Phillip Weiner Michael
Original Assignee
Encodia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Encodia Inc filed Critical Encodia Inc
Publication of MX2018013341A publication Critical patent/MX2018013341A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G01N33/6824—Sequencing of polypeptides involving N-terminal degradation, e.g. Edman degradation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6416—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C40B20/04—Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/619—Detection means characterised by use of a special device being a video camera
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Peptides Or Proteins (AREA)
MX2018013341A 2016-05-02 2017-05-02 Analisis de macromoleculas que emplea la codificacion de acido nucleico. MX2018013341A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662330841P 2016-05-02 2016-05-02
US201662339071P 2016-05-19 2016-05-19
US201662376886P 2016-08-18 2016-08-18
PCT/US2017/030702 WO2017192633A1 (en) 2016-05-02 2017-05-02 Macromolecule analysis employing nucleic acid encoding

Publications (1)

Publication Number Publication Date
MX2018013341A true MX2018013341A (es) 2019-09-18

Family

ID=60203299

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018013341A MX2018013341A (es) 2016-05-02 2017-05-02 Analisis de macromoleculas que emplea la codificacion de acido nucleico.

Country Status (12)

Country Link
US (10) US12123878B2 (enExample)
EP (2) EP3452591B1 (enExample)
JP (5) JP7120630B2 (enExample)
KR (3) KR102516168B1 (enExample)
CN (3) CN119574873A (enExample)
AU (1) AU2017259794B2 (enExample)
CA (1) CA3022863A1 (enExample)
DK (1) DK3452591T5 (enExample)
MX (1) MX2018013341A (enExample)
NZ (1) NZ747941A (enExample)
SG (2) SG10201911917WA (enExample)
WO (1) WO2017192633A1 (enExample)

Families Citing this family (191)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
WO2016069124A1 (en) 2014-09-15 2016-05-06 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
GB2577626B (en) 2011-06-23 2020-09-23 Univ Texas Identifying peptides at the single molecule level
EP3901280B1 (en) 2012-10-17 2025-03-12 10x Genomics Sweden AB Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
WO2014144340A1 (en) 2013-03-15 2014-09-18 Ancera, Inc. Systems and methods for three-dimensional extraction of target particles ferrofluids
US20160299132A1 (en) 2013-03-15 2016-10-13 Ancera, Inc. Systems and methods for bead-based assays in ferrofluids
AU2016207023B2 (en) 2015-01-12 2019-12-05 10X Genomics, Inc. Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
EP4321627A3 (en) 2015-04-10 2024-04-17 10x Genomics Sweden AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US11285490B2 (en) 2015-06-26 2022-03-29 Ancera, Llc Background defocusing and clearing in ferrofluid-based capture assays
KR102516168B1 (ko) 2016-05-02 2023-03-30 엔코디아, 인코포레이티드 암호화 핵산을 사용한 거대분자 분석
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
CN109790574A (zh) 2016-07-22 2019-05-21 哈佛学院院长及董事 用于蛋白质鉴别的方法和组合物
IL265478B2 (en) * 2016-09-26 2024-10-01 Becton Dickinson Co Measurement of protein expression using reagents with barcoded oligonucleotide sequences
KR102521152B1 (ko) 2016-11-16 2023-04-13 카탈로그 테크놀로지스, 인크. 핵산-기반 데이터 저장용 시스템
JP2020514746A (ja) 2016-12-01 2020-05-21 ノーティラス バイオテクノロジー インコーポレイテッド タンパク質をアッセイする方法
JP7093355B2 (ja) * 2016-12-16 2022-06-29 アラトム， エルエルシー ライゲーション増幅を使用する分子検出
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4310183B1 (en) 2017-01-30 2025-07-09 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
GB201707140D0 (en) * 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Method
JP7536450B2 (ja) 2017-06-05 2024-08-20 ベクトン・ディキンソン・アンド・カンパニー 単一細胞用のサンプルインデックス付加
GB201715684D0 (en) 2017-09-28 2017-11-15 Univ Gent Means and methods for single molecule peptide sequencing
US20200256862A1 (en) * 2017-10-23 2020-08-13 Massachusetts Institute Of Technology Functionalized solid support
US20210355483A1 (en) * 2017-10-31 2021-11-18 Encodia, Inc. Methods and kits using nucleic acid encoding and/or label
MX2020004559A (es) 2017-10-31 2020-10-05 Encodia Inc Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico.
EP3714053B1 (en) 2017-11-22 2025-12-31 The University of Chicago CHEMICALLY DEPENDENT PROBE EVALUATION OF PROTEIN ACTIVITY AND ITS USES
CA3086915A1 (en) 2017-12-29 2019-07-04 Sujal M. Patel Decoding approaches for protein identification
EP3752832A1 (en) 2018-02-12 2020-12-23 10X Genomics, Inc. Methods characterizing multiple analytes from individual cells or cell populations
KR102998495B1 (ko) 2018-03-16 2026-07-31 카탈로그 테크놀로지스, 인크. 핵산-기반 데이터를 저장하기 위한 화학적 방법들
JP7326778B2 (ja) * 2018-03-19 2023-08-16 株式会社リコー 核酸試料含有容器、核酸試料含有容器の製造方法、核酸試料含有容器の製造装置及び核酸試料含有容器の製造プログラム、並びに、核酸試料
CA3097976A1 (en) 2018-05-03 2019-11-07 Becton, Dickinson And Company High throughput multiomics sample analysis
AU2019301750A1 (en) 2018-07-12 2021-01-28 Board Of Regents, The University Of Texas System Molecular neighborhood detection by oligonucleotides
CN108866046A (zh) * 2018-07-25 2018-11-23 辽宁润基生物科技有限公司 一种分离、纯化样品中外泌体和/或游离核酸的方法
US20200032335A1 (en) 2018-07-27 2020-01-30 10X Genomics, Inc. Systems and methods for metabolome analysis
WO2020028912A2 (en) 2018-08-03 2020-02-06 Catolog Technologies, Inc Systems and methods for storing and reading nucleic acid-based data with error protection
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
AU2019334983A1 (en) * 2018-09-04 2021-03-18 Encodia, Inc. Proximity interaction analysis
US11828684B2 (en) 2018-09-17 2023-11-28 California Institute Of Technology Detection of molecular associations
US11078480B2 (en) * 2018-09-19 2021-08-03 California Institute Of Technology High-throughput identification of intermolecular interactions
US20210340192A1 (en) * 2018-10-05 2021-11-04 University Of Washington Reporter constructs for nanopore-based detection of biological activity
WO2020072907A1 (en) 2018-10-05 2020-04-09 Board Of Regents, The University Of Texas System Solid-phase n-terminal peptide capture and release
TWI863941B (zh) 2018-11-15 2024-12-01 美商寬騰矽公司 用於蛋白質定序之方法及組合物
US11459607B1 (en) 2018-12-10 2022-10-04 10X Genomics, Inc. Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
US12529094B2 (en) 2018-12-10 2026-01-20 10X Genomics, Inc. Imaging system hardware
EP3894585A2 (en) 2018-12-10 2021-10-20 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
WO2020146325A1 (en) * 2019-01-08 2020-07-16 Massachusetts Institute Of Technology Single-molecule protein and peptide sequencing
WO2020154208A1 (en) * 2019-01-21 2020-07-30 Encodia, Inc. Methods and compositions of accelerating reactions for polypeptide analysis and related uses
WO2020154307A1 (en) * 2019-01-22 2020-07-30 Singular Genomics Systems, Inc. Polynucleotide barcodes for multiplexed proteomics
WO2020163789A1 (en) * 2019-02-08 2020-08-13 The Trustees Of Columbia University In The City Of New York Single cell/exosome/vesicle protein profiling
CN113454234B (zh) 2019-02-14 2025-03-18 贝克顿迪金森公司 杂合体靶向和全转录物组扩增
MX2021011726A (es) * 2019-03-26 2021-10-22 Encodia Inc Escindasas modificadas, usos de las mismas y kits relacionados.
US11427814B2 (en) 2019-03-26 2022-08-30 Encodia, Inc. Modified cleavases, uses thereof and related kits
CA3137716A1 (en) * 2019-04-23 2020-10-29 Encodia, Inc. Methods for spatial analysis of proteins and related kits
EP3963070A4 (en) * 2019-04-30 2023-02-22 Encodia, Inc. METHODS OF PREPARATION OF ANALYTES AND RELATED KITS
CN114793437A (zh) * 2019-04-30 2022-07-26 Encodia 公司 用于从多肽上切割n端氨基酸的方法和试剂
KR20220017409A (ko) 2019-05-09 2022-02-11 카탈로그 테크놀로지스, 인크. Dna 기반 데이터 저장소에서 검색, 컴퓨팅 및 인덱싱하기 위한 데이터 구조 및 동작
US20220235405A1 (en) * 2019-05-20 2022-07-28 Encodia, Inc. Methods and related kits for spatial analysis
EP3976820A1 (en) 2019-05-30 2022-04-06 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2020254672A1 (en) * 2019-06-19 2020-12-24 Therycell Gmbh Spatial characterisation of target structures in a sample
US11346842B2 (en) 2019-06-20 2022-05-31 Massachusetts Institute Of Technology Single molecule peptide sequencing methods
AU2020310613B2 (en) * 2019-07-08 2026-02-05 Ludwig Institute For Cancer Research Ltd Bisulfite-free, whole genome methylation analysis
CN110689929B (zh) * 2019-08-29 2021-12-17 浙江工业大学 一种基于接触概率辅助的蛋白质atp对接方法
US11535842B2 (en) 2019-10-11 2022-12-27 Catalog Technologies, Inc. Nucleic acid security and authentication
MX2022005093A (es) * 2019-10-28 2022-08-11 Quantum Si Inc Métodos de secuenciación de proteína de una sola célula y ácido nucleico.
MX2022005092A (es) * 2019-10-28 2022-08-15 Quantum Si Inc Métodos, kits y dispositivos para preparar muestas para secuenciación de polipéptidos múltiplex.
EP4025711A2 (en) 2019-11-08 2022-07-13 10X Genomics, Inc. Enhancing specificity of analyte binding
EP4055160B1 (en) 2019-11-08 2024-04-10 Becton Dickinson and Company Using random priming to obtain full-length v(d)j information for immune repertoire sequencing
EP4081656A1 (en) 2019-12-23 2022-11-02 10X Genomics, Inc. Compositions and methods for using fixed biological samples in partition-based assays
CN121022991A (zh) 2019-12-23 2025-11-28 10X基因组学有限公司 使用rna模板化连接进行空间分析的方法
EP4752521A3 (en) 2019-12-23 2026-08-12 10X Genomics, Inc. Reversible fixing reagents and methods of use thereof
WO2021141922A1 (en) * 2020-01-07 2021-07-15 Encodia, Inc. Methods for information transfer and related kits
US11169157B2 (en) 2020-01-07 2021-11-09 Encodia, Inc. Methods for stable complex formation and related kits
WO2021141924A1 (en) 2020-01-07 2021-07-15 Encodia, Inc. Methods for stable complex formation and related kits
CN115279919A (zh) 2020-01-13 2022-11-01 贝克顿迪金森公司 使用含有du的寡核苷酸的细胞捕获
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
WO2021155057A1 (en) 2020-01-29 2021-08-05 Becton, Dickinson And Company Barcoded wells for spatial mapping of single cells through sequencing
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US12129516B2 (en) 2020-02-07 2024-10-29 10X Genomics, Inc. Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
CN116157533A (zh) * 2020-02-21 2023-05-23 10X基因组学有限公司 使用杂交方法捕获遗传靶标
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US12153043B2 (en) 2020-02-25 2024-11-26 Becton, Dickinson And Company Bi-specific probes to enable the use of single-cell samples as single color compensation control
KR102376443B1 (ko) * 2020-02-26 2022-03-17 포항공과대학교 산학협력단 나노구조체, 나노구조체를 포함하는 바이오센서, 및 스크리닝 방법
KR102482668B1 (ko) * 2020-03-10 2022-12-29 사회복지법인 삼성생명공익재단 고유 분자 식별자의 표지 정확도를 증진하는 방법
ES3069667T3 (en) 2020-03-24 2026-06-09 Encodia Inc Modified dipeptide cleavases, uses thereof and related kits
CN112280829B (zh) * 2020-04-07 2023-12-26 南方科技大学 一种试剂盒、样本标记方法、单细胞测序方法
EP4136255A4 (en) * 2020-04-16 2024-06-05 Singleron (Nanjing) Biotechnologies, Ltd. METHODS AND COMPOSITIONS FOR HIGH-THROUGHPUT SINGLE-CELL TARGET SEQUENCING
WO2021216763A1 (en) * 2020-04-22 2021-10-28 Quantum-Si Incorporated Devices and methods for sequencing
EP4139485B1 (en) 2020-04-22 2023-09-06 10X Genomics, Inc. Methods for spatial analysis using targeted rna depletion
CA3183416A1 (en) 2020-05-11 2021-11-18 Catalog Technologies, Inc. Programs and functions in dna-based data storage
WO2021231779A1 (en) 2020-05-14 2021-11-18 Becton, Dickinson And Company Primers for immune repertoire profiling
AU2021276522A1 (en) 2020-05-20 2023-01-05 Quantum-Si Incorporated Methods and compositions for protein sequencing
AU2021275906A1 (en) 2020-05-22 2022-12-22 10X Genomics, Inc. Spatial analysis to detect sequence variants
EP4153775B1 (en) 2020-05-22 2024-07-24 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
CN115803445A (zh) 2020-06-02 2023-03-14 贝克顿迪金森公司 用于5撇基因表达测定的寡核苷酸和珠
EP4025692A2 (en) 2020-06-02 2022-07-13 10X Genomics, Inc. Nucleic acid library methods
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
EP4421186B1 (en) 2020-06-08 2025-08-13 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
EP4446430A3 (en) 2020-06-10 2024-12-18 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
CA3182266A1 (en) 2020-06-11 2021-12-16 Vadim Lobanov Methods and systems for computational decoding of biological, chemical, and physical entities
EP4450639B1 (en) 2020-06-25 2025-10-15 10X Genomics, Inc. Spatial analysis of dna methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
WO2022015845A2 (en) * 2020-07-14 2022-01-20 Ancera Llc Systems, devices and methods for analysis
US11492662B2 (en) 2020-08-06 2022-11-08 Singular Genomics Systems, Inc. Methods for in situ transcriptomics and proteomics
US11434525B2 (en) 2020-08-06 2022-09-06 Singular Genomics Systems, Inc. Spatial sequencing
CN116685725A (zh) * 2020-08-19 2023-09-01 Encodia 公司 顺序编码方法和相关试剂盒
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
CA3188680A1 (en) * 2020-08-21 2022-02-24 Arjun Ganesan Systems, devices and methods for determining most probable number in biological sample analysis
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
WO2022094148A1 (en) 2020-10-30 2022-05-05 Encodia, Inc. Conjugation reagents and methods using 1,2-cyclohexanediones
EP4244382A1 (en) 2020-11-11 2023-09-20 Nautilus Subsidiary, Inc. Affinity reagents having enhanced binding and detection characteristics
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
WO2022140028A1 (en) 2020-12-21 2022-06-30 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
US20240067956A1 (en) * 2021-01-13 2024-02-29 The Regents Of The University Of Colorado, A Body Corporate Methods and compositions for molecular tracking in individual cells in vivo
CA3203106A1 (en) 2021-01-20 2022-07-28 Parag Mallick Systems and methods for biomolecule quantitation
US20220227890A1 (en) 2021-01-21 2022-07-21 Nautilus Biotechnology, Inc. Systems and methods for biomolecule preparation
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
EP4305196B1 (en) 2021-04-14 2025-04-02 10X Genomics, Inc. Methods of measuring mislocalization of an analyte
WO2022235764A1 (en) 2021-05-05 2022-11-10 Singular Genomics Systems, Inc. Multiomic analysis device and methods of use thereof
EP4320271B1 (en) 2021-05-06 2025-03-19 10X Genomics, Inc. Methods for increasing resolution of spatial analysis
CN117396613A (zh) * 2021-06-01 2024-01-12 10X基因组学有限公司 用于分析物检测和探针解析的方法和组合物
US12704508B2 (en) 2021-06-02 2026-08-11 Alamar Biosciences, Inc. Nucleic acid linked immune-sandwich assay (NULISA)
ES3030033T3 (en) 2021-06-03 2025-06-26 10X Genomics Inc Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
CA3222270A1 (en) 2021-06-24 2022-12-29 Vadim Lobanov Methods and systems for assay refinement
US11521947B1 (en) * 2021-07-14 2022-12-06 Nxp Usa, Inc. Space efficient flip chip joint design
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
EP4399528A1 (en) 2021-09-09 2024-07-17 Nautilus Subsidiary, Inc. Characterization and localization of protein modifications
EP4405683A1 (en) 2021-09-22 2024-07-31 Nautilus Subsidiary, Inc. Methods and systems for determining polypeptide interactions
WO2023081728A1 (en) 2021-11-03 2023-05-11 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
US12474346B2 (en) * 2021-11-05 2025-11-18 Encodia, Inc. Methods and kits for multicycle encoding assay
EP4419707A1 (en) 2021-11-10 2024-08-28 10X Genomics, Inc. Methods, compositions, and kits for determining the location of an analyte in a biological sample
WO2023086847A1 (en) * 2021-11-10 2023-05-19 Encodia, Inc. Methods for barcoding macromolecules in individual cells
EP4441503A1 (en) 2021-11-30 2024-10-09 Nautilus Subsidiary, Inc. Particle-based isolation of proteins and other analytes
EP4305195A2 (en) 2021-12-01 2024-01-17 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
CA3240747A1 (en) * 2021-12-14 2023-06-22 Daniel Masao Estandian Single-molecule peptide sequencing through molecular barcoding and ex-situ analysis
US20230193248A1 (en) * 2021-12-16 2023-06-22 Encodia, Inc. Methods for protein identification based on encoding reactions
EP4206674B1 (en) 2021-12-28 2025-10-22 Encodia, Inc. High-throughput serotyping and antibody profiling assays
CA3245990A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary, Inc. INTEGRATED NETWORKS FOR SINGLE-ANALYTE PROCESSES
US20230331770A1 (en) * 2022-04-13 2023-10-19 Encodia, Inc. Arginine modification and conjugation methods
EP4515026A1 (en) 2022-04-25 2025-03-05 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
US20240000947A1 (en) * 2022-05-24 2024-01-04 Encodia, Inc. Polypeptide modification and conjugation methods
WO2023250364A1 (en) 2022-06-21 2023-12-28 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
AU2023308308A1 (en) 2022-07-12 2025-02-13 Abrus Bio, Inc. Determination of protein information by recoding amino acid polymers into dna polymers
EP4565882A1 (en) * 2022-08-02 2025-06-11 Glyphic Biotechnologies, Inc. Protein sequencing via coupling of polymerizable molecules
WO2024040236A2 (en) 2022-08-19 2024-02-22 Abrus Bio, Inc. Determination of protein information by recoding amino acid polymers into dna polymers
WO2024058967A1 (en) 2022-09-13 2024-03-21 Nautilus Subsidiary, Inc. Systems and methods of validating new affinity reagents
WO2024059655A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
CN115951051B (zh) * 2022-10-18 2024-01-12 北京卓诚惠生生物科技股份有限公司 一种高灵敏度新型冠状病毒抗原胶体金检测试剂盒及其制备方法
EP4685239A1 (en) 2022-11-09 2026-01-28 10X Genomics, Inc. Methods, compositions, and kits for determining the location of multiple analytes in a biological sample
US20240192202A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. Fluidic media for single-analtye arrays
EP4634285A1 (en) 2022-12-15 2025-10-22 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
WO2024148174A1 (en) * 2023-01-05 2024-07-11 Oregon Health & Science University Peptide sequencer
AU2024226392A1 (en) * 2023-02-24 2025-09-11 The Board Of Trustees Of The Leland Stanford Junior University Methods of sequencing polypeptides and related compositions
US20240301469A1 (en) 2023-02-24 2024-09-12 Nautilus Subsidiary, Inc. Modifying, separating and detecting proteoforms
EP4689173A1 (en) 2023-03-24 2026-02-11 Nautilus Subsidiary, Inc. Improved transfer of nanoparticles to array surfaces
US20240394902A1 (en) 2023-05-24 2024-11-28 Nautilus Subsidiary, Inc. Systems and methods for machine vision
EP4720332A1 (en) 2023-06-01 2026-04-08 Singular Genomics Systems, Inc. Methods and probes for detecting polynucleotide sequences in cells and tissues
US20240426839A1 (en) 2023-06-21 2024-12-26 Nautilus Subsidiary, Inc. Compositions and methods for improving affinity reagent avidity
US20250066841A1 (en) 2023-08-24 2025-02-27 Nautilus Subsidiary, Inc. Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions
WO2025079184A1 (ja) * 2023-10-11 2025-04-17 中外製薬株式会社 複数のライブラリを用いたペプチドのスクリーニング方法
IL328221A (en) * 2023-11-09 2026-07-01 2026 Df Peptide Acquisition Llc Methods for identifying polypeptides
US20250154579A1 (en) * 2023-11-12 2025-05-15 Interplay Bio System and method for high throughput screening of small molecule-protein interactions
US20250189519A1 (en) 2023-12-11 2025-06-12 Nautilus Subsidiary, Inc. Methods and compositions of particle-based arrays
US20250205706A1 (en) 2023-12-20 2025-06-26 Nautilus Subsidiary, Inc. Fluidic devices for single-analyte assays
US20250298016A1 (en) 2024-03-22 2025-09-25 Nautilus Subsidiary, Inc. Plasmonic particle systems for single-analyte assays
US20250305034A1 (en) 2024-04-01 2025-10-02 Nautilus Subsidiary, Inc. Nanostructures for modulation of analyte conformation
CN120666033A (zh) * 2024-05-28 2025-09-19 岚图生物科技(苏州)有限公司 一种偶联含有索引的pcr引物的微粒及其应用
CN118335197B (zh) * 2024-06-17 2024-09-24 南方科技大学 一种基于纳米孔测序芯片的dna数据存储方法
CN118988183B (zh) * 2024-08-09 2025-07-15 中国农业科学院油料作物研究所 一种富含甘油二酯的健康食用油制备方法及其产品
US20260185996A1 (en) * 2024-08-16 2026-07-02 Quantum-Si Incorporated Methods of controlled cleavage
WO2026058694A1 (ja) * 2024-09-11 2026-03-19 国立大学法人 東京大学 核酸合成用固相担体（ｓｏｌｉｄ－ｐｈａｓｅ ｓｕｐｐｏｒｔ ｆｏｒ ｎｕｃｌｅｉｃ ａｃｉｄ ｓｙｎｔｈｅｓｉｓ）
US20260092914A1 (en) 2024-09-27 2026-04-02 Nautilus Subsidiary, Inc. Single analyte characterization under equilibrium binding conditions
KR102804035B1 (ko) 2024-12-09 2025-05-09 주식회사 비씨젠 이차전지 캡 용접 장치
US20260193640A1 (en) 2024-12-11 2026-07-09 Nautilus Subsidiary, Inc. Screening and characterization of binding reagents under equilibrium conditions
CN119851760B (zh) * 2025-01-14 2025-09-30 大连理工大学 一种基于三进制dna编码库的核酸检测方法

Family Cites Families (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863870A (en) 1988-03-10 1989-09-05 Bio-Affinity Systems, Inc. Method of thioacylation peptide sequencing with alcoholysis of thiazolinones
US5484735A (en) 1989-08-23 1996-01-16 Northwestern University Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids
US5049507A (en) 1989-12-21 1991-09-17 Applied Biosystems, Inc. Method of C-terminal peptide sequencing
EP0604552B1 (en) 1991-09-18 1997-02-12 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
SE9400088D0 (sv) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
CA2176414A1 (en) 1995-05-18 1996-11-19 S. David Kimball Acyl guanidine and amidine prodrugs
EP0841945B1 (en) 1995-08-03 2006-03-08 Rijksuniversiteit te Leiden Cell derived antigen presenting vesicles
JP3124507B2 (ja) 1996-05-24 2001-01-15 セイコーインスツルメンツ株式会社 タンパク質あるいはペプチドのカルボキシ末端からのアミノ酸配列を決定する方法
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
IL131016A (en) 1997-01-21 2004-12-15 Gen Hospital Corp Selection of proteins using RNA-protein blends
US6306588B1 (en) 1997-02-07 2001-10-23 Invitrogen Corporation Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof
AU2206800A (en) 1998-12-11 2000-06-26 Regents Of The University Of California, The Targeted molecular bar codes and methods for using the same
US6875851B1 (en) 1999-03-05 2005-04-05 University Of Georgia Research Foundation, Inc. Prolyl tripeptidyl peptidases nucleic acid of Porphyromonas gingivalis
SK13242001A3 (sk) * 1999-03-23 2002-09-10 Biovation Limited Izolácia a analýza proteínov
AU5723700A (en) 1999-05-25 2000-12-12 Praelux Incorporated Method for sequency and characterizing polymeric biomolecules using aptamers anda method for producing aptamers
CA2377468C (en) 1999-07-27 2010-04-20 Phylos, Inc. Peptide acceptor ligation methods
GB9927320D0 (en) 1999-11-18 2000-01-12 Chiron Spa Exosome separation
US7306904B2 (en) 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
US6511809B2 (en) 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
CA2314398A1 (en) 2000-08-10 2002-02-10 Edward Shipwash Microarrays and microsystems for amino acid analysis and protein sequencing
US6800453B2 (en) 2001-01-23 2004-10-05 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
US20030087232A1 (en) * 2001-01-25 2003-05-08 Fred Christians Methods for screening polypeptides
US7727713B2 (en) 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
WO2003004656A1 (en) 2001-07-06 2003-01-16 Institut Pasteur Method for obtaining cells with new properties
US7169894B2 (en) 2001-11-14 2007-01-30 Mirari Biosciences, Inc. Methods and compositions for reverse translation
US8013134B2 (en) 2001-11-23 2011-09-06 Olink Ab Kit for proximity probing with multivalent proximity probes
AU2003300257A1 (en) * 2002-05-21 2004-05-04 Northwestern University Peptide and protein arrays and direct-write lithographic printing of peptides and proteins
DE10242016A1 (de) 2002-09-11 2004-03-25 Esplora GmbH c/o TU Darmstadt Institut für Biochemie Verfahren zur Identifizierung BHS-spezifischer Proteine und Fragmente davon
CA2501645A1 (en) 2002-10-10 2004-04-22 Verenium Corporation Proteases, nucleic acids encoding them and methods for making and using them
US20090246879A1 (en) * 2002-12-20 2009-10-01 Callida Genomics Materials and Methods Relating to Nano-Tags and Nano-Brands
WO2005015239A2 (en) 2003-08-07 2005-02-17 Cornell Research Foundation, Inc. Method for n-terminal labeling of proteins
US7198900B2 (en) 2003-08-29 2007-04-03 Applera Corporation Multiplex detection compositions, methods, and kits
ATE447626T1 (de) * 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
US7579165B2 (en) 2003-10-16 2009-08-25 Shimadzu Corporation Methods for derivatizing protein or peptide with sulfonic acid groups
CN1898257B (zh) 2003-12-17 2010-06-23 普雷西斯药品公司 合成编码文库的方法
GB0404187D0 (en) 2004-02-25 2004-03-31 Biotransformations Ltd Binding agents
WO2005090566A2 (en) 2004-03-22 2005-09-29 Nuevolution A/S Ligational encoding using building block oligonucleotides
CA2563168A1 (en) 2004-04-14 2005-11-17 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US20060199279A1 (en) 2005-03-07 2006-09-07 Viorica Lopez-Avila Methods for identifying post-translationally modified polypeptides
US7229769B2 (en) 2005-03-25 2007-06-12 Illumina, Inc. Compositions and methods for detecting protease activity
US7883848B2 (en) 2005-07-08 2011-02-08 Olink Ab Regulation analysis by cis reactivity, RACR
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
US7611834B2 (en) 2005-09-30 2009-11-03 Sandia Corporation Methods and devices for protein assays
LT3018206T (lt) * 2005-12-01 2021-12-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei
US20070218503A1 (en) 2006-02-13 2007-09-20 Mitra Robi D Methods of polypeptide identification, and compositions therefor
DE102006015001A1 (de) 2006-03-31 2007-10-11 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Verfahren zum Nachweis und/oder zur Anreicherung von Analytproteinen und/oder Analytpeptiden aus einer komplexen Proteinmischung
US8758991B2 (en) 2006-04-26 2014-06-24 University Of Louisville Research Foundation, Inc. Isolation of membrane vesicles from biological fluids and methods of using same
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
WO2009019215A1 (en) 2007-08-03 2009-02-12 Dkfz Deutsches Krebsforschungszentrum Method for prenatal diagnosis using exosomes and cd24 as a marker
US20100311114A1 (en) 2007-10-19 2010-12-09 Pronota N.V. Preparation of samples for proteome analysis
WO2010065531A1 (en) 2008-12-01 2010-06-10 Robi David Mitra Single molecule protein screening
CA2745197A1 (en) 2008-12-01 2010-06-10 Research Triangle Institute Concurrent identification of multitudes of polypeptides
EP2370473B1 (en) * 2008-12-10 2016-05-11 The Scripps Research Institute Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US9566335B1 (en) 2009-09-25 2017-02-14 The Governing Council Of The University Of Toronto Protein sequencing method and reagents
WO2011056185A2 (en) 2009-11-04 2011-05-12 President And Fellows Of Harvard College Reactivity-dependent and interaction-dependent pcr
KR101866401B1 (ko) * 2010-04-05 2018-06-11 프로그노시스 바이오사이언스, 인코포레이티드 공간적으로 엔코딩된 생물학적 검정
US20110245101A1 (en) 2010-04-05 2011-10-06 Prognosys Biosciences, Inc. Co-localization affinity assays
KR20130043104A (ko) 2010-04-06 2013-04-29 카리스 라이프 사이언스 룩셈부르크 홀딩스 질병용 순환 생물학적 지표들
WO2011143583A1 (en) 2010-05-13 2011-11-17 Illumina, Inc. Binding assays for markers
CN103119165B (zh) 2010-09-27 2017-04-12 威泊根私人有限公司 制备富集文库的方法
CA2817111C (en) 2010-11-10 2019-03-05 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
WO2012112804A1 (en) * 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
US20120258871A1 (en) 2011-04-08 2012-10-11 Prognosys Biosciences, Inc. Peptide constructs and assay systems
EP3246416B1 (en) 2011-04-15 2024-06-05 The Johns Hopkins University Safe sequencing system
CA2835641C (en) 2011-05-11 2019-05-28 Exosome Diagnostics, Inc. Nucleic acid extraction from heterogeneous biological materials
WO2016069124A1 (en) 2014-09-15 2016-05-06 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
GB2577626B (en) 2011-06-23 2020-09-23 Univ Texas Identifying peptides at the single molecule level
EP3492606B1 (en) 2011-08-22 2023-10-04 Exosome Diagnostics, Inc. Urine biomarkers
US20130052665A1 (en) * 2011-08-25 2013-02-28 Bruce Xuefeng Ling Methods for diagnosis of systemic juvenile idiopathic arthritis
US9335292B2 (en) 2011-10-13 2016-05-10 Auburn University Electrochemical proximity assay
EP2776587A4 (en) 2011-11-10 2015-07-15 Exosome Diagnostics Inc LIQUOR ASSAY
US20150087526A1 (en) 2012-01-24 2015-03-26 The Regents Of The University Of Colorado, A Body Corporate Peptide identification and sequencing by single-molecule detection of peptides undergoing degradation
SMT202100154T1 (it) 2012-02-17 2021-05-07 Hutchinson Fred Cancer Res Composizioni e metodi per identificare precisamente mutazioni
US9862995B2 (en) 2012-03-13 2018-01-09 Abhijit Ajit Patel Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
WO2013142389A1 (en) 2012-03-20 2013-09-26 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
US9005888B2 (en) 2012-06-14 2015-04-14 System Biosciences, Llc Methods for microvesicle isolation and selective removal
NL2009191C2 (en) 2012-07-16 2014-01-20 Univ Delft Tech Single molecule protein sequencing.
CN114891871A (zh) 2012-08-14 2022-08-12 10X基因组学有限公司 微胶囊组合物及方法
US20140378322A1 (en) 2012-08-14 2014-12-25 10X Technologies, Inc. Compositions and methods for sample processing
US9557336B2 (en) * 2012-09-07 2017-01-31 University Of Rochester Methods and compositions for site-specific labeling of peptides and proteins
US20150252428A1 (en) 2012-10-03 2015-09-10 Exosome Diagnostics, Inc. Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions
AU2013340414B2 (en) 2012-10-23 2019-05-02 Caris Science, Inc. Aptamers and uses thereof
US9435810B2 (en) 2013-03-15 2016-09-06 Washington University Molecules and methods for iterative polypeptide analysis and processing
US10006919B2 (en) * 2013-03-15 2018-06-26 Arizona Board Of Regents On Behalf Of Arizona State University Peptide array quality control
WO2014142981A1 (en) 2013-03-15 2014-09-18 Illumina, Inc. Enzyme-linked nucleotides
EP2970959B1 (en) 2013-03-15 2018-05-30 Lineage Biosciences, Inc. Methods and compositions for tagging and analyzing samples
WO2014176355A1 (en) 2013-04-23 2014-10-30 President And Fellows Of Harvard College In situ interaction determination
WO2014189768A1 (en) * 2013-05-19 2014-11-27 The Board Of Trustees Of The Leland Devices and methods for display of encoded peptides, polypeptides, and proteins on dna
US20160122753A1 (en) * 2013-06-12 2016-05-05 Tarjei Mikkelsen High-throughput rna-seq
CN111500680B (zh) * 2013-06-25 2024-04-16 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
JP2016523978A (ja) * 2013-07-10 2016-08-12 プレジデント アンド フェローズ オブ ハーバード カレッジ 核酸−タンパク質複合体に関する組成物及び方法
BR112016004153A2 (pt) 2013-08-28 2019-09-17 Caris Life Sciences Switzerland Holdings Gmbh "método para caracterizar uma doença ou distúrbio, kit, composição, método para gerar uma biblioteca de entrada, oligonucleotídeo, pluralidade de oligonucleotídeos e método para identificar um aptâmero
WO2015042506A1 (en) 2013-09-23 2015-03-26 The Trustees Of Columbia University In The City Of New York High-throughput single molecule protein identification
US10288608B2 (en) 2013-11-08 2019-05-14 Prognosys Biosciences, Inc. Polynucleotide conjugates and methods for analyte detection
US9834814B2 (en) 2013-11-22 2017-12-05 Agilent Technologies, Inc. Spatial molecular barcoding of in situ nucleic acids
JP6156962B2 (ja) 2014-02-27 2017-07-05 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム エキソソームを単離するための方法および組成物
US10858698B2 (en) 2014-03-25 2020-12-08 President And Fellows Of Harvard College Barcoded protein array for multiplex single-molecule interaction profiling
EP3134536B1 (en) 2014-04-21 2019-12-18 President and Fellows of Harvard College Systems and methods for barcoding nucleic acids
WO2015163818A1 (en) 2014-04-24 2015-10-29 Nanyang Technological University Asx-specific protein ligase
WO2015166768A1 (ja) 2014-05-02 2015-11-05 国立大学法人金沢大学 単一細胞由来核酸の解析方法
EP3143165A4 (en) 2014-05-15 2018-05-16 Two Pore Guys, Inc. Scaffold data storage and target detection in a sample using a nanopore
KR20170026383A (ko) * 2014-06-26 2017-03-08 10엑스 제노믹스, 인크. 핵산 서열의 분석
EP4574974A3 (en) 2014-06-26 2025-10-08 10x Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
US11229607B2 (en) 2014-06-30 2022-01-25 President And Fellows Of Harvard College Hydrogel compositions comprising encapsulated cells and methods of use thereof
SG11201700146QA (en) 2014-07-09 2017-02-27 Exosome Diagnostics Inc Methods for isolating microvesicles and extracting nucleic acids from biological samples
US20170212101A1 (en) 2014-07-18 2017-07-27 Cdi Laboratories, Inc. Methods and compositions to identify, quantify, and characterize target analytes and binding moieties
AU2015296029B2 (en) * 2014-08-01 2022-01-27 Dovetail Genomics, Llc Tagging nucleic acids for sequence assembly
BR122021026779B1 (pt) 2014-10-17 2023-12-19 Illumina Cambridge Limited Transposon de preservação de contiguidade
US9771412B2 (en) 2014-10-31 2017-09-26 Wisconsin Alumni Research Foundation Engineered intein for improved production of protein-intein fusions
ES3062422T3 (en) 2015-02-10 2026-04-10 Illumina Inc Compositions for analyzing cellular components
WO2016138496A1 (en) * 2015-02-27 2016-09-01 Cellular Research, Inc. Spatially addressable molecular barcoding
US20180284125A1 (en) 2015-03-11 2018-10-04 The Broad Institute, Inc. Proteomic analysis with nucleic acid identifiers
WO2016164530A1 (en) 2015-04-07 2016-10-13 University Of Maryland, College Park Compositions and methods for high throughput protein sequencing
CA2988771A1 (en) 2015-06-09 2016-12-15 The Board Of Regents Of The University Of Texas System Diagnostic test for early stage cancer
EP3397764A4 (en) 2015-12-30 2019-05-22 Bio-Rad Laboratories, Inc. DIGITAL PROTEIN QUANTIFICATION
US11286517B2 (en) 2016-02-17 2022-03-29 President And Fellows Of Harvard College Molecular programming tools
KR102516168B1 (ko) 2016-05-02 2023-03-30 엔코디아, 인코포레이티드 암호화 핵산을 사용한 거대분자 분석
EP4108781A1 (en) 2016-05-27 2022-12-28 President and Fellows of Harvard College Conditional primer extension for single-molecule detection
WO2018005720A1 (en) 2016-06-30 2018-01-04 President And Fellows Of Harvard College Method of determining the molecular binding between libraries of molecules
CN109790574A (zh) 2016-07-22 2019-05-21 哈佛学院院长及董事 用于蛋白质鉴别的方法和组合物
EP4310183B1 (en) 2017-01-30 2025-07-09 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
DK3583214T5 (da) 2017-02-02 2024-09-02 New York Genome Center Inc Fremgangsmåder og sammensætninger til identificering eller kvantificering af mål i en biologisk prøve
WO2019089846A1 (en) 2017-10-31 2019-05-09 Encodia, Inc. Methods and compositions for polypeptide analysis
MX2020004559A (es) 2017-10-31 2020-10-05 Encodia Inc Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico.
US20210355483A1 (en) 2017-10-31 2021-11-18 Encodia, Inc. Methods and kits using nucleic acid encoding and/or label
CA3086915A1 (en) 2017-12-29 2019-07-04 Sujal M. Patel Decoding approaches for protein identification
EP3740567A4 (en) 2018-01-18 2022-03-09 Nanosomix Inc. DETECTION OF EXOSOMES AND EXOSOMAL BIOMARKERS FOR DIAGNOSIS AND PROGNOSIS OF DISEASES AND DISORDERS
US12270741B2 (en) 2018-04-03 2025-04-08 Tymora Analytical Operations, Llc Methods for affinity-based non-antibody capture and purification of extracellular vesicles

Also Published As

Publication number Publication date
US12517133B2 (en) 2026-01-06
KR102516168B1 (ko) 2023-03-30
EP4299803A2 (en) 2024-01-03
KR102741603B1 (ko) 2024-12-16
EP3452591A4 (en) 2019-12-04
CN119574874A (zh) 2025-03-07
US20240125792A1 (en) 2024-04-18
JP2019523635A (ja) 2019-08-29
DK3452591T5 (da) 2024-09-09
US20250164499A1 (en) 2025-05-22
US20240302382A1 (en) 2024-09-12
JP7796432B2 (ja) 2026-01-09
US20210302431A1 (en) 2021-09-30
NZ747941A (en) 2023-04-28
JP2020120682A (ja) 2020-08-13
DK3452591T3 (da) 2023-09-18
US12235276B2 (en) 2025-02-25
JP7333975B2 (ja) 2023-08-28
KR20220038549A (ko) 2022-03-28
JP2022126865A (ja) 2022-08-30
JP7120630B2 (ja) 2022-08-17
US12019077B2 (en) 2024-06-25
CA3022863A1 (en) 2017-11-09
WO2017192633A1 (en) 2017-11-09
SG11201809649WA (en) 2018-11-29
US12320813B2 (en) 2025-06-03
US20240295563A1 (en) 2024-09-05
AU2017259794A1 (en) 2018-11-22
CN110199019A (zh) 2019-09-03
KR20230047506A (ko) 2023-04-07
US20240393344A1 (en) 2024-11-28
WO2017192633A9 (en) 2017-12-14
US20230054691A1 (en) 2023-02-23
US20190145982A1 (en) 2019-05-16
EP3452591A1 (en) 2019-03-13
US11959922B2 (en) 2024-04-16
US12123878B2 (en) 2024-10-22
JP2022065157A (ja) 2022-04-26
AU2017259794B2 (en) 2023-04-13
CN110199019B (zh) 2024-09-10
EP4299803A3 (en) 2024-03-27
KR20190035613A (ko) 2019-04-03
JP2024041969A (ja) 2024-03-27
EP3452591B1 (en) 2023-08-16
US20240302381A1 (en) 2024-09-12
JP7097627B2 (ja) 2022-07-08
CN119574873A (zh) 2025-03-07
US12019078B2 (en) 2024-06-25
US20210405058A1 (en) 2021-12-30
KR102379048B1 (ko) 2022-03-28
SG10201911917WA (en) 2020-01-30

Similar Documents

Publication Publication Date Title
AU2017259794A1 (en) Macromolecule analysis employing nucleic acid encoding
CL2021001179A1 (es) Anticuerpos específicos para tl1a y ácidos nucleicos que los codifican (divisional de la solicitud no. 201801596).
CL2020003409A1 (es) Moléculas de unión específicas para cd73 y métodos de fabricación de las mismas (divisional de la solicitud no. 201701154)
EP3704249C0 (en) ANALYSIS KITS USING NUCLEIC ACID CODING AND/OR LABELING
IL282981A (en) Compositions, methods and systems for protein corona analysis and uses thereof
BR112017017025A2 (pt) métodos e composições para analizar componentes celulares
CL2018000490A1 (es) Anticuerpos anti-pd1 y sus métodos de uso
EA201990986A1 (ru) Способы и системы анализа хроматографических данных
MX2017012059A (es) Determinacion de modo de derivacion de informacion de movimiento en codificacion de video.
WO2014200912A3 (en) Mathematical processes for determination of peptidase cleavage
EA201890611A1 (ru) Библиотеки модульных полипептидов и способы их получения и применения
MX2016010791A (es) Inmunoterapia con multiples objetivos dirigida por biomarcadores.
DK3253795T3 (da) Hidtil ukendte bindende proteiner, der omfatter et ubiquitin-mutein, og antistoffer eller antistoffragmenter
EP3482325A4 (en) COMPUTER ANALYSIS OF PREDICTION OF CHEMICAL BINDING TARGETS
EP3403332C0 (en) CODING BLOCK SEGMENTATION FOR PAYLOAD-DEPENDENT ADAPTIVE CODING USING TURBO AND LDPC CODES
BR112017023131A2 (pt) anticorpos anti- fcrn
ITUA20161534A1 (it) Procedimento per analizzare un velivolo, relativo sistema di analisi di un velivolo e sistema di sghiacciamento e/o antigelo
MX2017005888A (es) Dispositivos, sistemas y metodos para la deteccion de analitos.
CL2020001137A1 (es) Anticuerpos anti-apoc3 y métodos de uso de estos.
BR112016026890A2 (pt) método de determinação de uma distância entre dois vértices método de determinação de uma distância entre dois nós em uma rede massiva e sistema para determinar uma distância entre dois nós em uma rede massiva
MX391968B (es) Metodo y sistema electronico para predecir al menos un valor de eficacia biologica de una proteina identificado con un producto de programa de computadora.
MX2016013849A (es) Un factor de secrecion de proteinas con alta eficacia secretora y un vector de expresion que lo comprende.
BR112017002622A2 (pt) métodos e sistemas para quantificação seletiva e detecção de alergênicos
BR112018071107A2 (pt) composições e métodos para a detecção de proteínas da célula hospedeira
MX388197B (es) Método para la reducción de proteínas de células hospederas en cromatografía de afinidad.